LOCUS       NM_001367292            1718 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens galectin 9B (LGALS9B), transcript variant 1, mRNA.
ACCESSION   NM_001367292
VERSION     NM_001367292.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Park,S.S., Stankiewicz,P., Bi,W., Shaw,C., Lehoczky,J., Dewar,K.,
            Birren,B. and Lupski,J.R.
  TITLE     Structure and evolution of the Smith-Magenis syndrome repeat gene
            clusters, SMS-REPs
  JOURNAL   Genome Res 12 (5), 729-738 (2002)
   PUBMED   11997339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015818.32.
            
            On Aug 13, 2020 this sequence version replaced NM_001367292.1.
            
            Summary: This gene was initially thought to represent a pseudogene
            of galectin 9; however, this transcript has good exon-intron
            structure and encodes a predicted protein of the same size as and
            highly similar to galectin 9. This gene is one of two similar loci
            on chromosome 17p similar to galectin 9 and now thought to be
            protein-encoding. This gene is the more centromeric gene. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290263.1, BC105943.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423676.8/ ENSP00000388841.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC015818.32        83451-83558         c
            109-200             AC015818.32        76371-76462         c
            201-402             AC015818.32        74202-74403         c
            403-513             AC015818.32        72580-72690         c
            514-609             AC015818.32        71322-71417         c
            610-645             AC015818.32        69591-69626         c
            646-696             AC015818.32        69036-69086         c
            697-741             AC015818.32        68370-68414         c
            742-830             AC015818.32        67814-67902         c
            831-993             AC015818.32        67500-67662         c
            994-1718            AC015818.32        65414-66138         c
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1718
                     /gene="LGALS9B"
                     /note="galectin 9B"
                     /db_xref="GeneID:284194"
                     /db_xref="HGNC:HGNC:24842"
     exon            1..108
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1140
                     /gene="LGALS9B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     galectin-9 like; galectin-9 pseudogene; gal-9B;
                     galectin-9-like protein A; lectin, galactoside-binding,
                     soluble, 9B"
                     /codon_start=1
                     /product="galectin-9B isoform 1"
                     /protein_id="NP_001354221.1"
                     /db_xref="CCDS:CCDS92280.1"
                     /db_xref="GeneID:284194"
                     /db_xref="HGNC:HGNC:24842"
                     /translation="MAFSGSQAPYLSPAVPFSGTIQGGLQDGFQITVNGAVLSSSGTR
                     FAVDFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQKGRWGPEERKMHMPFQKGMPFDLC
                     FLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFS
                     TVPFSQPVCFPPRPRGRRQKPPSVRPANPAPITQTVIHTVQSASGQMFSQTPAIPPMM
                     YPHPAYPMPFITTIPGGLYPSKSIILSGTVLPSAQRFHINLCSGSHIAFHMNPRFDEN
                     AVVRNTQINNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHVFEYYHRL
                     RNLPTINKLEVGGDIQLTHVQT"
     exon            109..200
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            201..402
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            403..513
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            514..609
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            610..645
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            646..696
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            697..741
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            742..830
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            831..993
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1718
                     /gene="LGALS9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS9B"
                     /note="hexamer: AATGAA"
     polyA_site      1718
                     /gene="LGALS9B"
                     /note="major polyA site"
ORIGIN      
        1 aagtcattcc ttctgcaaag gactgcctgg caggtgtgaa aggcagcggt ggccacagag
       61 gcggtggaga tggccttcag cggttcccag gctccctatc tgagcccagc cgtccccttt
      121 tctgggacta tccaaggggg tctccaggac ggatttcaga tcactgtcaa tggggccgtt
      181 ctcagctcca gtggaaccag gtttgctgtg gactttcaga cgggcttcag tggaaacgac
      241 attgccttcc acttcaaccc tcggtttgaa gacggagggt atgtggtgtg caacacgagg
      301 cagaaaggaa gatgggggcc cgaggagagg aagatgcaca tgcccttcca gaaggggatg
      361 ccctttgacc tctgcttcct ggtgcagagc tcagatttca aggtgatggt gaacgggagc
      421 ctcttcgtgc agtacttcca ccgcgtgccc ttccaccgtg tggacaccat ctccgtcaat
      481 ggctctgtgc agctgtccta catcagcttc cagaatcccc gcacagtccc cgttcagcct
      541 gccttctcca cggtgccgtt ctcccagcct gtctgtttcc cacccaggcc cagggggcgc
      601 agacaaaaac ctcccagcgt gcggcctgcc aacccagctc ccattaccca gacagtcatc
      661 cacacggtgc agagcgcctc tggacagatg ttctctcaga ctcccgccat cccacctatg
      721 atgtaccccc accctgccta tccgatgcct ttcatcacca ccattccggg agggctgtac
      781 ccatccaagt ccatcatcct gtcaggcact gtcctgccca gtgctcagag gttccacatc
      841 aacctgtgct ctgggagcca catcgccttc cacatgaacc cccgttttga tgagaatgct
      901 gtggtccgta acacccagat caacaactct tgggggtctg aggagcgaag tctgccccga
      961 aaaatgccct tcgtccgagg ccagagcttc tcggtgtgga tcttgtgtga agctcactgc
     1021 ctcaaggtgg ccgtggatgg tcagcacgtg tttgaatact accatcgcct gaggaacctg
     1081 cccaccatca acaaactgga agtgggtggc gacatccagc tgacccacgt gcagacatag
     1141 gcggctccct ggccctgggg ccgggggctg gggtgtgggg cagtcggggt cctctcatca
     1201 tccccacttc ccaggcccag cctttccaac cgtgcctggg atctgggctt taatgcagag
     1261 gccatgtcct tatctggtcc tgcttctggc tacagccacc ctggaattga gaaggcagct
     1321 gactgggatt gtcttcctca gccgcagcag cacctggggc gccagctgct ggaatcctac
     1381 aatcccagaa ggcgggcaca gccagggaga ggggaggagc gggcagtgaa gatgaagccc
     1441 catgctcagt cccctcccat cccccacgca gctccacccc agtctcaagc caccagctgt
     1501 ctgctcctgg tgggagatgg cctcctcagc ccctcctctc tgacctttaa cctcactctc
     1561 accttgcacc ctgcaccaac ccttcacccc tcctggaaag caggtctgat ggcttcccac
     1621 tggcctccac caactgacca gagtgttctc ttcaggggac tggctccttt cccagtgtcc
     1681 ttaaaataaa gaaatgaaaa tgcttgttgg cacattca
//
