LOCUS       NM_001388199             978 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens LHFPL tetraspan subfamily member 7 (LHFPL7),
            transcript variant 2, mRNA.
ACCESSION   NM_001388199
VERSION     NM_001388199.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 978)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 978)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   3  (bases 1 to 978)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL050312.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: CR456388.1, BC130647.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1968540,
                                    SAMEA1968832 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640159.2/ ENSP00000492160.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL050312.8         21535-21657         c
            124-341             AL050312.8         14298-14515         c
            342-480             AL050312.8         13112-13250         c
            481-978             AL050312.8         10061-10558         c
FEATURES             Location/Qualifiers
     source          1..978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..978
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /note="LHFPL tetraspan subfamily member 7"
                     /db_xref="GeneID:255349"
                     /db_xref="HGNC:HGNC:33725"
     exon            1..123
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /inference="alignment:Splign:2.1.0"
     exon            124..341
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..743
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; transmembrane protein 211; LHFPL tetraspan
                     subfamily member 7 protein"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 7 protein
                     isoform 2 precursor"
                     /protein_id="NP_001375128.1"
                     /db_xref="CCDS:CCDS93134.1"
                     /db_xref="GeneID:255349"
                     /db_xref="HGNC:HGNC:33725"
                     /translation="MLSSVWVALGLSLTCTSAFSLISPAWFQTPTFSFGILTYCSWPQ
                     GNSWNQSCVTFSSLEDIPDFAWKVSAVMLLGGWLLLAFNAIFLLSWAVAPKGLCPRRS
                     SVPMPGVQAVAATAMIVGLLIFPIGLASPFIKEVCEASSMYYGGKCRLGWGYMTAILN
                     AVLASLLPIISWPHTTKVQGRTIIFSSATERIIFVPEMNK"
     exon            342..480
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /inference="alignment:Splign:2.1.0"
     exon            481..978
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /inference="alignment:Splign:2.1.0"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /note="hexamer: AATAAA"
     polyA_site      978
                     /gene="LHFPL7"
                     /gene_synonym="bA9F11.1; TMEM211"
                     /note="major polyA site"
ORIGIN      
        1 attgttctac aagctaaatt attccttcaa aggagaggag aattgtataa ggtcacagac
       61 gtggatccaa agccggagcc tgagcagagg tggccacgct ggagggtctt gacctaaagt
      121 gtggtcagcg atactgccta atgttgagca gtgtgtgggt agctctgggg ctctctctga
      181 cctgcacctc agccttcagc ctcatctccc ctgcctggtt ccagaccccg accttctcct
      241 ttggcatcct cacctactgc tcctggcctc agggcaacag ttggaaccag agctgcgtga
      301 ccttcagttc cctggaggat attcctgact ttgcctggaa ggtctcagct gtgatgctcc
      361 tcggaggctg gctcctgttg gccttcaatg caattttcct cctgtcttgg gctgtggccc
      421 ccaaagggct gtgcccaagg agaagcagtg ttccaatgcc aggggtgcag gcagtggcag
      481 ctactgccat gattgtgggt ctgctgattt tcccaatcgg ccttgcctcc ccattcatca
      541 aggaagtgtg cgaagcctcc tccatgtatt atggtgggaa gtgccggctg ggttggggtt
      601 acatgactgc tatcctcaat gcagtcctgg ccagcctcct gcccatcatc agctggcccc
      661 acacaaccaa ggtccaaggg aggaccatca tcttctccag tgccaccgag agaatcatct
      721 ttgtgccaga aatgaacaaa taaaaatctc ctgggagtag cacaaagggc acactccaga
      781 gttttatgaa atcatcatgt agccaacttc aaatcccatc tctgctcctt cttgctgtgt
      841 gacttcaggc aagccacttt acctctctgg aacagttttt tcttctggaa aatgaaagtt
      901 gaaatcatac ctacctcata aggttgttct gagaattcac tggagatgct ctgtgtaaat
      961 aaagcacttt gcaccatg
//
