LOCUS       NM_022363               2739 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens LIM homeobox 5 (LHX5), mRNA.
ACCESSION   NM_022363
VERSION     NM_022363.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2739)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2739)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2739)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 2739)
  AUTHORS   Green,E.K., Elvidge,G.P., Owen,M.J. and Craddock,N.
  TITLE     Mutational analysis of two positional candidate susceptibility
            genes for bipolar disorder on chromosome 12q23-q24: phenylalanine
            hydroxylase and human LIM-homeobox LHX5
  JOURNAL   Psychiatr Genet 13 (2), 97-101 (2003)
   PUBMED   12782966
  REMARK    GeneRIF: Variation is not a highly penetrant autosomal dominant
            susceptibility locus for mood disorder in families.
REFERENCE   5  (bases 1 to 2739)
  AUTHORS   Paylor,R., Zhao,Y., Libbey,M., Westphal,H. and Crawley,J.N.
  TITLE     Learning impairments and motor dysfunctions in adult Lhx5-deficient
            mice displaying hippocampal disorganization
  JOURNAL   Physiol Behav 73 (5), 781-792 (2001)
   PUBMED   11566211
  REMARK    GeneRIF: In mice, this protein is involved in learning and motor
            functions.
REFERENCE   6  (bases 1 to 2739)
  AUTHORS   Zhao,Y., Hermesz,E., Yarolin,M.C. and Westphal,H.
  TITLE     Genomic structure, chromosomal localization and expression of the
            human LIM-homeobox gene LHX5
  JOURNAL   Gene 260 (1-2), 95-101 (2000)
   PUBMED   11137295
REFERENCE   7  (bases 1 to 2739)
  AUTHORS   Zhao,Y., Sheng,H.Z., Amini,R., Grinberg,A., Lee,E., Huang,S.,
            Taira,M. and Westphal,H.
  TITLE     Control of hippocampal morphogenesis and neuronal differentiation
            by the LIM homeobox gene Lhx5
  JOURNAL   Science 284 (5417), 1155-1158 (1999)
   PUBMED   10325223
  REMARK    GeneRIF: In mice, this protein is essential for the regulation of
            precursor cell proliferation and the control of neuronal
            differentiation and migration during hippocampal development.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009773.27.
            
            On Nov 26, 2018 this sequence version replaced NM_022363.2.
            
            Summary: This gene encodes a protein belonging to a large protein
            family, members of which carry the LIM domain, a unique
            cysteine-rich zinc-binding domain. The encoded protein may function
            as a transcriptional regulator and be involved in the control of
            differentiation and development of the forebrain. In mice, this
            protein is essential for the regulation of precursor cell
            proliferation and the control of neuronal differentiation and
            migration during hippocampal development. This protein is involved
            in learning and motor functions in adult mice. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF291181.1, BC109230.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142586,
                                           SAMEA2145743 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261731.4/ ENSP00000261731.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               AC009773.27        85830-86375
            547-770             AC009773.27        88356-88579
            771-1048            AC009773.27        89297-89574
            1049-1214           AC009773.27        90280-90445
            1215-2739           AC009773.27        94144-95668
FEATURES             Location/Qualifiers
     source          1..2739
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..2739
                     /gene="LHX5"
                     /note="LIM homeobox 5"
                     /db_xref="GeneID:64211"
                     /db_xref="HGNC:HGNC:14216"
                     /db_xref="MIM:605992"
     exon            1..546
                     /gene="LHX5"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1582
                     /gene="LHX5"
                     /note="LIM homeobox protein 5"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx5"
                     /protein_id="NP_071758.1"
                     /db_xref="CCDS:CCDS9171.1"
                     /db_xref="GeneID:64211"
                     /db_xref="HGNC:HGNC:14216"
                     /db_xref="MIM:605992"
                     /translation="MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCF
                     SREGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTG
                     EELYVIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNST
                     SSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETG
                     LNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPY
                     TYYGDYQGDYYAPGSNYDFFAHGPPSQAQSPADSSFLAASGPGSTPLGALEPPLAGPH
                     AADNPRFTDMISHPDTPSPEPGLPGTLHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHP
                     NPELNEAAVW"
     exon            547..770
                     /gene="LHX5"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1048
                     /gene="LHX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1214
                     /gene="LHX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2739
                     /gene="LHX5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2714..2719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX5"
                     /note="hexamer: AATAAA"
     polyA_site      2739
                     /gene="LHX5"
                     /note="major polyA site"
ORIGIN      
        1 agacaaagat gaggatccgg accgcttgaa agtgggggaa agtgccggcg cctccgccac
       61 cggggaaagc cgctccgcag cgccgaggcc agcagccacc cgagatacct ggggaagccc
      121 ggaacaggcg ccggggcgtg cggcccgtgg catgaggttg tgaacgccac ccgcccccca
      181 ccaccccact ccgggcagcc cagcgccagg ccagagattg cccaaggact ggaccggctg
      241 agtcttggtc cggaccagac tcgccctgca gctgctgaga caagaggcga agggcagcgg
      301 agggcccggc aggcccgagg gccaggggcc caaagggagg gcaaggcggc cgaagccgcc
      361 ggggcgcggg gctatgatgg tgcactgcgc cggttgcgag cggcccatcc tcgaccgctt
      421 tctgctgaac gtgctggacc gcgcgtggca catcaaatgt gttcagtgct gcgagtgcaa
      481 aaccaacctc tcggagaagt gcttctcgcg cgagggcaag ctctactgca aaaatgactt
      541 tttcaggcgc tttggcacga aatgcgccgg ctgcgcgcaa ggcatctcgc ccagcgacct
      601 ggtgcgcaag gcccggagca aagtctttca cctcaactgt ttcacctgca tggtgtgtaa
      661 caagcagctg tccaccggcg aggagctcta cgtcatcgac gagaacaagt tcgtgtgcaa
      721 agacgactac ctgagctcat ccagcctcaa ggagggcagc ctcaactcag tgtcatcctg
      781 tacggaccgc agtttgtccc cggacctcca ggacgcactg caggacgacc ccaaagagac
      841 ggacaactcg acctcgtcgg acaaggagac ggccaacaac gagaacgagg agcagaactc
      901 gggcaccaag cggcgcggcc cccgcaccac catcaaggcc aagcagctgg agacgctcaa
      961 ggctgccttc gccgccacgc ccaagcccac gcgccacatc cgcgagcagc tggcgcagga
     1021 gaccggcctc aacatgcgcg tcatccaggt gtggtttcag aaccgacggt ccaaagaacg
     1081 ccggatgaaa cagctgagcg ccctaggcgc ccggaggcac gccttcttcc ggagtccgcg
     1141 gcgcatgcgt ccgctgggcg gccgcttgga cgagtctgag atgttggggt ccaccccgta
     1201 cacctactac ggagactacc aaggcgacta ctacgcgccg ggaagcaact acgacttctt
     1261 cgcgcacggc ccgccttcgc aggcgcagtc cccggccgac tccagcttcc tggcggcctc
     1321 tggccccggc tcgacgccgc tgggagcgct ggaaccgccg ctcgccggcc cgcacgccgc
     1381 ggacaacccc aggttcaccg acatgatctc gcacccggac acaccgagcc ccgagccagg
     1441 cctgccgggc acgctgcacc ccatgcccgg cgaggtattc agcggcgggc ccagcccgcc
     1501 cttcccaatg agcggcacca gcggctacag cggacccctg tcgcatccca accccgagct
     1561 caacgaagcc gccgtgtggt aaggccgccg ggccgccccc cgcgctcggc ccccgggggc
     1621 cccgccccga agcagcctcc tgaaaccaaa acgcccgacg cagacgcggt gggagacgtg
     1681 ggtgtccctc gggggttctc tctcgggtcc gcactcaact ggcagctgct cctcggctgg
     1741 gcgccgaggg ggggccgacc cccatctcca ccccgcgggc tctccaggag cctcagccca
     1801 ccgccagtac tctcccagca accgcgagca atttcttggg accaaagtca atactccgga
     1861 gggtcaagag atttcgagca cgctctagac tttccccggg cccccaccca cccacccagc
     1921 caccgccacc tctttggact gagagagggt gaggccaagg ggcggagacg gtgtttttcc
     1981 ctctctctgc aatccgagtg gcattttgta atcttatttc tcgctgtgct ttccccgtct
     2041 ttaaaaaaaa agatgataag aaaaggagag agattgaaag agagggagag gaaagggggc
     2101 aagatgagga ggagatggag agacagcgtc agccagaggg agaagacgga gagcgagcga
     2161 ggaactcgcg tgaaccggga gccaccgaga gggagaccga gccacctgca cgctggcgct
     2221 ccctggtggc caatcttgag gctcaaggtc agcttctcta ggaatagggc tgtgggtcag
     2281 gaagtggcca gccgggtcca gctcccgctc ttccttactt tgacgtttat gttgagcccg
     2341 agggagcagg ccggactcga acacgcacac atcctgctct ccccctgggt ggggcgccag
     2401 gattgctggg ctcagaccca cagaccaccc tccctgccca gggcctggag gctgggccgt
     2461 caggatgtac aatattatac ttttttggaa gttgaacgct tctagtttcc ttattttgta
     2521 taaagaagaa acaaataaag tatgtttttg tgtttactgt ttatttattg tactctagtt
     2581 atccggggtt ggacattttt atatttttaa gaggaggtag ggcagagtga cggaggggaa
     2641 gcagaaagag gtttacctaa aaaaaacaaa aaacaaaaac aaaaaaaatc aacttttttt
     2701 aaagagaaag attaataaaa aaaaatcttt tttccctca
//
