LOCUS       NM_001190441             605 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens galectin 16 (LGALS16), mRNA.
ACCESSION   NM_001190441 XM_001721300 XM_001721341 XM_001723341 XM_001723342
            XM_086001 XM_942526
VERSION     NM_001190441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 605)
  AUTHORS   Kaminker,J.D., Butt,A.G., Killeen,H. and Timoshenko,A.V.
  TITLE     Insights into cAMP-dependent molecular mechanisms regulating
            expression and function of LGALS16 gene in choriocarcinoma JEG-3
            cells
  JOURNAL   Cell Biol Int 48 (3), 378-385 (2024)
   PUBMED   38212900
  REMARK    GeneRIF: Insights into cAMP-dependent molecular mechanisms
            regulating expression and function of LGALS16 gene in
            choriocarcinoma JEG-3 cells.
REFERENCE   2  (bases 1 to 605)
  AUTHORS   Kaminker,J.D. and Timoshenko,A.V.
  TITLE     Expression, Regulation, and Functions of the Galectin-16 Gene in
            Human Cells and Tissues
  JOURNAL   Biomolecules 11 (12), 1909 (2021)
   PUBMED   34944551
  REMARK    GeneRIF: Expression, Regulation, and Functions of the Galectin-16
            Gene in Human Cells and Tissues.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 605)
  AUTHORS   Si,Y., Yao,Y., Jaramillo Ayala,G., Li,X., Han,Q., Zhang,W., Xu,X.,
            Tai,G., Mayo,K.H., Zhou,Y. and Su,J.
  TITLE     Human galectin-16 has a pseudo ligand binding site and plays a role
            in regulating c-Rel-mediated lymphocyte activity
  JOURNAL   Biochim Biophys Acta Gen Subj 1865 (1), 129755 (2021)
   PUBMED   33011338
  REMARK    GeneRIF: Human galectin-16 has a pseudo ligand binding site and
            plays a role in regulating c-Rel-mediated lymphocyte activity.
REFERENCE   4  (bases 1 to 605)
  AUTHORS   Than,N.G., Romero,R., Goodman,M., Weckle,A., Xing,J., Dong,Z.,
            Xu,Y., Tarquini,F., Szilagyi,A., Gal,P., Hou,Z., Tarca,A.L.,
            Kim,C.J., Kim,J.S., Haidarian,S., Uddin,M., Bohn,H., Benirschke,K.,
            Santolaya-Forgas,J., Grossman,L.I., Erez,O., Hassan,S.S.,
            Zavodszky,P., Papp,Z. and Wildman,D.E.
  TITLE     A primate subfamily of galectins expressed at the maternal-fetal
            interface that promote immune cell death
  JOURNAL   Proc Natl Acad Sci U S A 106 (24), 9731-9736 (2009)
   PUBMED   19497882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FJ613352.1 and BX095861.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001190441.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD386476.1, FJ613352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392051.4/ ENSP00000375904.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               FJ613352.1         20-497
            479-605             BX095861.1         457-583
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..605
                     /gene="LGALS16"
                     /note="galectin 16"
                     /db_xref="GeneID:148003"
                     /db_xref="HGNC:HGNC:40039"
     exon            1..64
                     /gene="LGALS16"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..478
                     /gene="LGALS16"
                     /EC_number="3.1.1.5"
                     /note="beta-galactoside-binding lectin; lectin,
                     galactoside-binding, soluble, 16"
                     /codon_start=1
                     /product="galectin-16"
                     /protein_id="NP_001177370.2"
                     /db_xref="CCDS:CCDS54267.1"
                     /db_xref="GeneID:148003"
                     /db_xref="HGNC:HGNC:40039"
                     /translation="MSFLTVPYKLPVSLSVGSCVIIKGTLIDSSINEPQLQVDFYTEM
                     NEDSEIAFHLRVHLGRRVVMNSREFGIWMLEENLHYVPFEDGKPFDLRIYVCHNEYEV
                     KVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSVLVNNGRR"
     exon            65..141
                     /gene="LGALS16"
                     /inference="alignment:Splign:2.1.0"
     exon            142..352
                     /gene="LGALS16"
                     /inference="alignment:Splign:2.1.0"
     exon            353..605
                     /gene="LGALS16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      584..589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS16"
                     /note="hexamer: ATTAAA"
     polyA_site      605
                     /gene="LGALS16"
                     /note="major polyA site"
ORIGIN      
        1 actcagaaga ctggacacaa ttccgaaggt cgcccagaag gagaggacaa tgtcatttct
       61 aactgtgcca tacaaactgc ctgtgtcttt gtctgttggt tcctgcgtga taatcaaagg
      121 gacactgatc gactcttcta tcaacgaacc acagctgcag gtggatttct acactgagat
      181 gaatgaggac tcagaaattg ccttccattt gcgagtgcac ttaggccgtc gtgtggtcat
      241 gaacagtcgt gagtttggga tatggatgtt ggaggagaat ttacactatg tgccctttga
      301 ggatggcaaa ccatttgact tgcgcatcta cgtgtgtcac aatgagtatg aggtaaaggt
      361 aaatggtgaa tacatttatg cctttgtcca tcgaatcccg ccatcatatg tgaagatgat
      421 tcaagtgtgg agagatgtct ccctggactc agtgcttgtc aacaatggac ggagatgatc
      481 acactcctca ttgttgagga aaccctcttt ctacctgacc atgggattcc tagagcctgc
      541 taacagaata atccctcctc aaccccttcc cctacacttg gtcattaaaa cagcaccaaa
      601 ccgta
//
