LOCUS       NM_178175               1559 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens LHFPL tetraspan subfamily member 1 (LHFPL1), mRNA.
ACCESSION   NM_178175
VERSION     NM_178175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
  REMARK    GeneRIF: The authors present an overview of the LHFP gene family in
            mouse and humans
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Huang,C., Guo,J., Liu,S., Shan,Y., Wu,S., Cai,Y. and Yu,L.
  TITLE     Isolation, tissue distribution and prokaryotic expression of a
            novel human X-linked gene LHFPL1
  JOURNAL   DNA Seq 15 (4), 299-302 (2004)
   PUBMED   15620218
  REMARK    GeneRIF: Expressed widely in ER of all tissues, especially highly
            in lung, thymus, skeleton muscle, colon and ovary.
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Petit,M.M., Schoenmakers,E.F., Huysmans,C., Geurts,J.M., Mandahl,N.
            and Van de Ven,W.J.
  TITLE     LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a
            member of a new family of LHFP-like genes
  JOURNAL   Genomics 57 (3), 438-441 (1999)
   PUBMED   10329012
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY217350.1 and AC000114.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178175.3.
            
            Summary: This gene is a member of the lipoma HMGIC fusion partner
            (LHFP) gene family, which is a subset of the superfamily of
            tetraspan transmembrane protein encoding genes. Mutations in one
            LHFP-like gene result in deafness in humans and mice, and a second
            LHFP-like gene is fused to a high-mobility group gene in a
            translocation-associated lipoma. Alternatively spliced transcript
            variants have been found, but their biological validity has not
            been determined. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY217350.1, SRR1803615.141043.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371968.8/ ENSP00000361036.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1255              AY217350.1         117-1371
            1256-1556           AY217350.1         1373-1673
            1557-1559           AC000114.1         130945-130947       c
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..1559
                     /gene="LHFPL1"
                     /note="LHFPL tetraspan subfamily member 1"
                     /db_xref="GeneID:340596"
                     /db_xref="HGNC:HGNC:6587"
                     /db_xref="MIM:300566"
     exon            1..110
                     /gene="LHFPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..506
                     /gene="LHFPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..787
                     /gene="LHFPL1"
                     /note="LHFP-like protein 1; lipoma HMGIC fusion partner
                     like 1; lipoma HMGIC fusion partner-like 1 protein; LHFPL
                     tetraspan subfamily member 1 protein"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 1 protein
                     precursor"
                     /protein_id="NP_835469.1"
                     /db_xref="CCDS:CCDS14562.1"
                     /db_xref="GeneID:340596"
                     /db_xref="HGNC:HGNC:6587"
                     /db_xref="MIM:300566"
                     /translation="MRSSLTMVGTLWAFLSLVTAVTSSTSYFLPYWLFGSQMGKPVSF
                     STFRRCNYPVRGEGHSLIMVEECGRYASFNAIPSLAWQMCTVVTGAGCALLLLVALAA
                     VLGCCMEELISRMMGRCMGAAQFVGGLLISSGCALYPLGWNSPEIMQTCGNVSNQFQL
                     GTCRLGWAYYCAGGGAAAAMLICTWLSCFAGRNPKPVILVESIMRNTNSYAMELDHCL
                     KP"
     exon            507..605
                     /gene="LHFPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1559
                     /gene="LHFPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      965..970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHFPL1"
                     /note="hexamer: TATAAA"
     polyA_site      985
                     /gene="LHFPL1"
                     /note="major polyA site"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LHFPL1"
                     /note="hexamer: AATAAA"
     polyA_site      1559
                     /gene="LHFPL1"
                     /note="major polyA site"
ORIGIN      
        1 aaagggcagc tagtattccc atccttgtct aacaagctgt aaggagaagt tgtttctgag
       61 atctgagcct gaagagaggg aacaagtcag tcagccttcg tggtcagaag agaaacctgt
      121 gaccatgagg agcagcctga ccatggtggg aaccctctgg gccttcctgt cccttgttac
      181 tgctgtgacc agttctacca gttacttcct accttactgg ctctttggat cccagatggg
      241 gaagccagtg tcattcagca cattccggag gtgcaactac cctgtgcggg gagagggaca
      301 cagtctgatc atggtggaag aatgtgggcg ctatgccagc ttcaatgcca tcccaagcct
      361 ggcctggcag atgtgcacag tggtgacagg tgccggctgt gctctgctgc tcctggtggc
      421 actagctgct gtcctgggtt gctgcatgga ggagctcatc tccagaatga tgggacgttg
      481 catgggagca gcgcagtttg ttggagggct gctgataagc tcaggctgtg ccttataccc
      541 tttaggatgg aatagcccgg agataatgca aacatgtggg aatgtctcca atcaatttca
      601 gttaggtacc tgtcggcttg gctgggccta ttactgtgct ggaggtggag cagctgcagc
      661 catgttgatc tgcacctggc tctcttgctt tgctggaaga aaccccaagc ctgtcatatt
      721 ggtggagagc atcatgagga ataccaattc ttatgctatg gagcttgacc attgcctcaa
      781 accttgagct ttgaaagaag attggagagg gtgggaaagg ggaggaggga gccctgaaaa
      841 gaggtactaa ggattaggcc atttgtcatc tgactgtcat tagcatagcc tagtgtttgc
      901 atgcttttta aactaattgt cgttcatttt cacttatctt taagccagta ggtcactggc
      961 tgtttataaa attcatcaga ggaaacattc tcagacattt acccaactgg caagtcgtgc
     1021 taacccgaag acccaaagta cccctttatg caaaatagga tccaaagcta aggctgggta
     1081 agaatagttg tgcagggagg gagcacgaga tgggcagagc tggttcctac cactccattc
     1141 acacagttca tcagttcatt cccaagtatt tattgtcacc cccaaacatc tctggagtac
     1201 tactgctcaa tttttgtgtc gttatcagga gtataccttg gctcttcctt tttttctcct
     1261 gcttcccccc gcaccttgtg gggaagcttc aggggagcgg gggagggtga ttcccagtgg
     1321 tggggaaaac attaatcaag gatacttgca tttagcctgg agccccttcc tcattatgct
     1381 ttagaatatt cataggagtt ccatttgtat tctggctggg tgatgagcaa aaaaaatata
     1441 tagtagcaaa tattctctca tcctttagag ataaagaaat ggtgttcatc aaatgtactg
     1501 agaatagact agcatttgtg gggcactcaa taaatttaaa ttcatggtga cagtgacaa
//
