LOCUS       NM_001351317            2063 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LETM1 domain containing 1 (LETMD1), transcript variant
            10, mRNA.
ACCESSION   NM_001351317
VERSION     NM_001351317.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2063)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   2  (bases 1 to 2063)
  AUTHORS   Wen,N., Zhang,J. and Zhang,Q.
  TITLE     MiR-494 Inhibits the Proliferation, Migration and Invasion of
            Cervical Cancer Cells by Regulating LETMD1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 81-87 (2022)
   PUBMED   35818268
  REMARK    GeneRIF: MiR-494 Inhibits the Proliferation, Migration and Invasion
            of Cervical Cancer Cells by Regulating LETMD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2063)
  AUTHORS   Zheng,Z., Yang,X., Yu,Q., Li,L. and Qiao,L.
  TITLE     The regulating role of miR-494 on HCCR1 in cervical cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 131-137 (2022)
   PUBMED   35818261
  REMARK    GeneRIF: The regulating role of miR-494 on HCCR1 in cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2063)
  AUTHORS   Choi,K.M., Kim,J.H., Kong,X., Isik,M., Zhang,J., Lim,H.W. and
            Yoon,J.C.
  TITLE     Defective brown adipose tissue thermogenesis and impaired glucose
            metabolism in mice lacking Letmd1
  JOURNAL   Cell Rep 37 (11), 110104 (2021)
   PUBMED   34910916
REFERENCE   5  (bases 1 to 2063)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2063)
  AUTHORS   Shin,S.M., Chung,Y.J., Oh,S.T., Jeon,H.M., Hwang,L.J., Namkoong,H.,
            Kim,H.K., Cho,G.W., Hur,S.Y., Kim,T.E., Lee,Y.S., Park,Y.G., Ko,J.
            and Kim,J.W.
  TITLE     HCCR-1-interacting molecule 'deleted in polyposis 1' plays a
            tumor-suppressor role in colon carcinogenesis
  JOURNAL   Gastroenterology 130 (7), 2074-2086 (2006)
   PUBMED   16762630
REFERENCE   7  (bases 1 to 2063)
  AUTHORS   Jung,S.S., Park,H.S., Lee,I.J., Namkoong,H., Shin,S.M., Cho,G.W.,
            Ha,S.A., Park,Y.G., Lee,Y.S., Ko,J. and Kim,J.W.
  TITLE     The HCCR oncoprotein as a biomarker for human breast cancer
  JOURNAL   Clin Cancer Res 11 (21), 7700-7708 (2005)
   PUBMED   16278390
  REMARK    GeneRIF: HCCR oncoprotein has a role in development of human breast
            cancer
REFERENCE   8  (bases 1 to 2063)
  AUTHORS   Ko,J., Shin,S.M., Oh,Y.M., Lee,Y.S., Ryoo,Z.Y., Lee,Y.H., Na,D.S.
            and Kim,J.W.
  TITLE     Transgenic mouse model for breast cancer: induction of breast
            cancer in novel oncogene HCCR-2 transgenic mice
  JOURNAL   Oncogene 23 (10), 1950-1953 (2004)
   PUBMED   14691448
  REMARK    GeneRIF: HCCR-2 represents an oncoprotein that is related to breast
            cancer development and regulation of the p53 tumor suppressor.
REFERENCE   9  (bases 1 to 2063)
  AUTHORS   Ko,J., Lee,Y.H., Hwang,S.Y., Lee,Y.S., Shin,S.M., Hwang,J.H.,
            Kim,J., Kim,Y.W., Jang,S.W., Ryoo,Z.Y., Kim,I.K., Namkoong,S.E. and
            Kim,J.W.
  TITLE     Identification and differential expression of novel human cervical
            cancer oncogene HCCR-2 in human cancers and its involvement in p53
            stabilization
  JOURNAL   Oncogene 22 (30), 4679-4689 (2003)
   PUBMED   12879013
  REMARK    GeneRIF: HCCR-2 probably represents a new oncogene that is related
            to tumorigenesis, functioning as a negative regulator of the p53
            tumor suppressor
REFERENCE   10 (bases 1 to 2063)
  AUTHORS   Qi,Z.Y., Li,Y., Ying,K., Wu,C.Q., Tang,R., Zhou,Z.X., Chen,Z.P.,
            Hui,G.Z. and Xie,Y.
  TITLE     Isolation of novel differentially expressed genes related to human
            glioma using cDNA microarray and characterizations of two novel
            full-length genes
  JOURNAL   J Neurooncol 56 (3), 197-208 (2002)
   PUBMED   12061725
  REMARK    GeneRIF: Human, similar to bacterial ribosomal protein L14 and
            yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087884.18.
            
            On May 31, 2019 this sequence version replaced NM_001351317.1.
            
            Summary: This gene encodes a mitochondrial outer membrane protein.
            It has a potential role in tumorigenesis, which may result from
            negative regulation of the p53 tumor suppressor gene. Alternatively
            spliced transcript variants have been noted for this gene.
            [provided by RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.1197.1,
                                           SRR1803613.131578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18045496; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC087884.18        120991-121142       c
            153-304             AC087884.18        120284-120435       c
            305-420             AC087884.18        117262-117377       c
            421-503             AC087884.18        115609-115691       c
            504-690             AC087884.18        113448-113634       c
            691-792             AC087884.18        113224-113325       c
            793-945             AC087884.18        112967-113119       c
            946-999             AC087884.18        111341-111394       c
            1000-2063           AC087884.18        109045-110108       c
FEATURES             Location/Qualifiers
     source          1..2063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2063
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="LETM1 domain containing 1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
     exon            1..152
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..996
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="isoform h is encoded by transcript variant 10;
                     regulator of TP53; cervical cancer proto-oncogene 2
                     protein; cervical cancer 1 proto-oncogene protein p40;
                     human cervical cancer oncogene; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="LETM1 domain-containing protein 1 isoform h"
                     /protein_id="NP_001338246.1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
                     /translation="MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSK
                     LHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKK
                     ARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPPFANYLVFLLMYL
                     FPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLC
                     TKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRL
                     KTHTTVIHQLDKALAKLGIGQLTAQEVKSIGVELGWENGCRFPAA"
     exon            153..304
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..420
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..503
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            504..690
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..792
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..945
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..999
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..2063
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="hexamer: AGTAAA"
     polyA_site      2063
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctctc ccgcttctct cgctgtgaag atggcgctct ccagggtgtg ctgggctcgg
       61 tcggctgtgt ggggctcggc agtcacccct ggacattttg tcacccggag gctgcaactt
      121 ggtcgctctg gcctggcttg gggggcccct cggtcttcaa agcttcacct ttctccaaag
      181 gcagatgtga agaacttgat gtcttatgtg gtaaccaaga caaaagcgat taatgggaaa
      241 taccatcgtt tcttgggtcg tcatttcccc cgcttctatg tcctgtacac aatcttcatg
      301 aaaggattgc agatgttatg ggctgatgcc aaaaaggcta gaagaataaa gacaaatatg
      361 tggaagcaca atataaagtt tcatcaactt ccataccggg agatggagca tttgagacag
      421 ttccgccaag acgtcaccaa gtgtcttttc ctaggtatta tttccattcc accttttgcc
      481 aactacctgg tcttcttgct aatgtacctg tttcccaggc aactactgat caggcatttc
      541 tggaccccaa aacaacaaac tgatttctta gatatctatc atgctttccg gaagcagtcc
      601 cacccagaaa ttattagtta tttagaaaag gtcatccctc tcatttctga tgcaggactc
      661 cggtggcgtc tgacagatct gtgcaccaag atacagcgtg gtacccaccc agcaatacat
      721 gatatcttgg ctctgagaga gtgtttctct aaccatcctc tgggcatgaa ccaactccag
      781 gctttgcacg tgaaagcctt gagccgggcc atgcttctca catcttacct gcctcctccc
      841 ttgttgagac atcgtttgaa gactcataca actgtgattc accaactgga caaggctttg
      901 gcaaagctgg ggattggcca gctgactgct caggaagtaa aatcgatagg tgtcgaactt
      961 ggctgggaga atggctgcag atttcctgca gcctgaaaga agctgagctg tctctcttgc
     1021 tgcacaacgt ggtcctgctc tccaccaact accttgggac aaggcgctga atgaaccatg
     1081 gagcggatgg cattgtcctg cagtcgtata gtatagcagt gcaggaacaa acagcacttg
     1141 ccagcaaagt ctgtgtgtac tgttaagtgt gtgggaggca gagagaggag caggggccat
     1201 gggcttcaca gcatggcaca catgtgggaa ctgcagacat tcctctcaca gctagaactg
     1261 aaacaaaccc tcttgctagg ggtggtccgt gtgaggtgtc atcctgtccc cctcataatt
     1321 actaatagct ggaactggca gcagcctcta ctgggctttt actgtgatgt gttcagttca
     1381 tgtcctagga agtcagcttt tgccccaggt gggaatcctt atttggctta ggactgatcc
     1441 acttccatgt tacttacatc tgtgggtttt tgttgttgct gttagaaaat ttgtggctgg
     1501 tgaaaacagc actcctttgg ctggagcaca tgtgtccgtg catgtacttg ggtgtttccc
     1561 tccatccttt ctgatatgac caaaaatcaa gttgttttgt tttttgtcac cttcactggc
     1621 atgggctaac cacttctttt tcaaaccctc tgaacacctt tttctgatgg gtaacttgca
     1681 ggaatattct attggaaaag ataacaggaa gtacaagtgc ttcttgaccc cttcctcaat
     1741 gtttctagcc ttcactctcc attgtctttt ctgggctgta ttacagccct ctgtggatct
     1801 tcaactctgc tgcctccact gtgatgcagc agtccaactg taactgacag tggctgcctt
     1861 ctctgggcca tggatcacac ctgtaaggta ctaattactg cccagcctgg ggagatcagg
     1921 agaggtctgc atagttagta agttgggttt agcttttgtg tgtgcatcag tgacttagag
     1981 ttctgtaata acttattgta aatgcatgaa gcactgtttt taaacccaag taaagactgc
     2041 ttgaaacctg ttgatggaaa tga
//
