LOCUS       NM_199000               3234 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens LHFPL tetraspan subfamily member 3 (LHFPL3),
            transcript variant 1, mRNA.
ACCESSION   NM_199000 XM_351743
VERSION     NM_199000.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3234)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3234)
  AUTHORS   Li,Z., Qian,R., Zhang,J. and Shi,X.
  TITLE     MiR-218-5p targets LHFPL3 to regulate proliferation, migration, and
            epithelial-mesenchymal transitions of human glioma cells
  JOURNAL   Biosci Rep 39 (3) (2019)
   PUBMED   30314994
  REMARK    GeneRIF: Results show that miR-218-5p targeting lipoma HMGIC fusion
            partner-like 3 protein (LHFPL3) mRNA plays significant roles in
            preventing the invasiveness of glioma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3234)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   4  (bases 1 to 3234)
  AUTHORS   St Pourcain,B., Skuse,D.H., Mandy,W.P., Wang,K., Hakonarson,H.,
            Timpson,N.J., Evans,D.M., Kemp,J.P., Ring,S.M., McArdle,W.L.,
            Golding,J. and Smith,G.D.
  TITLE     Variability in the common genetic architecture of
            social-communication spectrum phenotypes during childhood and
            adolescence
  JOURNAL   Mol Autism 5 (1), 18 (2014)
   PUBMED   24564958
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3234)
  AUTHORS   Rietveld,C.A., Medland,S.E., Derringer,J., Yang,J., Esko,T.,
            Martin,N.W., Westra,H.J., Shakhbazov,K., Abdellaoui,A., Agrawal,A.,
            Albrecht,E., Alizadeh,B.Z., Amin,N., Barnard,J., Baumeister,S.E.,
            Benke,K.S., Bielak,L.F., Boatman,J.A., Boyle,P.A., Davies,G., de
            Leeuw,C., Eklund,N., Evans,D.S., Ferhmann,R., Fischer,K.,
            Gieger,C., Gjessing,H.K., Hagg,S., Harris,J.R., Hayward,C.,
            Holzapfel,C., Ibrahim-Verbaas,C.A., Ingelsson,E., Jacobsson,B.,
            Joshi,P.K., Jugessur,A., Kaakinen,M., Kanoni,S., Karjalainen,J.,
            Kolcic,I., Kristiansson,K., Kutalik,Z., Lahti,J., Lee,S.H., Lin,P.,
            Lind,P.A., Liu,Y., Lohman,K., Loitfelder,M., McMahon,G.,
            Vidal,P.M., Meirelles,O., Milani,L., Myhre,R., Nuotio,M.L.,
            Oldmeadow,C.J., Petrovic,K.E., Peyrot,W.J., Polasek,O., Quaye,L.,
            Reinmaa,E., Rice,J.P., Rizzi,T.S., Schmidt,H., Schmidt,R.,
            Smith,A.V., Smith,J.A., Tanaka,T., Terracciano,A., van der
            Loos,M.J., Vitart,V., Volzke,H., Wellmann,J., Yu,L., Zhao,W.,
            Allik,J., Attia,J.R., Bandinelli,S., Bastardot,F., Beauchamp,J.,
            Bennett,D.A., Berger,K., Bierut,L.J., Boomsma,D.I., Bultmann,U.,
            Campbell,H., Chabris,C.F., Cherkas,L., Chung,M.K., Cucca,F., de
            Andrade,M., De Jager,P.L., De Neve,J.E., Deary,I.J.,
            Dedoussis,G.V., Deloukas,P., Dimitriou,M., Eiriksdottir,G.,
            Elderson,M.F., Eriksson,J.G., Evans,D.M., Faul,J.D., Ferrucci,L.,
            Garcia,M.E., Gronberg,H., Guethnason,V., Hall,P., Harris,J.M.,
            Harris,T.B., Hastie,N.D., Heath,A.C., Hernandez,D.G., Hoffmann,W.,
            Hofman,A., Holle,R., Holliday,E.G., Hottenga,J.J., Iacono,W.G.,
            Illig,T., Jarvelin,M.R., Kahonen,M., Kaprio,J., Kirkpatrick,R.M.,
            Kowgier,M., Latvala,A., Launer,L.J., Lawlor,D.A., Lehtimaki,T.,
            Li,J., Lichtenstein,P., Lichtner,P., Liewald,D.C., Madden,P.A.,
            Magnusson,P.K., Makinen,T.E., Masala,M., McGue,M., Metspalu,A.,
            Mielck,A., Miller,M.B., Montgomery,G.W., Mukherjee,S., Nyholt,D.R.,
            Oostra,B.A., Palmer,L.J., Palotie,A., Penninx,B.W., Perola,M.,
            Peyser,P.A., Preisig,M., Raikkonen,K., Raitakari,O.T., Realo,A.,
            Ring,S.M., Ripatti,S., Rivadeneira,F., Rudan,I., Rustichini,A.,
            Salomaa,V., Sarin,A.P., Schlessinger,D., Scott,R.J., Snieder,H., St
            Pourcain,B., Starr,J.M., Sul,J.H., Surakka,I., Svento,R.,
            Teumer,A., Tiemeier,H., van Rooij,F.J., Van Wagoner,D.R.,
            Vartiainen,E., Viikari,J., Vollenweider,P., Vonk,J.M., Waeber,G.,
            Weir,D.R., Wichmann,H.E., Widen,E., Willemsen,G., Wilson,J.F.,
            Wright,A.F., Conley,D., Davey-Smith,G., Franke,L., Groenen,P.J.,
            Hofman,A., Johannesson,M., Kardia,S.L., Krueger,R.F., Laibson,D.,
            Martin,N.G., Meyer,M.N., Posthuma,D., Thurik,A.R., Timpson,N.J.,
            Uitterlinden,A.G., van Duijn,C.M., Visscher,P.M., Benjamin,D.J.,
            Cesarini,D. and Koellinger,P.D.
  CONSRTM   LifeLines Cohort Study
  TITLE     GWAS of 126,559 individuals identifies genetic variants associated
            with educational attainment
  JOURNAL   Science 340 (6139), 1467-1471 (2013)
   PUBMED   23722424
REFERENCE   6  (bases 1 to 3234)
  AUTHORS   Wang,K., Li,W.D., Zhang,C.K., Wang,Z., Glessner,J.T., Grant,S.F.,
            Zhao,H., Hakonarson,H. and Price,R.A.
  TITLE     A genome-wide association study on obesity and obesity-related
            traits
  JOURNAL   PLoS One 6 (4), e18939 (2011)
   PUBMED   21552555
  REMARK    Erratum:[PLoS One. 2012;7(2). doi:
            10.1371/annotation/a34ee94e-3e6a-48bd-a19e-398a4bb88580]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3234)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3234)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
  REMARK    GeneRIF: The authors present an overview of the LHFP gene family in
            mouse and humans
REFERENCE   9  (bases 1 to 3234)
  AUTHORS   Petit,M.M., Schoenmakers,E.F., Huysmans,C., Geurts,J.M., Mandahl,N.
            and Van de Ven,W.J.
  TITLE     LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a
            member of a new family of LHFP-like genes
  JOURNAL   Genomics 57 (3), 438-441 (1999)
   PUBMED   10329012
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002432.1, AC079796.5 and
            AC007384.3.
            
            On Aug 6, 2020 this sequence version replaced NM_199000.2.
            
            Summary: This gene is a member of the lipoma HMGIC fusion partner
            (LHFP) gene family, which is a subset of the superfamily of
            tetraspan transmembrane protein encoding genes. Mutations in one
            LHFP-like gene result in deafness in humans and mice, and a second
            LHFP-like gene is fused to a high-mobility group gene in a
            translocation-associated lipoma. A partial gene fragment named
            LHFPL4 corresponds to a portion of the first exon of this gene.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124251.1, AY260763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424859.7/ ENSP00000393128.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AC002432.1         45433-46054
            623-859             AC079796.5         81952-82188
            860-3234            AC007384.3         59696-62070
FEATURES             Location/Qualifiers
     source          1..3234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.2-q22.3"
     gene            1..3234
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /note="LHFPL tetraspan subfamily member 3"
                     /db_xref="GeneID:375612"
                     /db_xref="HGNC:HGNC:6589"
                     /db_xref="MIM:609719"
     exon            1..622
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..888
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipoma HMGIC fusion partner-like 4; LHFP-like protein 3;
                     lipoma HMGIC fusion partner-like 3 protein; LHFPL
                     tetraspan subfamily member 3 protein"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 3 protein
                     isoform 1"
                     /protein_id="NP_945351.1"
                     /db_xref="CCDS:CCDS94168.1"
                     /db_xref="GeneID:375612"
                     /db_xref="HGNC:HGNC:6589"
                     /db_xref="MIM:609719"
                     /translation="MPGAAAAAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFT
                     ICFAIVNVVCFIQPYWIGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPS
                     GAFKAASFFIGLSMMLIIACIICFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFP
                     DGWDSDEVKRMCGEKTDKYTLGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLM
                     AEELKAENKVLLSQYSLE"
     exon            623..859
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            860..3234
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3210..3215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /note="hexamer: AATAAG"
     polyA_site      3234
                     /gene="LHFPL3"
                     /gene_synonym="LHFPL4"
                     /note="major polyA site"
ORIGIN      
        1 gctcccccgc cctccttccg ggagcgagga tgcagactct gaaactggtg ctgctgggct
       61 gaggcggagg caggggagtt gcagcgcgcg aggctccgtg agtgtgtctc ctgcgcgctg
      121 agaggcgggg ggaggcggag gaccaggagg aggaggagga ggaggaggag ggggagaatg
      181 cccggagccg ccgccgctgc cgccgccgcc gccgccgcga tgctcccggc tcaggaggct
      241 gccaagctgt accacaccaa ctatgtgcgg aactcgcggg ccatcggcgt gctgtgggcc
      301 atcttcacca tctgctttgc catcgtcaac gtggtgtgct tcatccagcc ctactggata
      361 ggcgacggcg tggacacccc gcaagccggc tatttcgggc tcttccacta ctgcatcggc
      421 aacggcttct cccgggagct gacctgcagg ggcagcttca cggacttctc cacgctgccc
      481 tcgggcgcct tcaaagccgc ctccttcttt atcggcctct ccatgatgct catcattgcc
      541 tgcatcattt gctttaccct cttcttcttc tgcaacacgg ccactgtgta caagatatgt
      601 gcctggatgc agctcacctc cgctgcctgc cttgtgcttg gctgtatgat tttccctgat
      661 ggctgggact cagatgaagt aaaacggatg tgtggagaaa agacagacaa gtacactctt
      721 ggggcttgct cagtccgctg ggcatacatc ctggctatta ttggaatttt ggatgccctg
      781 atcctctcat ttctagcatt tgtgcttggt aatcgacaag acagcttgat ggcagaggaa
      841 ctgaaggcag aaaacaaagt tctgctaagc caatattctc tagaatgagc acaaaacaaa
      901 tcgaataaca gctaaacaaa tcgaataaca gctaaacgaa tcgaataaca gcttttgtac
      961 atcaacatca agaaggaata cgcctgagag agatcagagt atatagatga atatgaacaa
     1021 gaatggaaca ttcacttgtc aacgcacttt ctaaatctag atcagcagag atgggagtga
     1081 ttttctggaa agagatgtga tcatggatta aacaccagct cattggaaac tcattggatg
     1141 agatcagaaa acgttcatga aaaatcatat tcaggaaata aggaagagga atataaatgc
     1201 tctagagtta acatgtaaaa tatatacgta ctgaggtttg taaactgtcc tttttaaatc
     1261 aaactgaaaa caaaaagctt taacctttca acagaatttt taaaaaggca gttagttcta
     1321 aattattcct atctcaatag ccaagaggct gatcaagcgt catttattga ggaagcatct
     1381 tagaaaatgc ctctgaatgt tttcatagga gccgtgacct ttggttcttc atctctacca
     1441 ttcatttact tcactgtgta attagttaca accactcagt tattaagaga cgtaacgctt
     1501 caaacttttt accaagtctg tgttctgttt aatctgtcca tacaagttat tactgagaaa
     1561 gtgtttatgc catatactat tactccatca agctgtatat tacaggaagt acatctttac
     1621 atcataggtt cccaagcaac atagatttcc ctatctttca ggaaacagca tcaaggaact
     1681 ctgaaaaata tagaaaaagt tcattttcac cttggaagct cacgtgtaat attataggct
     1741 actatcaaat aaacactttt tttctaattc tccctagtat atgcatagga atttaatata
     1801 ctttataaat aagtatctaa aatgtctcct acttttttcc tatttctttg ccatacatgt
     1861 tatcagaaat ccatgtcttc tatttccctt actgatgggc actcattttt atttttttaa
     1921 aaatcattcc attaaacata tttctaaata atagtaagtg gtactaacaa aataaataat
     1981 aatttaatag ccttagaaat aaatgactgt atacttatac aggttgaaaa aaactcggta
     2041 ggaataagtt acctttttgt ttactaatgt tggtttcaaa aatactcaga ttcattttag
     2101 ttggctgaca tctggaagta gttaacaact aaccagtgga cttcaacaat catttgctcc
     2161 caggcttccc ccatcatcac cctcaccaca tatcctgcta atatccaaca acaaacaaat
     2221 atttaatatt gaaatagccc attgcctgag aatgaacaca agctaaaata catgcaaggg
     2281 tacttaatgg aagccaaacc atgttctata cctaaggaga aaacatggac atgtagaatg
     2341 cttttattca tgtattcaaa atcagaacaa atcagtgtat atcactagaa catcagatgg
     2401 aggataacac aagaagtgat acagatcagg gttcacttct cttaccctct ctctgttagg
     2461 accacattcc tattttagcc aaatgtttct ggtacgggcc atcttttcac cataaatggc
     2521 attatgtttc aaatggctaa aagcatatta tgggtatgct caaaggagta aaacccaatt
     2581 cacagagatg tggcttttct aaagaaccaa attaagggaa tacttagtat ctacaactaa
     2641 agtattagtc attctgagga ttatttgttg ctttaagtat tagctcccta ctacatccat
     2701 aacaccctac ttactaaatt taattacaca caacttttca agaattcgta ttttatttga
     2761 agggaggtac ctgtctactt tatctacaat aaaaacaaag ggtattggct ttctctaatc
     2821 catgcaaact acaaattcca tcgggagtcc tacatcacta acagtggtat gaacaaaact
     2881 aagaaagtac ttcctatcca catgtgaatg ttttaaaaaa gtttttgcca taaaacctaa
     2941 gtgtaattta gcataccaca gtgctctgaa gatgggtcat tgacgatgta ccatttgtat
     3001 ataggtaata cacatgtaaa tcactaattg ttaattaaat ataagaagta ggtttttatc
     3061 tttttaaaaa aaaaacaaaa aaggtgactc cctttctcat tctgttctgt tgtattgcgt
     3121 ccaaaagttg tgtgtaattt ttttaaggtc caagaaatgt aaagaaattt gttggaatac
     3181 ctgaatttct gtaaaaaaat aaaaataaaa ataagatttt gttacttaaa agaa
//
