LOCUS       NM_002307                494 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens galectin 7 (LGALS7), mRNA.
ACCESSION   NM_002307
VERSION     NM_002307.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Xie,J., Li,Y., Zeng,T., Fan,T., Shan,H., Shi,G., Zhou,W., Zou,J.
            and Lei,X.
  TITLE     ANGPTL4 plays a paradoxical role in gastric cancer through the
            LGALS7 and Hedgehog pathways
  JOURNAL   Sci Rep 14 (1), 23173 (2024)
   PUBMED   39369030
  REMARK    GeneRIF: ANGPTL4 plays a paradoxical role in gastric cancer through
            the LGALS7 and Hedgehog pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Seifert,C.T., Unverdorben,L., Knabl,J., Hutter,S., Keckstein,S.,
            Schmoeckel,E., Kessler,M., Jeschke,U., Mahner,S., Kolben,T. and
            Ganster,F.
  TITLE     Galectin-7 Expression in the Placentas of Women with Gestational
            Diabetes Mellitus
  JOURNAL   Int J Mol Sci 25 (18), 10186 (2024)
   PUBMED   39337670
  REMARK    GeneRIF: Galectin-7 Expression in the Placentas of Women with
            Gestational Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 494)
  AUTHORS   Sun,L., Liu,R., Wu,Z.J., Liu,Z.Y., Wan,A.H., Yan,S., Liu,C.,
            Liang,H., Xiao,M., You,N., Lou,Y., Deng,Y., Bu,X., Chen,D.,
            Huang,J., Zhang,X., Kuang,D.M. and Wan,G.
  TITLE     Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in
            Microsatellite Stability Colorectal Cancer
  JOURNAL   Gastroenterology 166 (3), 466-482 (2024)
   PUBMED   38065340
  REMARK    GeneRIF: Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity
            in Microsatellite Stability Colorectal Cancer.
REFERENCE   4  (bases 1 to 494)
  AUTHORS   Liang,Y., Wang,Y., Zhu,X., Cai,J., Shi,A., Huang,J., Zhu,Q. and
            Si,Y.
  TITLE     Binding of Glycerol to Human Galectin-7 Expands Stability and
            Modulates Its Functions
  JOURNAL   Int J Mol Sci 23 (20), 12318 (2022)
   PUBMED   36293173
  REMARK    GeneRIF: Binding of Glycerol to Human Galectin-7 Expands Stability
            and Modulates Its Functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 494)
  AUTHORS   Pham,N.T.H., Letourneau,M., Fortier,M., Begin,G.,
            Al-Abdul-Wahid,M.S., Pucci,F., Folch,B., Rooman,M., Chatenet,D.,
            St-Pierre,Y., Lague,P., Calmettes,C. and Doucet,N.
  TITLE     Perturbing dimer interactions and allosteric communication
            modulates the immunosuppressive activity of human galectin-7
  JOURNAL   J Biol Chem 297 (5), 101308 (2021)
   PUBMED   34673030
  REMARK    GeneRIF: Perturbing dimer interactions and allosteric communication
            modulates the immunosuppressive activity of human galectin-7.
REFERENCE   6  (bases 1 to 494)
  AUTHORS   Leonidas,D.D., Vatzaki,E.H., Vorum,H., Celis,J.E., Madsen,P. and
            Acharya,K.R.
  TITLE     Structural basis for the recognition of carbohydrates by human
            galectin-7
  JOURNAL   Biochemistry 37 (40), 13930-13940 (1998)
   PUBMED   9760227
REFERENCE   7  (bases 1 to 494)
  AUTHORS   Magnaldo,T., Fowlis,D. and Darmon,M.
  TITLE     Galectin-7, a marker of all types of stratified epithelia
  JOURNAL   Differentiation 63 (3), 159-168 (1998)
   PUBMED   9697310
REFERENCE   8  (bases 1 to 494)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
REFERENCE   9  (bases 1 to 494)
  AUTHORS   Magnaldo,T., Bernerd,F. and Darmon,M.
  TITLE     Galectin-7, a human 14-kDa S-lectin, specifically expressed in
            keratinocytes and sensitive to retinoic acid
  JOURNAL   Dev Biol 168 (2), 259-271 (1995)
   PUBMED   7729568
REFERENCE   10 (bases 1 to 494)
  AUTHORS   Madsen,P., Rasmussen,H.H., Flint,T., Gromov,P., Kruse,T.A.,
            Honore,B., Vorum,H. and Celis,J.E.
  TITLE     Cloning, expression, and chromosome mapping of human galectin-7
  JOURNAL   J Biol Chem 270 (11), 5823-5829 (1995)
   PUBMED   7534301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP225960.1.
            
            On Feb 27, 2020 this sequence version replaced NM_002307.3.
            
            Summary: The galectins are a family of beta-galactoside-binding
            proteins implicated in modulating cell-cell and cell-matrix
            interactions. Differential and in situ hybridization studies
            indicate that this lectin is specifically expressed in
            keratinocytes and found mainly in stratified squamous epithelium. A
            duplicate copy of this gene (GeneID:653499) is found adjacent to,
            but on the opposite strand on chromosome 19. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP225960.1, W61024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378626.5/ ENSP00000367891.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               BP225960.1         1-494
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..494
                     /gene="LGALS7"
                     /gene_synonym="GAL7; LGALS7A"
                     /note="galectin 7"
                     /db_xref="GeneID:3963"
                     /db_xref="HGNC:HGNC:6568"
                     /db_xref="MIM:600615"
     exon            1..31
                     /gene="LGALS7"
                     /gene_synonym="GAL7; LGALS7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..436
                     /gene="LGALS7"
                     /gene_synonym="GAL7; LGALS7A"
                     /note="lectin, galactoside-binding, soluble, 7"
                     /codon_start=1
                     /product="galectin-7"
                     /protein_id="NP_002298.1"
                     /db_xref="CCDS:CCDS33012.1"
                     /db_xref="GeneID:3963"
                     /db_xref="HGNC:HGNC:6568"
                     /db_xref="MIM:600615"
                     /translation="MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQG
                     SDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVV
                     GDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF"
     exon            32..120
                     /gene="LGALS7"
                     /gene_synonym="GAL7; LGALS7A"
                     /inference="alignment:Splign:2.1.0"
     exon            121..322
                     /gene="LGALS7"
                     /gene_synonym="GAL7; LGALS7A"
                     /inference="alignment:Splign:2.1.0"
     exon            323..494
                     /gene="LGALS7"
                     /gene_synonym="GAL7; LGALS7A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggctgccc aacccggtcc cagccatgtc caacgtcccc cacaagtcct cactgcccga
       61 gggcatccgc cctggcacgg tgctgagaat tcgcggcttg gttcctccca atgccagcag
      121 gttccatgta aacctgctgt gcggggagga gcagggctcc gatgccgcgc tgcatttcaa
      181 cccccggctg gacacgtcgg aggtggtctt caacagcaag gagcaaggct cctggggccg
      241 cgaggagcgc gggccgggcg ttcctttcca gcgcgggcag cccttcgagg tgctcatcat
      301 cgcgtcagac gacggcttca aggccgtggt tggggacgcc cagtaccacc acttccgcca
      361 ccgcctgccg ctggcgcgcg tgcgcctggt ggaggtgggc ggggacgtgc agctggactc
      421 cgtgaggatc ttctgagcag aagcccaggc gggcccgggg ccttggctgg caaataaagc
      481 gttagcccgc agcg
//
