LOCUS       NM_006498                596 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens galectin 2 (LGALS2), mRNA.
ACCESSION   NM_006498
VERSION     NM_006498.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 596)
  AUTHORS   Meister,S., Hahn,L., Beyer,S., Mannewitz,M., Perleberg,C.,
            Schnell,K., Anz,D., Corradini,S., Schmoeckel,E., Mayr,D.,
            Hasbargen,U., Zati Zehni,A., Mahner,S., Jeschke,U. and Kolben,T.
  TITLE     Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by
            Gal-2
  JOURNAL   Int J Mol Sci 23 (3), 1880 (2022)
   PUBMED   35163802
  REMARK    GeneRIF: Regulatory T Cell Apoptosis during Preeclampsia May Be
            Prevented by Gal-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 596)
  AUTHORS   Xu,W.D., Wu,Q., He,Y.W., Huang,A.F., Lan,Y.Y., Fu,L., Zhou,J. and
            Liu,X.Y.
  TITLE     Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with
            rheumatoid arthritis
  JOURNAL   Cell Immunol 368, 104419 (2021)
   PUBMED   34371260
  REMARK    GeneRIF: Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in
            patients with rheumatoid arthritis.
REFERENCE   3  (bases 1 to 596)
  AUTHORS   Li,H., Zhao,L., Lau,Y.S., Zhang,C. and Han,R.
  TITLE     Genome-wide CRISPR screen identifies LGALS2 as an oxidative
            stress-responsive gene with an inhibitory function on colon tumor
            growth
  JOURNAL   Oncogene 40 (1), 177-188 (2021)
   PUBMED   33110234
  REMARK    GeneRIF: Genome-wide CRISPR screen identifies LGALS2 as an
            oxidative stress-responsive gene with an inhibitory function on
            colon tumor growth.
REFERENCE   4  (bases 1 to 596)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 596)
  AUTHORS   Hepp,P., Unverdorben,L., Hutter,S., Kuhn,C., Ditsch,N., Gross,E.,
            Mahner,S., Jeschke,U., Knabl,J. and Heidegger,H.H.
  TITLE     Placental Galectin-2 Expression in Gestational Diabetes: A
            Systematic, Histological Analysis
  JOURNAL   Int J Mol Sci 21 (7), 2404 (2020)
   PUBMED   32244351
  REMARK    GeneRIF: Placental Galectin-2 Expression in Gestational Diabetes: A
            Systematic, Histological Analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 596)
  AUTHORS   Lobsanov,Y.D., Gitt,M.A., Leffler,H., Barondes,S.H. and Rini,J.M.
  TITLE     X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II,
            in complex with lactose at 2.9-A resolution
  JOURNAL   J Biol Chem 268 (36), 27034-27038 (1993)
   PUBMED   8262940
REFERENCE   7  (bases 1 to 596)
  AUTHORS   Lobsanov,Y.D., Gitt,M.A., Leffler,H., Barondes,S. and Rini,J.M.
  TITLE     Crystallization and preliminary X-ray diffraction analysis of the
            human dimeric S-Lac lectin (L-14-II)
  JOURNAL   J Mol Biol 233 (3), 553-555 (1993)
   PUBMED   8411163
REFERENCE   8  (bases 1 to 596)
  AUTHORS   Gitt,M.A., Massa,S.M., Leffler,H. and Barondes,S.H.
  TITLE     Isolation and expression of a gene encoding L-14-II, a new human
            soluble lactose-binding lectin
  JOURNAL   J Biol Chem 267 (15), 10601-10606 (1992)
   PUBMED   1375225
REFERENCE   9  (bases 1 to 596)
  AUTHORS   Gitt,M.A. and Barondes,S.H.
  TITLE     Genomic sequence and organization of two members of a human lectin
            gene family
  JOURNAL   Biochemistry 30 (1), 82-89 (1991)
   PUBMED   1988031
REFERENCE   10 (bases 1 to 596)
  AUTHORS   Gitt,M.A. and Barondes,S.H.
  TITLE     Evidence that a human soluble beta-galactoside-binding lectin is
            encoded by a family of genes
  JOURNAL   Proc Natl Acad Sci U S A 83 (20), 7603-7607 (1986)
   PUBMED   3020551
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022315.1, CD701729.1 and
            BC059782.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006498.2.
            
            Summary: The protein encoded by this gene is a soluble
            beta-galactoside binding lectin. The encoded protein is found as a
            homodimer and can bind to lymphotoxin-alpha. A single nucleotide
            polymorphism in an intron of this gene can alter the
            transcriptional level of the protein, with a resultant increased
            risk of myocardial infarction. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP303532.1, ERR279840.1904.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215886.6/ ENSP00000215886.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL022315.1         82379-82448         c
            71-144              CD701729.1         75-148
            145-596             BC059782.1         1-452
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..596
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /note="galectin 2"
                     /db_xref="GeneID:3957"
                     /db_xref="HGNC:HGNC:6562"
                     /db_xref="MIM:150571"
     exon            1..188
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..581
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /note="beta-galactoside-binding lectin L-14-II;
                     lactose-binding lectin 2; S-Lac lectin 2; gal-2; lectin,
                     galactoside-binding, soluble, 2"
                     /codon_start=1
                     /product="galectin-2"
                     /protein_id="NP_006489.1"
                     /db_xref="CCDS:CCDS13950.1"
                     /db_xref="GeneID:3957"
                     /db_xref="HGNC:HGNC:6562"
                     /db_xref="MIM:150571"
                     /translation="MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNL
                     HFNPRFSESTIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHE
                     LTFPNRLGHSHLSYLSVRGGFNMSSFKLKE"
     exon            189..271
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /inference="alignment:Splign:2.1.0"
     exon            272..431
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /inference="alignment:Splign:2.1.0"
     exon            432..596
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      577..582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /note="hexamer: AATAAA"
     polyA_site      596
                     /gene="LGALS2"
                     /gene_synonym="HL14"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttgtgc tgggtactgg gagatgcagg cggggagaca caaggtagaa ggggcaaagt
       61 cctcacctag gaccttgagg gagttaatgt gtaatattct aggatataag cttgaccacg
      121 agttgagacc ctgagcacag gcctccagga gccgctggga gctgccgcca ggagctgtca
      181 ccatgacggg ggaacttgag gttaagaaca tggacatgaa gccggggtca accctgaaga
      241 tcacaggcag catcgccgat ggcactgatg gctttgtaat taatctgggc caggggacag
      301 acaagctgaa cctgcatttc aaccctcgct tcagcgaatc caccattgtc tgcaactcat
      361 tggacggcag caactggggg caagaacaac gggaagatca cctgtgcttc agcccagggt
      421 cagaggtcaa gttcacagtg acctttgaga gtgacaaatt caaggtgaag ctgccagatg
      481 ggcacgagct gacttttccc aacaggctgg gtcacagcca cctgagctac ctgagcgtaa
      541 ggggcgggtt caacatgtcc tctttcaagt taaaagaata aaagacttcc agccga
//
