LOCUS       NM_013268                600 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens galectin 13 (LGALS13), mRNA.
ACCESSION   NM_013268
VERSION     NM_013268.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 600)
  AUTHORS   Lestari,P.M., Wibowo,N., Prasmusinto,D., Yamin,M., Siregar,N.C.,
            Prihartono,J., Timan,I.S., Mose,J.C., Liberty,I.A., Kesty,C. and
            Stevanny,B.
  TITLE     Placental Protein 13 and Syncytiotrophoblast Basement Membrane
            Ultrastructures in Preeclampsia
  JOURNAL   Medicina (Kaunas) 60 (7), 1077 (2024)
   PUBMED   39064506
  REMARK    GeneRIF: Placental Protein 13 and Syncytiotrophoblast Basement
            Membrane Ultrastructures in Preeclampsia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 600)
  AUTHORS   Fu,J.H., Huo,J., Han,Y.M. and Chen,C.J.
  TITLE     [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse
            pregnancy outcomes of gestational diabetes mellitus]
  JOURNAL   Zhonghua Yu Fang Yi Xue Za Zhi 57 (12), 2140-2146 (2023)
   PUBMED   38186168
  REMARK    GeneRIF: [Predictive value of serum Gal-13, GLP-1 and VEGF levels
            in adverse pregnancy outcomes of gestational diabetes mellitus].
REFERENCE   3  (bases 1 to 600)
  AUTHORS   Bhati,T., Ray,A., Arora,R., Siraj,F., Parvez,S. and Rastogi,S.
  TITLE     Intronic variants of LGALS13 gene encoding placental protein (PP13)
            are linked with increased risk of infection-associated spontaneous
            preterm birth
  JOURNAL   Am J Reprod Immunol 90 (3), e13759 (2023)
   PUBMED   37641375
  REMARK    GeneRIF: Intronic variants of LGALS13 gene encoding placental
            protein (PP13) are linked with increased risk of
            infection-associated spontaneous preterm birth.
REFERENCE   4  (bases 1 to 600)
  AUTHORS   Kazatsker,M.M., Sharabi-Nov,A., Meiri,H., Sammour,R. and Sammar,M.
  TITLE     Augmented Placental Protein 13 in Placental-Associated
            Extracellular Vesicles in Term and Preterm Preeclampsia Is Further
            Elevated by Corticosteroids
  JOURNAL   Int J Mol Sci 24 (15), 12051 (2023)
   PUBMED   37569423
  REMARK    GeneRIF: Augmented Placental Protein 13 in Placental-Associated
            Extracellular Vesicles in Term and Preterm Preeclampsia Is Further
            Elevated by Corticosteroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 600)
  AUTHORS   Piskun,A., Dmytro,K., Honcharenko,O., Rud,V. and Klimas,L.
  TITLE     PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE
            PREECLAMPSIA
  JOURNAL   Wiad Lek 75 (12), 3041-3045 (2022)
   PUBMED   36723324
  REMARK    GeneRIF: PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY
            AND LATE PREECLAMPSIA.
REFERENCE   6  (bases 1 to 600)
  AUTHORS   Visegrady,B., Than,N.G., Kilar,F., Sumegi,B., Than,G.N. and Bohn,H.
  TITLE     Homology modelling and molecular dynamics studies of human
            placental tissue protein 13 (galectin-13)
  JOURNAL   Protein Eng 14 (11), 875-880 (2001)
   PUBMED   11742106
  REMARK    GeneRIF: The primary structure of the newly sequence analysed
            placental tissue protein 13 (PP13) was highly homologous to several
            members of the beta-galactoside-binding S-type lectin (galectin)
            family
REFERENCE   7  (bases 1 to 600)
  AUTHORS   Than,N.G., Sumegi,B., Than,G.N., Berente,Z. and Bohn,H.
  TITLE     Isolation and sequence analysis of a cDNA encoding human placental
            tissue protein 13 (PP13), a new lysophospholipase, homologue of
            human eosinophil Charcot-Leyden Crystal protein
  JOURNAL   Placenta 20 (8), 703-710 (1999)
   PUBMED   10527825
REFERENCE   8  (bases 1 to 600)
  AUTHORS   Uhlmann,J., Wiemann,S. and Ponstingl,H.
  TITLE     DelGEF, an RCC1-related protein encoded by a gene on chromosome
            11p14 critical for two forms of hereditary deafness
  JOURNAL   FEBS Lett 460 (1), 153-160 (1999)
   PUBMED   10571079
REFERENCE   9  (bases 1 to 600)
  AUTHORS   Wang,A. and Dennis,E.A.
  TITLE     Mammalian lysophospholipases
  JOURNAL   Biochim Biophys Acta 1439 (1), 1-16 (1999)
   PUBMED   10395961
  REMARK    Review article
REFERENCE   10 (bases 1 to 600)
  AUTHORS   Bohn,H., Kraus,W. and Winckler,W.
  TITLE     Purification and characterization of two new soluble placental
            tissue proteins (PP13 and PP17)
  JOURNAL   Oncodev Biol Med 4 (5), 343-350 (1983)
   PUBMED   6856484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005205.1.
            
            On Nov 26, 2018 this sequence version replaced NM_013268.2.
            
            Summary: Lysophospholipases are enzymes that act on biological
            membranes to regulate the multifunctional lysophospholipids. The
            protein encoded by this gene has lysophospholipase activity. It is
            composed of two identical subunits which are held together by
            disulfide bonds. This protein has structural similarity to several
            members of the beta-galactoside-binding S-type lectin family.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066304.1, CB995660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221797.5/ ENSP00000221797.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC005205.1         14481-14540
            61-137              AC005205.1         16559-16635
            138-348             AC005205.1         17135-17345
            349-600             AC005205.1         19180-19431
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..600
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /note="galectin 13"
                     /db_xref="GeneID:29124"
                     /db_xref="HGNC:HGNC:15449"
                     /db_xref="MIM:608717"
     exon            1..60
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..465
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /EC_number="3.1.1.5"
                     /note="placental protein 13; beta-galactoside-binding
                     lectin; gal-13; placental tissue protein 13; lectin,
                     galactoside-binding, soluble, 13"
                     /codon_start=1
                     /product="galactoside-binding soluble lectin 13"
                     /protein_id="NP_037400.1"
                     /db_xref="CCDS:CCDS33024.1"
                     /db_xref="GeneID:29124"
                     /db_xref="HGNC:HGNC:15449"
                     /db_xref="MIM:608717"
                     /translation="MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDM
                     DEDSDIAFRFRVHFGNHVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEI
                     KVNGIRIYGFVHRIPPSFVKMVQVSRDISLTSVCVCN"
     exon            61..137
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /inference="alignment:Splign:2.1.0"
     exon            138..348
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /inference="alignment:Splign:2.1.0"
     exon            349..600
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      579..584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /note="hexamer: ATTAAA"
     polyA_site      600
                     /gene="LGALS13"
                     /gene_synonym="GAL13; PLAC8; PP13"
                     /note="major polyA site"
ORIGIN      
        1 agaagactgg actcaattct gaaggtcgcc aagaaggaga gaacaatgtc ttctttaccc
       61 gtgccataca aactgcctgt gtctttgtct gttggttcct gcgtgataat caaagggaca
      121 ccaatccact cttttatcaa tgacccacag ctgcaggtgg atttctacac tgacatggat
      181 gaggattcag atattgcctt ccgtttccga gtgcactttg gcaatcatgt ggtcatgaac
      241 aggcgtgagt ttgggatatg gatgttggag gagacaacag actacgtgcc ctttgaggat
      301 ggcaaacaat ttgagctgtg catctacgta cattacaatg agtatgagat aaaggtcaat
      361 ggcatacgca tttacggctt tgtccatcga atcccgccat catttgtgaa gatggtgcaa
      421 gtgtcgagag atatctccct gacctcagtg tgtgtctgca attgagggag atgatcacac
      481 tcctcattgt tgaggaatcc ctctttctac ctgaccatgg gattcccaga acctgctaac
      541 agaataatcc ctgctcacat tttcccctac actttgtcat taaaacagca cgaaaactca
//
