LOCUS       NM_001351337            2270 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LETM1 domain containing 1 (LETMD1), transcript variant
            28, mRNA.
ACCESSION   NM_001351337 XM_017019168
VERSION     NM_001351337.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2270)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   2  (bases 1 to 2270)
  AUTHORS   Wen,N., Zhang,J. and Zhang,Q.
  TITLE     MiR-494 Inhibits the Proliferation, Migration and Invasion of
            Cervical Cancer Cells by Regulating LETMD1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 81-87 (2022)
   PUBMED   35818268
  REMARK    GeneRIF: MiR-494 Inhibits the Proliferation, Migration and Invasion
            of Cervical Cancer Cells by Regulating LETMD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2270)
  AUTHORS   Zheng,Z., Yang,X., Yu,Q., Li,L. and Qiao,L.
  TITLE     The regulating role of miR-494 on HCCR1 in cervical cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 131-137 (2022)
   PUBMED   35818261
  REMARK    GeneRIF: The regulating role of miR-494 on HCCR1 in cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2270)
  AUTHORS   Choi,K.M., Kim,J.H., Kong,X., Isik,M., Zhang,J., Lim,H.W. and
            Yoon,J.C.
  TITLE     Defective brown adipose tissue thermogenesis and impaired glucose
            metabolism in mice lacking Letmd1
  JOURNAL   Cell Rep 37 (11), 110104 (2021)
   PUBMED   34910916
REFERENCE   5  (bases 1 to 2270)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2270)
  AUTHORS   Shin,S.M., Chung,Y.J., Oh,S.T., Jeon,H.M., Hwang,L.J., Namkoong,H.,
            Kim,H.K., Cho,G.W., Hur,S.Y., Kim,T.E., Lee,Y.S., Park,Y.G., Ko,J.
            and Kim,J.W.
  TITLE     HCCR-1-interacting molecule 'deleted in polyposis 1' plays a
            tumor-suppressor role in colon carcinogenesis
  JOURNAL   Gastroenterology 130 (7), 2074-2086 (2006)
   PUBMED   16762630
REFERENCE   7  (bases 1 to 2270)
  AUTHORS   Jung,S.S., Park,H.S., Lee,I.J., Namkoong,H., Shin,S.M., Cho,G.W.,
            Ha,S.A., Park,Y.G., Lee,Y.S., Ko,J. and Kim,J.W.
  TITLE     The HCCR oncoprotein as a biomarker for human breast cancer
  JOURNAL   Clin Cancer Res 11 (21), 7700-7708 (2005)
   PUBMED   16278390
  REMARK    GeneRIF: HCCR oncoprotein has a role in development of human breast
            cancer
REFERENCE   8  (bases 1 to 2270)
  AUTHORS   Ko,J., Shin,S.M., Oh,Y.M., Lee,Y.S., Ryoo,Z.Y., Lee,Y.H., Na,D.S.
            and Kim,J.W.
  TITLE     Transgenic mouse model for breast cancer: induction of breast
            cancer in novel oncogene HCCR-2 transgenic mice
  JOURNAL   Oncogene 23 (10), 1950-1953 (2004)
   PUBMED   14691448
  REMARK    GeneRIF: HCCR-2 represents an oncoprotein that is related to breast
            cancer development and regulation of the p53 tumor suppressor.
REFERENCE   9  (bases 1 to 2270)
  AUTHORS   Ko,J., Lee,Y.H., Hwang,S.Y., Lee,Y.S., Shin,S.M., Hwang,J.H.,
            Kim,J., Kim,Y.W., Jang,S.W., Ryoo,Z.Y., Kim,I.K., Namkoong,S.E. and
            Kim,J.W.
  TITLE     Identification and differential expression of novel human cervical
            cancer oncogene HCCR-2 in human cancers and its involvement in p53
            stabilization
  JOURNAL   Oncogene 22 (30), 4679-4689 (2003)
   PUBMED   12879013
  REMARK    GeneRIF: HCCR-2 probably represents a new oncogene that is related
            to tumorigenesis, functioning as a negative regulator of the p53
            tumor suppressor
REFERENCE   10 (bases 1 to 2270)
  AUTHORS   Qi,Z.Y., Li,Y., Ying,K., Wu,C.Q., Tang,R., Zhou,Z.X., Chen,Z.P.,
            Hui,G.Z. and Xie,Y.
  TITLE     Isolation of novel differentially expressed genes related to human
            glioma using cDNA microarray and characterizations of two novel
            full-length genes
  JOURNAL   J Neurooncol 56 (3), 197-208 (2002)
   PUBMED   12061725
  REMARK    GeneRIF: Human, similar to bacterial ribosomal protein L14 and
            yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087884.18 and KF455649.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001351337.1.
            
            Summary: This gene encodes a mitochondrial outer membrane protein.
            It has a potential role in tumorigenesis, which may result from
            negative regulation of the p53 tumor suppressor gene. Alternatively
            spliced transcript variants have been noted for this gene.
            [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.193074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18045496; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC087884.18        120991-121142       c
            153-304             AC087884.18        120284-120435       c
            305-420             AC087884.18        117262-117377       c
            421-573             AC087884.18        112967-113119       c
            574-762             AC087884.18        102019-102207       c
            763-1139            KF455649.1         1-377
            1140-2270           AC087884.18        100511-101641       c
FEATURES             Location/Qualifiers
     source          1..2270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2270
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="LETM1 domain containing 1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
     exon            1..152
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..600
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="isoform s is encoded by transcript variant 28;
                     regulator of TP53; cervical cancer proto-oncogene 2
                     protein; cervical cancer 1 proto-oncogene protein p40;
                     human cervical cancer oncogene; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="LETM1 domain-containing protein 1 isoform s"
                     /protein_id="NP_001338266.1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
                     /translation="MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSK
                     LHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKK
                     ARRIKTNMWKHNIKFHQLPYREMEHLRQKALSRAMLLTSYLPPPLLRHRLKTHTTVIH
                     QLDKALAKLGIGQLTAQEVKSLLLITSEK"
     exon            153..304
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..420
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..573
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..2270
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2246..2251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="hexamer: AAGAAA"
     polyA_site      2270
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctctc ccgcttctct cgctgtgaag atggcgctct ccagggtgtg ctgggctcgg
       61 tcggctgtgt ggggctcggc agtcacccct ggacattttg tcacccggag gctgcaactt
      121 ggtcgctctg gcctggcttg gggggcccct cggtcttcaa agcttcacct ttctccaaag
      181 gcagatgtga agaacttgat gtcttatgtg gtaaccaaga caaaagcgat taatgggaaa
      241 taccatcgtt tcttgggtcg tcatttcccc cgcttctatg tcctgtacac aatcttcatg
      301 aaaggattgc agatgttatg ggctgatgcc aaaaaggcta gaagaataaa gacaaatatg
      361 tggaagcaca atataaagtt tcatcaactt ccataccggg agatggagca tttgagacag
      421 aaagccttga gccgggccat gcttctcaca tcttacctgc ctcctccctt gttgagacat
      481 cgtttgaaga ctcatacaac tgtgattcac caactggaca aggctttggc aaagctgggg
      541 attggccagc tgactgctca ggaagtaaaa tcgctgcttc ttatcacctc tgagaaatga
      601 aacaaaaaaa gatgagatac ctccacagcc taagaatcct gtcatgcttg ttttctttgc
      661 aaaaatttta agagacaggg tctcactctg tgacccaggc tggcgtgcac tggtgtgaac
      721 tcagctcact gcagccttga cctcctggac tcaagagatc ctcctacctc agcctcccac
      781 atagctagga ttagaggtgt gagccaccat gcctggccgt gtgctgtttg cttactctgt
      841 tgacggagga gggttgtgga actggagagt gttcacaacc atagggaatc cacccctgaa
      901 tgggcctccc atgttcagtg gcacccacac ctcaccccgc tgaccctggt gtagatatac
      961 tatctcaggc caacttggac tgacctggca tttaatccca gcctggctgc aggcacacgc
     1021 ttctgggtca caatacagtc ggcagtcaca accacattct tcccgtgaca ggcggatggc
     1081 tcgaagttct tgcttctctt cagcatcaat acggtggacc ccagaagccc tcagcagggc
     1141 ccgtcgccgt ttggtgggca gaggctgcag gaagaagtaa tcatccacct ccacattttc
     1201 cacatcaata tcttcatctg acacatcatc cagcgtcagg ccatcagcct ccaccgactc
     1261 cactgtccca ttcttggtca gctgccaaga gacaggaaag gttagcctca tagacatgag
     1321 cggcatgcac ctcctcagtg accatcccag agcagcactg tcccttgaac cttctgcaat
     1381 catgggaata tctgtgctgt ccaaaatgat ggcagctact agcacatgtg gctactgagc
     1441 actagaaatg cagcaattgg aaaactgtca ttttatttat ttttttgaga caaaagtctc
     1501 attctgtcgt ccaggcggga gtgcagtggt gcagtcttgg ctcactacaa cctccgcctc
     1561 ccgggttcaa gcgattctcc tgcctcccaa gtagttggga ttacaggcgt gagtcaccag
     1621 cctggctaat tttttctatt ttcagtaaag acagggtttc actgtgttgg ccaggctagt
     1681 cttgaactgc tggcctcaag tgatccacac acctcggcct cccaaagtgc tggggtccac
     1741 tgtgccagcc caatttacat aattttaatt gaatagccgt atgtgactac tggctgctat
     1801 attcactagc acaagtcaaa agaataaatc cagagtggga agatgggaaa tcttacgtac
     1861 catcaccttt ctgggtccaa gcttctcaaa aacccgtctc atcttccctc ctacacgaaa
     1921 atctatttcc acaaacatac cgtctatttc cagacatgta tcccctaatt tacactcact
     1981 tgccttctaa cacagagagg aaaaggtatg tgaatgactg gatgatcctt ggatatacag
     2041 aaaaatgtga aacacccttc aacttgcacc cactgaatgc aaaactacct tcttgaaaaa
     2101 aaaagggcaa attaaagtgt agtaaaaggc taccaggtct taatcaatga acccaaatcc
     2161 ccacagtgtg aacaattatc tgtgcatgca ctaaagagct tcattctact gtaaggagaa
     2221 aaagcaaata tattaacagg tattaaagaa agcccttggc cgagaaaaaa
//
