LOCUS       NM_018490               5250 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing G protein-coupled
            receptor 4 (LGR4), transcript variant 1, mRNA.
ACCESSION   NM_018490
VERSION     NM_018490.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5250)
  AUTHORS   Bi,Y., Zhang,L., Song,Y., Sun,L., Mulholland,M.W., Yin,Y. and
            Zhang,W.
  TITLE     Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via
            activation of Wnt/beta-catenin signaling pathway
  JOURNAL   Gastroenterol Hepatol 47 (4), 352-365 (2024)
   PUBMED   37437654
  REMARK    GeneRIF: Rspo2-LGR4 exacerbates hepatocellular carcinoma
            progression via activation of Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 5250)
  AUTHORS   Dodin,Y.
  TITLE     Identification of LGR4 as a prognostic biomarker in KRAS-mutant
            lung adenocarcinoma: Evidence from integrated bioinformatics
            analysis
  JOURNAL   Medicine (Baltimore) 102 (46), e36084 (2023)
   PUBMED   37986325
  REMARK    GeneRIF: Identification of LGR4 as a prognostic biomarker in
            KRAS-mutant lung adenocarcinoma: Evidence from integrated
            bioinformatics analysis.
REFERENCE   3  (bases 1 to 5250)
  AUTHORS   Yi,Z., Ma,T., Liu,J., Tie,W., Li,Y., Bai,J., Li,L. and Zhang,L.
  TITLE     LGR4 promotes tumorigenesis by activating TGF-beta1/Smad signaling
            pathway in multiple myeloma
  JOURNAL   Cell Signal 110, 110814 (2023)
   PUBMED   37473901
  REMARK    GeneRIF: LGR4 promotes tumorigenesis by activating TGF-beta1/Smad
            signaling pathway in multiple myeloma.
REFERENCE   4  (bases 1 to 5250)
  AUTHORS   Zhang,N., Yuan,M. and Wang,J.
  TITLE     LGR4: A New Receptor Member in Endocrine and Metabolic Diseases
  JOURNAL   Endocr Rev 44 (4), 647-667 (2023)
   PUBMED   36791020
  REMARK    GeneRIF: LGR4: A New Receptor Member in Endocrine and Metabolic
            Diseases.
            Review article
REFERENCE   5  (bases 1 to 5250)
  AUTHORS   Lucas,C., Sauter,K.S., Steigert,M., Mallet,D., Wilmouth,J.,
            Olabe,J., Plotton,I., Morel,Y., Aeberli,D., Wagner,F., Clevers,H.,
            Pandey,A.V., Val,P., Roucher-Boulez,F. and Fluck,C.E.
  TITLE     Loss of LGR4/GPR48 causes severe neonatal salt wasting due to
            disrupted WNT signaling altering adrenal zonation
  JOURNAL   J Clin Invest 133 (4), e164915 (2023)
   PUBMED   36538378
  REMARK    GeneRIF: Loss of LGR4/GPR48 causes severe neonatal salt wasting due
            to disrupted WNT signaling altering adrenal zonation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5250)
  AUTHORS   Weng,J., Luo,J., Cheng,X., Jin,C., Zhou,X., Qu,J., Tu,L., Ai,D.,
            Li,D., Wang,J., Martin,J.F., Amendt,B.A. and Liu,M.
  TITLE     Deletion of G protein-coupled receptor 48 leads to ocular anterior
            segment dysgenesis (ASD) through down-regulation of Pitx2
  JOURNAL   Proc Natl Acad Sci U S A 105 (16), 6081-6086 (2008)
   PUBMED   18424556
REFERENCE   7  (bases 1 to 5250)
  AUTHORS   Gao,Y., Kitagawa,K., Hiramatsu,Y., Kikuchi,H., Isobe,T.,
            Shimada,M., Uchida,C., Hattori,T., Oda,T., Nakayama,K.,
            Nakayama,K.I., Tanaka,T., Konno,H. and Kitagawa,M.
  TITLE     Up-regulation of GPR48 induced by down-regulation of p27Kip1
            enhances carcinoma cell invasiveness and metastasis
  JOURNAL   Cancer Res 66 (24), 11623-11631 (2006)
   PUBMED   17178856
  REMARK    GeneRIF: GPR48 may play an important role in invasiveness and
            metastasis of carcinoma and might represent a potential prognostic
            marker or therapeutic target.
REFERENCE   8  (bases 1 to 5250)
  AUTHORS   Loh,E.D., Broussard,S.R. and Kolakowski,L.F.
  TITLE     Molecular characterization of a novel glycoprotein hormone
            G-protein-coupled receptor
  JOURNAL   Biochem Biophys Res Commun 282 (3), 757-764 (2001)
   PUBMED   11401528
REFERENCE   9  (bases 1 to 5250)
  AUTHORS   Loh,E.D., Broussard,S.R., Liu,Q., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Kolakowski,L.F. Jr.
  TITLE     Chromosomal localization of GPR48, a novel glycoprotein hormone
            receptor like GPCR, in human and mouse with radiation hybrid and
            interspecific backcross mapping
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 2-5 (2000)
   PUBMED   10894923
REFERENCE   10 (bases 1 to 5250)
  AUTHORS   Hsu,S.Y., Liang,S.G. and Hsueh,A.J.
  TITLE     Characterization of two LGR genes homologous to gonadotropin and
            thyrotropin receptors with extracellular leucine-rich repeats and a
            G protein-coupled, seven-transmembrane region
  JOURNAL   Mol Endocrinol 12 (12), 1830-1845 (1998)
   PUBMED   9849958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100771.2 and AC090597.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_018490.4.
            
            Summary: The protein encoded by this gene is a G-protein coupled
            receptor that binds R-spondins and activates the Wnt signaling
            pathway. This Wnt signaling pathway activation is necessary for
            proper development of many organs of the body. [provided by RefSeq,
            Oct 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF257182.1, SRR14038194.2428183.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379214.9/ ENSP00000368516.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-673               AC100771.2         78984-79656         c
            674-745             AC100771.2         19655-19726         c
            746-817             AC090597.9         146761-146832       c
            818-889             AC090597.9         145408-145479       c
            890-1105            AC090597.9         139567-139782       c
            1106-1177           AC090597.9         138650-138721       c
            1178-1246           AC090597.9         136502-136570       c
            1247-1318           AC090597.9         135209-135280       c
            1319-1390           AC090597.9         134954-135025       c
            1391-1459           AC090597.9         134585-134653       c
            1460-1531           AC090597.9         133011-133082       c
            1532-1597           AC090597.9         131472-131537       c
            1598-1669           AC090597.9         130613-130684       c
            1670-1741           AC090597.9         128289-128360       c
            1742-1867           AC090597.9         127865-127990       c
            1868-1983           AC090597.9         126597-126712       c
            1984-2067           AC090597.9         125929-126012       c
            2068-5250           AC090597.9         120275-123457       c
FEATURES             Location/Qualifiers
     source          1..5250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..5250
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /note="leucine rich repeat containing G protein-coupled
                     receptor 4"
                     /db_xref="GeneID:55366"
                     /db_xref="HGNC:HGNC:13299"
                     /db_xref="MIM:606666"
     exon            1..673
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..3344
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; G protein-coupled receptor 48"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 4 isoform 1 precursor"
                     /protein_id="NP_060960.2"
                     /db_xref="CCDS:CCDS31449.1"
                     /db_xref="GeneID:55366"
                     /db_xref="HGNC:HGNC:13299"
                     /db_xref="MIM:606666"
                     /translation="MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCS
                     GKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALS
                     GLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWL
                     DDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQ
                     HCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRT
                     IHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSI
                     PNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLR
                     ILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEA
                     LAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTS
                     TLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFAS
                     CTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFL
                     AVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLF
                     HRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSEN
                     SQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNP
                     VLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLT
                     VCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCGTQSAHSDYADEEDS
                     FVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD"
     exon            674..745
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            746..817
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            818..889
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1105
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1177
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1246
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1318
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1390
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1459
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1531
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1597
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1669
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1741
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1867
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1983
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2067
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..5250
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5089..5094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /note="hexamer: ATTAAA"
     polyA_site      5109
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /note="major polyA site"
     regulatory      5230..5235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /note="hexamer: ATTAAA"
     polyA_site      5250
                     /gene="LGR4"
                     /gene_synonym="BNMD17; DPSL; GPR48"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtgca accctagaag ggaaaaggac gggaagagat tgagccgcgg ctgggagaca
       61 gcgagccaga gtctgggtgt ttgtgcgaga gccacggcgg gggctggggc gagtggccgg
      121 catggctgaa ggctgcgctc tgcaaccttg aagagccgct gcattgagag gccagggaca
      181 gggagaccgg tgcgatggca gagcgcggcc cccgccgctg cgccgggccg gcccggctgg
      241 cgtgagccgc cggaggagcg gggctgcctc tgcgcgtcca tggagcagcg ggaagggcga
      301 aactccggag cgccgcgtcc ctgcgccgct gcggcggact gctgaagggg ccgagcccgc
      361 gcggaccgcc gaggaagaga cccccgctcc agcccgcagg ccggctgccc gggggcggcg
      421 ggggacatcg gagggcagcg gagcgagcag cgccgcggga gaggccggcg cgggaggcgg
      481 ccgcagcaat gccgggcccg ctagggctgc tctgcttcct cgccctgggg ctgctcggct
      541 cggccgggcc cagcggcgcg gcgccgcctc tctgcgcggc gccctgcagc tgcgacggcg
      601 accgtcgggt ggactgctcc gggaaggggc tgacggccgt gcccgagggg ctcagcgcct
      661 tcacccaagc gctggatatc agtatgaaca acattactca gttgccagaa gatgcattta
      721 agaactttcc ttttctagaa gagctacaat tggcgggcaa cgacctttct tttatccacc
      781 caaaggcctt gtctgggttg aaagaactca aagttctaac gctccagaat aatcagttga
      841 aaacagtacc cagtgaagcc attcgagggc tgagtgcttt gcagtctttg cgtttagatg
      901 ccaaccatat tacctcagtc cccgaggaca gttttgaagg acttgttcag ttacggcatc
      961 tgtggctgga tgacaacagc ttgacggagg tgcctgtgca ccccctcagc aatctgccca
     1021 ccctacaggc gctgaccctg gctctcaaca agatctcaag catccctgac tttgcattta
     1081 ccaacctttc aagcctggta gttctgcatc ttcataacaa taaaattaga agcctgagtc
     1141 aacactgttt tgatggacta gataacctgg agaccttaga cttgaattat aataacttgg
     1201 gggaatttcc tcaggctatt aaagcccttc ctagccttaa agagctagga tttcatagta
     1261 attctatttc tgttatccct gatggagcat ttgatggtaa tccactctta agaactatac
     1321 atttgtatga taatcctctg tcttttgtgg ggaactcagc atttcacaat ttatctgatc
     1381 ttcattccct agtcattcgt ggtgcaagca tggtgcagca gttccccaat cttacaggaa
     1441 ctgtccacct ggaaagtctg actttgacag gtacaaagat aagcagcata cctaataatt
     1501 tgtgtcaaga acaaaagatg cttaggactt tggacttgtc ttacaataat ataagagacc
     1561 ttccaagttt taatggttgc catgctctgg aagaaatttc tttacagcgt aatcaaatct
     1621 accaaataaa ggaaggcacc tttcaaggcc tgatatctct aaggattcta gatctgagta
     1681 gaaacctgat acatgaaatt cacagtagag cttttgccac acttgggcca ataactaacc
     1741 tagatgtaag tttcaatgaa ttaacttcct ttcctacgga aggcctgaat gggctaaatc
     1801 aactgaaact tgtgggcaac ttcaagctga aagaagcctt agcagcaaaa gactttgtta
     1861 acctcaggtc tttatcagta ccatatgctt atcagtgctg tgcattttgg ggttgtgact
     1921 cttatgcaaa tttaaacaca gaagataaca gcctccagga ccacagtgtg gcacaggaga
     1981 aaggtactgc tgatgcagca aatgtcacaa gcactcttga aaatgaagaa catagtcaaa
     2041 taattatcca ttgtacacct tcaacaggtg cttttaagcc ctgtgaatat ttactgggaa
     2101 gctggatgat tcgtcttact gtgtggttca ttttcttggt tgcattattt ttcaacctgc
     2161 ttgttatttt aacaacattt gcatcttgta catcactgcc ttcgtccaaa ttgtttatag
     2221 gcttgatttc tgtgtctaac ttattcatgg gaatctatac tggcatccta acttttcttg
     2281 atgctgtgtc ctggggcaga ttcgctgaat ttggcatttg gtgggaaact ggcagtggct
     2341 gcaaagtagc tgggtttctt gcagttttct cctcagaaag tgccatattt ttattaatgc
     2401 tagcaactgt cgaaagaagc ttatctgcaa aagatataat gaaaaatggg aagagcaatc
     2461 atctcaaaca gttccgggtt gctgcccttt tggctttcct aggtgctaca gtagcaggct
     2521 gttttcccct tttccataga ggggaatatt ctgcatcacc cctttgtttg ccatttccta
     2581 caggtgaaac gccatcatta ggattcactg taacgttagt gctattaaac tcactagcat
     2641 ttttattaat ggccgttatc tacactaaac tatactgcaa cttggaaaaa gaggacctct
     2701 cagaaaactc acaatctagc atgattaagc atgtcgcttg gctaatcttc accaattgca
     2761 tctttttctg ccctgtggcg tttttttcat ttgcaccatt gatcactgca atctctatca
     2821 gccccgaaat aatgaagtct gttactctga tattttttcc attgcctgct tgcctgaatc
     2881 cagtcctgta tgttttcttc aacccaaagt ttaaagaaga ctggaagtta ctgaagcgac
     2941 gtgttaccaa gaaaagtgga tcagtttcag tttccatcag tagccaaggt ggttgtctgg
     3001 aacaggattt ctactacgac tgtggcatgt actcacattt gcagggcaac ctgactgttt
     3061 gcgactgctg cgaatcgttt cttttaacaa agccagtatc atgcaaacac ttgataaaat
     3121 cacacagctg tcctgcattg gcagtggctt cttgccaaag acctgagggc tactggtccg
     3181 actgtggcac acagtcggcc cactctgatt atgcagatga agaagattcc tttgtctcag
     3241 acagttctga ccaggtgcag gcctgtggac gagcctgctt ctaccagagt agaggattcc
     3301 ctttggtgcg ctatgcttac aatctaccaa gagttaaaga ctgaactact gtgtgtgtaa
     3361 ccgtttcccc cgtcaaccaa aatcagtgtt tatagagtga accctattct catctttcat
     3421 ctgggaagca cttctgtaat cactgcctgg tgtcacttag aagaaggaga ggtggcagtt
     3481 tatttctcaa accagtcatt ttcaaagaac aggtgcctaa attataaatt ggtgaaaaat
     3541 gcaatgtcca agcaatgtat gatctgtttg aaacaaatat atgacttgaa aaggatctta
     3601 ggtgtagtag agcaatataa tgttagtttt ttctgatcca taagaagcaa atttatacct
     3661 atttgtgtat taagcacaag ataaagaaca gctgttaata ttttttaaaa atctatttta
     3721 aaatgtgatt ttctataact gaagaaaata tcttgctaat tttacctaat gtttcatcct
     3781 taatctcagg acaacttact gcagggccaa aaaagggact gtcccagcta gaactgtgag
     3841 agtatacata ggcattactt tattatgttt tcacttgcca tccttgacat aagagaacta
     3901 taaattttgt ttaagcaatt tataaatcta aaacctgaag atgtttttaa aacaatatta
     3961 acagctgtta ggttaaaaaa atagctggac atttgttttc agtcattata cattgctttg
     4021 gtccaatcag taattttttc ttaagtgttt tgtgattaca ctactagaaa aaaagtaaaa
     4081 ggctaattgc tgtgtgggtt tagtcgattt ggctaaacta ctaactaatg tgggggttta
     4141 atagtatctg agggatttgg tggcttcatg taatgttctc attaatgaat acttcctaat
     4201 atcgttggct ctactaatat tttccaattt gctgggatgt cacctagcaa tagcttggat
     4261 tatatagaaa gtaaactgtg gtcaatactt gcatttaatt agacgaaacg gggagtaatt
     4321 atgacacgaa gtacttatgt ttatttctta gtgagctgga ttatcttgaa cctgtgctat
     4381 taaatggaaa tttccataca tcttccccat actatttttt ataaaagagc ctattcaata
     4441 gctcagaggt tgaactctgg ttaaacaaga taatatgtta ttaataaaaa tagaagaaga
     4501 aagaataaag cttagtcctg tgtctttaaa aattaaaaat tttacttgat tcccatctat
     4561 gggctttaga cctattactg ggtggagtct taaagttata attgttcaat atgttttttg
     4621 aacagtgtgc taaatcaata gcaaacccac tgccatatta gttattctga atatactaaa
     4681 aaaatccagc tagattgcag tttaataatt aaactgtaca tactgtgcat ataatgaatt
     4741 tttatcttat gtaaattatt tttagaacac aagttgggaa atgtggcttc tgttcatttc
     4801 gtttaattaa agctacctcc taaactatag tggctgccag tagcagactg ttaaattgtg
     4861 gtttatatac tttttgcatt gtaaatagtc tttgttgtac attgtcagtg taataaaaac
     4921 agaatctttg tatatcaaaa tcatgtagtt tgtataaaat gtgggaagga tttatttaca
     4981 gtgtgttgta attttgtaag gccaactatt tacaagtttt aaaaattgct atcatgtata
     5041 tttacacatc tgataaatat taaatcataa cttggtaaga aactcctaat taaaaggttt
     5101 tttccaaaat tcaggttatt gaaaactttt cattttattc atttaaaaac tagaataaca
     5161 gatatataaa agtgttaatc tttgtgctat atggtatgaa atacaatatt gtactcagtg
     5221 ttttgaatta ttaaagtttc tagaaagcaa
//
