LOCUS       NM_014181               3856 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens galectin like (LGALSL), mRNA.
ACCESSION   NM_014181
VERSION     NM_014181.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Zheng,J., Zhang,M., Zhang,L., Ding,X., Li,W. and Lu,S.
  TITLE     HSPC159 promotes proliferation and metastasis by inducing
            epithelial-mesenchymal transition and activating the PI3K/Akt
            pathway in breast cancer
  JOURNAL   Cancer Sci 109 (7), 2153-2163 (2018)
   PUBMED   29737572
  REMARK    GeneRIF: our findings showed that HSPC159 contributed to breast
            cancer progression through the PI3K/Akt pathway
REFERENCE   3  (bases 1 to 3856)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   4  (bases 1 to 3856)
  AUTHORS   Zhou,D., Ge,H., Sun,J., Gao,Y., Teng,M. and Niu,L.
  TITLE     Crystal structure of the C-terminal conserved domain of human GRP,
            a galectin-related protein, reveals a function mode different from
            those of galectins
  JOURNAL   Proteins 71 (3), 1582-1588 (2008)
   PUBMED   18320588
  REMARK    GeneRIF: Galectin-related protein is a novel protein that has a
            close similarity to galectin sequences but is not a member of the
            galectin family because of its lack of lactose-binding activity.
            The crystal structure has been solved.
REFERENCE   5  (bases 1 to 3856)
  AUTHORS   Komatsuda,A., Wakui,H., Iwamoto,K., Harada,M., Okumoto,Y. and
            Sawada,K.
  TITLE     Gene expression profiling of peripheral blood mononuclear cells
            from patients with minimal change nephrotic syndrome by cDNA
            microarrays
  JOURNAL   Am J Nephrol 28 (4), 539-547 (2008)
   PUBMED   18219197
  REMARK    GeneRIF: CCL13 and HSPC159 mRNA expressions in PBMC are
            up-regulated specifically in MCNS patients during the nephrosis
            phase.
REFERENCE   6  (bases 1 to 3856)
  AUTHORS   Zhou,D., Sun,J., Zhao,W., Zhang,X., Shi,Y., Teng,M., Niu,L.,
            Dong,Y. and Liu,P.
  TITLE     Expression, purification, crystallization and preliminary X-ray
            characterization of the GRP carbohydrate-recognition domain from
            Homo sapiens
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 62 (Pt 5), 474-476
            (2006)
   PUBMED   16682780
  REMARK    GeneRIF: Galectin-related protein named GRP comprises only one
            conserved carbohydrate-recognition domain with 38 additional
            N-terminal residues.  The crystals belong to the monoclinic space
            group C2.
REFERENCE   7  (bases 1 to 3856)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008074.3, DR001728.1, BC062691.1, BC036082.1 and AK025603.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014181.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036082.1, SRR3476690.1174056.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238875.10/ ENSP00000238875.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC008074.3         141527-141557       c
            32-317              DR001728.1         9-294
            318-1128            BC062691.1         4-814
            1129-2504           BC036082.1         770-2145
            2505-3856           AK025603.1         1013-2364
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..3856
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /note="galectin like"
                     /db_xref="GeneID:29094"
                     /db_xref="HGNC:HGNC:25012"
                     /db_xref="MIM:617902"
     exon            1..420
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..903
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /note="lectin galactoside-binding-like protein; lectin,
                     galactoside binding like; galectin-like protein"
                     /codon_start=1
                     /product="galectin-related protein"
                     /protein_id="NP_054900.2"
                     /db_xref="CCDS:CCDS1877.1"
                     /db_xref="GeneID:29094"
                     /db_xref="HGNC:HGNC:25012"
                     /db_xref="MIM:617902"
                     /translation="MAGSVADSDAVVKLDDGHLNNSLSSPVQADVYFPRLIVPFCGHI
                     KGGMRPGKKVLVMGIVDLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCI
                     SGERGEEQSAIPYFPFIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTI
                     KINGDLQITKLG"
     exon            421..492
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /inference="alignment:Splign:2.1.0"
     exon            493..581
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /inference="alignment:Splign:2.1.0"
     exon            582..759
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /inference="alignment:Splign:2.1.0"
     exon            760..3856
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /note="hexamer: AATAAA"
     polyA_site      3856
                     /gene="LGALSL"
                     /gene_synonym="GRP; HSPC159"
                     /note="major polyA site"
ORIGIN      
        1 gttcccggtt cccgagccgg gccccggagg cctttaaatg ctgcccaggg ccgacgcggc
       61 acggccctcg ccacttttct tggtcgggca gcggcagcgg cagcggcagc aagcagcccc
      121 gtcggcccgg gtccggggcc gttctgggcc gcggcaagca ccttcgccct cccagctcgc
      181 gctgcctccc tcccctcccc tcctcccagg ctctgcctgc caggtcggcg ccgggccccg
      241 ggcgcgcgcg cgcgcgcccc ctcgtgtgtg cgcgcgcccg ccgccagctc ggacccgcgc
      301 ccccgccccc gccccgcgca ggacagcccc gggatccccg cccgcgcgcc gcgtcccacg
      361 taccccgccg cgccgggcaa gaagatggcg ggatcagtgg ccgacagcga tgccgtggtg
      421 aaactagatg atggccattt aaacaactct ttgagctctc cagttcaagc ggacgtgtac
      481 ttcccacgac tgatagttcc attttgtggg cacattaaag gtggcatgag accaggcaag
      541 aaggtgttag tgatgggcat cgtagacctc aacccagaga gctttgcaat cagcttgacc
      601 tgtggggact cagaagaccc tcctgccgat gtggcaatcg aactcaaagc tgtgttcaca
      661 gatcggcagc tactcagaaa ttcttgtata tctggggaga ggggtgaaga acagtcagca
      721 atcccttact ttccattcat tccagaccag ccattcaggg tggaaattct ttgtgagcac
      781 ccacgtttcc gagtgtttgt ggatggacac caactttttg atttttacca tcgcattcaa
      841 acgttatctg caattgacac cataaagata aatggagacc tccagatcac caagcttggc
      901 tgatttaaac cacctctatt tcaaatagga tcacgtgcca caactatctg actgttggtc
      961 tggaagaagt gtcctagcaa gatctggaga cttaaaaaga aaacaaaaac aaatggcaag
     1021 tttcacttaa gggtggtttg cccttaagaa gaaagctgtt gggacaaaga caccgagcca
     1081 ttatacccag aataaaataa tacatttatg ctggatttta ttcagaccaa actaaaatgg
     1141 atttgtgatg atttgtgatt tggtagcaaa ttattcatct tttcaaagca aggcaatgct
     1201 tagaaacaga agtgctaaag acacttaaaa agccaacaac aacggtacag tgaaatcaat
     1261 gcatttctgc actaaagtgg aattgtgtag cacaaccaat attttagtca gggtatttac
     1321 atagaatgta ggttgttcaa ggtttgactt tttttttgtt ttttgttttt gtttttgttt
     1381 ttgttttgca cagcataatg ttaattcaga ttgttgaagc tttcttgtag ttatttattt
     1441 atactcaatg tatgtattaa agaatgaaca atgtctcaag aacagcaagt tgtaaacttt
     1501 tgaatgtata aatatcttag gtccaagggg agaaaattac atattacaat tatgaaacag
     1561 gtgaatttct gctttaaaga attgagattc tccatacccc taaacttagg atctcttgat
     1621 ataaactgct gtaagtgctt ttgggaaacc tttgcaaaac cattttgata aaactgcttt
     1681 ccaagttatt gttggttatg taaaattcta tttacattgc tttttctcct tactgggaat
     1741 tagcacatta ttggcttcct taagactaat tatttctctc ttgatttata taatagctca
     1801 ttaagttgtt attaatcaaa aacacaaaga ggtgattgct tagacaattt ttaaagtgac
     1861 tatagtataa acttttaaaa gaataatatg aaaatgactg tggaatgcag tgtaaagcag
     1921 aagcaaacgg ccctgaataa cttacttgga agtaatttat atcaacttaa gctgttagct
     1981 cattgtataa cttttcttat gtgaccctca ccaatatccc taagtaatgc ctttggaagc
     2041 ttcagagtag aagatgcttc ctactgtgtt ggctctgagg agatagtagg attagatagg
     2101 atccagatta ggaaatgatc cagttagttt atctgaaagg ttaactccca ggactccagg
     2161 tctttgaatc cagccagtag agtgaatgct tccaattaag ctgtaggtgt taccctgcac
     2221 ttacggaact gatcaaacag gtgactccaa caggaggttg cagtactgta aacgtcaccg
     2281 caaggcaagg gatgcttaaa gtcctgggtt ctggacttta aaagctacat tggccctgga
     2341 gggagggacc cttggcattg ctttgatcag gtagtgaggg aagacagggt tctggggtgg
     2401 gggtgtattt atatataatt taggttttgt ttgtacagca tactgtgtct tgtaatgaca
     2461 catccttgtc ctgctttcct tttttgagtt tttttttttt ttttacacaa catgcagagg
     2521 cactgaagtg accatgtcat tttcaagtgt caagaatgta gacagtgttt cagtaccaaa
     2581 gtctaaaata aactaaaatt atgaattttt tataggtgat acatttggat tcttctcaac
     2641 tttgaaactg tttagcacag ttccattgta ttatataaga agacactgta tccaacaaga
     2701 ctggctgtac attgaaaagc tttatgtacc agccaactta tttaaccata ttcagcctgt
     2761 tccgtggggg ctgttctgtg gttccaggta ttttcaagcc tgtgattaac ttctcatggc
     2821 ttgtcactta aaagtcccta aatttgagag acttaaaggg caccttgaaa tacatttgtg
     2881 gagttttgat ccaacttatg gtggaagagc cccataggaa gactgttttg agtggccaac
     2941 cattcccacc cactgcataa ttcagcagaa actagaggag cagggcgtgt actgattgga
     3001 attgacacgc ttattctgtc tacctatcag ctaactcatt agcagccaag cccttaggca
     3061 gcttagtgtg aaaatacaat gttaactgtt tgtttctctg tgaggttagt gggaaccgct
     3121 tggataagcc tattgggatt aatctaaatg atgtgatgat ttgattcagg tatagcccaa
     3181 attagtaagg ggctttagct gtaaactgaa aacaatattc acaccctctc ctgggcctgt
     3241 aaggtctaag gtgagaattt caggatggaa aatgcaatgt aaagcttcca caggaaagta
     3301 ttcgggtatg taaggtgtta tttctgacca gagccctagt tctgcaataa ccaaaaccaa
     3361 ggagtataaa taacaatcag gctctggggg aatagaaagc aggctttaga caatctgtcc
     3421 atttctacag taaaattgga gtgagtgtgt atatctactt aaaacttaat agaagtgact
     3481 tctacttttt gggctattcc agaagtattt taaaattatt atttaaaatt ttgaagcccc
     3541 atttcaaatc ttgccgacct tagttcaaag ccccctgaga gatcactttt agaattgagg
     3601 atttgttaaa atggcaagtc atttcatttg tgttaaaaag aaaataccca aaaggaagga
     3661 gggagccctg tttgccttga gataaacggc cttggcattt tctggcatta atgtagaaat
     3721 aatgttccta tgatgacata ttttcaaaga aacactttct tatttactgt gtggtgtaaa
     3781 atgttgctaa atgtgttgtt acattatgtc actgctgaaa gtaatttgca ctataataaa
     3841 ggaattttct acaaaa
//
