LOCUS       NM_018176               6495 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat LGI family member 2 (LGI2), mRNA.
ACCESSION   NM_018176
VERSION     NM_018176.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6495)
  AUTHORS   Limviphuvadh,V., Chua,L.L., Rahim,R.A., Eisenhaber,F.,
            Maurer-Stroh,S. and Adhikari,S.
  TITLE     Similarity of molecular phenotype between known epilepsy gene LGI1
            and disease candidate gene LGI2
  JOURNAL   BMC Biochem 11, 39 (2010)
   PUBMED   20863412
  REMARK    GeneRIF: The similarity of LGI2 share a common molecular disease
            mechanism causing genotypically distinct but phenotypically related
            forms of epilepsy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6495)
  AUTHORS   Limviphuvadh,V., Chua,L.L., Eisenhaber,F., Adhikari,S. and
            Maurer-Stroh,S.
  TITLE     Is LGI2 the candidate gene for partial epilepsy with pericentral
            spikes?
  JOURNAL   J Bioinform Comput Biol 8 (1), 117-127 (2010)
   PUBMED   20183877
  REMARK    GeneRIF: protein sequence analysis and patient-specific chromosomal
            deletions are provided for LGI2 as the prime candidate gene for
            partial epilepsy with pericentral spikes among the 52 genes known
            at locus 4p15
REFERENCE   3  (bases 1 to 6495)
  AUTHORS   Gu,W., Gibert,Y., Wirth,T., Elischer,A., Bloch,W., Meyer,A.,
            Steinlein,O.K. and Begemann,G.
  TITLE     Using gene-history and expression analyses to assess the
            involvement of LGI genes in human disorders
  JOURNAL   Mol Biol Evol 22 (11), 2209-2216 (2005)
   PUBMED   16014869
REFERENCE   4  (bases 1 to 6495)
  AUTHORS   Wang,L., Zhu,Y.F., Guo,X.J., Huo,R., Ma,X., Lin,M., Zhou,Z.M. and
            Sha,J.H.
  TITLE     A two-dimensional electrophoresis reference map of human ovary
  JOURNAL   J Mol Med (Berl) 83 (10), 812-821 (2005)
   PUBMED   16021519
REFERENCE   5  (bases 1 to 6495)
  AUTHORS   Staub,E., Perez-Tur,J., Siebert,R., Nobile,C., Moschonas,N.K.,
            Deloukas,P. and Hinzmann,B.
  TITLE     The novel EPTP repeat defines a superfamily of proteins implicated
            in epileptic disorders
  JOURNAL   Trends Biochem Sci 27 (9), 441-444 (2002)
   PUBMED   12217514
  REMARK    Review article
REFERENCE   6  (bases 1 to 6495)
  AUTHORS   Scheel,H., Tomiuk,S. and Hofmann,K.
  TITLE     A common protein interaction domain links two recently identified
            epilepsy genes
  JOURNAL   Hum Mol Genet 11 (15), 1757-1762 (2002)
   PUBMED   12095917
REFERENCE   7  (bases 1 to 6495)
  AUTHORS   Gu,W., Wevers,A., Schroder,H., Grzeschik,K.H., Derst,C.,
            Brodtkorb,E., de Vos,R. and Steinlein,O.K.
  TITLE     The LGI1 gene involved in lateral temporal lobe epilepsy belongs to
            a new subfamily of leucine-rich repeat proteins
  JOURNAL   FEBS Lett 519 (1-3), 71-76 (2002)
   PUBMED   12023020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113614.4 and BC101761.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018176.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. The extent of this
            RefSeq transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067503.1, SRR1803617.203015.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382114.9/ ENSP00000371548.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC113614.4         101011-101164       c
            155-1770            BC101761.1         1-1616
            1771-6493           AC113614.4         69067-73789         c
            6494-6495           AC113614.4         69065-69066         c
FEATURES             Location/Qualifiers
     source          1..6495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..6495
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /note="leucine rich repeat LGI family member 2"
                     /db_xref="GeneID:55203"
                     /db_xref="HGNC:HGNC:18710"
                     /db_xref="MIM:608301"
     exon            1..450
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1891
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /note="leucine-rich, glioma inactivated 2; LGI1-like
                     protein 2; leucine-rich glioma-inactivated protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat LGI family member 2
                     precursor"
                     /protein_id="NP_060646.2"
                     /db_xref="CCDS:CCDS3431.1"
                     /db_xref="GeneID:55203"
                     /db_xref="HGNC:HGNC:18710"
                     /db_xref="MIM:608301"
                     /translation="MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTK
                     ESIICVGSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRD
                     DAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLI
                     ELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTT
                     DFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQS
                     IVGCKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQI
                     DDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKSHLILSSR
                     SQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNS
                     KQFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQ
                     APRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLSL"
     exon            451..522
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..594
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..666
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..738
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..908
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1073
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..6495
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3550..3555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /note="hexamer: AATAAA"
     polyA_site      3573
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /note="major polyA site"
     regulatory      6473..6478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /note="hexamer: AATAAA"
     polyA_site      6495
                     /gene="LGI2"
                     /gene_synonym="LGIL2"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgagt gcggcgggcg cagcggcggc ggccgcccag cagcccgggc tcgggtgggg
       61 gggcgccgag tgggggtggc ggccagcatg ctgctcggct gcggctcggc ctcccacacc
      121 cgcggctccc tagtcctcgc cagcagcggc ggcggcagag cagcgagcgg cgcccgcgtc
      181 tgcagcggcg ccgggtccga gcgcgcggcg cggcggtggg ggtcggggcc cgggcgggga
      241 gcggggaccg ggcatggcgc tgcggagagg cggctgcgga gcgctcgggc tgctgctgct
      301 gctgctgggc gccgcgtgcc tgataccgcg gagcgcgcag gtgaggcggc tggcgcgctg
      361 ccccgccact tgcagctgta ccaaggagtc tatcatctgc gtgggctctt cctgggtgcc
      421 caggatcgtg ccgggcgaca tcagctccct gagcctggta aatgggacgt tttcagaaat
      481 caaggaccga atgttttccc atctgccttc tctgcagctg ctattgctga attctaactc
      541 attcacgatc atccgggatg atgcttttgc tggacttttt catcttgaat acctgttcat
      601 tgaagggaac aaaatagaaa ccatttcaag aaatgccttt cgtggcctcc gtgacctgac
      661 tcacctttct ttggccaata accacataaa agcactacca agggatgtct tcagtgattt
      721 agactctctg attgaactag atttgagggg taataaattt gaatgtgact gcaaagccaa
      781 gtggctatac ctgtggttga agatgacaaa ttccaccgtt tctgatgtgc tgtgtattgg
      841 tccaccagag tatcaggaaa agaagctaaa tgacgtgacc agctttgact atgaatgcac
      901 aactacagat tttgttgttc atcagacttt accctaccag tcggtttcag tggatacgtt
      961 caactccaag aacgatgtgt acgtggccat cgcgcagccc agcatggaga actgcatggt
     1021 gctggagtgg gaccacattg aaatgaattt ccggagctat gacaacatta caggtcagtc
     1081 catcgtgggc tgtaaggcca ttctcatcga tgatcaggtc tttgtggtgg tagcccagct
     1141 cttcggtggc tctcacattt acaaatacga cgagagttgg accaaatttg tcaaattcca
     1201 agacatagag gtctctcgca tttccaagcc caatgacatc gagctgtttc agatcgacga
     1261 cgagacgttc tttgtcatcg cagacagctc aaaggctggt ctgtccacag tttataaatg
     1321 gaacagcaaa ggattctatt cttaccagtc actgcacgag tggttcaggg acacggatgc
     1381 ggagtttgtt gatatcgatg gaaaatcgca tctcatcctg tccagccgct cccaggtccc
     1441 catcatcctc cagtggaata aaagctctaa gaagtttgtc ccccatggtg acatccccaa
     1501 catggaggac gtactggctg tgaagagctt ccgaatgcaa aataccctct acctttccct
     1561 tacccgcttc atcggggact cccgggtcat gaggtggaac agtaagcagt ttgtggagat
     1621 ccaagctctt ccatcccggg gggccatgac cctgcagccc ttttctttta aagataatca
     1681 ctacctggcc ctggggagtg actatacatt ctctcagata taccagtggg ataaagagaa
     1741 gcagctattc aaaaagttta aggagattta cgtgcaggcg cctcgttcat tcacagctgt
     1801 ctccaccgac aggagagatt tcttttttgc atccagtttc aaagggaaaa caaagatttt
     1861 tgaacatata attgttgact taagtttgtg aaggtgtggt gggtgaaact aagagaaatg
     1921 tagcattagc tctcacaaaa gaggaccaag aaaaatcaac aaacaaatca aagccaggct
     1981 cagagctctg aaattaaaaa gcactgaaat agttagatgt tttcaaactt ttagaactca
     2041 cattttaatc agggattgca tttattggct aactgcatga catgcccatt ctaccattta
     2101 aaaaaaaatc ttaaagcctg taatttctga gaaaagagta cagcatttac tcttatcatc
     2161 tagaaatgta atatgcttcc cccccgcttt ttgatgagga agaagacaat tggataagat
     2221 gggacagcac ttataatgaa ataaaaaaaa actttgagcc cctctcattc cactttagca
     2281 atctttttgg taagaactct taaagccaaa agtctgctga aaagatttgc tgattattag
     2341 tttaaaaatc ttgtaacact cagcagtgct attttgagtc atcccagttt cctgaaagta
     2401 atgcccagtc ttcctgaatc ctccttaata gcagaacctt ggtgattttg ttggctcata
     2461 tgaatgcttg tcatggatat gttaacaatt tagtgtttga cattgcttcc tctgccacaa
     2521 agacaatact ctggtgacac atgtctagac ccagcacagg ctgtaggccc aggagtgact
     2581 caaaggagtt tttccctctt tcttacggtt caaaggtgac cctggtggtg gccagagcag
     2641 taatgcttgt ttgatgctct tcatggctca tctgcttctc agaacccacc cgttgagttt
     2701 gtgggtaacc agcaggcagg ccaaagactg gtgcttttca tttcatcctt tagagggatg
     2761 aaacagttat ttccgtctga tgagcattcg gtagaatttt tgaagtgaga ttttatgaag
     2821 tcaaagggga ctttacacag atctcgacct gctttgaaac ctagaggtgg ccctttgatt
     2881 tgtgcgtgtc cttgccctct ggacaactta atatttcaag taatcgaata ccaacttccc
     2941 tgccagccca cctgccttcc gccccgcttg tgtaacagtc ctgttttgtt gagttgctgc
     3001 tattgcactg ccagtgcagc ccacaccaaa tcacaaccca agatactcag ataggaagac
     3061 tccttcctct cccagtactt taccaaagga acccccgcca ggacccacat ggggccacgt
     3121 gttggcagtg gaatcagcct gtgcaggctg gggatctcag gctgatcagt aggggccagc
     3181 tttggagcca gccaagctga atcccacact ccaggtctgt gctcaagaga ccagatggtg
     3241 tatttccaaa tgggcctctc tggtatgggc aataggcaag ctcctggggt ctggttatgt
     3301 ggaagattct tagtggatgt tccgcctggt tagctggttc tcttcagaga atataaagtg
     3361 aatgccttta ggggtagctc tgaaagagaa acccaacaac ttcattccta gccatgaaag
     3421 tagcacgatc atattgtact gtattgttat tgtaaaatga ctatttgcca tgtcatgagt
     3481 aggtagatgt tttgccacaa atatgaatgt gtttgttgtt tcctgacttt aagcaatgaa
     3541 gattgagaca ataaatagca ctcagagaat gaagcattga tgttacatca gcactcttgg
     3601 gtacattctg ggactgtagg ctgaggcttc tagcctcaga aaccacggat tttaatgaac
     3661 gaactcaccc acgcatagta gtgttgttac ttgaaacttc tgcaaaatac caagcaaaca
     3721 ggagaaaagt ggtttgtttt catttttaag tgcaaattac ttttcttctg cacttttttt
     3781 tccctcttgg tttctttgaa caggctacaa atgcccaggt ccccccattg gaggctgaaa
     3841 gggaaagagc tttgccattc ctccagtcct aaagatggca agctattctt tctgttgcat
     3901 ggaaccactc agataaacct gggcagaaaa atgggtactt ggcaaactgt aggagatatt
     3961 tagacagtcc cagcaactat gccagatcaa agtgatgttc ccaattccag ccacctgtag
     4021 agatggcaag gtggcatctt ttcacagtgt tgctactgca gagaggtatc acattcccag
     4081 ctgcccctct gagggtaaat gagcgactga ccccctgcac tcactattct gctcacattg
     4141 ccagattctg ggaaaccagg aaacacagga tgctgggctt aggatgggga gagctgttga
     4201 gtccagatgg ggaattagga ggtgaaagaa cgatctaaac aggtgatggg tggggtgtga
     4261 gaagggggtg acccactcaa ctgcaatcag gttttccttt tttataatgt tattttatac
     4321 aagactaaag cctgtagtct acagagcgcc tgtgctgtgg aaggagatat ttgttctggc
     4381 caacttacta aaggagcata gatgttcttg gcacggggtg gtgatatctt tgcttcatta
     4441 atcttactgc tccatcccaa gaatccctga agttttaaac aacttctgca agaagcattc
     4501 ttccagtaat aatgtaaaac aaaaaaccaa ccaagcaaca gcaaaaatgc aaagcagaga
     4561 aatatgtgga ccgtccccag tggagatcag cttgaaggag ggggtggatc tttcttctac
     4621 tttccctccc atcacccact gggtggtcgt ctgctcagct tatttcttct ttatgaactt
     4681 tgtggcgagg ctcctggact gatccctctg tgcggccatg tggctttaag gcctttcctt
     4741 aaagggggct tgtccccata ctccatgggg tcgggaatgg gtctattatc aagactctaa
     4801 aaataactct tagacatgaa gagcactgtg ttattggaca gtggatgata aggccacctt
     4861 acatttagca aagctttata tttttccaat gcacattagt actcacctca tttgttcata
     4921 aatagctctg aagtttattg cagggcaggt attattctaa tttcagagag aaggaaatag
     4981 acatgaaaac tatatgaatt gcctgccatg gttatccaat agggactggc aaagcaataa
     5041 ctttccctct gatcagcaga cattgtattt tctttctaag acaccctgct atactctccc
     5101 agagaaagac tttcatttct agcatgattt tgaatttggc agcaccttga gataaagtaa
     5161 aaagtgcaat aaaatatgca tagccagaag aaaaatcata ctgaatagac accattcaat
     5221 caactggtcc atttaacaat taacaaacat gcaattgcat gccccactct ttttacattc
     5281 aaggccccac tcttgaaagt ggtccagaaa ttttggatag ttttctgttg tactaaggag
     5341 gatatctagc tggtctggtt gtttctcccc ctgcatagct atggggagga tgttgaggtt
     5401 gagacacatc tggttcttgt cacattgtcc accagataaa caagaagaga tctgtgaagg
     5461 aaaaattcaa aacctgaatg cacgagtggt gatgaattgc tctcggccgt catcagcctt
     5521 caggaagcac actggaaatg gcagagttgc attttttctt ccccatggag tgagagtctg
     5581 tgtattttta ggaaagaaat cagcatggga tgccagaggt ttggcggtca ggagtgctca
     5641 tgatggaaat ttctctggcc tggggtataa tgaaggtgag atgaagatct gcaggagggg
     5701 agtctatttg catgccacct aaagaaaacc tcttaagctg gcttcctgat tcttctgcag
     5761 aggtatcagc ctctccttcg cagctgcgga aggaagttct ttaattaggc agcggccaaa
     5821 gattctgttc aacagcttcc tggagtggaa tacaataatc tagttgtatg caatgatgca
     5881 attagaaagt ggtccggatt tgggtggcaa tggaagggga atggcaaagt ggggcagatg
     5941 gctctggagg aaacttggga aagtaaaaac aaactgaaag aaaaggaaaa aaggatgatg
     6001 atttcttttg cctcagccag gcaagcagag ggtagaatga ccaggaagat taacaacatc
     6061 tcaattatta atgaagagag ccaactgtaa tgctcattca aataagaagc atattgtaaa
     6121 gctactgaga tcgaaaccaa gttattatta tccttactgt attccattgc ttgtatcaaa
     6181 atctactttt tttctagtag gaaactatgc attccctatc agtccctttg attatcagga
     6241 atgtataaga attgtgataa aataggccaa tatgctattt ggtaccattt gtatgtattt
     6301 taagtgcata acctaggtaa aataagaata gtttctatgt gtaaagaagc aagttttaca
     6361 gtatgcagac tacagtggat gtattttagg ctgtatacat atttagctct ttttggtaaa
     6421 tagggtatac aaactatatg cctcttaatt caatatattc ggtaagccta tgaataaaaa
     6481 gtggttcatg cctaa
//
