LOCUS       NM_015416               2106 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LETM1 domain containing 1 (LETMD1), transcript variant
            1, mRNA.
ACCESSION   NM_015416
VERSION     NM_015416.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   2  (bases 1 to 2106)
  AUTHORS   Wen,N., Zhang,J. and Zhang,Q.
  TITLE     MiR-494 Inhibits the Proliferation, Migration and Invasion of
            Cervical Cancer Cells by Regulating LETMD1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 81-87 (2022)
   PUBMED   35818268
  REMARK    GeneRIF: MiR-494 Inhibits the Proliferation, Migration and Invasion
            of Cervical Cancer Cells by Regulating LETMD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2106)
  AUTHORS   Zheng,Z., Yang,X., Yu,Q., Li,L. and Qiao,L.
  TITLE     The regulating role of miR-494 on HCCR1 in cervical cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 131-137 (2022)
   PUBMED   35818261
  REMARK    GeneRIF: The regulating role of miR-494 on HCCR1 in cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2106)
  AUTHORS   Choi,K.M., Kim,J.H., Kong,X., Isik,M., Zhang,J., Lim,H.W. and
            Yoon,J.C.
  TITLE     Defective brown adipose tissue thermogenesis and impaired glucose
            metabolism in mice lacking Letmd1
  JOURNAL   Cell Rep 37 (11), 110104 (2021)
   PUBMED   34910916
REFERENCE   5  (bases 1 to 2106)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2106)
  AUTHORS   Shin,S.M., Chung,Y.J., Oh,S.T., Jeon,H.M., Hwang,L.J., Namkoong,H.,
            Kim,H.K., Cho,G.W., Hur,S.Y., Kim,T.E., Lee,Y.S., Park,Y.G., Ko,J.
            and Kim,J.W.
  TITLE     HCCR-1-interacting molecule 'deleted in polyposis 1' plays a
            tumor-suppressor role in colon carcinogenesis
  JOURNAL   Gastroenterology 130 (7), 2074-2086 (2006)
   PUBMED   16762630
REFERENCE   7  (bases 1 to 2106)
  AUTHORS   Jung,S.S., Park,H.S., Lee,I.J., Namkoong,H., Shin,S.M., Cho,G.W.,
            Ha,S.A., Park,Y.G., Lee,Y.S., Ko,J. and Kim,J.W.
  TITLE     The HCCR oncoprotein as a biomarker for human breast cancer
  JOURNAL   Clin Cancer Res 11 (21), 7700-7708 (2005)
   PUBMED   16278390
  REMARK    GeneRIF: HCCR oncoprotein has a role in development of human breast
            cancer
REFERENCE   8  (bases 1 to 2106)
  AUTHORS   Ko,J., Shin,S.M., Oh,Y.M., Lee,Y.S., Ryoo,Z.Y., Lee,Y.H., Na,D.S.
            and Kim,J.W.
  TITLE     Transgenic mouse model for breast cancer: induction of breast
            cancer in novel oncogene HCCR-2 transgenic mice
  JOURNAL   Oncogene 23 (10), 1950-1953 (2004)
   PUBMED   14691448
  REMARK    GeneRIF: HCCR-2 represents an oncoprotein that is related to breast
            cancer development and regulation of the p53 tumor suppressor.
REFERENCE   9  (bases 1 to 2106)
  AUTHORS   Ko,J., Lee,Y.H., Hwang,S.Y., Lee,Y.S., Shin,S.M., Hwang,J.H.,
            Kim,J., Kim,Y.W., Jang,S.W., Ryoo,Z.Y., Kim,I.K., Namkoong,S.E. and
            Kim,J.W.
  TITLE     Identification and differential expression of novel human cervical
            cancer oncogene HCCR-2 in human cancers and its involvement in p53
            stabilization
  JOURNAL   Oncogene 22 (30), 4679-4689 (2003)
   PUBMED   12879013
  REMARK    GeneRIF: HCCR-2 probably represents a new oncogene that is related
            to tumorigenesis, functioning as a negative regulator of the p53
            tumor suppressor
REFERENCE   10 (bases 1 to 2106)
  AUTHORS   Qi,Z.Y., Li,Y., Ying,K., Wu,C.Q., Tang,R., Zhou,Z.X., Chen,Z.P.,
            Hui,G.Z. and Xie,Y.
  TITLE     Isolation of novel differentially expressed genes related to human
            glioma using cDNA microarray and characterizations of two novel
            full-length genes
  JOURNAL   J Neurooncol 56 (3), 197-208 (2002)
   PUBMED   12061725
  REMARK    GeneRIF: Human, similar to bacterial ribosomal protein L14 and
            yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087884.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_015416.4.
            
            Summary: This gene encodes a mitochondrial outer membrane protein.
            It has a potential role in tumorigenesis, which may result from
            negative regulation of the p53 tumor suppressor gene. Alternatively
            spliced transcript variants have been noted for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            protein-coding transcript, and encodes isoform a (also known as
            HCCR-1 or 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195651.2, AK000639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18045496; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000262055.9/
                                                  ENSP00000262055.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC087884.18        120991-121142       c
            153-304             AC087884.18        120284-120435       c
            305-420             AC087884.18        117262-117377       c
            421-503             AC087884.18        115609-115691       c
            504-690             AC087884.18        113448-113634       c
            691-792             AC087884.18        113224-113325       c
            793-945             AC087884.18        112967-113119       c
            946-1042            AC087884.18        111341-111437       c
            1043-2106           AC087884.18        109045-110108       c
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2106
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="LETM1 domain containing 1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
     exon            1..152
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1113
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="isoform a is encoded by transcript variant 1;
                     regulator of TP53; cervical cancer proto-oncogene 2
                     protein; cervical cancer 1 proto-oncogene protein p40;
                     human cervical cancer oncogene; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="LETM1 domain-containing protein 1 isoform a"
                     /protein_id="NP_056231.3"
                     /db_xref="CCDS:CCDS8806.1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
                     /translation="MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSK
                     LHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKK
                     ARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPPFANYLVFLLMYL
                     FPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLC
                     TKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRL
                     KTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGEDRCRTWLGEWLQISC
                     SLKEAELSLLLHNVVLLSTNYLGTRR"
     exon            153..304
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..420
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..503
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            504..690
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..792
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..945
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1042
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2106
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2072..2077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="hexamer: AGTAAA"
     polyA_site      2106
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctctc ccgcttctct cgctgtgaag atggcgctct ccagggtgtg ctgggctcgg
       61 tcggctgtgt ggggctcggc agtcacccct ggacattttg tcacccggag gctgcaactt
      121 ggtcgctctg gcctggcttg gggggcccct cggtcttcaa agcttcacct ttctccaaag
      181 gcagatgtga agaacttgat gtcttatgtg gtaaccaaga caaaagcgat taatgggaaa
      241 taccatcgtt tcttgggtcg tcatttcccc cgcttctatg tcctgtacac aatcttcatg
      301 aaaggattgc agatgttatg ggctgatgcc aaaaaggcta gaagaataaa gacaaatatg
      361 tggaagcaca atataaagtt tcatcaactt ccataccggg agatggagca tttgagacag
      421 ttccgccaag acgtcaccaa gtgtcttttc ctaggtatta tttccattcc accttttgcc
      481 aactacctgg tcttcttgct aatgtacctg tttcccaggc aactactgat caggcatttc
      541 tggaccccaa aacaacaaac tgatttctta gatatctatc atgctttccg gaagcagtcc
      601 cacccagaaa ttattagtta tttagaaaag gtcatccctc tcatttctga tgcaggactc
      661 cggtggcgtc tgacagatct gtgcaccaag atacagcgtg gtacccaccc agcaatacat
      721 gatatcttgg ctctgagaga gtgtttctct aaccatcctc tgggcatgaa ccaactccag
      781 gctttgcacg tgaaagcctt gagccgggcc atgcttctca catcttacct gcctcctccc
      841 ttgttgagac atcgtttgaa gactcataca actgtgattc accaactgga caaggctttg
      901 gcaaagctgg ggattggcca gctgactgct caggaagtaa aatcggcttg ttatctccgt
      961 ggcctgaatt ctacgcatat tggtgaagat aggtgtcgaa cttggctggg agaatggctg
     1021 cagatttcct gcagcctgaa agaagctgag ctgtctctct tgctgcacaa cgtggtcctg
     1081 ctctccacca actaccttgg gacaaggcgc tgaatgaacc atggagcgga tggcattgtc
     1141 ctgcagtcgt atagtatagc agtgcaggaa caaacagcac ttgccagcaa agtctgtgtg
     1201 tactgttaag tgtgtgggag gcagagagag gagcaggggc catgggcttc acagcatggc
     1261 acacatgtgg gaactgcaga cattcctctc acagctagaa ctgaaacaaa ccctcttgct
     1321 aggggtggtc cgtgtgaggt gtcatcctgt ccccctcata attactaata gctggaactg
     1381 gcagcagcct ctactgggct tttactgtga tgtgttcagt tcatgtccta ggaagtcagc
     1441 ttttgcccca ggtgggaatc cttatttggc ttaggactga tccacttcca tgttacttac
     1501 atctgtgggt ttttgttgtt gctgttagaa aatttgtggc tggtgaaaac agcactcctt
     1561 tggctggagc acatgtgtcc gtgcatgtac ttgggtgttt ccctccatcc tttctgatat
     1621 gaccaaaaat caagttgttt tgttttttgt caccttcact ggcatgggct aaccacttct
     1681 ttttcaaacc ctctgaacac ctttttctga tgggtaactt gcaggaatat tctattggaa
     1741 aagataacag gaagtacaag tgcttcttga ccccttcctc aatgtttcta gccttcactc
     1801 tccattgtct tttctgggct gtattacagc cctctgtgga tcttcaactc tgctgcctcc
     1861 actgtgatgc agcagtccaa ctgtaactga cagtggctgc cttctctggg ccatggatca
     1921 cacctgtaag gtactaatta ctgcccagcc tggggagatc aggagaggtc tgcatagtta
     1981 gtaagttggg tttagctttt gtgtgtgcat cagtgactta gagttctgta ataacttatt
     2041 gtaaatgcat gaagcactgt ttttaaaccc aagtaaagac tgcttgaaac ctgttgatgg
     2101 aaatga
//
