LOCUS       NM_020129                599 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens galectin 14 (LGALS14), transcript variant 1, mRNA.
ACCESSION   NM_020129
VERSION     NM_020129.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Si,Y., Li,Y., Yang,T., Li,X., Ayala,G.J., Mayo,K.H., Tai,G., Su,J.
            and Zhou,Y.
  TITLE     Structure-function studies of galectin-14, an important effector
            molecule in embryology
  JOURNAL   FEBS J 288 (3), 1041-1055 (2021)
   PUBMED   32525264
  REMARK    GeneRIF: Structure-function studies of galectin-14, an important
            effector molecule in embryology.
REFERENCE   2  (bases 1 to 599)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 599)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 599)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 599)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 599)
  AUTHORS   Than,N.G., Romero,R., Goodman,M., Weckle,A., Xing,J., Dong,Z.,
            Xu,Y., Tarquini,F., Szilagyi,A., Gal,P., Hou,Z., Tarca,A.L.,
            Kim,C.J., Kim,J.S., Haidarian,S., Uddin,M., Bohn,H., Benirschke,K.,
            Santolaya-Forgas,J., Grossman,L.I., Erez,O., Hassan,S.S.,
            Zavodszky,P., Papp,Z. and Wildman,D.E.
  TITLE     A primate subfamily of galectins expressed at the maternal-fetal
            interface that promote immune cell death
  JOURNAL   Proc Natl Acad Sci U S A 106 (24), 9731-9736 (2009)
   PUBMED   19497882
REFERENCE   7  (bases 1 to 599)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 599)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 599)
  AUTHORS   Yang,X.Y., Lai,X.G., Zhang,Y., Pei,J.M., Yang,A.G. and Zhou,S.S.
  TITLE     [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of
            human U-87 glioma cells]
  JOURNAL   Ai Zheng 25 (7), 805-810 (2006)
   PUBMED   16831268
  REMARK    GeneRIF: CIC-2 siRNA could inhibit the cell proliferation of a
            human glioma cell line U-87.
REFERENCE   10 (bases 1 to 599)
  AUTHORS   Yang,Q.S., Ying,K., Yuan,H.L., Chen,J.Z., Meng,X.F., Wang,Z.,
            Xie,Y. and Mao,Y.M.
  TITLE     Cloning and expression of a novel human galectin cDNA,
            predominantly expressed in placenta(1)
  JOURNAL   Biochim Biophys Acta 1574 (3), 407-411 (2002)
   PUBMED   11997112
  REMARK    GeneRIF: cloning and expression in placenta - base sequence and
            amino acid sequences are given
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF267852.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020129.2.
            
            Summary: This gene is predominantly expressed in placenta. The
            encoded protein belongs to the galectin (galaptin/S-lectin) family.
            The members of galectin family contain one or two carbohydrate
            recognition domains, which can bind beta-galactoside. Two
            alternatively spliced transcript variants encoding distinct
            isoforms have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) appears to be the major
            transcript. It lacks an exon compared to variant 2. The resulting
            isoform (1) has a distinct and shorter N-terminus, as compared to
            isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022257.1, AF267852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392052.8/ ENSP00000375905.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-599               AF267852.1         176-774
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..599
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /note="galectin 14"
                     /db_xref="GeneID:56891"
                     /db_xref="HGNC:HGNC:30054"
                     /db_xref="MIM:607260"
     exon            1..63
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..468
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     placental protein 13-like protein; Charcot-Leyden crystal
                     protein 2; gal-14; lectin, galactoside-binding, soluble,
                     14"
                     /codon_start=1
                     /product="placental protein 13-like isoform 1"
                     /protein_id="NP_064514.1"
                     /db_xref="CCDS:CCDS46073.1"
                     /db_xref="GeneID:56891"
                     /db_xref="HGNC:HGNC:30054"
                     /db_xref="MIM:607260"
                     /translation="MSSLPVPYTLPVSLPVGSCVIITGTPILTFVKDPQLEVNFYTGM
                     DEDSDIAFQFRLHFGHPAIMNSCVFGIWRYEEKCYYLPFEDGKPFELCIYVRHKEYKV
                     MVNGQRIYNFAHRFPPASVKMLQVFRDISLTRVLISD"
     exon            64..140
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /inference="alignment:Splign:2.1.0"
     exon            141..351
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /inference="alignment:Splign:2.1.0"
     exon            352..599
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      582..587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /note="hexamer: ATTAAA"
     polyA_site      599
                     /gene="LGALS14"
                     /gene_synonym="CLC2; PPL13"
                     /note="major polyA site"
ORIGIN      
        1 acagaagact ggacacaatt ccgaagagct gcccagaagg agagaacaat gtcatcacta
       61 cccgtaccat acacactgcc tgtttccttg cctgttggtt cgtgcgtgat aatcacaggg
      121 acaccgatcc tcacttttgt caaggaccca cagctggagg tgaatttcta cactgggatg
      181 gatgaggact cagatattgc tttccaattc cgactgcact ttggtcatcc tgcaatcatg
      241 aacagttgtg tgtttggcat atggagatat gaggagaaat gctactattt accctttgaa
      301 gatggcaaac catttgagct gtgcatctat gtgcgtcaca aggaatacaa ggtaatggta
      361 aatggccaac gcatttacaa ctttgcccat cgattcccgc cagcatctgt gaagatgctg
      421 caagtcttca gagatatctc cctgaccaga gtgcttatca gcgattgagg gagatgatca
      481 gactcctcat tgttgaggaa tccctctttc tacctgacca tgggattccc agagcctact
      541 aacagaataa tccctcctca ccccttcccc tacacttgat cattaaaaca gcaccaaac
//
