LOCUS       NM_198560               4900 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens LHFPL tetraspan subfamily member 4 (LHFPL4), mRNA.
ACCESSION   NM_198560 XM_351534
VERSION     NM_198560.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4900)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4900)
  AUTHORS   Davenport,E.C., Pendolino,V., Kontou,G., McGee,T.P., Sheehan,D.F.,
            Lopez-Domenech,G., Farrant,M. and Kittler,J.T.
  TITLE     An Essential Role for the Tetraspanin LHFPL4 in the
            Cell-Type-Specific Targeting and Clustering of Synaptic GABAA
            Receptors
  JOURNAL   Cell Rep 21 (1), 70-83 (2017)
   PUBMED   28978485
REFERENCE   3  (bases 1 to 4900)
  AUTHORS   Yamasaki,T., Hoyos-Ramirez,E., Martenson,J.S., Morimoto-Tomita,M.
            and Tomita,S.
  TITLE     GARLH Family Proteins Stabilize GABAA Receptors at Synapses
  JOURNAL   Neuron 93 (5), 1138-1152 (2017)
   PUBMED   28279354
REFERENCE   4  (bases 1 to 4900)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
  REMARK    GeneRIF: The authors present an overview of the LHFP gene family in
            mouse and humans
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026194.4, AY278320.1,
            AC018506.5 and BC029607.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198560.2.
            
            Summary: This gene is a member of the lipoma HMGIC fusion partner
            (LHFP) gene family, which is a subset of the superfamily of
            tetraspan transmembrane protein encoding genes. Mutations in one
            LHFP-like gene result in deafness in humans and mice, and a second
            LHFP-like gene is fused to a high-mobility group gene in a
            translocation-associated lipoma. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY278320.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287585.8/ ENSP00000287585.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC026194.4         52174-52193
            21-1464             AY278320.1         1-1444
            1465-4579           AC018506.5         9062-12176
            4580-4900           BC029607.1         888-1208
FEATURES             Location/Qualifiers
     source          1..4900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..4900
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /note="LHFPL tetraspan subfamily member 4"
                     /db_xref="GeneID:375323"
                     /db_xref="HGNC:HGNC:29568"
                     /db_xref="MIM:610240"
     exon            1..138
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /inference="alignment:Splign:2.1.0"
     exon            139..712
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1050
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /note="LHFP-like protein 4; lipoma HMGIC fusion
                     partner-like 4 protein; GABAA receptor regulatory Lhfpl4"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 4 protein"
                     /protein_id="NP_940962.1"
                     /db_xref="CCDS:CCDS33691.1"
                     /db_xref="GeneID:375323"
                     /db_xref="HGNC:HGNC:29568"
                     /db_xref="MIM:610240"
                     /translation="MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQP
                     YWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLS
                     MVLILGCITCFSLFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCG
                     AKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVG
                     STVSSVLRPGGDVSGWGVLPCPVAHSQGP"
     exon            713..949
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /inference="alignment:Splign:2.1.0"
     exon            950..4900
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /note="hexamer: AATAAA"
     polyA_site      4900
                     /gene="LHFPL4"
                     /gene_synonym="GARLH4"
                     /note="major polyA site"
ORIGIN      
        1 gcgccccggg gagaacccga gcaagatgga ggccgcgcag aggccgccgc ctgggccgag
       61 gcagccgctg ctgggagcgc cgagccgcgg cgcctaggcc gtgccagtcc cggatccgct
      121 gcctccggcc gtgcccagca gctcccagac gcccccagct ctgccccagg ccccgccctc
      181 gcgggttcct tgactcaggg ccgcttctcg cgtgcgtccc cagctcccgc ccggcagccc
      241 ggcgctccgt cccgggccgg cggcccccgc cagccgccgc cgccgccggc cccgcctccg
      301 ggcaccatgc tgccctcgca ggaggcctcc aagctctacc acgagcacta catgcggaac
      361 tcgcgggcca tcggcgtgct gtgggccatc ttcaccatct gcttcgccat catcaacgtg
      421 gtggtcttca tccagcccta ctgggtgggc gacagcgtga gcacccccaa gcctggctac
      481 ttcggcctct tccactactg cgtgggcagc gggctggcgg gccgcgagct cacctgccgg
      541 ggctccttca ccgacttcag caccatcccg tccagcgcct tcaaggcggc cgccttcttc
      601 gtgctgctct ccatggtgct gatcctcggc tgcatcacct gcttttcgct tttcttcttc
      661 tgcaacacgg ctacggtcta caagatctgc gcctggatgc agctcttggc agctctgtgc
      721 ctcgtcctgg gctgcatgat ctttcctgat ggctgggatg ccgagaccat ccgggacatg
      781 tgtggggcca agacggggaa gtactccctg ggggactgtt cagtgcgctg ggcatacatc
      841 ctggccatca tcggcatcct caacgccctc atcctctcct tcctcgcctt cgtgctgggc
      901 aaccggcaaa cagacctgct gcaggaggag ctcaagccgg agaacaaaga ttttgtgggc
      961 tctacagtaa gctccgtgtt gcggcccggg ggtgatgtct ctggatgggg agtccttccc
     1021 tgccccgtgg ctcactcaca gggaccctga aaggccagga tcacagccca gtaattggcc
     1081 tgacctcagc ttgtcctgcc ttctgccctc tcgtcactcc attcaagctc tgagggaaga
     1141 ccctgatctc agacttactt ctcaccgact accctgcaag ctccaggctt tgaggagagg
     1201 aaagcctgga tgtggcctgg gggagaggag aggccctcca aaccttggga gggtctaatt
     1261 cttgctcctc cctcaatttg acctaaggga gcctgcatct gcgtaggccc ttgggcttct
     1321 cctctcctct ctagactggc ctggaggtcc ctgcagatcc ccagggagag cggagctgta
     1381 gttccagctc cccaggcccc ctcagtctgg agggctgccg cctggctgta tccgcacctc
     1441 ttctggtccc tgcctcttca agaaatttat tctagatact gctccagggt gggctggact
     1501 ctttcctact tttttttttt ttcttttttg gctgatgttg gttccaccac atctgccaca
     1561 aagctccagg tgccaccagt ctcccctggg acctcctctg ctccattccg gcctgctccc
     1621 agctcaccct gagggagagc tgcaccgagg gatgcacagg gccctgctgt cagctgcaga
     1681 ccggggccct gatcagccca gagtcagaaa agactttcag gctctggagg tagcgggagg
     1741 gggtacgtgg cctcggcagt tggagcttag aagctgctca gcccgggctg gcctggcctc
     1801 ctcttcctct ctgctggaac atctcactga tgactgagcc cttgaccttg gcctcttttg
     1861 cccaggcctc ctctctgctg ggatgtctca ccaatgactg gacccttgac cctggcctgt
     1921 tttgtacagc acagacttct tggccctgtt gtcagggttg ggggtgtgga ggggacccca
     1981 gaggtgggga gttgggggat gcattacccc ttctgcccct tttcatgccc tccatacccc
     2041 aggcgtctac caagggcaga gactgtcttg tctctttgat acttttctgc ataacttgaa
     2101 cttgcaggtc atctctgaac agggtacccc tgtccccctt cctaagcctt gttaccctgt
     2161 cccagcctct tcctcctcct ggcccacctc tcgccttgcg atatgcccag ggtctgcacc
     2221 tatgggcagt gcttggagcc gaggcatgag tgtatgtgta tgtgggtgaa atgtgtgtgc
     2281 gtgtgtgtgc gcgtgtgagc gtgtgtgtgt gtgtgtgtgt tgggggacag gtgagaagtt
     2341 tctcccccct ccacccactg tgggggcgtc tcccttcccc ttggcaggga gcaggtgagg
     2401 gagactcctg gtattttttg aacacccgtc attcccctgt gggtctggcg gcagagccat
     2461 ctctcccggg gagcctccct gccctggggc ctggacagct ccctcagcac tagttgctgg
     2521 tgcagaccgg cttcgtccag cgccccctcc tggcggcctg gacctgcagg gaaggggcgg
     2581 tgccctgcag gatgccaggg gaagccgcct cgggcctcgg cggaggggag agggtcgctt
     2641 gagcgccatg tgtttgccaa ccttgtgttc atttccacag gacttggacc tgagagttag
     2701 ggtttccaag aaagacccta gaagtcccct gcctgtctcc ccactctgga ccctagccgg
     2761 aatcagatgt tgggacctag tgggttcctg ccacctggaa cttaccaagt cccgacttca
     2821 ctcctccact tactcctccc gggcaaagcc tccccgcagt gctctggtcc cagcgctggg
     2881 ctccccttcc ccgccggcgc cttcccggac agtccagtcg gcctggggta ggggcgctgc
     2941 gggacagagg gtccgagtta aatgcgggag gatgcgggag ccccgtggga gggagttggg
     3001 gtaggaggga gttcctcaaa gatgcaaacc aagcccagcg ttggaggggg agagcagagt
     3061 taggagagag tgaggggagg ggcgcagcaa gcgactggga atgggagaag acactggggt
     3121 gaggagaaga ggggtgcaga gacagggaga tgagagatga ttggagaagg agcgaggggg
     3181 acgcacaggc acagagaaac agcgcgagga ggagagatcg agagagacgg ggcagaggtg
     3241 gagagagatg agagaccagc tgagaggctg cccgagagct tggggtgggg gaggggaaat
     3301 ggatgaaaag gcggaaaaag gactcgggag cggggaagag gtaaatggag atgtgggttg
     3361 ggggcaagaa tgggatgcag aggaaggaga ggaggatgaa ggagccagga tgcggggcag
     3421 tggggagggg gttgctatct gggcactggg tgaggggaga gcttgttccc ccaaggacgc
     3481 ctgccaccag gtgtccttgc cacaccttgt tccccaagga cacccaccaa acctgtgccc
     3541 tggtgcgggg gatagaactg acctttcaga ggctggaggc ccggggcaca ggcagccaag
     3601 gccgcatcct tttgggaaga actggagtga aggaagccac ttcagaggac gtagtgggtc
     3661 cagctgactt aggagtgggt cagcgccggg tggagaggag ggaggctagt tccctggtgg
     3721 ggtagcctgg caacattccc attccaccgc acctggccag ctgccatctt ggcagagcca
     3781 gggggagatg caccagggag tttggagtca ggaaggcaga gttgtgtggg ctgaagtctg
     3841 cgggaacccc agggtgacac aggcaagggg tagaagtcag agtggggacc aaaccataga
     3901 ctggggccct gggttctgca gaggtgtgga tggggcaggt ggcaggtgct ccagtggggg
     3961 ccccaggtga ggccctgatg gccctcctgg ggcaataaag acatcatggg aagggggctt
     4021 tgtggtttgc ctctgctctc gtcgggcgat ctggctttag ccttcaggag gaggtaagca
     4081 gaggagatca gtgcctgttt ctgaccccag gagggccttg ttgggctcca acctagagcc
     4141 ttccggcttc aggtcccaag agaagtcccc ccctaactgt gaccccccta actgtgatca
     4201 ggggtctgcc attgcccgct tttctctgcc tgatctgggg actcaggaga ggccacggca
     4261 gccacagcct aggggtggtt cagtccctgg cccacagtct ggtcagttga gtccttctgg
     4321 gaaccggggc tatgaaaact ttcgtctttg gggaccggta cccatgaagg aaaactttcc
     4381 tgagggggtg aggaccaaag aatcaagatc cttttcaggc ctgatagcca agatgatgag
     4441 aacttttaga taaggctgtg gggagagtcc ctggcctttt gagcatcctg cttgggcaca
     4501 cggggaataa cctttctcca gcttccagtg tgaactgaga aagagaaagg gaaaccctgt
     4561 ctttggagaa gctgggatgt tcccagcacc agaaacttct gcaggcccct gcctggccca
     4621 cggctaacct ttgggtggga ctggagtttc ctgaacaggg aacaagggag ccttccgcag
     4681 agctctgatg ggcaggcctc cgagggcctg tgctgtgtgc tgttaggata gcttggtgtt
     4741 gtctataccc cattagtaag ttttgtctga gtgtgtcctc gctgttcatt gtctaatttg
     4801 gtaacattta ttttggtcct gaccccttct gctgctgctg ggtttaagct tcagtgcagg
     4861 tggaatgaca ttcaaataaa gaaacacttt ctatcaccca
//
