LOCUS       NM_002306                958 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens galectin 3 (LGALS3), transcript variant 1, mRNA.
ACCESSION   NM_002306
VERSION     NM_002306.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 958)
  AUTHORS   Chou,Y.L., Chen,H.L., Hsu,B.G., Yang,C.Y., Chen,C.H., Lee,Y.C.,
            Tsai,I.L., Sung,C.C., Wu,C.C., Yang,S.R., Suzuki,Y., Yates,E.,
            Hua,K.F., Yu,L.G., Liu,F.T., Chen,A. and Ka,S.M.
  TITLE     Galectin-3 contributes to pathogenesis of IgA nephropathy
  JOURNAL   Kidney Int 106 (4), 658-670 (2024)
   PUBMED   39084257
  REMARK    GeneRIF: Galectin-3 contributes to pathogenesis of IgA nephropathy.
REFERENCE   2  (bases 1 to 958)
  AUTHORS   Zhou,X., Su,J., Zhang,C.L., Dai,H. and Wang,W.H.
  TITLE     Decreased expression of galectin-3 in the epidermis of psoriasis
            patients
  JOURNAL   Eur J Dermatol 34 (4), 371-377 (2024)
   PUBMED   39193673
  REMARK    GeneRIF: Decreased expression of galectin-3 in the epidermis of
            psoriasis patients.
REFERENCE   3  (bases 1 to 958)
  AUTHORS   Andric,K., Jakovljevic,V., Zivkovic,V., Veselinovic,M.,
            Bolevicg,S., Petrovich Fisenko,V., Joksimovic Jovic,J., Andjic,M.,
            Lazarevic,N., Andric,N., Dimkic Milenkovic,A. and Vulovic,D.
  TITLE     Oxidative stress and galectin-3 levels during skin grafting after
            hand injury: gender differences
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (7), 38-48 (2024)
   PUBMED   39097896
  REMARK    GeneRIF: Oxidative stress and galectin-3 levels during skin
            grafting after hand injury: gender differences.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 958)
  AUTHORS   Kohatsu,L., Hsu,D.K., Jegalian,A.G., Liu,F.T. and Baum,L.G.
  TITLE     Galectin-3 induces death of Candida species expressing specific
            beta-1,2-linked mannans
  JOURNAL   J Immunol 177 (7), 4718-4726 (2006)
   PUBMED   16982911
  REMARK    GeneRIF: The antimicrobial protein galectin-3 has direct fungicidal
            activity against fungal pathogens.
REFERENCE   5  (bases 1 to 958)
  AUTHORS   Raimond,J., Zimonjic,D.B., Mignon,C., Mattei,M., Popescu,N.C.,
            Monsigny,M. and Legrand,A.
  TITLE     Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at
            region 14q21-22
  JOURNAL   Mamm Genome 8 (9), 706-707 (1997)
   PUBMED   9271684
REFERENCE   6  (bases 1 to 958)
  AUTHORS   Rosenberg,I., Cherayil,B.J., Isselbacher,K.J. and Pillai,S.
  TITLE     Mac-2-binding glycoproteins. Putative ligands for a cytosolic
            beta-galactoside lectin
  JOURNAL   J Biol Chem 266 (28), 18731-18736 (1991)
   PUBMED   1917996
REFERENCE   7  (bases 1 to 958)
  AUTHORS   Raz,A., Carmi,P., Raz,T., Hogan,V., Mohamed,A. and Wolman,S.R.
  TITLE     Molecular cloning and chromosomal mapping of a human
            galactoside-binding protein
  JOURNAL   Cancer Res 51 (8), 2173-2178 (1991)
   PUBMED   2009535
REFERENCE   8  (bases 1 to 958)
  AUTHORS   Oda,Y., Leffler,H., Sakakura,Y., Kasai,K. and Barondes,S.H.
  TITLE     Human breast carcinoma cDNA encoding a galactoside-binding lectin
            homologous to mouse Mac-2 antigen
  JOURNAL   Gene 99 (2), 279-283 (1991)
   PUBMED   2022338
REFERENCE   9  (bases 1 to 958)
  AUTHORS   Gitt,M.A. and Barondes,S.H.
  TITLE     Genomic sequence and organization of two members of a human lectin
            gene family
  JOURNAL   Biochemistry 30 (1), 82-89 (1991)
   PUBMED   1988031
REFERENCE   10 (bases 1 to 958)
  AUTHORS   Cherayil,B.J., Chaitovitz,S., Wong,C. and Pillai,S.
  TITLE     Molecular cloning of a human macrophage lectin specific for
            galactose
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7324-7328 (1990)
   PUBMED   2402511
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB006780.1 and BU681070.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002306.3.
            
            Summary: This gene encodes a member of the galectin family of
            carbohydrate binding proteins. Members of this protein family have
            an affinity for beta-galactosides. The encoded protein is
            characterized by an N-terminal proline-rich tandem repeat domain
            and a single C-terminal carbohydrate recognition domain. This
            protein can self-associate through the N-terminal domain allowing
            it to bind to multivalent saccharide ligands. This protein
            localizes to the extracellular matrix, the cytoplasm and the
            nucleus. This protein plays a role in numerous cellular functions
            including apoptosis, innate immunity, cell adhesion and T-cell
            regulation. The protein exhibits antimicrobial activity against
            bacteria and fungi. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.42191.1,
                                           SRR5189655.11650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000254301.14/
                                                  ENSP00000254301.9
            Protein has antimicrobial activity :: PMID: 16982911
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-943               AB006780.1         1-943
            944-958             BU681070.1         25-39               c
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..958
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /note="galectin 3"
                     /db_xref="GeneID:3958"
                     /db_xref="HGNC:HGNC:6563"
                     /db_xref="MIM:153619"
     exon            1..49
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            50..71
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..806
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     galactose-specific lectin 3; MAC-2 antigen; IgE-binding
                     protein; carbohydrate-binding protein 35; laminin-binding
                     protein; lectin L-29; 35 kDa lectin; advanced glycation
                     end-product receptor 3; epididymis secretory sperm binding
                     protein; lectin, galactoside-binding, soluble, 3"
                     /codon_start=1
                     /product="galectin-3 isoform 1"
                     /protein_id="NP_002297.2"
                     /db_xref="CCDS:CCDS41956.1"
                     /db_xref="GeneID:3958"
                     /db_xref="HGNC:HGNC:6563"
                     /db_xref="MIM:153619"
                     /translation="MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGA
                     YPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYP
                     ATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFN
                     PRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHL
                     LQYNHRVKKLNEISKLGISGDIDLTSASYTMI"
     exon            72..395
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..484
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..650
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..958
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      928..933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /note="hexamer: AATAAA"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /note="hexamer: ATTACA"
     polyA_site      945
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
                     /note="major polyA site"
     polyA_site      958
                     /gene="LGALS3"
                     /gene_synonym="CBP35; GAL3; GALBP; GALIG; L31; LGALS2;
                     MAC2"
ORIGIN      
        1 gcccgcagca cctcctcgcc agcagccgtc cggagccagc caacgagcgg aaaatggcag
       61 acaatttttc gctccatgat gcgttatctg ggtctggaaa cccaaaccct caaggatggc
      121 ctggcgcatg ggggaaccag cctgctgggg cagggggcta cccaggggct tcctatcctg
      181 gggcctaccc cgggcaggca cccccagggg cttatcctgg acaggcacct ccaggcgcct
      241 accctggagc acctggagct tatcccggag cacctgcacc tggagtctac ccagggccac
      301 ccagcggccc tggggcctac ccatcttctg gacagccaag tgccaccgga gcctaccctg
      361 ccactggccc ctatggcgcc cctgctgggc cactgattgt gccttataac ctgcctttgc
      421 ctgggggagt ggtgcctcgc atgctgataa caattctggg cacggtgaag cccaatgcaa
      481 acagaattgc tttagatttc caaagaggga atgatgttgc cttccacttt aacccacgct
      541 tcaatgagaa caacaggaga gtcattgttt gcaatacaaa gctggataat aactggggaa
      601 gggaagaaag acagtcggtt ttcccatttg aaagtgggaa accattcaaa atacaagtac
      661 tggttgaacc tgaccacttc aaggttgcag tgaatgatgc tcacttgttg cagtacaatc
      721 atcgggttaa aaaactcaat gaaatcagca aactgggaat ttctggtgac atagacctca
      781 ccagtgcttc atataccatg atataatctg aaaggggcag attaaaaaaa aaaaaagaat
      841 ctaaacctta catgtgtaaa ggtttcatgt tcactgtgag tgaaaatttt tacattcatc
      901 aatatccctc ttgtaagtca tctacttaat aaatattaca gtgaattacc tgtctcaa
//
