LOCUS       NM_139278               3241 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat LGI family member 3 (LGI3), mRNA.
ACCESSION   NM_139278
VERSION     NM_139278.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3241)
  AUTHORS   Marafi,D., Kozar,N., Duan,R., Bradley,S., Yokochi,K., Al
            Mutairi,F., Saadi,N.W., Whalen,S., Brunet,T., Kotzaeridou,U.,
            Choukair,D., Keren,B., Nava,C., Kato,M., Arai,H., Froukh,T.,
            Faqeih,E.A., AlAsmari,A.M., Saleh,M.M., Pinto E Vairo,F.,
            Pichurin,P.N., Klee,E.W., Schmitz,C.T., Grochowski,C.M., Mitani,T.,
            Herman,I., Calame,D.G., Fatih,J.M., Du,H., Coban-Akdemir,Z.,
            Pehlivan,D., Jhangiani,S.N., Gibbs,R.A., Miyatake,S., Matsumoto,N.,
            Wagstaff,L.J., Posey,J.E., Lupski,J.R., Meijer,D. and Wagner,M.
  TITLE     A reverse genetics and genomics approach to gene paralog function
            and disease: Myokymia and the juxtaparanode
  JOURNAL   Am J Hum Genet 109 (9), 1713-1723 (2022)
   PUBMED   35948005
REFERENCE   2  (bases 1 to 3241)
  AUTHORS   Kim,S.Y., Kim,Y.Y., Kim,I.W., Yun,H.Y. and Kim,D.S.
  TITLE     LGI3 promotes human keratinocyte migration in high-glucose
            environments by increasing the expression of beta-catenin
  JOURNAL   Pharmazie 77 (6), 186-190 (2022)
   PUBMED   35751164
  REMARK    GeneRIF: LGI3 promotes human keratinocyte migration in high-glucose
            environments by increasing the expression of beta-catenin.
REFERENCE   3  (bases 1 to 3241)
  AUTHORS   Lee,S.H., Kwon,N.S., Baek,K.J., Yun,H.Y. and Kim,D.S.
  TITLE     LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-kappaB
            pathway in response to LPS in human keratinocytes
  JOURNAL   Cytokine 126, 154872 (2020)
   PUBMED   31627033
  REMARK    GeneRIF: LGI3 is secreted and binds to ADAM22 via TRIF-dependent
            NF-kappaB pathway in response to LPS in human keratinocytes.
REFERENCE   4  (bases 1 to 3241)
  AUTHORS   Kim,I.W., Jeong,H.S., Kwon,N.S., Baek,K.J., Yun,H.Y. and Kim,D.S.
  TITLE     LGI3 promotes human keratinocyte differentiation via the Akt
            pathway
  JOURNAL   Exp Dermatol 27 (11), 1224-1229 (2018)
   PUBMED   30091803
  REMARK    GeneRIF: Taken together, these results suggest that LGI3 promotes
            keratinocyte differentiation.
REFERENCE   5  (bases 1 to 3241)
  AUTHORS   Kwon,N.S., Baek,K.J., Kim,D.S. and Yun,H.Y.
  TITLE     Leucine-rich glioma inactivated 3: Integrative analyses reveal its
            potential prognostic role in cancer
  JOURNAL   Mol Med Rep 17 (3), 3993-4002 (2018)
   PUBMED   29257304
  REMARK    GeneRIF: The expression of LGI3 was significantly associated with
            the prognosis of brain, colorectal and lung cancer.
REFERENCE   6  (bases 1 to 3241)
  AUTHORS   Okabayashi,S. and Kimura,N.
  TITLE     Leucine-rich glioma inactivated 3 is involved in amyloid beta
            peptide uptake by astrocytes and endocytosis itself
  JOURNAL   Neuroreport 19 (12), 1175-1179 (2008)
   PUBMED   18628660
REFERENCE   7  (bases 1 to 3241)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 3241)
  AUTHORS   Staub,E., Perez-Tur,J., Siebert,R., Nobile,C., Moschonas,N.K.,
            Deloukas,P. and Hinzmann,B.
  TITLE     The novel EPTP repeat defines a superfamily of proteins implicated
            in epileptic disorders
  JOURNAL   Trends Biochem Sci 27 (9), 441-444 (2002)
   PUBMED   12217514
  REMARK    Review article
REFERENCE   9  (bases 1 to 3241)
  AUTHORS   Scheel,H., Tomiuk,S. and Hofmann,K.
  TITLE     A common protein interaction domain links two recently identified
            epilepsy genes
  JOURNAL   Hum Mol Genet 11 (15), 1757-1762 (2002)
   PUBMED   12095917
REFERENCE   10 (bases 1 to 3241)
  AUTHORS   Gu,W., Wevers,A., Schroder,H., Grzeschik,K.H., Derst,C.,
            Brodtkorb,E., de Vos,R. and Steinlein,O.K.
  TITLE     The LGI1 gene involved in lateral temporal lobe epilepsy belongs to
            a new subfamily of leucine-rich repeat proteins
  JOURNAL   FEBS Lett 519 (1-3), 71-76 (2002)
   PUBMED   12023020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105206.8.
            
            On Aug 31, 2019 this sequence version replaced NM_139278.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ487961.1, AJ487518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306317.7/ ENSP00000302297.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-470               AC105206.8         131042-131511
            471-542             AC105206.8         132385-132456
            543-614             AC105206.8         133217-133288
            615-686             AC105206.8         133635-133706
            687-758             AC105206.8         133809-133880
            759-928             AC105206.8         135848-136017
            929-1093            AC105206.8         136195-136359
            1094-3241           AC105206.8         138871-141018
FEATURES             Location/Qualifiers
     source          1..3241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3241
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /note="leucine rich repeat LGI family member 3"
                     /db_xref="GeneID:203190"
                     /db_xref="HGNC:HGNC:18711"
                     /db_xref="MIM:608302"
     exon            1..470
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1911
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /note="LGI1-like protein 4; leucine-rich
                     glioma-inactivated protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat LGI family member 3
                     precursor"
                     /protein_id="NP_644807.1"
                     /db_xref="CCDS:CCDS6025.1"
                     /db_xref="GeneID:203190"
                     /db_xref="HGNC:HGNC:18711"
                     /db_xref="MIM:608302"
                     /translation="MAGLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCS
                     CTRDTAFCVDSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTL
                     IGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLD
                     ILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDC
                     ITTDFVLYQTLAFPAVSAEPFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIP
                     APSAVHCKPMVVDSQLYVVVAQLFGGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEA
                     FRIDGDWYFAVADSSKAGATSLYRWHQNGFYSHQALHPWHRDTDLEFVDGEGKPRLIV
                     SSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAVKHFRAGRDSYLCLSRYIGDSKILR
                     WEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQWDEGRQKFVRFQEL
                     AVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHIVVDLSA"
     exon            471..542
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..614
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..686
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            687..758
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            759..928
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1093
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..3241
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3219..3224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /note="hexamer: AATAAA"
     polyA_site      3241
                     /gene="LGI3"
                     /gene_synonym="IDDMDS; LGIL4"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcagc cacccggcgc ggtcagcccc ggctgcggct ccagctccgc gctccgctct
       61 tctctcccga gccggatcgc gggagcgagc aggggagggg accgcagccg gcgcccgagg
      121 gcaggaggag tccgcaggcg ggcccctggc tgcggtagca gctgccggtg gcagggaggt
      181 gccagcccgc gcggggtggc ccagccgcgg gagcggtggg gcgggggccg cggccgccgg
      241 ccccagggag agatcgcggg cagcatggcg gggctgcggg ccaggggggg cccggggccg
      301 gggctgctgg cgctctccgc gctcggcttc tgcctcatgc tgcaagtcag cgctaagagg
      361 ccccccaaga cgcccccctg cccgcccagc tgctcttgca ccagggacac cgccttctgc
      421 gtggactcaa aggcggtgcc caggaacctg ccctcggagg tcatctccct gaccctggtg
      481 aatgccgcct tctcagagat ccaggatgga gcgttctccc acctcccgct gctgcagttc
      541 ttgttactca actccaacaa gtttacactg attggagaca acgccttcac aggactgtcg
      601 cacctgcagt atctcttcat tgagaacaat gacatctggg cactatccaa gttcaccttc
      661 cgaggactca agtccttgac tcacctctcg ctggccaaca ataacctgca gacactgccc
      721 agagacatct tccggcccct ggacatcctg aatgacttgg acctgcgggg caactcactc
      781 aactgtgact gcaaggtgaa gtggttggtg gagtggctgg cacacaccaa caccacggtg
      841 gcacccatct actgcgccag cccgccccgc ttccaggagc acaaggtgca ggacctgccg
      901 ctgcgggagt tcgattgcat caccacagat tttgtgttgt accagaccct ggccttccca
      961 gcagtgtcgg ctgagccctt cctctactcc agtgacctct atttggctct ggcccagcca
     1021 ggagtcagtg cctgcaccat cctgaagtgg gactatgttg agcggcagct tcgagactat
     1081 gatagaatcc cagccccctc tgcagtgcac tgcaagccga tggtggtgga cagccagctg
     1141 tacgtggtcg tggcccagct gtttggcggc tcttacattt accactggga tcccaacacc
     1201 acgcgcttca ccaggctgca agacattgac ccgcagcgcg tgcgcaagcc taacgaccta
     1261 gaagccttcc gcatcgacgg tgactggtac tttgccgtgg ctgacagctc caaggcaggc
     1321 gccaccagcc tctaccgctg gcaccagaat ggcttctact cccaccaggc actgcacccc
     1381 tggcaccgtg acaccgacct ggagtttgtg gacggcgagg gcaagccacg gctgattgtg
     1441 tccagcagct cccaggcacc cgtcatctat cagtggagtc gcacccagaa gcagtttgtg
     1501 gcccagggtg aggtgaccca ggtgcctgat gcccaagctg tgaaacactt tcgtgccggc
     1561 cgcgacagct acctgtgcct cagccgctac attggcgact ccaagatcct gcgctgggag
     1621 ggtacccgct tctcggaggt gcaggccctg ccctcccggg gctcgctggc cctgcagccc
     1681 ttccttgtgg gtggccgccg ctacctggca ctgggcagtg atttctcctt cacccagatc
     1741 taccagtggg atgagggacg acagaagttt gtacggttcc aggagctggc tgtgcaggct
     1801 cctcgggcct tctgctacat gcctgctggg gacgcccagc tactcctggc ccccagcttc
     1861 aagggacaga cgctggtgta tagacacatt gtggtggatc tcagtgccta gggggtgccg
     1921 aggcctctgg tctcctcagg gtggccactg gaggatgggt gggggcctct gtgagcacca
     1981 cgtatgcctg tgtgaagaca agcgaccaac ctgcattcat gcccttgtat ccgcacacgc
     2041 ccagtgtgta caggcgcacc ccgtggactg gcccaggagg acgtgcatca tcactgcaat
     2101 cagcatgaac accaggcacc cctgggacac ctaacgccca gttcccgtga ccccaactgc
     2161 aggccccccc tactctgcag cctttcccat gctctgcccc ctgtctcatg cacgagtggt
     2221 gcggggtgct gggagcgagg ggggccgcat cctcctgtcc ttgtgcttct ccttctgccc
     2281 ctctggtctt tcctgttggt gctccaggca ttgtttacct gctcttgctc cccgctgtag
     2341 cccacagcca tatctgtcat gcttccccgg ggccactcac ccctgcccca ccccgtctgc
     2401 atgctcacat ggacgcggac ggacacactc attacacact cacacgcccc gactgcaccc
     2461 ggtgtccatc tataaacatg tcagggcacg tgtgcataca agcagattca gcactgccta
     2521 ccaggctctc ctgttacctt gcctctctgc ttggaggggg ccccctctgc tcacccccag
     2581 cgtgcccccc ccggaactga taaggatgag aatggtggtg ccagcttctg agggcctgct
     2641 tggcctcctg ggggcaaagc ccctctgccc gaagcaataa caacagcagc agaagcaatc
     2701 ccggggagct gccaggggtg tctgtctctg ttctccttgg cgtttccttc atggccgtga
     2761 atcccagctc acccatggac agaagacctc ccctcatctg aaagcctttc tgccttcctt
     2821 cctgtagctg tcgctttctc aggcttggac tgtcccctgg ttcaccctgt ctttgggatg
     2881 tggcccttga gctgggcggg ctccttgggt ggattagaga gctggccgag ctgcaagcac
     2941 ctgagttacc tgcgagggtg cccagagtgg agcttggcct gagggcgtgt tgcagccctg
     3001 gccccaccag tccacagagg cccccaggag cactgccttt cagtggaccg ggtggggcct
     3061 ggtgggaggg gccccactag ctgagcttct gctgccctct gctgtctgct gagatgccag
     3121 gctagtggag agggcacacc atgtgcccaa atggtgtgat gctccttgta gcaggatacc
     3181 agggtactgg ggggcaatgc tatgattaac ttgcttcaaa taaaaagttc ccgccccata
     3241 a
//
