LOCUS       NM_009587               1724 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens galectin 9 (LGALS9), transcript variant 1, mRNA.
ACCESSION   NM_009587
VERSION     NM_009587.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Dey,D., Biswas,S., Pal,S., Nandi,S., Khatun,N., Jha,R.,
            Chakraborty,B.C., Baidya,A., Ghosh,R., Banerjee,S., Ahammed,S.M.,
            Chowdhury,A. and Datta,S.
  TITLE     Monocyte-derived Galectin-9 and PD-L1 differentially impair
            adaptive and innate immune response in chronic HBV infection and
            their expression remain unaltered after antiviral therapy
  JOURNAL   Front Immunol 15, 1474853 (2024)
   PUBMED   39445017
  REMARK    GeneRIF: Monocyte-derived Galectin-9 and PD-L1 differentially
            impair adaptive and innate immune response in chronic HBV infection
            and their expression remain unaltered after antiviral therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   Ling,J., You,S., Chen,W., Yang,X., Xv,Y. and Zhu,B.
  TITLE     Galectin-9 as a new biomarker of acute-on-chronic liver failure
  JOURNAL   Sci Rep 14 (1), 22303 (2024)
   PUBMED   39333198
  REMARK    GeneRIF: Galectin-9 as a new biomarker of acute-on-chronic liver
            failure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Mendoza,M., Ballesteros,A., Rendon-Correa,E., Tonk,R., Warren,J.,
            Snow,A.L., Stowell,S.R., Blois,S.M. and Dveksler,G.
  TITLE     Modulation of galectin-9 mediated responses in monocytes and
            T-cells by pregnancy-specific glycoprotein 1
  JOURNAL   J Biol Chem 300 (9), 107638 (2024)
   PUBMED   39121996
  REMARK    GeneRIF: Modulation of galectin-9 mediated responses in monocytes
            and T-cells by pregnancy-specific glycoprotein 1.
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Ji,J., Tang,M., Zhao,Y., Zhang,C., Shen,Y., Zhou,B., Liu,C.,
            Maurer,M. and Jiao,Q.
  TITLE     In chronic spontaneous urticaria, increased Galectin-9 expression
            on basophils and eosinophils is linked to high disease activity,
            endotype-specific markers, and response to omalizumab treatment
  JOURNAL   Allergy 79 (9), 2435-2447 (2024)
   PUBMED   39021347
  REMARK    GeneRIF: In chronic spontaneous urticaria, increased Galectin-9
            expression on basophils and eosinophils is linked to high disease
            activity, endotype-specific markers, and response to omalizumab
            treatment.
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Beyer,S., Wehrmann,M., Meister,S., Trillsch,F., Ganster,F.,
            Schmoeckel,E., Corradini,S., Mahner,S., Jeschke,U., Kessler,M.,
            Burges,A. and Kolben,T.
  TITLE     Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer
  JOURNAL   Int J Mol Sci 25 (13), 6907 (2024)
   PUBMED   39000016
  REMARK    GeneRIF: Expression of Intracellular Galectin-8 and -9 in
            Endometrial Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   Imaizumi,T., Kumagai,M., Sasaki,N., Kurotaki,H., Mori,F., Seki,M.,
            Nishi,N., Fujimoto,K., Tanji,K., Shibata,T., Tamo,W., Matsumiya,T.,
            Yoshida,H., Cui,X.F., Takanashi,S., Hanada,K., Okumura,K.,
            Yagihashi,S., Wakabayashi,K., Nakamura,T., Hirashima,M. and
            Satoh,K.
  TITLE     Interferon-gamma stimulates the expression of galectin-9 in
            cultured human endothelial cells
  JOURNAL   J Leukoc Biol 72 (3), 486-491 (2002)
   PUBMED   12223516
  REMARK    GeneRIF: IFN-gamma-induced production of galectin-9 by endothelial
            cells may play an important role in immune responses by regulating
            interactions between vascular wall & eosinophils. In situ
            endothelium from inflammatory diseases expressed galectin-9.
REFERENCE   7  (bases 1 to 1724)
  AUTHORS   Kageshita,T., Kashio,Y., Yamauchi,A., Seki,M., Abedin,M.J.,
            Nishi,N., Shoji,H., Nakamura,T., Ono,T. and Hirashima,M.
  TITLE     Possible role of galectin-9 in cell aggregation and apoptosis of
            human melanoma cell lines and its clinical significance
  JOURNAL   Int J Cancer 99 (6), 809-816 (2002)
   PUBMED   12115481
  REMARK    GeneRIF: overexpression of galectin 9 is associated with cell
            aggregation and apoptosis of melanoma cells
REFERENCE   8  (bases 1 to 1724)
  AUTHORS   Matsumoto,R., Hirashima,M., Kita,H. and Gleich,G.J.
  TITLE     Biological activities of ecalectin: a novel eosinophil-activating
            factor
  JOURNAL   J Immunol 168 (4), 1961-1967 (2002)
   PUBMED   11823532
  REMARK    GeneRIF: ecalectin is a novel eosinophil-activating factor
REFERENCE   9  (bases 1 to 1724)
  AUTHORS   Matsumoto,R., Matsumoto,H., Seki,M., Hata,M., Asano,Y.,
            Kanegasaki,S., Stevens,R.L. and Hirashima,M.
  TITLE     Human ecalectin, a variant of human galectin-9, is a novel
            eosinophil chemoattractant produced by T lymphocytes
  JOURNAL   J Biol Chem 273 (27), 16976-16984 (1998)
   PUBMED   9642261
REFERENCE   10 (bases 1 to 1724)
  AUTHORS   Tureci,O., Schmitt,H., Fadle,N., Pfreundschuh,M. and Sahin,U.
  TITLE     Molecular definition of a novel human galectin which is immunogenic
            in patients with Hodgkin's disease
  JOURNAL   J Biol Chem 272 (10), 6416-6422 (1997)
   PUBMED   9045665
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB006782.1 and BC110340.1.
            
            On Nov 22, 2018 this sequence version replaced NM_009587.2.
            
            Summary: The galectins are a family of beta-galactoside-binding
            proteins implicated in modulating cell-cell and cell-matrix
            interactions. The protein encoded by this gene is an S-type lectin.
            It is overexpressed in Hodgkin's disease tissue and might
            participate in the interaction between the H&RS cells with their
            surrounding cells and might thus play a role in the pathogenesis of
            this disease and/or its associated immunodeficiency. Multiple
            alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (long).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.215793.1, AB006782.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395473.7/ ENSP00000378856.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1722              AB006782.1         4-1725
            1723-1724           BC110340.1         1608-1609
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1724
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /note="galectin 9"
                     /db_xref="GeneID:3965"
                     /db_xref="HGNC:HGNC:6570"
                     /db_xref="MIM:601879"
     exon            1..117
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1146
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /note="isoform long is encoded by transcript variant 1;
                     ecalectin; urate transporter/channel protein; gal-9; tumor
                     antigen HOM-HD-21; lectin, galactoside-binding, soluble,
                     9"
                     /codon_start=1
                     /product="galectin-9 isoform long"
                     /protein_id="NP_033665.1"
                     /db_xref="CCDS:CCDS11222.1"
                     /db_xref="GeneID:3965"
                     /db_xref="HGNC:HGNC:6570"
                     /db_xref="MIM:601879"
                     /translation="MAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTR
                     FAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDLC
                     FLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFS
                     TVPFSQPVCFPPRPRGRRQKPPGVWPANPAPITQTVIHTVQSAPGQMFSTPAIPPMMY
                     PHPAYPMPFITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENA
                     VVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLR
                     NLPTINRLEVGGDIQLTHVQT"
     exon            118..209
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            210..411
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            412..522
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            523..618
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            619..654
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            655..705
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            706..747
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            748..836
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            837..999
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1724
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1691..1696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /note="hexamer: AATAAA"
     polyA_site      1692
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
     polyA_site      1724
                     /gene="LGALS9"
                     /gene_synonym="HUAT; LGALS9A"
                     /note="major polyA site"
ORIGIN      
        1 ctttgttaag tcgttccctc tacaaaggac ttcctagtgg gtgtgaaagg cagcggtggc
       61 cacagaggcg gcggagagat ggccttcagc ggttcccagg ctccctacct gagtccagct
      121 gtcccctttt ctgggactat tcaaggaggt ctccaggacg gacttcagat cactgtcaat
      181 gggaccgttc tcagctccag tggaaccagg tttgctgtga actttcagac tggcttcagt
      241 ggaaatgaca ttgccttcca cttcaaccct cggtttgaag atggagggta cgtggtgtgc
      301 aacacgaggc agaacggaag ctgggggccc gaggagagga agacacacat gcctttccag
      361 aaggggatgc cctttgacct ctgcttcctg gtgcagagct cagatttcaa ggtgatggtg
      421 aacgggatcc tcttcgtgca gtacttccac cgcgtgccct tccaccgtgt ggacaccatc
      481 tccgtcaatg gctctgtgca gctgtcctac atcagcttcc agaacccccg cacagtccct
      541 gttcagcctg ccttctccac ggtgccgttc tcccagcctg tctgtttccc acccaggccc
      601 agggggcgca gacaaaaacc tcccggcgtg tggcctgcca acccggctcc cattacccag
      661 acagtcatcc acacagtgca gagcgcccct ggacagatgt tctctactcc cgccatccca
      721 cctatgatgt acccccaccc cgcctatccg atgcctttca tcaccaccat tctgggaggg
      781 ctgtacccat ccaagtccat cctcctgtca ggcactgtcc tgcccagtgc tcagaggttc
      841 cacatcaacc tgtgctctgg gaaccacatc gccttccacc tgaacccccg ttttgatgag
      901 aatgctgtgg tccgcaacac ccagatcgac aactcctggg ggtctgagga gcgaagtctg
      961 ccccgaaaaa tgcccttcgt ccgtggccag agcttctcag tgtggatctt gtgtgaagct
     1021 cactgcctca aggtggccgt ggatggtcag cacctgtttg aatactacca tcgcctgagg
     1081 aacctgccca ccatcaacag actggaagtg gggggcgaca tccagctgac ccatgtgcag
     1141 acataggcgg cttcctggcc ctggggccgg gggctggggt gtggggcagt ctgggtcctc
     1201 tcatcatccc cacttcccag gcccagcctt tccaaccctg cctgggatct gggctttaat
     1261 gcagaggcca tgtccttgtc tggtcctgct tctggctaca gccaccctgg aacggagaag
     1321 gcagctgacg gggattgcct tcctcagccg cagcagcacc tggggctcca gctgctggaa
     1381 tcctaccatc ccaggaggca ggcacagcca gggagagggg aggagtgggc agtgaagatg
     1441 aagccccatg ctcagtcccc tcccatcccc cacgcagctc caccccagtc ccaagccacc
     1501 agctgtctgc tcctggtggg aggtggcctc ctcagcccct cctctctgac ctttaacctc
     1561 actctcacct tgcaccgtgc accaaccctt cacccctcct ggaaagcagg cctgatggct
     1621 tcccactggc ctccaccacc tgaccagagt gttctcttca gaggactggc tcctttccca
     1681 gtgtccttaa aataaagaaa tgaaaatgct tgttggcaca ttca
//
