LOCUS       NM_005567               2202 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens galectin 3 binding protein (LGALS3BP), mRNA.
ACCESSION   NM_005567
VERSION     NM_005567.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2202)
  AUTHORS   Liu,Y., Liang,L., Li,J., Pang,T., Zhang,S.H. and Xia,Z.Y.
  TITLE     Aberrant expression of LGALS3BP drives an unfavorable prognosis and
            more aggressive in HCC via regulating PI3K/AKT signaling
  JOURNAL   Tissue Cell 89, 102471 (2024)
   PUBMED   39029315
  REMARK    GeneRIF: Aberrant expression of LGALS3BP drives an unfavorable
            prognosis and more aggressive in HCC via regulating PI3K/AKT
            signaling.
REFERENCE   2  (bases 1 to 2202)
  AUTHORS   Panigrahi,A., Benicky,J., Aljuhani,R., Mukherjee,P., Novakova,Z.,
            Barinka,C. and Goldman,R.
  TITLE     Galectin-3-Binding Protein Inhibits Extracellular Heparan
            6-O-Endosulfatase Sulf-2
  JOURNAL   Mol Cell Proteomics 23 (7), 100793 (2024)
   PUBMED   38825040
  REMARK    GeneRIF: Galectin-3-Binding Protein Inhibits Extracellular Heparan
            6-O-Endosulfatase Sulf-2.
REFERENCE   3  (bases 1 to 2202)
  AUTHORS   Yamanaka,T., Araki,K., Yokobori,T., Muranushi,R., Hoshino,K.,
            Hagiwara,K., Gantumur,D., Ishii,N., Tsukagoshi,M., Watanabe,A.,
            Harimoto,N., Masamune,A., Uojima,H., Mizokami,M., Ito,K. and
            Shirabe,K.
  TITLE     Potential of Mac-2-binding protein glycan isomer as a new
            therapeutic target in pancreatic cancer
  JOURNAL   Cancer Sci 115 (4), 1241-1249 (2024)
   PUBMED   38321872
  REMARK    GeneRIF: Potential of Mac-2-binding protein glycan isomer as a new
            therapeutic target in pancreatic cancer.
REFERENCE   4  (bases 1 to 2202)
  AUTHORS   Li,L., Qin,S., Tan,H. and Zhou,J.
  TITLE     LGALS3BP is a novel and potential biomarker in clear cell renal
            cell carcinoma
  JOURNAL   Aging (Albany NY) 16 (4), 4033-4051 (2024)
   PUBMED   38393692
  REMARK    GeneRIF: LGALS3BP is a novel and potential biomarker in clear cell
            renal cell carcinoma.
REFERENCE   5  (bases 1 to 2202)
  AUTHORS   Li,M., Pan,W., Tian,D., Chen,D., Zhang,X., Zhang,Y., Chen,S.,
            Zhou,D. and Ge,J.
  TITLE     Diagnostic Value of Serum Galectin-3 Binding Protein Level in
            Patients with Pulmonary Arterial Hypertension
  JOURNAL   Curr Vasc Pharmacol 22 (1), 67-77 (2024)
   PUBMED   38038005
  REMARK    GeneRIF: Diagnostic Value of Serum Galectin-3 Binding Protein Level
            in Patients with Pulmonary Arterial Hypertension.
REFERENCE   6  (bases 1 to 2202)
  AUTHORS   Calabrese,G., Sures,I., Pompetti,F., Natoli,G., Palka,G. and
            Iacobelli,S.
  TITLE     The gene (LGALS3BP) encoding the serum protein 90K, associated with
            cancer and infection by the human immunodeficiency virus, maps at
            17q25
  JOURNAL   Cytogenet Cell Genet 69 (3-4), 223-225 (1995)
   PUBMED   7698018
REFERENCE   7  (bases 1 to 2202)
  AUTHORS   Yu,B. and Wright,S.D.
  TITLE     LPS-dependent interaction of Mac-2-binding protein with immobilized
            CD14
  JOURNAL   J Inflamm 45 (2), 115-125 (1995)
   PUBMED   7583357
REFERENCE   8  (bases 1 to 2202)
  AUTHORS   Ullrich,A., Sures,I., D'Egidio,M., Jallal,B., Powell,T.J.,
            Herbst,R., Dreps,A., Azam,M., Rubinstein,M., Natoli,C. et al.
  TITLE     The secreted tumor-associated antigen 90K is a potent immune
            stimulator
  JOURNAL   J Biol Chem 269 (28), 18401-18407 (1994)
   PUBMED   8034587
REFERENCE   9  (bases 1 to 2202)
  AUTHORS   Koths,K., Taylor,E., Halenbeck,R., Casipit,C. and Wang,A.
  TITLE     Cloning and characterization of a human Mac-2-binding protein, a
            new member of the superfamily defined by the macrophage scavenger
            receptor cysteine-rich domain
  JOURNAL   J Biol Chem 268 (19), 14245-14249 (1993)
   PUBMED   8390986
REFERENCE   10 (bases 1 to 2202)
  AUTHORS   Rosenberg,I., Cherayil,B.J., Isselbacher,K.J. and Pillai,S.
  TITLE     Mac-2-binding glycoproteins. Putative ligands for a cytosolic
            beta-galactoside lectin
  JOURNAL   J Biol Chem 266 (28), 18731-18736 (1991)
   PUBMED   1917996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L13210.1 and BC002403.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005567.3.
            
            Summary: The galectins are a family of beta-galactoside-binding
            proteins implicated in modulating cell-cell and cell-matrix
            interactions. LGALS3BP has been found elevated in the serum of
            patients with cancer and in those infected by the human
            immunodeficiency virus (HIV). It appears to be implicated in immune
            response associated with natural killer (NK) and
            lymphokine-activated killer (LAK) cell cytotoxicity. Using
            fluorescence in situ hybridization the full length 90K cDNA has
            been localized to chromosome 17q25. The native protein binds
            specifically to a human macrophage-associated lectin known as Mac-2
            and also binds galectin 1. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.560849.1, BC015761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262776.8/ ENSP00000262776.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               L13210.1           57-238
            183-2202            BC002403.2         172-2191
FEATURES             Location/Qualifiers
     source          1..2202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2202
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /note="galectin 3 binding protein"
                     /db_xref="GeneID:3959"
                     /db_xref="HGNC:HGNC:6564"
                     /db_xref="MIM:600626"
     exon            1..100
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /inference="alignment:Splign:2.1.0"
     exon            101..175
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1881
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /EC_number="3.6.1.6"
                     /note="L3 antigen; Mac-2-binding protein; serum protein
                     90K; MAC2BP; transport and golgi organization 10 homolog
                     B; mac-2 BP; tumor-associated antigen 90K; basement
                     membrane autoantigen p105; lectin galactoside-binding
                     soluble 3-binding protein"
                     /codon_start=1
                     /product="galectin-3-binding protein precursor"
                     /protein_id="NP_005558.1"
                     /db_xref="CCDS:CCDS11759.1"
                     /db_xref="GeneID:3959"
                     /db_xref="HGNC:HGNC:6564"
                     /db_xref="MIM:600626"
                     /translation="MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQ
                     WGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD
                     CKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVN
                     VQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRID
                     ITLSSVKCFHKLASAYGARQLQGYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLE
                     KLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERA
                     SHEEVEGLVEKIRFPMMLPEELFELQFNLSLYWSHEALFQKKTLQALEFHTVPFQLLA
                     RYKGLNLTEDTYKPRIYTSPTWSAFVTDSSWSARKSQLVYQSRRGPLVKYSSDYFQAP
                     SDYRYYPYQSFQTPQHPSFLFQDKRVSWSLVYLPTIQSCWNYGFSCSSDELPVLGLTK
                     SGGSDRTIAYENKALMLCEGLFVADVTDFEGWKAAIPSALDTNSSKSTSSFPCPAGHF
                     NGFRTVIRPFYLTNSSGVD"
     exon            176..367
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /inference="alignment:Splign:2.1.0"
     exon            368..499
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /inference="alignment:Splign:2.1.0"
     exon            500..752
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /inference="alignment:Splign:2.1.0"
     exon            753..2202
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2179..2184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /note="hexamer: ATTAAA"
     polyA_site      2202
                     /gene="LGALS3BP"
                     /gene_synonym="90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP;
                     TANGO10B"
                     /note="major polyA site"
ORIGIN      
        1 atactgggag aggcttctgg gtcaaaggac cagtctgcag agggatcctg tggctggaag
       61 cgaggaggct ccacacggcc gttgcagcta ccgcagccag gatctgggca tccaggcacg
      121 gccatgaccc ctccgaggct cttctgggtg tggctgctgg ttgcaggaac ccaaggcgtg
      181 aacgatggtg acatgcggct ggccgatggg ggcgccacca accagggccg cgtggagatc
      241 ttctacagag gccagtgggg cactgtgtgt gacaacctgt gggacctgac tgatgccagc
      301 gtcgtctgcc gggccctggg cttcgagaac gccacccagg ctctgggcag agctgccttc
      361 gggcaaggat caggccccat catgctggat gaggtccagt gcacgggaac cgaggcctca
      421 ctggccgact gcaagtccct gggctggctg aagagcaact gcaggcacga gagagacgct
      481 ggtgtggtct gcaccaatga aaccaggagc acccacaccc tggacctctc cagggagctc
      541 tcggaggccc ttggccagat ctttgacagc cagcggggct gcgacctgtc catcagcgtg
      601 aatgtgcagg gcgaggacgc cctgggcttc tgtggccaca cggtcatcct gactgccaac
      661 ctggaggccc aggccctgtg gaaggagccg ggcagcaatg tcaccatgag tgtggatgct
      721 gagtgtgtgc ccatggtcag ggaccttctc aggtacttct actcccgaag gattgacatc
      781 accctgtcgt cagtcaagtg cttccacaag ctggcctctg cctatggggc caggcagctg
      841 cagggctact gcgcaagcct ctttgccatc ctcctccccc aggacccctc gttccagatg
      901 cccctggacc tgtatgccta tgcagtggcc acaggggacg ccctgctgga gaagctctgc
      961 ctacagttcc tggcctggaa cttcgaggcc ttgacgcagg ccgaggcctg gcccagtgtc
     1021 cccacagacc tgctccaact gctgctgccc aggagcgacc tggcggtgcc cagcgagctg
     1081 gccctactga aggccgtgga cacctggagc tggggggagc gtgcctccca tgaggaggtg
     1141 gagggcttgg tggagaagat ccgcttcccc atgatgctcc ctgaggagct ctttgagctg
     1201 cagttcaacc tgtccctgta ctggagccac gaggccctgt tccagaagaa gactctgcag
     1261 gccctggaat tccacactgt gcccttccag ttgctggccc ggtacaaagg cctgaacctc
     1321 accgaggata cctacaagcc ccggatttac acctcgccca cctggagtgc ctttgtgaca
     1381 gacagttcct ggagtgcacg gaagtcacaa ctggtctatc agtccagacg ggggcctttg
     1441 gtcaaatatt cttctgatta cttccaagcc ccctctgact acagatacta cccctaccag
     1501 tccttccaga ctccacaaca ccccagcttc ctcttccagg acaagagggt gtcctggtcc
     1561 ctggtctacc tccccaccat ccagagctgc tggaactacg gcttctcctg ctcctcggac
     1621 gagctccctg tcctgggcct caccaagtct ggcggctcag atcgcaccat tgcctacgaa
     1681 aacaaagccc tgatgctctg cgaagggctc ttcgtggcag acgtcaccga tttcgagggc
     1741 tggaaggctg cgattcccag tgccctggac accaacagct cgaagagcac ctcctccttc
     1801 ccctgcccgg cagggcactt caacggcttc cgcacggtca tccgcccctt ctacctgacc
     1861 aactcctcag gtgtggacta gacggcgtgg cccaagggtg gtgagaaccg gagaacccca
     1921 ggacgccctc actgcaggct cccctcctcg gcttccttcc tctctgcaat gaccttcaac
     1981 aaccggccac cagatgtcgc cctactcacc tgagcgctca gcttcaagaa attactggaa
     2041 ggcttccact agggtccacc aggagttctc ccaccacctc accagtttcc aggtggtaag
     2101 caccaggacg ccctcgaggt tgctctggga tccccccaca gcccctggtc agtctgccct
     2161 tgtcactggt ctgaggtcat taaaattaca ttgaggttcc ta
//
