LOCUS       NM_033101               1699 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens galectin 12 (LGALS12), transcript variant 2, mRNA.
ACCESSION   NM_033101
VERSION     NM_033101.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Tazhitdinova,R., Cristiano,S., Yi,J., Zhurov,V., DeKoter,R.P. and
            Timoshenko,A.V.
  TITLE     Expression and secretion of galectin-12 in the context of
            neutrophilic differentiation of human promyeloblastic HL-60 cells
  JOURNAL   J Cell Physiol 239 (6), e31288 (2024)
   PUBMED   38685860
  REMARK    GeneRIF: Expression and secretion of galectin-12 in the context of
            neutrophilic differentiation of human promyeloblastic HL-60 cells.
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Buschmann,C., Unverdorben,L., Knabl,J., Hutter,S., Meister,S.,
            Beyer,S., Burgmann,M., Zati Zehni,A., Schmoeckel,E., Kessler,M.,
            Jeschke,U., Eggersmann,T.K., Mahner,S., Kolben,T. and Ganster,F.
  TITLE     Placental expression of inflammatory Galectin-12 is associated with
            gestational diabetes
  JOURNAL   J Reprod Immunol 163, 104240 (2024)
   PUBMED   38492532
  REMARK    GeneRIF: Placental expression of inflammatory Galectin-12 is
            associated with gestational diabetes.
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Galdino,L.V., Albuquerque,A.P.B., Lira,M.M.M., de Lima,L.R.A.,
            Pitta,M.G.D.R. and Rego,M.J.B.M.
  TITLE     Galectin-12 in Pancreatic Cancer: A New Player in the
            Microenvironment?
  JOURNAL   Pancreas 50 (9), e78-e79 (2021)
   PUBMED   34860822
  REMARK    GeneRIF: Galectin-12 in Pancreatic Cancer: A New Player in the
            Microenvironment?
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Lin,E.S., Hsu,Y.A., Chang,C.Y., Lin,H.J., Chen,C.S. and Wan,L.
  TITLE     Ablation of Galectin-12 Inhibits Atherosclerosis through
            Enhancement of M2 Macrophage Polarization
  JOURNAL   Int J Mol Sci 21 (15), 5511 (2020)
   PUBMED   32752134
  REMARK    GeneRIF: Ablation of Galectin-12 Inhibits Atherosclerosis through
            Enhancement of M2 Macrophage Polarization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Katzenmaier,E.M., Fuchs,V., Warnken,U., Schnolzer,M., Gebert,J. and
            Kopitz,J.
  TITLE     Deciphering the galectin-12 protein interactome reveals a major
            impact of galectin-12 on glutamine anaplerosis in colon cancer
            cells
  JOURNAL   Exp Cell Res 379 (2), 129-139 (2019)
   PUBMED   30935948
  REMARK    GeneRIF: that binding of galectin-12 to SLC1A5 significantly
            reduced glutamine uptake
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Xue,H., Yang,R.Y., Tai,G. and Liu,F.T.
  TITLE     Galectin-12 inhibits granulocytic differentiation of human NB4
            promyelocytic leukemia cells while promoting lipogenesis
  JOURNAL   J Leukoc Biol 100 (4), 657-664 (2016)
   PUBMED   27256573
  REMARK    GeneRIF: Overexpression of galectin-12 contributes to a
            differentiation block in acute promyelocytic leukemia cells, and
            suppression of galectin-12 facilitates granulocytic
            differentiation.
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   El Leithy,A.A., Helwa,R., Assem,M.M. and Hassan,N.H.
  TITLE     Expression profiling of cancer-related galectins in acute myeloid
            leukemia
  JOURNAL   Tumour Biol 36 (10), 7929-7939 (2015)
   PUBMED   25953264
  REMARK    GeneRIF: Lower LGALS12 gene expression is associated with acute
            myeloid leukemia.
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Yang,R.Y., Hsu,D.K., Yu,L., Chen,H.Y. and Liu,F.T.
  TITLE     Galectin-12 is required for adipogenic signaling and adipocyte
            differentiation
  JOURNAL   J Biol Chem 279 (28), 29761-29766 (2004)
   PUBMED   15131127
  REMARK    GeneRIF: results suggest that mouse galectin-12 is a major
            regulator of adipose tissue development
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Hotta,K., Funahashi,T., Matsukawa,Y., Takahashi,M., Nishizawa,H.,
            Kishida,K., Matsuda,M., Kuriyama,H., Kihara,S., Nakamura,T.,
            Tochino,Y., Bodkin,N.L., Hansen,B.C. and Matsuzawa,Y.
  TITLE     Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing
            Apoptosis-inducing Activity
  JOURNAL   J Biol Chem 276 (36), 34089-34097 (2001)
   PUBMED   11435439
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Yang,R.Y., Hsu,D.K., Yu,L., Ni,J. and Liu,F.T.
  TITLE     Cell cycle regulation by galectin-12, a new member of the galectin
            superfamily
  JOURNAL   J Biol Chem 276 (23), 20252-20260 (2001)
   PUBMED   11283015
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001591.5.
            
            On May 23, 2019 this sequence version replaced NM_033101.3.
            
            Summary: This gene encodes a member of the galectin superfamily, a
            group of beta-galactoside-binding proteins with conserved
            carbohydrate recognition domains. The related mouse protein is a
            primary regulator of the early stages of adipose tissue
            development. Alternatively spliced transcript variants encoding
            different isoforms have been described. [provided by RefSeq, May
            2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF244974.1, BC028222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000394618.9/
                                                ENSP00000378116.4
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AP001591.5         28175-28618
            445-533             AP001591.5         30644-30732
            534-747             AP001591.5         30869-31082
            748-867             AP001591.5         31869-31988
            868-906             AP001591.5         32554-32592
            907-933             AP001591.5         33170-33196
            934-1022            AP001591.5         33843-33931
            1023-1173           AP001591.5         37654-37804
            1174-1699           AP001591.5         38338-38863
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1699
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /note="galectin 12"
                     /db_xref="GeneID:85329"
                     /db_xref="HGNC:HGNC:15788"
                     /db_xref="MIM:606096"
     exon            1..444
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1320
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     galectin-related inhibitor of proliferation; testicular
                     secretory protein Li 26; lectin, galactoside-binding,
                     soluble, 12"
                     /codon_start=1
                     /product="galectin-12 isoform 2"
                     /protein_id="NP_149092.3"
                     /db_xref="CCDS:CCDS8045.2"
                     /db_xref="GeneID:85329"
                     /db_xref="HGNC:HGNC:15788"
                     /db_xref="MIM:606096"
                     /translation="MSPGEKLDPIPDSFILQPPVFHPVVPYVTTIFGGLHAGKMVMLQ
                     GVVPLDAHRFQVDFQCGCSLCPRPDIAFHFNPRFHTTKPHVICNTLHGGRWQREARWP
                     HLALRRGSSFLILFLFGNEEVKVSVNGQHFLHFRYRLPLSHVDTLGIFGDILVEAVGF
                     LNINPFVEGSREYPAGHPFLLMSPRLEVPCSHALPQGLSPGQVIIVRGLVLQEPKHFT
                     VSLRDQAAHAPVTLRASFADRTLAWISRWGQKKLISAPFLFYPQRFFEVLLLFQEGGL
                     KLALNGQGLGATSMNQQALEQLRELRISGSVQLYCVHS"
     exon            445..533
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..747
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..867
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..906
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..933
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1022
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1173
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1699
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /note="hexamer: AATACA"
     polyA_site      1636
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /note="major polyA site"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /note="hexamer: AATAAA"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1694
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
     polyA_site      1699
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
ORIGIN      
        1 acaaaccctc gttggcccca caggagccag cctctggctt ctctctgcaa tggccatgtg
       61 ctgcagaccc ggagtgggta gttagttggt taatgccagt cttcctcccc tggacactga
      121 gttctgctga cagcccccgc ccagccagag ctctgctgta taccaccggg agtggggctg
      181 gtgtggagcc tggaggtcgc ccgctgccct cctagggctg ctccagacag cattaaaacg
      241 ctgcaggtcg caggtgagac taacagctgg gagagctgct ccaggcattt aggaccctga
      301 ctggggcaga tgagtcagcc cagtgggggc agggctcctg gaacgaggat ctacagttgg
      361 agttgcccca ctgtcatgtc acctggagaa aaactggacc caattcctga cagcttcatt
      421 ctgcaaccac cagtcttcca cccggtggtt ccttatgtca cgacgatttt tggaggcctg
      481 catgcaggca agatggtcat gctgcaagga gtggtccctc tagatgcaca caggtttcag
      541 gtggacttcc agtgtggctg cagcctgtgt ccccggccag atatcgcctt ccacttcaac
      601 cctcgcttcc ataccaccaa gccccatgtc atctgcaaca ccctgcatgg tggacgctgg
      661 caaagggagg cccggtggcc ccacctggcc ctgcgaagag gctccagctt cctcatcctc
      721 tttctcttcg ggaatgagga agtgaaggtg agtgtgaatg gacagcactt tctccacttc
      781 cgctaccggc tcccactgtc tcatgtggac acgctgggta tatttggtga catcctggta
      841 gaggctgttg gattcctgaa catcaatcca tttgtggagg gcagcagaga gtacccagct
      901 ggacatcctt tcctgctgat gagccccagg ctggaggtgc cctgctcaca tgctcttccc
      961 cagggtctct cgcctgggca ggtcatcata gtacggggac tggtcttgca agagccgaag
     1021 cattttactg tgagcctgag ggaccaggct gcccatgctc ctgtgacact cagggcctcc
     1081 ttcgcagaca gaactctggc ctggatctcc cgctgggggc agaagaaact gatctcagcc
     1141 cccttcctct tttaccccca gagattcttt gaggtgctgc tcctgttcca ggagggaggg
     1201 ctgaagctgg cgctcaatgg gcaggggctg ggggccacca gcatgaacca gcaggccctg
     1261 gagcagctgc gggagctccg gatcagtgga agtgtccagc tctactgtgt ccactcctga
     1321 ggatggttcc agggaaatac cgccagaaaa caagaaggtc agcccactcc cagggcccca
     1381 ctctcctccc ctcattaaac catccacctg acaccagcac atcaggcctg gttcacctct
     1441 ggggtcacga gactgagtct acaggagctt tgggcctgag ggaaggcaca agagtgcaaa
     1501 ggttcctcga actctgcacc ttcctccacc aggagcctgg gatatggctc catctgcctt
     1561 cagggcctgg actgcactca cagaggcaag tgttgtagac taacaaagat actccaaaat
     1621 acaatggctt aaagaatgtg gtcatttatt ctttattatt tatttatttg tggtcaaata
     1681 aataaataag gttatttat
//
