LOCUS       NM_006149               1121 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens galectin 4 (LGALS4), mRNA.
ACCESSION   NM_006149
VERSION     NM_006149.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1121)
  AUTHORS   Tsuchida,A., Hachisu,K., Mizuno,M., Takada,Y. and Ideo,H.
  TITLE     High expression of B3GALT5 suppresses the galectin-4-mediated
            peritoneal dissemination of poorly differentiated gastric cancer
            cells
  JOURNAL   Glycobiology 34 (10) (2024)
   PUBMED   39163480
  REMARK    GeneRIF: High expression of B3GALT5 suppresses the
            galectin-4-mediated peritoneal dissemination of poorly
            differentiated gastric cancer cells.
REFERENCE   2  (bases 1 to 1121)
  AUTHORS   Hachisu,K., Tsuchida,A., Takada,Y., Mizuno,M. and Ideo,H.
  TITLE     Galectin-4 Is Involved in the Structural Changes of
            Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer
            Cells with High Metastatic Potential
  JOURNAL   Int J Mol Sci 24 (15), 12305 (2023)
   PUBMED   37569679
  REMARK    GeneRIF: Galectin-4 Is Involved in the Structural Changes of
            Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer
            Cells with High Metastatic Potential.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1121)
  AUTHORS   Kaur,S., Singh,J. and Kaur,M.
  TITLE     Multifaceted role of galectin-4 in cancer: A systematic review
  JOURNAL   Eur J Clin Invest 53 (7), e13987 (2023)
   PUBMED   36932875
  REMARK    GeneRIF: Multifaceted role of galectin-4 in cancer: A systematic
            review.
            Review article
REFERENCE   4  (bases 1 to 1121)
  AUTHORS   Ideo,H., Tsuchida,A., Takada,Y., Kinoshita,J., Inaki,N. and
            Minamoto,T.
  TITLE     Suppression of galectin-4 attenuates peritoneal metastasis of
            poorly differentiated gastric cancer cells
  JOURNAL   Gastric Cancer 26 (3), 352-363 (2023)
   PUBMED   36695981
  REMARK    GeneRIF: Suppression of galectin-4 attenuates peritoneal metastasis
            of poorly differentiated gastric cancer cells.
REFERENCE   5  (bases 1 to 1121)
  AUTHORS   Nagasaki,S.C., Fukuda,T.D., Yamada,M., Suzuki,Y.I., Kakutani,R.,
            Guy,A.T. and Imayoshi,I.
  TITLE     Enhancement of Vivid-based photo-activatable Gal4 transcription
            factor in mammalian cells
  JOURNAL   Cell Struct Funct 48 (1), 31-47 (2023)
   PUBMED   36529516
  REMARK    GeneRIF: Enhancement of Vivid-based photo-activatable Gal4
            transcription factor in mammalian cells.
REFERENCE   6  (bases 1 to 1121)
  AUTHORS   Ideo,H., Seko,A. and Yamashita,K.
  TITLE     Galectin-4 binds to sulfated glycosphingolipids and
            carcinoembryonic antigen in patches on the cell surface of human
            colon adenocarcinoma cells
  JOURNAL   J Biol Chem 280 (6), 4730-4737 (2005)
   PUBMED   15546874
  REMARK    GeneRIF: SB1a and CEA in the patches on the cell surface of human
            colon adenocarcinoma cells could be biologically important ligands
            for galectin-4
REFERENCE   7  (bases 1 to 1121)
  AUTHORS   Ideo,H., Seko,A., Ohkura,T., Matta,K.L. and Yamashita,K.
  TITLE     High-affinity binding of recombinant human galectin-4 to
            SO(3)(-)-->3Galbeta1-->3GalNAc pyranoside
  JOURNAL   Glycobiology 12 (3), 199-208 (2002)
   PUBMED   11971864
  REMARK    GeneRIF: results suggest that galectin-4 has a unique carbohydrate
            binding specificity and interacts with O-linked sulfoglycans
REFERENCE   8  (bases 1 to 1121)
  AUTHORS   Rechreche,H., Mallo,G.V., Montalto,G., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning and expression of the mRNA of human galectin-4, an S-type
            lectin down-regulated in colorectal cancer
  JOURNAL   Eur J Biochem 248 (1), 225-230 (1997)
   PUBMED   9310382
REFERENCE   9  (bases 1 to 1121)
  AUTHORS   Huflejt,M.E., Jordan,E.T., Gitt,M.A., Barondes,S.H. and Leffler,H.
  TITLE     Strikingly different localization of galectin-3 and galectin-4 in
            human colon adenocarcinoma T84 cells. Galectin-4 is localized at
            sites of cell adhesion
  JOURNAL   J Biol Chem 272 (22), 14294-14303 (1997)
   PUBMED   9162064
REFERENCE   10 (bases 1 to 1121)
  AUTHORS   Barondes,S.H., Cooper,D.N., Gitt,M.A. and Leffler,H.
  TITLE     Galectins. Structure and function of a large family of animal
            lectins
  JOURNAL   J Biol Chem 269 (33), 20807-20810 (1994)
   PUBMED   8063692
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA130458.1 and AK290269.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006149.3.
            
            Summary: The galectins are a family of beta-galactoside-binding
            proteins implicated in modulating cell-cell and cell-matrix
            interactions. The expression of this gene is restricted to small
            intestine, colon, and rectum, and it is underexpressed in
            colorectal cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290269.1, SRR5189664.114077.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307751.9/ ENSP00000302100.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AA130458.1         156-206
            52-1121             AK290269.1         52-1121
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1121
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /note="galectin 4"
                     /db_xref="GeneID:3960"
                     /db_xref="HGNC:HGNC:6565"
                     /db_xref="MIM:602518"
     exon            1..104
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1031
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /note="lactose-binding lectin 4; L-36 lactose-binding
                     protein; gal-4; antigen NY-CO-27; lectin,
                     galactoside-binding, soluble, 4"
                     /codon_start=1
                     /product="galectin-4"
                     /protein_id="NP_006140.1"
                     /db_xref="CCDS:CCDS12521.1"
                     /db_xref="GeneID:3960"
                     /db_xref="HGNC:HGNC:6565"
                     /db_xref="MIM:602518"
                     /translation="MAYVPAPGYQPTYNPTLPYYQPIPGGLNVGMSVYIQGVASEHMK
                     RFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFE
                     LVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSINFIGGQPLRPQGP
                     PMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTG
                     KSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDL
                     SIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDTLEIQGDVTLSYVQI"
     exon            105..193
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            194..398
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            399..533
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            534..560
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            561..599
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            600..629
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            630..718
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            719..884
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1121
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="LGALS4"
                     /gene_synonym="GAL4; L36LBP"
                     /note="major polyA site"
ORIGIN      
        1 accatctccc actcctgcag ctcttctcac aggaccagcc actagcgcag cctcgagcga
       61 tggcctatgt ccccgcaccg ggctaccagc ccacctacaa cccgacgctg ccttactacc
      121 agcccatccc gggcgggctc aacgtgggaa tgtctgttta catccaagga gtggccagcg
      181 agcacatgaa gcggttcttc gtgaactttg tggttgggca ggatccgggc tcagacgtcg
      241 ccttccactt caatccgcgg tttgacggct gggacaaggt ggtcttcaac acgttgcagg
      301 gcgggaagtg gggcagcgag gagaggaaga ggagcatgcc cttcaaaaag ggtgccgcct
      361 ttgagctggt cttcatagtc ctggctgagc actacaaggt ggtggtaaat ggaaatccct
      421 tctatgagta cgggcaccgg cttcccctac agatggtcac ccacctgcaa gtggatgggg
      481 atctgcaact tcaatcaatc aacttcatcg gaggccagcc cctccggccc cagggacccc
      541 cgatgatgcc accttaccct ggtcccggac attgccatca acagctgaac agcctgccca
      601 ccatggaagg acccccaacc ttcaacccgc ctgtgccata tttcgggagg ctgcaaggag
      661 ggctcacagc tcgaagaacc atcatcatca agggctatgt gcctcccaca ggcaagagct
      721 ttgctatcaa cttcaaggtg ggctcctcag gggacatagc tctgcacatt aatccccgca
      781 tgggcaacgg taccgtggtc cggaacagcc ttctgaatgg ctcgtgggga tccgaggaga
      841 agaagatcac ccacaaccca tttggtcccg gacagttctt tgatctgtcc attcgctgtg
      901 gcttggatcg cttcaaggtt tacgccaatg gccagcacct ctttgacttt gcccatcgcc
      961 tctcggcctt ccagagggtg gacacattgg aaatccaggg tgatgtcacc ttgtcctatg
     1021 tccagatcta atctattcct ggggccataa ctcatgggaa aacagaatta tcccctagga
     1081 ctcctttcta agcccctaat aaaatgtctg agggtgtctc a
//
