LOCUS       NM_001040078            1715 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens galectin 9C (LGALS9C), mRNA.
ACCESSION   NM_001040078 XM_930339 XM_934665 XM_934667 XM_934670
VERSION     NM_001040078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Pelletier,I., Hashidate,T., Urashima,T., Nishi,N., Nakamura,T.,
            Futai,M., Arata,Y., Kasai,K.-., Hirashima,M., Hirabayashi,J. and
            Sato,S.
  TITLE     Specific recognition of Leishmania major poly-beta-galactosyl
            epitopes by galectin-9: possible implication of galectin-9 in
            interaction between L. major and host cells
  JOURNAL   J Biol Chem 278 (25), 22223-22230 (2003)
   PUBMED   12684513
  REMARK    GeneRIF: Specific recognition of Leishmania major
            poly-beta-galactosyl epitopes by this compound implicates it in
            interactions between L. major and host cells.
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   Park,S.S., Stankiewicz,P., Bi,W., Shaw,C., Lehoczky,J., Dewar,K.,
            Birren,B. and Lupski,J.R.
  TITLE     Structure and evolution of the Smith-Magenis syndrome repeat gene
            clusters, SMS-REPs
  JOURNAL   Genome Res 12 (5), 729-738 (2002)
   PUBMED   11997339
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Sato,M., Nishi,N., Shoji,H., Seki,M., Hashidate,T., Hirabayashi,J.,
            Kasai Ki,K., Hata,Y., Suzuki,S., Hirashima,M. and Nakamura,T.
  TITLE     Functional analysis of the carbohydrate recognition domains and a
            linker peptide of galectin-9 as to eosinophil chemoattractant
            activity
  JOURNAL   Glycobiology 12 (3), 191-197 (2002)
   PUBMED   11971863
  REMARK    GeneRIF: Functional analysis of the carbohydrate recognition
            domains and a linker peptide as to eosinophil chemoattractant
            activity
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA426549.1, BC073889.1 and BM769737.1.
            
            On May 17, 2019 this sequence version replaced NM_001040078.2.
            
            Summary: This gene was initially thought to represent a pseudogene
            of galectin 9; however, this transcript has good exon-intron
            structure and encodes a predicted protein of the same size as and
            highly similar to galectin 9. This gene is one of two similar loci
            on chromosome 17p similar to galectin 9 and now thought to be
            protein-encoding. This gene is the more telomeric gene. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073889.1, AK315818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328114.11/ ENSP00000329932.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA426549.1         5-31
            28-606              BC073889.1         1-579
            607-642             BM769737.1         38-73
            643-1715            BC073889.1         616-1688
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1715
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /note="galectin 9C"
                     /db_xref="GeneID:654346"
                     /db_xref="HGNC:HGNC:33874"
     exon            1..105
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1137
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /note="galectin 9 like; lectin, galactoside-binding,
                     soluble, 9 (galectin 9) pseudogene; gal-9C;
                     galectin-9-like protein B; lectin, galactoside-binding,
                     soluble, 9C; Galectin-9B; Galectin-9-like protein A"
                     /codon_start=1
                     /product="galectin-9C"
                     /protein_id="NP_001035167.2"
                     /db_xref="CCDS:CCDS32587.1"
                     /db_xref="GeneID:654346"
                     /db_xref="HGNC:HGNC:33874"
                     /translation="MAFSGCQAPYLSPAVPFSGTIQGGLQDGFQITVNGAVLSCSGTR
                     FAVDFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQKGTWGPEERKMHMPFQKGMPFDLC
                     FLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRAVPVQPAFS
                     TVPFSQPVCFPPRPRGRRQKPPSVRPANPAPITQTVIHTVQSASGQMFSQTPAIPPMM
                     YPHPAYPMPFITTIPGGLYPSKSIILSGTVLPSAQRFHINLCSGSHIAFHMNPRFDEN
                     AVVRNTQINNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHVFEYYHRL
                     RNLPTINKLEVGGDIQLTHVQT"
     exon            106..197
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            198..399
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            400..510
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            511..606
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            607..642
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            643..693
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            694..738
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            739..827
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            828..990
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1715
                     /gene="LGALS9C"
                     /gene_synonym="Gal-9B; LGALS9B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccttctg caaaggactg cctggcaggt gtcaaaggca gtggtggcca cagaggcggt
       61 ggagagatgg ccttcagcgg ttgccaggct ccctatctga gcccagccgt ccccttttct
      121 gggactatcc aagggggtct ccaggacgga tttcagatca ctgtcaatgg ggccgttctc
      181 agctgcagtg gaaccaggtt tgctgtggac tttcagacgg gcttcagtgg aaacgacatt
      241 gccttccact tcaaccctcg gtttgaagac ggagggtatg tggtgtgcaa cacgaggcag
      301 aaaggaacat gggggcccga ggagaggaag atgcacatgc ccttccagaa ggggatgccc
      361 tttgacctct gcttcctggt gcagagctca gatttcaagg tgatggtgaa cgggagcctc
      421 ttcgtgcagt acttccaccg cgtgcccttc caccgtgtgg acaccatctc cgtcaatggc
      481 tctgtgcagc tgtcctacat cagcttccag aatccccgcg cagtccccgt tcagcctgcc
      541 ttctccacgg tgccgttctc ccagcctgtc tgtttcccac ccaggcccag ggggcgcaga
      601 caaaaacctc ccagcgtgcg gcctgccaac ccagctccca ttacccagac agtcatccac
      661 acggtgcaga gtgcctctgg acagatgttc tctcagactc ccgccatccc acctatgatg
      721 tacccccacc ctgcctatcc gatgcctttc atcaccacca ttccgggagg gctgtaccca
      781 tccaagtcca tcatcctgtc aggcactgtc ctgcccagtg ctcagaggtt ccacatcaac
      841 ctgtgctctg ggagccacat cgccttccac atgaaccccc gttttgatga gaatgctgtg
      901 gtccgtaaca cccagatcaa caactcttgg gggtctgagg agcgaagtct gccccgaaaa
      961 atgcccttcg tccgaggcca gagcttctcg gtgtggatct tgtgtgaagc tcactgcctc
     1021 aaggtggccg tggatggtca gcacgtgttt gaatactacc atcgcctgag gaacctgccc
     1081 accatcaaca aactggaagt gggtggcgac atccagctga cccacgtgca gacataggcg
     1141 gctccctggc cctggggccg ggggctgggg tgtggggcag tctgggtcct ctcatcatcc
     1201 ccacttccca ggcccagcct ttccaaccgt gcctgggatc tgggctttaa tgcagaggcc
     1261 atgtccttat ctggtcctgc ttctggctac agccaccctg gaatcgagaa ggcagctgac
     1321 tgggattgcc ttcctcagcc gcagcagcac ctggggcgcc agctgctgga atcctacaat
     1381 cccagaaggc gggcacagcc agggagaggg gaggagtggg cagtgaagat gaagccccat
     1441 gctcagtccc ctcccatccc ccacgcagct ccaccccagt ctcaagccac cagctgtctg
     1501 ctcctggtgg gagatggcct cctcagcccc tcctctctga cctttaacct cactctcacc
     1561 ttgcaccctg caccaaccct tcacccctcc tggaaagcag gcctgatggc ttcccactgg
     1621 cctccaccaa ctgaccagag tgttctcttc aggggactgg ctcctttccc agtgtcctta
     1681 aaataaagaa atgaaaatgc ttgttggcac attca
//
