LOCUS       NM_001351328            1755 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LETM1 domain containing 1 (LETMD1), transcript variant
            21, mRNA.
ACCESSION   NM_001351328 XM_011538165
VERSION     NM_001351328.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Wen,N., Zhang,J. and Zhang,Q.
  TITLE     MiR-494 Inhibits the Proliferation, Migration and Invasion of
            Cervical Cancer Cells by Regulating LETMD1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 81-87 (2022)
   PUBMED   35818268
  REMARK    GeneRIF: MiR-494 Inhibits the Proliferation, Migration and Invasion
            of Cervical Cancer Cells by Regulating LETMD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Zheng,Z., Yang,X., Yu,Q., Li,L. and Qiao,L.
  TITLE     The regulating role of miR-494 on HCCR1 in cervical cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 131-137 (2022)
   PUBMED   35818261
  REMARK    GeneRIF: The regulating role of miR-494 on HCCR1 in cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Choi,K.M., Kim,J.H., Kong,X., Isik,M., Zhang,J., Lim,H.W. and
            Yoon,J.C.
  TITLE     Defective brown adipose tissue thermogenesis and impaired glucose
            metabolism in mice lacking Letmd1
  JOURNAL   Cell Rep 37 (11), 110104 (2021)
   PUBMED   34910916
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Shin,S.M., Chung,Y.J., Oh,S.T., Jeon,H.M., Hwang,L.J., Namkoong,H.,
            Kim,H.K., Cho,G.W., Hur,S.Y., Kim,T.E., Lee,Y.S., Park,Y.G., Ko,J.
            and Kim,J.W.
  TITLE     HCCR-1-interacting molecule 'deleted in polyposis 1' plays a
            tumor-suppressor role in colon carcinogenesis
  JOURNAL   Gastroenterology 130 (7), 2074-2086 (2006)
   PUBMED   16762630
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Jung,S.S., Park,H.S., Lee,I.J., Namkoong,H., Shin,S.M., Cho,G.W.,
            Ha,S.A., Park,Y.G., Lee,Y.S., Ko,J. and Kim,J.W.
  TITLE     The HCCR oncoprotein as a biomarker for human breast cancer
  JOURNAL   Clin Cancer Res 11 (21), 7700-7708 (2005)
   PUBMED   16278390
  REMARK    GeneRIF: HCCR oncoprotein has a role in development of human breast
            cancer
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Ko,J., Shin,S.M., Oh,Y.M., Lee,Y.S., Ryoo,Z.Y., Lee,Y.H., Na,D.S.
            and Kim,J.W.
  TITLE     Transgenic mouse model for breast cancer: induction of breast
            cancer in novel oncogene HCCR-2 transgenic mice
  JOURNAL   Oncogene 23 (10), 1950-1953 (2004)
   PUBMED   14691448
  REMARK    GeneRIF: HCCR-2 represents an oncoprotein that is related to breast
            cancer development and regulation of the p53 tumor suppressor.
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Ko,J., Lee,Y.H., Hwang,S.Y., Lee,Y.S., Shin,S.M., Hwang,J.H.,
            Kim,J., Kim,Y.W., Jang,S.W., Ryoo,Z.Y., Kim,I.K., Namkoong,S.E. and
            Kim,J.W.
  TITLE     Identification and differential expression of novel human cervical
            cancer oncogene HCCR-2 in human cancers and its involvement in p53
            stabilization
  JOURNAL   Oncogene 22 (30), 4679-4689 (2003)
   PUBMED   12879013
  REMARK    GeneRIF: HCCR-2 probably represents a new oncogene that is related
            to tumorigenesis, functioning as a negative regulator of the p53
            tumor suppressor
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Qi,Z.Y., Li,Y., Ying,K., Wu,C.Q., Tang,R., Zhou,Z.X., Chen,Z.P.,
            Hui,G.Z. and Xie,Y.
  TITLE     Isolation of novel differentially expressed genes related to human
            glioma using cDNA microarray and characterizations of two novel
            full-length genes
  JOURNAL   J Neurooncol 56 (3), 197-208 (2002)
   PUBMED   12061725
  REMARK    GeneRIF: Human, similar to bacterial ribosomal protein L14 and
            yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087884.18.
            
            On May 31, 2019 this sequence version replaced NM_001351328.1.
            
            Summary: This gene encodes a mitochondrial outer membrane protein.
            It has a potential role in tumorigenesis, which may result from
            negative regulation of the p53 tumor suppressor gene. Alternatively
            spliced transcript variants have been noted for this gene.
            [provided by RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ222136.1, ERR3218375.51268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18045496; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC087884.18        120991-121142       c
            153-325             AC087884.18        120284-120456       c
            326-441             AC087884.18        117262-117377       c
            442-594             AC087884.18        112967-113119       c
            595-691             AC087884.18        111341-111437       c
            692-1755            AC087884.18        109045-110108       c
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..1755
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="LETM1 domain containing 1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
     exon            1..152
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..762
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="isoform p is encoded by transcript variant 21;
                     regulator of TP53; cervical cancer proto-oncogene 2
                     protein; cervical cancer 1 proto-oncogene protein p40;
                     human cervical cancer oncogene; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="LETM1 domain-containing protein 1 isoform p"
                     /protein_id="NP_001338257.1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
                     /translation="MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRLFD
                     LPCRSSKLHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQM
                     LWADAKKARRIKTNMWKHNIKFHQLPYREMEHLRQKALSRAMLLTSYLPPPLLRHRLK
                     THTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGEDRCRTWLGEWLQISCS
                     LKEAELSLLLHNVVLLSTNYLGTRR"
     exon            153..325
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            326..441
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..594
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..691
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1755
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="hexamer: AGTAAA"
     polyA_site      1755
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctctc ccgcttctct cgctgtgaag atggcgctct ccagggtgtg ctgggctcgg
       61 tcggctgtgt ggggctcggc agtcacccct ggacattttg tcacccggag gctgcaactt
      121 ggtcgctctg gcctggcttg gggggcccct cgtctctttg atcttccttg taggtcttca
      181 aagcttcacc tttctccaaa ggcagatgtg aagaacttga tgtcttatgt ggtaaccaag
      241 acaaaagcga ttaatgggaa ataccatcgt ttcttgggtc gtcatttccc ccgcttctat
      301 gtcctgtaca caatcttcat gaaaggattg cagatgttat gggctgatgc caaaaaggct
      361 agaagaataa agacaaatat gtggaagcac aatataaagt ttcatcaact tccataccgg
      421 gagatggagc atttgagaca gaaagccttg agccgggcca tgcttctcac atcttacctg
      481 cctcctccct tgttgagaca tcgtttgaag actcatacaa ctgtgattca ccaactggac
      541 aaggctttgg caaagctggg gattggccag ctgactgctc aggaagtaaa atcggcttgt
      601 tatctccgtg gcctgaattc tacgcatatt ggtgaagata ggtgtcgaac ttggctggga
      661 gaatggctgc agatttcctg cagcctgaaa gaagctgagc tgtctctctt gctgcacaac
      721 gtggtcctgc tctccaccaa ctaccttggg acaaggcgct gaatgaacca tggagcggat
      781 ggcattgtcc tgcagtcgta tagtatagca gtgcaggaac aaacagcact tgccagcaaa
      841 gtctgtgtgt actgttaagt gtgtgggagg cagagagagg agcaggggcc atgggcttca
      901 cagcatggca cacatgtggg aactgcagac attcctctca cagctagaac tgaaacaaac
      961 cctcttgcta ggggtggtcc gtgtgaggtg tcatcctgtc cccctcataa ttactaatag
     1021 ctggaactgg cagcagcctc tactgggctt ttactgtgat gtgttcagtt catgtcctag
     1081 gaagtcagct tttgccccag gtgggaatcc ttatttggct taggactgat ccacttccat
     1141 gttacttaca tctgtgggtt tttgttgttg ctgttagaaa atttgtggct ggtgaaaaca
     1201 gcactccttt ggctggagca catgtgtccg tgcatgtact tgggtgtttc cctccatcct
     1261 ttctgatatg accaaaaatc aagttgtttt gttttttgtc accttcactg gcatgggcta
     1321 accacttctt tttcaaaccc tctgaacacc tttttctgat gggtaacttg caggaatatt
     1381 ctattggaaa agataacagg aagtacaagt gcttcttgac cccttcctca atgtttctag
     1441 ccttcactct ccattgtctt ttctgggctg tattacagcc ctctgtggat cttcaactct
     1501 gctgcctcca ctgtgatgca gcagtccaac tgtaactgac agtggctgcc ttctctgggc
     1561 catggatcac acctgtaagg tactaattac tgcccagcct ggggagatca ggagaggtct
     1621 gcatagttag taagttgggt ttagcttttg tgtgtgcatc agtgacttag agttctgtaa
     1681 taacttattg taaatgcatg aagcactgtt tttaaaccca agtaaagact gcttgaaacc
     1741 tgttgatgga aatga
//
