LOCUS       NM_033343               5844 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LIM homeobox 4 (LHX4), mRNA.
ACCESSION   NM_033343
VERSION     NM_033343.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5844)
  AUTHORS   Kirkgoz,T., Gursoy,S., Acar,S., Nalbantoglu,O., Ozkaya,B., Anil
            Korkmaz,H., Hazan,F. and Ozkan,B.
  TITLE     Genetic diagnosis of congenital hypopituitarism in Turkish patients
            by a target gene panel: novel pathogenic variants in GHRHR, GLI2,
            LHX4 and POU1F1 genes
  JOURNAL   Arch Endocrinol Metab 68, e220254 (2023)
   PUBMED   37948564
  REMARK    GeneRIF: Genetic diagnosis of congenital hypopituitarism in Turkish
            patients by a target gene panel: novel pathogenic variants in
            GHRHR, GLI2, LHX4 and POU1F1 genes.
REFERENCE   2  (bases 1 to 5844)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5844)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5844)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5844)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5844)
  AUTHORS   Sobrier,M.L., Attie-Bitach,T., Netchine,I., Encha-Razavi,F.,
            Vekemans,M. and Amselem,S.
  TITLE     Pathophysiology of syndromic combined pituitary hormone deficiency
            due to a LHX3 defect in light of LHX3 and LHX4 expression during
            early human development
  JOURNAL   Gene Expr Patterns 5 (2), 279-284 (2004)
   PUBMED   15567726
  REMARK    GeneRIF: LHX4 expression is transient, and, at 6 weeks of
            development, is stronger at the caudal than at the cervical level.
REFERENCE   7  (bases 1 to 5844)
  AUTHORS   Kawamata,N., Sakajiri,S., Sugimoto,K.J., Isobe,Y., Kobayashi,H. and
            Oshimi,K.
  TITLE     A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute
            lymphoblastic leukemia involves the LIM homeodomain protein gene,
            Lhx4
  JOURNAL   Oncogene 21 (32), 4983-4991 (2002)
   PUBMED   12118377
REFERENCE   8  (bases 1 to 5844)
  AUTHORS   Liu,Y., Fan,M., Yu,S., Zhou,Y., Wang,J., Yuan,J. and Qiang,B.
  TITLE     cDNA cloning, chromosomal localization and expression pattern
            analysis of human LIM-homeobox gene LHX4
  JOURNAL   Brain Res 928 (1-2), 147-155 (2002)
   PUBMED   11844481
REFERENCE   9  (bases 1 to 5844)
  AUTHORS   Machinis,K., Pantel,J., Netchine,I., Leger,J., Camand,O.J.,
            Sobrier,M.L., Dastot-Le Moal,F., Duquesnoy,P., Abitbol,M.,
            Czernichow,P. and Amselem,S.
  TITLE     Syndromic short stature in patients with a germline mutation in the
            LIM homeobox LHX4
  JOURNAL   Am J Hum Genet 69 (5), 961-968 (2001)
   PUBMED   11567216
  REMARK    GeneRIF: germline mutations; phenotype characterized by short
            stature and by pituitary, hindbrain, and skull abnormalities
REFERENCE   10 (bases 1 to 5844)
  AUTHORS   Li,H., Witte,D.P., Branford,W.W., Aronow,B.J., Weinstein,M.,
            Kaur,S., Wert,S., Singh,G., Schreiner,C.M., Whitsett,J.A. et al.
  TITLE     Gsh-4 encodes a LIM-type homeodomain, is expressed in the
            developing central nervous system and is required for early
            postnatal survival
  JOURNAL   EMBO J 13 (12), 2876-2885 (1994)
   PUBMED   7913017
  REMARK    GeneRIF: In mice, a similar protein plays a critical role in the
            development of respiratory control mechanisms and in the normal
            growth and maturation of the lung.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139141.23, BX954266.1,
            AF179849.1 and BC011759.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_033343.3.
            
            Summary: This gene encodes a member of a large protein family which
            contains the LIM domain, a unique cysteine-rich zinc-binding
            domain. The encoded protein is a transcription factor involved in
            the control of differentiation and development of the pituitary
            gland. Mutations in this gene cause combined pituitary hormone
            deficiency 4. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.111766.1, AF179849.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263726.4/ ENSP00000263726.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL139141.23        6067-6100
            35-43               BX954266.1         2-10
            44-65               AF179849.1         14-35
            66-66               AL139141.23        6132-6132
            67-223              AF179849.1         37-193
            224-1913            BC011759.2         1-1690
            1914-5844           AL139141.23        50857-54787
FEATURES             Location/Qualifiers
     source          1..5844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..5844
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="LIM homeobox 4"
                     /db_xref="GeneID:89884"
                     /db_xref="HGNC:HGNC:21734"
                     /db_xref="MIM:602146"
     exon            1..342
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1439
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="LIM homeobox protein 4"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx4"
                     /protein_id="NP_203129.1"
                     /db_xref="CCDS:CCDS1338.1"
                     /db_xref="GeneID:89884"
                     /db_xref="HGNC:HGNC:21734"
                     /db_xref="MIM:602146"
                     /translation="MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILK
                     VLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVV
                     RKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRP
                     RTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKD
                     AGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGN
                     VGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTV
                     DSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF"
     exon            343..514
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:2.1.0"
     exon            515..717
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:2.1.0"
     exon            718..872
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1044
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..5844
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="hexamer: AATAAA"
     polyA_site      1913
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="major polyA site"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="hexamer: ATTAAA"
     polyA_site      1975
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
     regulatory      5822..5827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="hexamer: AATAAA"
     polyA_site      5844
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcag caacagcgtc tcaacctggg atgtgcacca accccggaga gcgagatcaa
       61 agggactgga aacagactgg ggactggcgg ggggaggggg ccggccagcc tgtggagtcc
      121 tccctgagaa gcggagggcc cggcttccac cgtgactcca gcggcctgct tggggtttta
      181 attattattt tgaaatttct gaatcgagct agagcgagag agcgagagat ctccgtagac
      241 tgcgactcgc tggctttcgc tccgagatga tgcagagtgc gactgtcccc gcggaagggg
      301 ctgtcaaggg gctcccggag atgctaggtg tgccgatgca acagattccc cagtgcgctg
      361 gctgcaacca gcacatcctg gacaagttca tcctgaaggt cctggacaga cactggcaca
      421 gctcctgcct caagtgtgca gactgccaga tgcagctggc ggacaggtgc ttctccaggg
      481 ctgggagcgt ctactgcaag gaggacttct tcaagcgctt cggcacaaaa tgcacggcct
      541 gccagcaggg tatcccccca acccaggtgg tccgcaaggc ccaggacttt gtctaccacc
      601 tgcactgctt tgcttgcatc atctgcaacc ggcagctggc cacgggggac gaattctacc
      661 tcatggagga cgggcggctg gtgtgcaagg aagactacga gacagccaag cagaacgatg
      721 actcagaggc tggagctaag cggccccgga ccaccatcac agccaagcag ctggagacat
      781 taaagaatgc atacaagaac tcccccaagc ctgcccggca cgtgagggag cagctgtcct
      841 cagagacagg cctggacatg agggtcgtac aggtttggtt tcagaacaga agggccaaag
      901 agaaacgcct gaagaaggat gcagggcggc accgctgggg gcagttctat aagagcgtca
      961 agaggagccg gggcagcagc aagcaggaga aggagagctc tgcagaggac tgtggggtta
     1021 gtgacagtga gctgagcttc cgagaggatc aaattctctc agaacttggc cacaccaata
     1081 ggatttatgg caacgtgggg gacgttacag gcggacagtt aatgaatggg agcttctcca
     1141 tggacgggac aggacaatcc tatcaggact tgagggatgg gagcccctat ggaatccccc
     1201 agtctccatc ctccatatcg tccctgccat cccacgctcc tttgctcaat gggctggatt
     1261 acacggtgga cagtaatttg ggcatcattg cgcatgcagg gcagggagta agccagacgc
     1321 tgagagccat ggctggggga cccacctctg acatctccac aggaagcagt gtaggctatc
     1381 ccgactttcc aactagccca ggctcttggc tcgatgaaat ggatcatcct cctttttaaa
     1441 cttctctcct ccccacccta cctgcccccc tggcttgaga gaatatcttc aaggatcaaa
     1501 agagacttgc cttttaagga tcgaaagtac gccaatgtga atttccatta ttttcaatgg
     1561 aagtcctccg ctgattccta gaaggctgtg agaccacact agggcattgt ttccctgggg
     1621 aagcagtggg agagcagact catctcagaa cacagcacag ggggtaatgg cctagagctc
     1681 tagggacact ggcttgttgg gtctctcccc tgctgttctg cttaggggct tggctgctca
     1741 gtgctttggt agcacaaggt gactgtgata ggcccccttg gcctttggga actttgctcc
     1801 aactggtgtg tctcacacaa tgcctcccaa aacactgctc tcaccagaac tgagactcct
     1861 aaggtagagg cctcacagcc cttgagtaaa ataaaagtga tttctggacc atccttattg
     1921 aaccctatat ttcaaaatga aaagatcagt tattaaaggt cagtgaacac tttgatggcc
     1981 agtttgatat taaaaacatg ccccctcctt ttttattttt gctgtgaaga tatgaattct
     2041 ttcctacaaa ccagagaata tgaacctgtt ttggttttta agtgtcccat ctatatcatt
     2101 gactctgatg gcaagaggtg gttttcattg caggtgactg aggctgagct gagtagccct
     2161 ggaccaccgc tgcagattgc ctgagtcgtc cccttggtgc acagtgtgcc ttcttcaatt
     2221 gcttgtatca tttattccac aagacaggct gtgggctgta aaatgagcaa aactaaaatg
     2281 tggggagaac aaaatgacaa tcaatcagtg aacatttgta gacacatttg gattccaaac
     2341 ctgcagtctg ttcagccata tcggctgatg ccagtcttcc agagttcccc atcccttgta
     2401 gggtgaaata tttggagtct gttttgaagg agttggttta gatgagcttg caagtctacc
     2461 cctctgaaag ctttctctgc tgtcctagct gactcaattg gaggacagtt ttggtcattt
     2521 ccaggaacca gcaatttttt tttggcctac cttggttggg aagagtaatt tagggagcag
     2581 ccctaaaatt gtccaaaggg ttctaagtgg ttcttgggct gcatctctct ggattgctgg
     2641 ctggacacct gccatgcctt gggctgcagt cccatggtca gaaagccaga actctctggc
     2701 cagtggtggt gcagggactc cccgttgtgc aggtttgcag tagcaaatca ctaagcctga
     2761 ggccagagca aggccaaccc ccgctttacg agttgccact cctgcgacag actgcactgc
     2821 tgtgggaaac gctgtcctga atggtgctgc agctcccacc caccttgtgc acccatctac
     2881 catcaggaag ctctccatgt gcaaactgga atttagccag ctggaattta ttcctgtccc
     2941 tctgggaagc tgtgtttgct tcttctggcc tcccattctc ttaaatgaga tcagcagagt
     3001 aggaaagggt gagaaggcat tgcctatcac atgaagtgat ggggccagag accctaagga
     3061 cccttccttc tacgaatggt tggtcacctt ttgaggactg caaagactta ggcatgtcat
     3121 aggcagacta aaggaagaat acacagttcc tcttggactg ctacatcttt tgtaagccct
     3181 tttccaggac taaactaagt tcaattaagt aagttcttta aaacagtaaa ttccgggatc
     3241 agccttcggg ccctcttctc tgaccaattt tatagcgtac cctcgttttt tggtgtgctg
     3301 cagtggtcat gatttttgct tgagaagtct gcaaacatag acacttctct tgaggttcca
     3361 tgtttatgga tgatgttgtg ttaatcctag ccaattctgt gctattggga attctccaat
     3421 catgaacact ggggtgggga ggaagacaca aatgccatgt gaggaaagga aaatgcagtc
     3481 gtctttttgg aggatggctt tttaaataca cccttcttag caggctgctt aaaatacaca
     3541 ggagaaaagg ctctgctggg caatgaacca gatgaaaagc tgcccaccca gatcactgtt
     3601 gcaggttgac tatttggctt agcaactcat gggatttcag aggcccttga agtttttggt
     3661 gagtatagtg tgggggagag caggcttttt aaaagggggg ggggcatcct cctctgtgta
     3721 gcactgttta agatcactgt aagtaagttg accagttttt gtaagttaat catactaatt
     3781 cccagttcaa tagtggaagg agaggccttc ctcatttata ctaataatat aataaatctc
     3841 ttgaggaact cagtgagcag ttgacgaggt caatagttct ttggcatcag tagggctggt
     3901 tagctggaaa aacccttgag agcactggcc tgaaaaccag gagagctttg ttttccagag
     3961 ccacctcccc agaaagcagc aaacactgct gcctgtttag aagcacagcc acagtaggtc
     4021 taagatttta aatggatctc cctacaggtt gggttagcat tatgggtggg ctggtgccac
     4081 taatgagcca ttgcatgaca ggactcttct ggggtttgga aatggagaaa agccgggcat
     4141 tcattacttt tagcttctct tagaggcact cctctgttgc ttggaagtct attatggggt
     4201 ataaggtgct acatggtagc tgtttccccc cttgctaaaa tgacatggat gaattttaaa
     4261 aatgaaatga gaccttctag aggcaaccat tatctgcagt gcctggctgg tcgactttag
     4321 agtaggaagc tcttgaatcc aggagcaaat tagttaaaac cccaagttcc agtggtaact
     4381 ggtataagca aaatggaaac tgaggggcta tggaggaatc tctgtttgtt ggaacgtaat
     4441 gaaaccatgg aggaaatacc agatttaagg gctaagaagc tggcccgatg ggtaaatcag
     4501 tgttgggagt caggttcttg gcccttcaag gacttgctat gcaacctcag gcaaattcct
     4561 ctcagtcttt gtgctttctc tttcttgtct catctgacag ttatgaatat aacgtaaaat
     4621 aaagatcaac tatcattgat aacactgttc ctgcaaatga atactgtgaa acatcaggga
     4681 aagaggaaaa aattaagcca caagaaaacc atttggcagt gtccttaaac tttttttggg
     4741 ggggggcagt gtaaaacatg aaacctagta agataattgg gccattagat cttcatcatt
     4801 aaactcactt tgcaaggaag tgtaagaaat ctgtaaaaca aaagacattc ctatctcaga
     4861 agctcaaact ggtgatttcc aactgcctct ttacaggagg gggctcaagg cttctgatga
     4921 gcaaaggctg tgtgttgtat gacagtccac tctctgcacc tacacttcca cgtgccacga
     4981 ctgacaactt ggttataacc atgaaaataa tgaccatacc tccccagcca gcagggtctg
     5041 gaaggcctga ggaggctcat ttttaaacac tgcactttaa aaattggaaa ccgtgagatg
     5101 aagaaaaatt caattaagcg gaaatgagtt ttgttttatt gcctgctgct gaagggctct
     5161 gggcatgctg aaagctaaat gaaaagcaca tcactggctc tcttctttct tggattggtc
     5221 aattggccct ttttgcagta gttgctccaa ctgttctaaa cagtgagtga ctggagccaa
     5281 aaagagagag ctcagcaaag ccatcccatc cacactctgc ttggtaggac cacactaaaa
     5341 gcacagtttc atgctgctag ctctggtaag gagacagctg caggtttggg aggtgcacca
     5401 agcattcctt tgcttaggga ggcagagcac aggtgaacag aggaaggaca cccccactct
     5461 catctattgc ccaccgagag gcaagaatca caccaacttt cccacttgag gactgtgttc
     5521 ggccaaacaa gcaggttcag ggctgcggga ttccagaagt tgctctgagc ttgcaatcag
     5581 acctcaaagc cccagatccc ctcagctctg gatcgttgcc ctcatccttc acaatgtaaa
     5641 ttttgtacag ttaaagagaa atgaagtctc gtttcctggg gaaaaaaaag aaaaaaagaa
     5701 aaaaaaaaga cccacccatc cttatttatt gccatatgac tttggaaaac agaagctggt
     5761 gcgtttgttt gtatatgcct cctgtgtgtt ggcatgagat gtgtacggta aaattatgta
     5821 aaataaatat ggaaattctt taga
//
