LOCUS       NM_022126               1634 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate
            phosphatase (LHPP), transcript variant 1, mRNA.
ACCESSION   NM_022126
VERSION     NM_022126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Gao,K., Yin,N., Shen,Z., Li,Q., Chen,P. and Yang,K.
  TITLE     LHPP promotes the intracellular reactive oxygen species
            accumulation and sensitivity of gastric cancer to cisplatin via JNK
            and p38 MAPK pathways
  JOURNAL   Histol Histopathol 38 (9), 1055-1068 (2023)
   PUBMED   36546683
  REMARK    GeneRIF: LHPP promotes the intracellular reactive oxygen species
            accumulation and sensitivity of gastric cancer to cisplatin via JNK
            and p38 MAPK pathways.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Zhao,X., Zhu,X., Wang,L., Chen,Y., Chen,R., Zheng,Z., Yang,H.,
            Xia,W., Yao,J. and Zhao,K.
  TITLE     Identification of Tumor Suppressor Gene LHPP-Based 5-microRNA
            Signature That Predicts the Early- and Midstage Esophageal Squamous
            Cell Carcinoma: A Two-Stage Case-Control Study in the Chinese Han
            Population
  JOURNAL   Lab Med 54 (4), 411-423 (2023)
   PUBMED   36355716
  REMARK    GeneRIF: Identification of Tumor Suppressor Gene LHPP-Based
            5-microRNA Signature That Predicts the Early- and Midstage
            Esophageal Squamous Cell Carcinoma: A Two-Stage Case-Control Study
            in the Chinese Han Population.
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Xia,Z., Zhao,S., Gao,X., Sun,H., Yang,F., Zhu,H., Gao,H., Lu,J. and
            Zhou,X.
  TITLE     LHPP Inhibits the Viability, Migration, and Proliferation of PDAC
            Cells and Significantly Affects the Expression of SDC1 and S100p
  JOURNAL   Technol Cancer Res Treat 22, 15330338231177807 (2023)
   PUBMED   37321804
  REMARK    GeneRIF: LHPP Inhibits the Viability, Migration, and Proliferation
            of PDAC Cells and Significantly Affects the Expression of SDC1 and
            S100p.
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Ma,L., Sun,H., Xu,X., Chen,Y., Zhang,L., Li,S. and Tang,L.
  TITLE     Tumor suppressor LHPP suppresses cell proliferation and
            epithelial-mesenchymal transition in hepatocellular carcinoma cell
            lines
  JOURNAL   J Physiol Biochem 78 (4), 807-817 (2022)
   PUBMED   35796893
  REMARK    GeneRIF: Tumor suppressor LHPP suppresses cell proliferation and
            epithelial-mesenchymal transition in hepatocellular carcinoma cell
            lines.
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Liu,S., Gao,W., Lu,Y., Zhou,Q., Su,R., Hasegawa,T., Du,J. and Li,M.
  TITLE     As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting
            the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma
  JOURNAL   Int J Biol Sci 18 (2), 491-506 (2022)
   PUBMED   35002505
  REMARK    GeneRIF: As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by
            Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell
            Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
            Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
  TITLE     Genome wide association study for plasma levels of natural
            anticoagulant inhibitors and protein C anticoagulant pathway: the
            MARTHA project
  JOURNAL   Br J Haematol 157 (2), 230-239 (2012)
   PUBMED   22443383
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Neff,C.D., Abkevich,V., Packer,J.C., Chen,Y., Potter,J., Riley,R.,
            Davenport,C., DeGrado Warren,J., Jammulapati,S., Bhathena,A.,
            Choi,W.S., Kroeger,P.E., Metzger,R.E., Gutin,A., Skolnick,M.H.,
            Shattuck,D. and Katz,D.A.
  TITLE     Evidence for HTR1A and LHPP as interacting genetic risk factors in
            major depression
  JOURNAL   Mol Psychiatry 14 (6), 621-630 (2009)
   PUBMED   18268499
  REMARK    GeneRIF: Lhpp or a product of a collinear brain-specific
            transcript, therefore, may interact with Htr1a in the pathogenesis
            of major depression
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Koike,E., Toda,S., Yokoi,F., Izuhara,K., Koike,N., Itoh,K.,
            Miyazaki,K. and Sugihara,H.
  TITLE     Expression of new human inorganic pyrophosphatase in thyroid
            diseases: its intimate association with hyperthyroidism
  JOURNAL   Biochem Biophys Res Commun 341 (3), 691-696 (2006)
   PUBMED   16430861
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Yokoi,F., Hiraishi,H. and Izuhara,K.
  TITLE     Molecular cloning of a cDNA for the human phospholysine
            phosphohistidine inorganic pyrophosphate phosphatase
  JOURNAL   J Biochem 133 (5), 607-614 (2003)
   PUBMED   12801912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC113631.1, AL445237.16, AK055532.1 and BC007324.2.
            
            On Nov 23, 2018 this sequence version replaced NM_022126.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.537639.1,
                                           SRR3476690.673550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368842.10/ ENSP00000357835.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               BC113631.1         52-371
            321-321             AL445237.16        155414-155414
            322-503             AK055532.1         302-483
            504-504             AL445237.16        159692-159692
            505-1633            AK055532.1         485-1613
            1634-1634           BC007324.2         1522-1522
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..1634
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /note="phospholysine phosphohistidine inorganic
                     pyrophosphate phosphatase"
                     /db_xref="GeneID:64077"
                     /db_xref="HGNC:HGNC:30042"
                     /db_xref="MIM:617231"
     exon            1..165
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..853
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /EC_number="3.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hLHPP"
                     /codon_start=1
                     /product="phospholysine phosphohistidine inorganic
                     pyrophosphate phosphatase isoform 1"
                     /protein_id="NP_071409.3"
                     /db_xref="CCDS:CCDS7640.1"
                     /db_xref="GeneID:64077"
                     /db_xref="HGNC:HGNC:30042"
                     /db_xref="MIM:617231"
                     /translation="MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLK
                     RSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLI
                     HDGVRSEFDQIDTSNPNCVVIADAGESFSYQNMNNAFQVLMELEKPVLISLGKGRYYK
                     ETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVG
                     DVGGAQRCGMRALQVRTGKFRPSDEHHPEVKADGYVDNLAEAVDLLLQHADK"
     exon            166..353
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     exon            354..507
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     exon            508..571
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     exon            572..664
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     exon            665..756
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1634
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1612..1617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /note="hexamer: AGTAAA"
     polyA_site      1634
                     /gene="LHPP"
                     /gene_synonym="HDHD2B"
                     /note="major polyA site"
ORIGIN      
        1 gtcggttggg acgcggagct gaggagcagg gccgggcgcc atggcaccgt ggggcaagcg
       61 gctggctggc gtgcgcgggg tgctgcttga catctcgggc gtgctgtacg acagcggcgc
      121 gggcggcggc acggccatcg ccggctcggt ggaggcggtg gccagactga agcgttcccg
      181 gctgaaggtg aggttctgca ccaacgagtc gcagaagtcc cgggcagagc tggtggggca
      241 gcttcagagg ctgggatttg acatctctga gcaggaggtg accgccccgg caccagctgc
      301 ctgccagatc ctgaaggagc aaggcctgcg accatacctg ctcatccatg acggagtccg
      361 ctcagaattt gatcagatcg acacatccaa cccaaactgt gtggtaattg cagacgcagg
      421 agaaagcttt tcttatcaaa acatgaataa cgccttccag gtgctcatgg agctggaaaa
      481 acctgtgctc atatcactgg gaaaagggcg ttactacaag gagacctctg gcctgatgct
      541 ggacgttggt ccctacatga aggcgcttga gtatgcctgt ggcatcaaag ccgaggtggt
      601 ggggaagcct tctcctgagt ttttcaagtc tgccctgcaa gcgataggag tggaagccca
      661 ccaggccgtc atgattgggg acgatatcgt gggcgacgtc ggcggtgccc agcggtgtgg
      721 aatgagagcg ctgcaggtgc gcaccgggaa gttcaggccc agtgacgagc accatccgga
      781 agtgaaggct gatgggtacg tggacaacct cgcagaggca gtggacctgc tgctgcagca
      841 cgccgacaag tgatggcctc ctgggagagc cccgcctcct ccacccctgc ctctcctcca
      901 cccctgcctc ccctccaccc ctgcctctcc tccacccgcc caggagagcc ccacctcctc
      961 cacccctgcc tctcctccac ccctgcctcc cctccacctg ccccagtgcc cagaccaacc
     1021 aaggccctga cagccctgcc ttctgccctc tgccctgcat gggcaggcat ttgttcccta
     1081 cctgggtggc ctgctcccct gcctgggccc tgacttcagc tccctgtagt gaagtccagg
     1141 agggtgggac aggcctgtca ggcctctggg aatctcccaa atcccagaac tcaccactca
     1201 ccatgggcct ttaaatgcag taaactccac ctaaccagat tcaggggcac tatgcccact
     1261 gcctcctctt cagactcttt gcatttcagt gaagagcctg gaagaaaccc aggggcctcc
     1321 tatgcacaga tcttgcagcc cagaaccaag tcagcctccc tgcgactgcc caggcacact
     1381 gcccaccacc ccacccccga aacaatgcca gcccgctgct ttttctatcc tcccagtcac
     1441 ctttgcagac aaagaccagg ggcagctccc gagggcactg tgaaggctcc catgccacac
     1501 agtgagaact gtagcctctg cgtccaaggc acacagggta ctttctggac ccactgctgg
     1561 acagacttga aggtgtcatg cccggtgtgt gcaggaggaa actaacagtt cagtaaactc
     1621 tgccttgacc agca
//
