LOCUS       NM_001017403            3649 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing G protein-coupled
            receptor 6 (LGR6), transcript variant 1, mRNA.
ACCESSION   NM_001017403
VERSION     NM_001017403.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3649)
  AUTHORS   Sunaga,N., Kaira,K., Shimizu,K., Tanaka,I., Miura,Y., Nakazawa,S.,
            Ohtaki,Y., Kawabata-Iwakawa,R., Sato,M., Girard,L., Minna,J.D. and
            Hisada,T.
  TITLE     The oncogenic role of LGR6 overexpression induced by aberrant
            Wnt/beta-catenin signaling in lung cancer
  JOURNAL   Thorac Cancer 15 (2), 131-141 (2024)
   PUBMED   38014454
  REMARK    GeneRIF: The oncogenic role of LGR6 overexpression induced by
            aberrant Wnt/beta-catenin signaling in lung cancer.
REFERENCE   2  (bases 1 to 3649)
  AUTHORS   Deng,Y., Xu,W., Ni,M., Sun,X., Wang,X., Zhang,T. and Pan,F.
  TITLE     DNA methylation and expression of LGR6 gene in ankylosing
            spondylitis: A case-control study
  JOURNAL   Hum Immunol 84 (12), 110719 (2023)
   PUBMED   37802707
  REMARK    GeneRIF: DNA methylation and expression of LGR6 gene in ankylosing
            spondylitis: A case-control study.
REFERENCE   3  (bases 1 to 3649)
  AUTHORS   Wang,J., Koch,D.T., Hofmann,F.O., Hartwig,D., Beirith,I.,
            Janssen,K.P., Bazhin,A.V., Niess,H., Werner,J., Renz,B.W. and
            Ilmer,M.
  TITLE     WNT enhancing signals in pancreatic cancer are transmitted by LGR6
  JOURNAL   Aging (Albany NY) 15 (20), 10897-10914 (2023)
   PUBMED   37770230
  REMARK    GeneRIF: WNT enhancing signals in pancreatic cancer are transmitted
            by LGR6.
REFERENCE   4  (bases 1 to 3649)
  AUTHORS   Cortesi,E.E., Meeusen,B., Vanstapel,A., Verleden,S.E.,
            Vanaudenaerde,B.M., Wuyts,W.A., Janssens,W., Janssens,V.,
            Roskams,T. and Ventura,J.J.
  TITLE     Increased LGR6 Expression Sustains Long-Term Wnt Activation and
            Acquisition of Senescence in Epithelial Progenitors in Chronic Lung
            Diseases
  JOURNAL   Cells 10 (12), 3437 (2021)
   PUBMED   34943945
  REMARK    GeneRIF: Increased LGR6 Expression Sustains Long-Term Wnt
            Activation and Acquisition of Senescence in Epithelial Progenitors
            in Chronic Lung Diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3649)
  AUTHORS   Li,X., Wang,W.P., Zhou,M., Xu,X.R. and Gao,J.Z.
  TITLE     [Expression and Significance of Leucine-rich Repeat-containing
            G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with
            Acute Lymphoblastic Leukemia]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 43 (4), 595-602 (2021)
   PUBMED   34494532
  REMARK    GeneRIF: [Expression and Significance of Leucine-rich
            Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in
            Children with Acute Lymphoblastic Leukemia].
REFERENCE   6  (bases 1 to 3649)
  AUTHORS   Garcia-Closas,M., Couch,F.J., Lindstrom,S., Michailidou,K.,
            Schmidt,M.K., Brook,M.N., Orr,N., Rhie,S.K., Riboli,E.,
            Feigelson,H.S., Le Marchand,L., Buring,J.E., Eccles,D., Miron,P.,
            Fasching,P.A., Brauch,H., Chang-Claude,J., Carpenter,J.,
            Godwin,A.K., Nevanlinna,H., Giles,G.G., Cox,A., Hopper,J.L.,
            Bolla,M.K., Wang,Q., Dennis,J., Dicks,E., Howat,W.J., Schoof,N.,
            Bojesen,S.E., Lambrechts,D., Broeks,A., Andrulis,I.L., Guenel,P.,
            Burwinkel,B., Sawyer,E.J., Hollestelle,A., Fletcher,O.,
            Winqvist,R., Brenner,H., Mannermaa,A., Hamann,U., Meindl,A.,
            Lindblom,A., Zheng,W., Devillee,P., Goldberg,M.S., Lubinski,J.,
            Kristensen,V., Swerdlow,A., Anton-Culver,H., Dork,T., Muir,K.,
            Matsuo,K., Wu,A.H., Radice,P., Teo,S.H., Shu,X.O., Blot,W.,
            Kang,D., Hartman,M., Sangrajrang,S., Shen,C.Y., Southey,M.C.,
            Park,D.J., Hammet,F., Stone,J., Veer,L.J., Rutgers,E.J.,
            Lophatananon,A., Stewart-Brown,S., Siriwanarangsan,P., Peto,J.,
            Schrauder,M.G., Ekici,A.B., Beckmann,M.W., Dos Santos Silva,I.,
            Johnson,N., Warren,H., Tomlinson,I., Kerin,M.J., Miller,N.,
            Marme,F., Schneeweiss,A., Sohn,C., Truong,T., Laurent-Puig,P.,
            Kerbrat,P., Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Milne,R.L.,
            Perez,J.I., Menendez,P., Muller,H., Arndt,V., Stegmaier,C.,
            Lichtner,P., Lochmann,M., Justenhoven,C., Ko,Y.D., Muranen,T.A.,
            Aittomaki,K., Blomqvist,C., Greco,D., Heikkinen,T., Ito,H.,
            Iwata,H., Yatabe,Y., Antonenkova,N.N., Margolin,S., Kataja,V.,
            Kosma,V.M., Hartikainen,J.M., Balleine,R., Tseng,C.C., Berg,D.V.,
            Stram,D.O., Neven,P., Dieudonne,A.S., Leunen,K., Rudolph,A.,
            Nickels,S., Flesch-Janys,D., Peterlongo,P., Peissel,B., Bernard,L.,
            Olson,J.E., Wang,X., Stevens,K., Severi,G., Baglietto,L.,
            McLean,C., Coetzee,G.A., Feng,Y., Henderson,B.E., Schumacher,F.,
            Bogdanova,N.V., Labreche,F., Dumont,M., Yip,C.H., Taib,N.A.,
            Cheng,C.Y., Shrubsole,M., Long,J., Pylkas,K., Jukkola-Vuorinen,A.,
            Kauppila,S., Knight,J.A., Glendon,G., Mulligan,A.M.,
            Tollenaar,R.A., Seynaeve,C.M., Kriege,M., Hooning,M.J., van den
            Ouweland,A.M., van Deurzen,C.H., Lu,W., Gao,Y.T., Cai,H.,
            Balasubramanian,S.P., Cross,S.S., Reed,M.W., Signorello,L., Cai,Q.,
            Shah,M., Miao,H., Chan,C.W., Chia,K.S., Jakubowska,A., Jaworska,K.,
            Durda,K., Hsiung,C.N., Wu,P.E., Yu,J.C., Ashworth,A., Jones,M.,
            Tessier,D.C., Gonzalez-Neira,A., Pita,G., Alonso,M.R., Vincent,D.,
            Bacot,F., Ambrosone,C.B., Bandera,E.V., John,E.M., Chen,G.K.,
            Hu,J.J., Rodriguez-Gil,J.L., Bernstein,L., Press,M.F.,
            Ziegler,R.G., Millikan,R.M., Deming-Halverson,S.L., Nyante,S.,
            Ingles,S.A., Waisfisz,Q., Tsimiklis,H., Makalic,E., Schmidt,D.,
            Bui,M., Gibson,L., Muller-Myhsok,B., Schmutzler,R.K., Hein,R.,
            Dahmen,N., Beckmann,L., Aaltonen,K., Czene,K., Irwanto,A., Liu,J.,
            Turnbull,C., Rahman,N., Meijers-Heijboer,H., Uitterlinden,A.G.,
            Rivadeneira,F., Olswold,C., Slager,S., Pilarski,R., Ademuyiwa,F.,
            Konstantopoulou,I., Martin,N.G., Montgomery,G.W., Slamon,D.J.,
            Rauh,C., Lux,M.P., Jud,S.M., Bruning,T., Weaver,J., Sharma,P.,
            Pathak,H., Tapper,W., Gerty,S., Durcan,L., Trichopoulos,D.,
            Tumino,R., Peeters,P.H., Kaaks,R., Campa,D., Canzian,F.,
            Weiderpass,E., Johansson,M., Khaw,K.T., Travis,R.,
            Clavel-Chapelon,F., Kolonel,L.N., Chen,C., Beck,A., Hankinson,S.E.,
            Berg,C.D., Hoover,R.N., Lissowska,J., Figueroa,J.D., Chasman,D.I.,
            Gaudet,M.M., Diver,W.R., Willett,W.C., Hunter,D.J., Simard,J.,
            Benitez,J., Dunning,A.M., Sherman,M.E., Chenevix-Trench,G.,
            Chanock,S.J., Hall,P., Pharoah,P.D., Vachon,C., Easton,D.F.,
            Haiman,C.A. and Kraft,P.
  CONSRTM   Gene ENvironmental Interaction and breast CAncer (GENICA) Network;
            kConFab Investigators; Familial Breast Cancer Study (FBCS);
            Australian Breast Cancer Tissue Bank (ABCTB) Investigators
  TITLE     Genome-wide association studies identify four ER negative-specific
            breast cancer risk loci
  JOURNAL   Nat Genet 45 (4), 392-398 (2013)
   PUBMED   23535733
REFERENCE   7  (bases 1 to 3649)
  AUTHORS   Gong,X., Carmon,K.S., Lin,Q., Thomas,A., Yi,J. and Liu,Q.
  TITLE     LGR6 is a high affinity receptor of R-spondins and potentially
            functions as a tumor suppressor
  JOURNAL   PLoS One 7 (5), e37137 (2012)
   PUBMED   22615920
  REMARK    GeneRIF: Overexpression of wild-type LGR6 in HeLa cells leads to
            increased cell migration.
REFERENCE   8  (bases 1 to 3649)
  AUTHORS   de Lau,W., Barker,N., Low,T.Y., Koo,B.K., Li,V.S., Teunissen,H.,
            Kujala,P., Haegebarth,A., Peters,P.J., van de Wetering,M.,
            Stange,D.E., van Es,J.E., Guardavaccaro,D., Schasfoort,R.B.,
            Mohri,Y., Nishimori,K., Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     Lgr5 homologues associate with Wnt receptors and mediate R-spondin
            signalling
  JOURNAL   Nature 476 (7360), 293-297 (2011)
   PUBMED   21727895
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3649)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 3649)
  AUTHORS   Hsu,S.Y., Kudo,M., Chen,T., Nakabayashi,K., Bhalla,A., van der
            Spek,P.J., van Duin,M. and Hsueh,A.J.
  TITLE     The three subfamilies of leucine-rich repeat-containing G
            protein-coupled receptors (LGR): identification of LGR6 and LGR7
            and the signaling mechanism for LGR7
  JOURNAL   Mol Endocrinol 14 (8), 1257-1271 (2000)
   PUBMED   10935549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356953.17, BM699180.1,
            AB049405.1, BC047905.1 and AF088074.1.
            
            On Aug 11, 2020 this sequence version replaced NM_001017403.1.
            
            Summary: This gene encodes a member of the leucine-rich
            repeat-containing subgroup of the G protein-coupled 7-transmembrane
            protein superfamily. The encoded protein is a glycoprotein hormone
            receptor with a large N-terminal extracellular domain that contains
            leucine-rich repeats important for the formation of a
            horseshoe-shaped interaction motif for ligand binding. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049405.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367278.8/ ENSP00000356247.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AL356953.17        10818-11008
            192-306             BM699180.1         84-198
            307-1435            AB049405.1         1-1129
            1436-3583           BC047905.1         1115-3262
            3584-3649           AF088074.1         476-541
FEATURES             Location/Qualifiers
     source          1..3649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3649
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /note="leucine rich repeat containing G protein-coupled
                     receptor 6"
                     /db_xref="GeneID:59352"
                     /db_xref="HGNC:HGNC:19719"
                     /db_xref="MIM:606653"
     exon            1..403
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..3095
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gonadotropin receptor"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 6 isoform 1 precursor"
                     /protein_id="NP_001017403.1"
                     /db_xref="CCDS:CCDS30971.1"
                     /db_xref="GeneID:59352"
                     /db_xref="HGNC:HGNC:19719"
                     /db_xref="MIM:606653"
                     /translation="MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQED
                     GIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHL
                     SHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEG
                     LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLH
                     NNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA
                     FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILT
                     LTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGAD
                     TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL
                     KGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESS
                     KRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRL
                     AVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDAL
                     TFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPS
                     LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMN
                     SFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASML
                     GLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAA
                     GELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEG
                     SHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV"
     exon            404..475
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            476..547
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            548..619
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            620..835
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            836..907
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            908..976
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1048
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1120
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1189
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1261
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1327
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1399
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1471
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1597
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1758
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1839
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..3649
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3556..3561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /note="hexamer: ATTAAA"
     polyA_site      3578
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /note="major polyA site"
     regulatory      3626..3631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
                     /note="hexamer: AATAAA"
     polyA_site      3649
                     /gene="LGR6"
                     /gene_synonym="GPCR; VTS20631"
ORIGIN      
        1 actcaacaat gcctgcccct ctctgactgc accgtcccgg cgctcccacc gccgccgccg
       61 ccgcccaata gagcccctgg ggcggtcccc accgacggtg cagcccgccg ggaccgggag
      121 gaagcagctg cggccatcgc gccgtgcgtc cgcgcccggc cgccaggtgc cccagtagcc
      181 cgaccgccga gatgcccagc ccgccggggc tccgggcgct atggctttgc gccgcgctgt
      241 gcgcttcccg gagggccggc ggcgcccccc agcccggccc ggggcccacc gcctgcccgg
      301 ccccctgcca ctgccaggag gacggcatca tgctgtctgc cgactgctct gagctcgggc
      361 tgtccgccgt tccgggggac ctggaccccc tgacggctta cctggacctc agcatgaaca
      421 acctcacaga gcttcagcct ggcctcttcc accacctgcg cttcttggag gagctgcgtc
      481 tctctgggaa ccatctctca cacatcccag gacaagcatt ctctggtctc tacagcctga
      541 aaatcctgat gctgcagaac aatcagctgg gaggaatccc cgcagaggcg ctgtgggagc
      601 tgccgagcct gcagtcgctg cgcctagatg ccaacctcat ctccctggtc ccggagagga
      661 gctttgaggg gctgtcctcc ctccgccacc tctggctgga cgacaatgca ctcacggaga
      721 tccctgtcag ggccctcaac aacctccctg ccctgcaggc catgaccctg gccctcaacc
      781 gcatcagcca catccccgac tacgcgttcc agaatctcac cagccttgtg gtgctgcatt
      841 tgcataacaa ccgcatccag catctgggga cccacagctt cgaggggctg cacaatctgg
      901 agacactaga cctgaattat aacaagctgc aggagttccc tgtggccatc cggaccctgg
      961 gcagactgca ggaactgggg ttccataaca acaacatcaa ggccatccca gaaaaggcct
     1021 tcatggggaa ccctctgcta cagacgatac acttttatga taacccaatc cagtttgtgg
     1081 gaagatcggc attccagtac ctgcctaaac tccacacact atctctgaat ggtgccatgg
     1141 acatccagga gtttccagat ctcaaaggca ccaccagcct ggagatcctg accctgaccc
     1201 gcgcaggcat ccggctgctc ccatcgggga tgtgccaaca gctgcccagg ctccgagtcc
     1261 tggaactgtc tcacaatcaa attgaggagc tgcccagcct gcacaggtgt cagaaattgg
     1321 aggaaatcgg cctccaacac aaccgcatct gggaaattgg agctgacacc ttcagccagc
     1381 tgagctccct gcaagccctg gatcttagct ggaacgccat ccggtccatc caccccgagg
     1441 ccttctccac cctgcactcc ctggtcaagc tggacctgac agacaaccag ctgaccacac
     1501 tgcccctggc tggacttggg ggcttgatgc atctgaagct caaagggaac cttgctctct
     1561 cccaggcctt ctccaaggac agtttcccaa aactgaggat cctggaggtg ccttatgcct
     1621 accagtgctg tccctatggg atgtgtgcca gcttcttcaa ggcctctggg cagtgggagg
     1681 ctgaagacct tcaccttgat gatgaggagt cttcaaaaag gcccctgggc ctccttgcca
     1741 gacaagcaga gaaccactat gaccaggacc tggatgagct ccagctggag atggaggact
     1801 caaagccaca ccccagtgtc cagtgtagcc ctactccagg ccccttcaag ccctgtgagt
     1861 acctctttga aagctggggc atccgcctgg ccgtgtgggc catcgtgttg ctctccgtgc
     1921 tctgcaatgg actggtgctg ctgaccgtgt tcgctggcgg gcctgtcccc ctgcccccgg
     1981 tcaagtttgt ggtaggtgcg attgcaggcg ccaacacctt gactggcatt tcctgtggcc
     2041 ttctagcctc agtcgatgcc ctgacctttg gtcagttctc tgagtacgga gcccgctggg
     2101 agacggggct aggctgccgg gccactggct tcctggcagt acttgggtcg gaggcatcgg
     2161 tgctgctgct cactctggcc gcagtgcagt gcagcgtctc cgtctcctgt gtccgggcct
     2221 atgggaagtc cccctccctg ggcagcgttc gagcaggggt cctaggctgc ctggcactgg
     2281 cagggctggc cgccgcgctg cccctggcct cagtgggaga atacggggcc tccccactct
     2341 gcctgcccta cgcgccacct gagggtcagc cagcagccct gggcttcacc gtggccctgg
     2401 tgatgatgaa ctccttctgt ttcctggtcg tggccggtgc ctacatcaaa ctgtactgtg
     2461 acctgccgcg gggcgacttt gaggccgtgt gggactgcgc catggtgagg cacgtggcct
     2521 ggctcatctt cgcagacggg ctcctctact gtcccgtggc cttcctcagc tttgcctcca
     2581 tgctgggcct cttccctgtc acgcccgagg ccgtcaagtc tgtcctgctg gtggtgctgc
     2641 ccctgcctgc ctgcctcaac ccactgctgt acctgctctt caacccccac ttccgggatg
     2701 accttcggcg gcttcggccc cgcgcagggg actcagggcc cctagcctat gctgcggccg
     2761 gggagctgga gaagagctcc tgtgattcta cccaggccct ggtagccttc tctgatgtgg
     2821 atctcattct ggaagcttct gaagctgggc ggccccctgg gctggagacc tatggcttcc
     2881 cctcagtgac cctcatctcc tgtcagcagc caggggcccc caggctggag ggcagccatt
     2941 gtgtagagcc agaggggaac cactttggga acccccaacc ctccatggat ggagaactgc
     3001 tgctgagggc agagggatct acgccagcag gtggaggctt gtcagggggt ggcggctttc
     3061 agccctctgg cttggccttt gcttcacacg tgtaaatatc cctccccatt cttctcttcc
     3121 cctctcttcc ctttcctctc tccccctcgg tgaatgatgg ctgcttctaa aacaaataca
     3181 accaaaactc agcagtgtga tctatagcag gatggcccag tccctggctc cactgatcac
     3241 ctctctcctg tgaccatcac caacgggtgc ctcttggcct ggctttccct tggccttcct
     3301 cagcttcacc ttgatactgg gcctcttcct tgtcatgtct gaagctgtgg accagagacc
     3361 tggacttttg tctgcttaag ggaaatgagg gaagtaaaga cagtgaaggg gtggagggtt
     3421 gatcagggca cagtggacag ggagacctca cagagaaagg cctggaaggt gatttcccgt
     3481 gtgactcatg gataggatac aaaatgtgtt ccatgtacca ttaatcttga catatgccat
     3541 gcataaagac ttcctattaa aataagcttt ggaagagatt acacatgatg tctttttctt
     3601 agagattcac agtgcatgtt agtgtaataa agagataagt cctacagta
//
