LOCUS       NM_020204               7865 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens LIM homeobox 9 (LHX9), transcript variant 1, mRNA.
ACCESSION   NM_020204
VERSION     NM_020204.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7865)
  AUTHORS   Zhao,H., Jiang,R., Feng,Z., Wang,X. and Zhang,C.
  TITLE     Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase
            PKM2 activity to induce glycolytic metabolic reprogramming in
            cancer stem cells, promoting gastric cancer progression
  JOURNAL   J Transl Med 21 (1), 833 (2023)
   PUBMED   37980488
  REMARK    GeneRIF: Transcription factor LHX9 (LIM Homeobox 9) enhances
            pyruvate kinase PKM2 activity to induce glycolytic metabolic
            reprogramming in cancer stem cells, promoting gastric cancer
            progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7865)
  AUTHORS   Okutomo,K., Fujino,N., Yamada,M., Saito,T., Ono,Y., Okada,Y.,
            Ichinose,M. and Sugiura,H.
  TITLE     Increased LHX9 expression in alveolar epithelial type 2 cells of
            patients with chronic obstructive pulmonary disease
  JOURNAL   Respir Investig 60 (1), 119-128 (2022)
   PUBMED   34548271
  REMARK    GeneRIF: Increased LHX9 expression in alveolar epithelial type 2
            cells of patients with chronic obstructive pulmonary disease.
REFERENCE   3  (bases 1 to 7865)
  AUTHORS   Luo,X., Ge,J., Chen,T., Liu,J., Liu,Z., Bi,C. and Lan,S.
  TITLE     LHX9, a p53-binding protein, inhibits the progression of glioma by
            suppressing glycolysis
  JOURNAL   Aging (Albany NY) 13 (18), 22109-22119 (2021)
   PUBMED   34536269
  REMARK    GeneRIF: LHX9, a p53-binding protein, inhibits the progression of
            glioma by suppressing glycolysis.
REFERENCE   4  (bases 1 to 7865)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7865)
  AUTHORS   Hu,F., Zhu,Q., Sun,B., Cui,C., Li,C. and Zhang,L.
  TITLE     Smad ubiquitylation regulatory factor 1 promotes LIM-homeobox gene
            9 degradation and represses testosterone production in Leydig cells
  JOURNAL   FASEB J 32 (9), 4627-4640 (2018)
   PUBMED   29565736
  REMARK    GeneRIF: that Smurf1 promotes Lhx9 ubiquitylation and is involved
            in testosterone production in Leydig cells directly
REFERENCE   6  (bases 1 to 7865)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 7865)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 7865)
  AUTHORS   Ottolenghi,C., Moreira-Filho,C., Mendonca,B.B., Barbieri,M.,
            Fellous,M., Berkovitz,G.D. and McElreavey,K.
  TITLE     Absence of mutations involving the LIM homeobox domain gene LHX9 in
            46,XY gonadal agenesis and dysgenesis
  JOURNAL   J Clin Endocrinol Metab 86 (6), 2465-2469 (2001)
   PUBMED   11397841
REFERENCE   9  (bases 1 to 7865)
  AUTHORS   Retaux,S., Rogard,M., Bach,I., Failli,V. and Besson,M.J.
  TITLE     Lhx9: a novel LIM-homeodomain gene expressed in the developing
            forebrain
  JOURNAL   J Neurosci 19 (2), 783-793 (1999)
   PUBMED   9880598
REFERENCE   10 (bases 1 to 7865)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590115.7 and AY273889.2.
            
            On Nov 23, 2018 this sequence version replaced NM_020204.2.
            
            Summary: This gene encodes a member of the LIM homeobox gene family
            of developmentally expressed transcription factors. The encoded
            protein contains a homeodomain and two cysteine-rich zinc-binding
            LIM domains involved in protein-protein interactions. The protein
            is highly similar to a mouse protein that causes gonadal agenesis
            when inactivated, suggesting a role in gonadal development.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY273889.2, BC131622.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367387.6/ ENSP00000356357.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL590115.7         138173-138187
            16-2530             AY273889.2         1-2515
            2531-7865           AL590115.7         150945-156279
FEATURES             Location/Qualifiers
     source          1..7865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.3"
     gene            1..7865
                     /gene="LHX9"
                     /note="LIM homeobox 9"
                     /db_xref="GeneID:56956"
                     /db_xref="HGNC:HGNC:14222"
                     /db_xref="MIM:606066"
     exon            1..626
                     /gene="LHX9"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1646
                     /gene="LHX9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LIM/homeobox protein Lhx9; LIM homeobox protein 9"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx9 isoform 1"
                     /protein_id="NP_064589.2"
                     /db_xref="CCDS:CCDS1393.1"
                     /db_xref="GeneID:56956"
                     /db_xref="HGNC:HGNC:14222"
                     /db_xref="MIM:606066"
                     /translation="MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTE
                     ARLAKGAQLNGRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECK
                     LALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFT
                     CSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNG
                     TGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKH
                     HQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGV
                     DKADGTSLPAPPSADSGALTPPGTATTLTDLTNPTITVVTSVTSNMDSHESGSPSQTT
                     LTNLF"
     exon            627..829
                     /gene="LHX9"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1185
                     /gene="LHX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1388
                     /gene="LHX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..7865
                     /gene="LHX9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX9"
                     /note="hexamer: ATTAAA"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX9"
                     /note="hexamer: AATAAA"
     polyA_site      3846
                     /gene="LHX9"
                     /note="major polyA site"
     polyA_site      3860
                     /gene="LHX9"
     regulatory      4953..4958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX9"
                     /note="hexamer: AATAAA"
     polyA_site      4975
                     /gene="LHX9"
     regulatory      5644..5649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX9"
                     /note="hexamer: ATTAAA"
     polyA_site      5666
                     /gene="LHX9"
     regulatory      7843..7848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX9"
                     /note="hexamer: AATAAA"
     polyA_site      7865
                     /gene="LHX9"
ORIGIN      
        1 agtccccaac ccaatctaca ggcactggga acttgcaagc agccagggaa cgctgaaaat
       61 agcacgtctt tttctttctt tgtgttcaaa actattttct ttcttcacca gattttgttt
      121 tcctcccccc gctgcagttg tttcccatta gtaactcgat ctctcagagc agtaagattc
      181 gccttctacg cctctttttc cctccgcccg aattgtttgt tttctgcaca tctccttcag
      241 ggagccgctg aggcttcccc ccaactcttc ccagttcttt ttgcttcccc tcggcccccc
      301 aagcagaccg atttccactc catctgtttc ttctcctcct ttctctccct ctttccctcc
      361 atcctcgagc gtctctgcgc tcctacaggg cagccctctc tggtcccttg cctccttcac
      421 tcggatgagc tgaaagcccc gggcgtgtgt atatggaaat agtggggtgc cgagcagaag
      481 acaactcgtg tcctttccgc cccccagcca tgctctttca cgggatctcc ggaggccaca
      541 tccaaggcat catggaggag atggagcgca gatccaagac tgaggcccgt ctggccaaag
      601 gcgcccagct caacggccgc gacgcgggca tgcccccgct cagcccggag aagcccgccc
      661 tgtgcgccgg ctgcgggggc aagatctcgg acaggtacta tctgctggct gtggacaaac
      721 agtggcatct gagatgcctg aagtgctgtg aatgtaagct ggccctcgag tccgagctca
      781 cctgctttgc caaggacggt agcatttact gcaaggagga ttactacaga aggttctctg
      841 tgcagagatg tgcccgctgc caccttggca tttccgcctc ggagatggtc atgcgcgccc
      901 gagactctgt ctaccacctg agctgcttca cctgctccac ttgcaacaag actctgacca
      961 cgggcgacca tttcggcatg aaggacagcc tggtgtactg ccgcgcccac ttcgagaccc
     1021 tcttgcaagg agagtatcca ccgcagctga gctacacgga gctggcggcc aagagcggcg
     1081 gcctggccct gccttacttc aacggtacgg gcaccgtgca gaaagggcgg ccccggaagc
     1141 ggaagagccc agcgctggga gtggacatcg tcaattacaa ctcaggttgt aatgagaatg
     1201 aggcagacca cttggaccgg gaccagcagc cttatccacc ctcgcagaag accaagcgca
     1261 tgcgaacctc tttcaagcat caccagctcc ggaccatgaa atcctacttt gccatcaacc
     1321 acaacccgga tgccaaggac ctcaagcagc ttgcccagaa aacaggtctg accaaaagag
     1381 ttttgcaggt ttggttccaa aacgcacgag ccaaattcag aaggaacctt ttgcggcagg
     1441 agaatggggg tgttgataaa gctgacggca cgtcgcttcc ggccccgccc tcagcagaca
     1501 gcggagctct cactccaccc ggcactgcga ccactttaac agacctgacc aatcccacta
     1561 tcactgtagt gacatccgtg acctctaaca tggacagcca cgaatccgga agcccctcac
     1621 aaactacctt aacaaacctt ttctaacatt ggtttttttt ttttagtttt taaattcttc
     1681 ctcttctttt tattattatt ctaattatta ttattttatt atttacaaga cttttttttt
     1741 cttctaaccc acaagatatt tggggaataa aaataacagc ttggtgtgta gcatctgcag
     1801 ccacttggca aatgagttta cagtattgtc tcctttaagt gaatatattt tgtctacaaa
     1861 gtgtatttgg atttaaaaaa attaattagg tctttcagtt ggtaaggaga gtttttgaat
     1921 aattctaata agtgcctctt aaaattgtat gttacttatt tccagaatct cgaagaaaaa
     1981 agaaaaaaga gtggtattat tatgggcaaa taatcatatt cccacttaaa tgattaggtt
     2041 aataaagaac cagataatta attagttact ttttaaatct tgcaattgta tgtgtgatta
     2101 tggagttttg aaaacgttac attttttaaa tcttaaaact gaaaacttgt ttttagtatt
     2161 tctatttctt acctgaactg ttaattcaag tgaggaatat gatgaaataa aagcattaac
     2221 tacagacatt ttaaatagta atgattaatt aggtgagaaa tctattacag gaatgtgact
     2281 tttccttctc ttaggggtgt acaactctaa aaacttttta cttggttatt tgtttttcaa
     2341 catttgaaaa atacttaagc tccctatgta tccatgaaaa ttccgcattg attttgacat
     2401 tccatacttt taacctccta aagctaaaaa caatagctcg gaaaccattc tttctagtta
     2461 ctttttttcc cagggaaaat ggaaataagc aaaatataat gttttaagaa gtaaaaaaat
     2521 caatataatt taattaatag ctctattaat tggcttcagc tgtaccatga tattgtatct
     2581 ggcattctat atgaataatg tttaaaatac ccagcctggt agacttatac caacaattgg
     2641 ttttgttttg ttttatttta ttttgacata ggttgactta tgtattgaaa ataatttttc
     2701 tgatattaga gatttgaagt tattagtctt aaagtagata aactcagaag ccttgtggat
     2761 gctgatctga atatatttcc tagtttacag tagcattttt ttcttttaat ttaagctaaa
     2821 atcttaatgg tctgggcagt ggtgaatgtt catctattac gcttctgttg tagttaaata
     2881 ccaattagat tgtggatttc ctaaaaaaat aaaaaagaag tcaagatata tgtcttgctt
     2941 tagtggattg ttaagaataa ctttgcacat attttccact ttttggaccc cttaaatctc
     3001 ctttggtggt cgaagtggct atttaataga ttttaaaggt gtccttctgg ctgtataaat
     3061 gtgtggttac atattgacag ttcactgccc acattaaagt gcattattgt aacttttgct
     3121 cagggtcttt agaaaattag cacagaaagt agcttatttt ttaaaaaaag atgatggaag
     3181 ataagttaac actgtaacag aagaaaggtg tgattgccat tatatattta gcaagtatgg
     3241 ttatcatctt atatggagct taaatcttga cttttcatac ttctattaca ttttgggcat
     3301 ttaccactaa ccagaccaaa caaccttggt aaggctgaga tcttattaat acacttttac
     3361 aggtaaaata ttgacactta taaattttgt tctttgacag aacaatatat ggtactatat
     3421 agatctactt tattaagtag actaattata actcagttct cctatgtgcc ttatgatata
     3481 acttggaagt aagtttgtga aaaatcagga tatatgtgtt gtttgttaaa ttaactgttt
     3541 taagcccttt taacacctca ctagttttgt actgttttac ctcttatttc tgaaactctt
     3601 tttatggtgt atcctgttag aggggacaaa catgtcatag aaagcagttg tgcactcttt
     3661 caaatatagt tgataaattc aataatctta tatattgagc ttcgtgttta tagtacagta
     3721 agtggtctag caaaattgtc catgtttctt tgtttattga taaatgcatt gtatagaaac
     3781 tatttcccct aaatatttat ggaccaaaca attgtgatat atcctattaa atttgtgtga
     3841 ataaaacatt ttgaatctaa ggagttttct ttcccatcag ttttatttaa gttttaaccg
     3901 tactagtgtg ttccagcatc tatatgtaaa agcttttcaa atggtaatac aacattgtta
     3961 gaaatattta aacatacaaa tagtttttag acttccaaac ttctgattca tatgaaatgt
     4021 tacacattgt tgcacaggca gtgtaattca acctagaaat acctttgaat atatttgctt
     4081 ataacaaaag taatgcccca ctgatttgac tcagtccaat ttttagaata aaaaggctaa
     4141 ttagcatata aagtaattgc atggaacgaa accttaaata tgattaagat ttcatgttag
     4201 gtctattgag cacaaatgga tatttgtaaa tctaaataga aattgcagac ccctaaaagc
     4261 caagttgctc tgtagttaat aaattgtcac tatgattttt ttcagggaga acaaatcttg
     4321 gggcattaca gccaaacatc ccgacgtttg aaaattccct aaagtattaa aagaagggga
     4381 aaagtttgat cggaaatcca ctgcagtgaa gacaaagaca ctattaggtt atgataatca
     4441 tacattaaaa aatttattaa gccaaaaaaa aagagagaga gagagactta aatgtcattt
     4501 actgaatgtt aacgaaactt gtgttcttta tggtgtctaa cacaactgaa ggcctaaaat
     4561 tatgtggttt aaacaaaatt agataaacca tgtacaaaac cagagcaacc tggcagtaat
     4621 atgcccaccc catatttgaa aaaaattatt attgaaaaaa atttcacaca tttgtcaagc
     4681 acagttgtaa aataaagtcc aaaacattca tttcacctgc ttgctaatgt gtattagtcc
     4741 tgttaatggc attttccaac tgtaaattca aagaaaagct atcacccatt taagagtata
     4801 gggatcaaac cccagtaatt ttagcattat tgtttatcac ttccttttta aacagaaatc
     4861 tctgcatgca cttttacata tgtcacctct agtgtacacc tctgtatgat gacttatctt
     4921 tgctgtttct tgtatgataa atagctttca ttaataaaca tttatttgat gcaaacatag
     4981 ttaactttat gttaaacaca tgctgttgaa attaattttg aacacttaaa gaggcagcac
     5041 agtacattta caacttgtta tactaatgaa aaaatacaaa cagcatagtg agattaaatt
     5101 ctggtaatct aggataaaat tacttacttg gtttttacct tttcatgact tattttcatt
     5161 tgttgtattc aattgccaca tgtattaaaa ataaaaaaca aagtgaaccc aaattacaac
     5221 aaaataaacc ttagaataaa ctattgtgta aaatttcagc aactttttta gattactagg
     5281 gtaaaattta tagatcctat gtgagtttac atgtttgcta tgcaatgaac aaatttattg
     5341 atgtatacaa atatattctg aactataaaa agatccaatc tttgcatagt tcaattacat
     5401 atgattatta caaacaaaaa agcaaatgga aagacagaca aatatttagg aatgaggttt
     5461 tttttaattg ttaaagggaa tatttgaaga ataaaatttt agctattcct atttagccgt
     5521 atatccaaag catatgttaa acaaactaac atatactttc cagaaaattt ttcattatga
     5581 tgaaattttt attatataca aatgaaccct atgtaaatga tgtaactttt atgaatgaca
     5641 gacattaaat atttcactta catgtattct cagaattttg aatgttttct taaatgcttt
     5701 cacttcctga ataataaaaa gaaaaaattt taaagaagag agagcaactt actaataaaa
     5761 aaaagcaatg caccatgaca agtagactat tttgagtgat cacaaatcat gctggttttg
     5821 tcagtaactt gaatgtttat gcctcattga aacctcatcc acagctatag caacttaaat
     5881 agattttcca atgcatttcc agccagttta ttcaaatctt tgccctacag tcttgccttc
     5941 tttccctgtt ctgtcacctg tggcaatttc atttagaagt attttggaac ttcgcctggt
     6001 tttacagacc tttaaatatt tgtctggtat gtgaaatgca ggaagagacc agagagggaa
     6061 agaacataac tgaaattaga catctgaaaa aaaaatacaa atttgaaaca ggcacatttt
     6121 ttaaaaccaa aaaaaaaaaa aaaaagagag agagagagaa aggagtacta attatgtgag
     6181 tgggaagagg aagcgtgtga tgcagagctg gaaggtctgt tgtgctttac tgtgatgtaa
     6241 agcagtcttt gagtctgggc aactgcacat ttactgtttg gtgtggaata gaaaaatgtg
     6301 gacctcttag ttgagagcag gacactaaat tttcatagct tctacctccc agttgcctgg
     6361 gttagtctaa cttctggcag attgatcttg ggcaaaaagc ttcactgaga gttagtgtct
     6421 gtgtgctttg gttgaatagc caccttaata ctgacttaca tagtgggtag gtttttgata
     6481 cctcaaataa ggataaaact ccataataaa ggacccaaag caaatacttt taaaacttag
     6541 gtgatttttc atcacctaaa acataaatag ctttatttag caaaatccca gtggaatcta
     6601 ccacacattc ttttataata accctttttt gggagtcaaa gtattgtttt tttattagcc
     6661 acatataaat atcatctcat tttctgttgc agtgtgactg caaggcatgt tgtggtggaa
     6721 atcattagaa ctgggaagct ctggaatgga aatttggaat cgtgtcattc taggctctta
     6781 aagagaatat tagggataat actgttgtaa aaaataaata taaacaccta attttgtatg
     6841 aagttttgct atttaaattt taactatgtt ataaacaaag ctagctttac ttgtagagag
     6901 ttcgtgtact cttgagctca ttcaatagct tttacatttt gtagtctctt ccacaacagg
     6961 gcaaaataag cacagtagga cttagtccaa attgacgaaa tatcattgaa ttttctttga
     7021 aagcatatat atagataaac tctggattgg tcttttagat ctgttttctg tttttagtaa
     7081 ttgggaacaa actcttgata ttaaaataaa taaaatgcct ctaatgtaaa gccacagccc
     7141 tgcttctagc caatgtcaaa aataggaagt ttttttaatg gtttactgtt gattttaaac
     7201 attttaataa tagtgctctg ccctcacaac agtttttttt tcagaataat attatgattt
     7261 accttatttt aaaaataaat tataattcta acttaaaata ttattttaaa tgcccctctg
     7321 ggaagatttc cgttttattt tatgaggttc cctggcagtt gggggggtgg tgaggttggg
     7381 agagggaaag tttagaactg tgcatgatac tcaaggaaaa gtctatgaat atgatgtaag
     7441 tagtaacatt attgccacaa ctaaatttct gtttaactgt gttgcagaat atgataatgt
     7501 catctaacat cactccctac ttgcaacatt cctctgtgaa tattaatata gttaaccctc
     7561 ccttattatg tatcatatca ataagtttct cttcccttgg attaattttt gcttctttgc
     7621 attacatttt atcttgtgct aagataacaa aaagcaagca agaataaaga tccagatatt
     7681 agccatatgt agaaagttcc tggtgtgcat ttctgtgtac ttttccctca catattagaa
     7741 ttgtcaggaa agtttttttc ttttggaact ttctgtttac attttgcatg atcttataaa
     7801 ttaacctgaa gagtaattgg atacctttta tggttatttg aaaataaaat ttgctacaaa
     7861 taaga
//
