LOCUS       NM_002305                528 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens galectin 1 (LGALS1), mRNA.
ACCESSION   NM_002305
VERSION     NM_002305.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Zhang,L., Chen,W., Li,X., Wang,G., Xing,F. and Zhu,X.
  TITLE     Galectin-1 overexpression induces normal fibroblasts translate into
            cancer-associated fibroblasts and attenuates the sensitivity of
            anlotinib in lung cancer
  JOURNAL   Cell Adh Migr 18 (1), 1-11 (2024)
   PUBMED   38557441
  REMARK    GeneRIF: Galectin-1 overexpression induces normal fibroblasts
            translate into cancer-associated fibroblasts and attenuates the
            sensitivity of anlotinib in lung cancer.
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Qin,H., Peng,M., Cheng,J., Wang,Z., Cui,Y., Huang,Y., Gui,Y.,
            Sun,Y., Xiang,W., Huang,X., Huang,T., Wang,L., Chen,J. and Hou,Y.
  TITLE     A novel LGALS1-depended and immune-associated fatty acid metabolism
            risk model in acute myeloid leukemia stem cells
  JOURNAL   Cell Death Dis 15 (7), 482 (2024)
   PUBMED   38965225
  REMARK    GeneRIF: A novel LGALS1-depended and immune-associated fatty acid
            metabolism risk model in acute myeloid leukemia stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 528)
  AUTHORS   Pan,Z., Xu,G., Zhang,Y., Wu,M., Yu,J., He,X., Zhang,W. and Hu,J.
  TITLE     Galectin-1 Promotes Gastric Carcinoma Progression and Cisplatin
            Resistance Through the NRP-1/c-JUN/Wee1 Pathway
  JOURNAL   J Gastric Cancer 24 (3), 300-315 (2024)
   PUBMED   38960889
  REMARK    GeneRIF: Galectin-1 Promotes Gastric Carcinoma Progression and
            Cisplatin Resistance Through the NRP-1/c-JUN/Wee1 Pathway.
REFERENCE   4  (bases 1 to 528)
  AUTHORS   Arvidsson,D., Rodrigues Silva,V.R., Ekblom,O., Ekblom-Bak,E.,
            Fryk,E., Jansson,P.A. and Borjesson,M.
  TITLE     Cardiorespiratory fitness and the association with galectin-1 in
            middle-aged individuals
  JOURNAL   PLoS One 19 (4), e0301412 (2024)
   PUBMED   38578722
  REMARK    GeneRIF: Cardiorespiratory fitness and the association with
            galectin-1 in middle-aged individuals.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 528)
  AUTHORS   Jover,E., Martin-Nunez,E., Garaikoetxea,M., Matilla,L.,
            Blanco-Colio,L.M., Perez-Saez,J.M., Navarro,A., Fernandez-Celis,A.,
            Gainza,A., Alvarez,V., Sadaba,R., Tamayo,I., Rabinovich,G.A.,
            Martin-Ventura,J.L. and Lopez-Andres,N.
  TITLE     Sex-dependent expression of galectin-1, a cardioprotective
            beta-galactoside-binding lectin, in human calcific aortic stenosis
  JOURNAL   FASEB J 38 (3), e23447 (2024)
   PUBMED   38329326
  REMARK    GeneRIF: Sex-dependent expression of galectin-1, a cardioprotective
            beta-galactoside-binding lectin, in human calcific aortic stenosis.
REFERENCE   6  (bases 1 to 528)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 528)
  AUTHORS   Goldstone,S.D. and Lavin,M.F.
  TITLE     Isolation of a cDNA clone, encoding a human beta-galactoside
            binding protein, overexpressed during glucocorticoid-induced cell
            death
  JOURNAL   Biochem Biophys Res Commun 178 (2), 746-750 (1991)
   PUBMED   1713454
REFERENCE   8  (bases 1 to 528)
  AUTHORS   Gitt,M.A. and Barondes,S.H.
  TITLE     Genomic sequence and organization of two members of a human lectin
            gene family
  JOURNAL   Biochemistry 30 (1), 82-89 (1991)
   PUBMED   1988031
REFERENCE   9  (bases 1 to 528)
  AUTHORS   Allen,H.J., Sucato,D., Gottstine,S., Kisailus,E., Nava,H.,
            Petrelli,N., Castillo,N. and Wilson,D.
  TITLE     Localization of endogenous beta-galactoside-binding lectin in human
            cells and tissues
  JOURNAL   Tumour Biol 12 (1), 52-60 (1991)
   PUBMED   1996404
REFERENCE   10 (bases 1 to 528)
  AUTHORS   Sharma,A., Chemelli,R. and Allen,H.J.
  TITLE     Human splenic galaptin: physicochemical characterization
  JOURNAL   Biochemistry 29 (22), 5309-5314 (1990)
   PUBMED   2383549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020675.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002305.3.
            
            Summary: The galectins are a family of beta-galactoside-binding
            proteins implicated in modulating cell-cell and cell-matrix
            interactions. This gene product may act as an autocrine negative
            growth factor that regulates cell proliferation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020675.1, GQ891519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215909.10/ ENSP00000215909.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               BC020675.1         1-528
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..528
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /note="galectin 1"
                     /db_xref="GeneID:3956"
                     /db_xref="HGNC:HGNC:6561"
                     /db_xref="MIM:150570"
     exon            1..76
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..475
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /note="beta-galactoside-binding lectin L-14-I;
                     lactose-binding lectin 1; galaptin; S-Lac lectin 1; HBL;
                     HPL; gal-1; HLBP14; 14 kDa lectin; 14 kDa laminin-binding
                     protein; putative MAPK-activating protein PM12;
                     beta-galactoside-binding protein 14kDa; lectin,
                     galactoside-binding, soluble, 1; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="galectin-1"
                     /protein_id="NP_002296.1"
                     /db_xref="CCDS:CCDS13954.1"
                     /db_xref="GeneID:3956"
                     /db_xref="HGNC:HGNC:6561"
                     /db_xref="MIM:150570"
                     /translation="MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCL
                     HFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLP
                     DGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD"
     exon            77..156
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            157..328
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /inference="alignment:Splign:2.1.0"
     exon            329..528
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      498..503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /note="hexamer: AATAAA"
     polyA_site      528
                     /gene="LGALS1"
                     /gene_synonym="GAL1; GBP"
                     /note="major polyA site"
ORIGIN      
        1 atctctctcg ggtggagtct tctgacagct ggtgcgcctg cccgggaaca tcctcctgga
       61 ctcaatcatg gcttgtggtc tggtcgccag caacctgaat ctcaaacctg gagagtgcct
      121 tcgagtgcga ggcgaggtgg ctcctgacgc taagagcttc gtgctgaacc tgggcaaaga
      181 cagcaacaac ctgtgcctgc acttcaaccc tcgcttcaac gcccacggcg acgccaacac
      241 catcgtgtgc aacagcaagg acggcggggc ctgggggacc gagcagcggg aggctgtctt
      301 tcccttccag cctggaagtg ttgcagaggt gtgcatcacc ttcgaccagg ccaacctgac
      361 cgtcaagctg ccagatggat acgaattcaa gttccccaac cgcctcaacc tggaggccat
      421 caactacatg gcagctgacg gtgacttcaa gatcaaatgt gtggcctttg actgaaatca
      481 gccagcccat ggcccccaat aaaggcagct gcctctgctc cctctgaa
//
