LOCUS       NM_001042507             499 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens galectin 7B (LGALS7B), mRNA.
ACCESSION   NM_001042507 XM_927748 XM_940513
VERSION     NM_001042507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Lenza,M.P., Oyenarte,I., Diercks,T., Quintana,J.I., Gimeno,A.,
            Coelho,H., Diniz,A., Peccati,F., Delgado,S., Bosch,A., Valle,M.,
            Millet,O., Abrescia,N.G.A., Palazon,A., Marcelo,F.,
            Jimenez-Oses,G., Jimenez-Barbero,J., Arda,A. and Ereno-Orbea,J.
  TITLE     Structural Characterization of N-Linked Glycans in the Receptor
            Binding Domain of the SARS-CoV-2 Spike Protein and their
            Interactions with Human Lectins
  JOURNAL   Angew Chem Int Ed Engl 59 (52), 23763-23771 (2020)
   PUBMED   32915505
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 499)
  AUTHORS   Menkhorst,E., Koga,K., Van Sinderen,M. and Dimitriadis,E.
  TITLE     Galectin-7 serum levels are altered prior to the onset of
            pre-eclampsia
  JOURNAL   Placenta 35 (4), 281-285 (2014)
   PUBMED   24534543
  REMARK    GeneRIF: serum concentration was significantly elevated in women
            (weeks 10-12 and 17-20) who subsequently developed pre-eclampsia
REFERENCE   4  (bases 1 to 499)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 499)
  AUTHORS   Saussez,S., Decaestecker,C., Lorfevre,F., Chevalier,D.,
            Mortuaire,G., Kaltner,H., Andre,S., Toubeau,G., Gabius,H.J. and
            Leroy,X.
  TITLE     Increased expression and altered intracellular distribution of
            adhesion/growth-regulatory lectins galectins-1 and -7 during tumour
            progression in hypopharyngeal and laryngeal squamous cell
            carcinomas
  JOURNAL   Histopathology 52 (4), 483-493 (2008)
   PUBMED   18315601
  REMARK    GeneRIF: An association was seen between the level of presence of
            galectins-1 and -7 and neoplastic progression of hypopharyngeal and
            laryngeal squamous cell carcinomas.
REFERENCE   6  (bases 1 to 499)
  AUTHORS   Kopitz,J., Andre,S., von Reitzenstein,C., Versluis,K., Kaltner,H.,
            Pieters,R.J., Wasano,K., Kuwabara,I., Liu,F.T., Cantz,M., Heck,A.J.
            and Gabius,H.J.
  TITLE     Homodimeric galectin-7 (p53-induced gene 1) is a negative growth
            regulator for human neuroblastoma cells
  JOURNAL   Oncogene 22 (40), 6277-6288 (2003)
   PUBMED   13679866
REFERENCE   7  (bases 1 to 499)
  AUTHORS   Kuwabara,I., Kuwabara,Y., Yang,R.Y., Schuler,M., Green,D.R.,
            Zuraw,B.L., Hsu,D.K. and Liu,F.T.
  TITLE     Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK
            activation and mitochondrial cytochrome c release
  JOURNAL   J Biol Chem 277 (5), 3487-3497 (2002)
   PUBMED   11706006
REFERENCE   8  (bases 1 to 499)
  AUTHORS   Leonidas,D.D., Vatzaki,E.H., Vorum,H., Celis,J.E., Madsen,P. and
            Acharya,K.R.
  TITLE     Structural basis for the recognition of carbohydrates by human
            galectin-7
  JOURNAL   Biochemistry 37 (40), 13930-13940 (1998)
   PUBMED   9760227
REFERENCE   9  (bases 1 to 499)
  AUTHORS   Magnaldo,T., Bernerd,F. and Darmon,M.
  TITLE     Galectin-7, a human 14-kDa S-lectin, specifically expressed in
            keratinocytes and sensitive to retinoic acid
  JOURNAL   Dev Biol 168 (2), 259-271 (1995)
   PUBMED   7729568
REFERENCE   10 (bases 1 to 499)
  AUTHORS   Madsen,P., Rasmussen,H.H., Flint,T., Gromov,P., Kruse,T.A.,
            Honore,B., Vorum,H. and Celis,J.E.
  TITLE     Cloning, expression, and chromosome mapping of human galectin-7
  JOURNAL   J Biol Chem 270 (11), 5823-5829 (1995)
   PUBMED   7534301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022144.8, L07769.1,
            AW015224.1 and BC042911.2.
            
            On May 17, 2019 this sequence version replaced NM_001042507.3.
            
            Summary: The galectins are a family of beta-galactoside-binding
            proteins implicated in modulating cell-cell and cell-matrix
            interactions. Differential and in situ hybridization studies
            indicate that this lectin is specifically expressed in
            keratinocytes and found mainly in stratified squamous epithelium. A
            duplicate copy of this gene (GeneID:3963) is found adjacent to, but
            on the opposite strand on chromosome 19. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145893,
                              SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314980.5/ ENSP00000313571.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC022144.8         16070-16079         c
            11-53               L07769.1           2-44
            54-493              AW015224.1         17-456              c
            494-499             BC042911.2         460-465
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..499
                     /gene="LGALS7B"
                     /gene_synonym="Gal-7; GAL7; HKL-14; LGALS7; PI7"
                     /note="galectin 7B"
                     /db_xref="GeneID:653499"
                     /db_xref="HGNC:HGNC:34447"
                     /db_xref="MIM:617139"
     exon            1..33
                     /gene="LGALS7B"
                     /gene_synonym="Gal-7; GAL7; HKL-14; LGALS7; PI7"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..438
                     /gene="LGALS7B"
                     /gene_synonym="Gal-7; GAL7; HKL-14; LGALS7; PI7"
                     /note="keratinocyte lectin 14; p53-induced protein 1;
                     lectin galactoside-binding soluble 7; p53-induced gene 1
                     protein; lectin, galactoside-binding, soluble, 7B"
                     /codon_start=1
                     /product="galectin-7"
                     /protein_id="NP_001035972.1"
                     /db_xref="CCDS:CCDS42565.1"
                     /db_xref="GeneID:653499"
                     /db_xref="HGNC:HGNC:34447"
                     /db_xref="MIM:617139"
                     /translation="MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQG
                     SDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVV
                     GDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF"
     exon            34..122
                     /gene="LGALS7B"
                     /gene_synonym="Gal-7; GAL7; HKL-14; LGALS7; PI7"
                     /inference="alignment:Splign:2.1.0"
     exon            123..324
                     /gene="LGALS7B"
                     /gene_synonym="Gal-7; GAL7; HKL-14; LGALS7; PI7"
                     /inference="alignment:Splign:2.1.0"
     exon            325..499
                     /gene="LGALS7B"
                     /gene_synonym="Gal-7; GAL7; HKL-14; LGALS7; PI7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacggctgc ccaacccggt cccagccatg tccaacgtcc cccacaagtc ctcactgccc
       61 gagggcatcc gccctggcac ggtgctgaga attcgcggct tggttcctcc caatgccagc
      121 aggttccatg taaacctgct gtgcggggag gagcagggct ccgatgccgc cctgcatttc
      181 aacccccggc tggacacgtc ggaggtggtc ttcaacagca aggagcaagg ctcctggggc
      241 cgcgaggagc gcgggccggg cgttcctttc cagcgcgggc agcccttcga ggtgctcatc
      301 atcgcgtcag acgacggctt caaggccgtg gttggggacg cccagtacca ccacttccgc
      361 caccgcctgc cgctggcgcg cgtgcgcctg gtggaggtgg gcggggacgt gcagctggac
      421 tccgtgagga tcttctgagc agaagcccag gcgggcccgg ggccttggct ggcaaataaa
      481 gcgttagccc gcagcgcga
//
