LOCUS       NM_001243689            2145 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LETM1 domain containing 1 (LETMD1), transcript variant
            3, mRNA.
ACCESSION   NM_001243689
VERSION     NM_001243689.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Wen,N., Zhang,J. and Zhang,Q.
  TITLE     MiR-494 Inhibits the Proliferation, Migration and Invasion of
            Cervical Cancer Cells by Regulating LETMD1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 81-87 (2022)
   PUBMED   35818268
  REMARK    GeneRIF: MiR-494 Inhibits the Proliferation, Migration and Invasion
            of Cervical Cancer Cells by Regulating LETMD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Zheng,Z., Yang,X., Yu,Q., Li,L. and Qiao,L.
  TITLE     The regulating role of miR-494 on HCCR1 in cervical cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 131-137 (2022)
   PUBMED   35818261
  REMARK    GeneRIF: The regulating role of miR-494 on HCCR1 in cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Choi,K.M., Kim,J.H., Kong,X., Isik,M., Zhang,J., Lim,H.W. and
            Yoon,J.C.
  TITLE     Defective brown adipose tissue thermogenesis and impaired glucose
            metabolism in mice lacking Letmd1
  JOURNAL   Cell Rep 37 (11), 110104 (2021)
   PUBMED   34910916
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Shin,S.M., Chung,Y.J., Oh,S.T., Jeon,H.M., Hwang,L.J., Namkoong,H.,
            Kim,H.K., Cho,G.W., Hur,S.Y., Kim,T.E., Lee,Y.S., Park,Y.G., Ko,J.
            and Kim,J.W.
  TITLE     HCCR-1-interacting molecule 'deleted in polyposis 1' plays a
            tumor-suppressor role in colon carcinogenesis
  JOURNAL   Gastroenterology 130 (7), 2074-2086 (2006)
   PUBMED   16762630
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Jung,S.S., Park,H.S., Lee,I.J., Namkoong,H., Shin,S.M., Cho,G.W.,
            Ha,S.A., Park,Y.G., Lee,Y.S., Ko,J. and Kim,J.W.
  TITLE     The HCCR oncoprotein as a biomarker for human breast cancer
  JOURNAL   Clin Cancer Res 11 (21), 7700-7708 (2005)
   PUBMED   16278390
  REMARK    GeneRIF: HCCR oncoprotein has a role in development of human breast
            cancer
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Ko,J., Shin,S.M., Oh,Y.M., Lee,Y.S., Ryoo,Z.Y., Lee,Y.H., Na,D.S.
            and Kim,J.W.
  TITLE     Transgenic mouse model for breast cancer: induction of breast
            cancer in novel oncogene HCCR-2 transgenic mice
  JOURNAL   Oncogene 23 (10), 1950-1953 (2004)
   PUBMED   14691448
  REMARK    GeneRIF: HCCR-2 represents an oncoprotein that is related to breast
            cancer development and regulation of the p53 tumor suppressor.
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Ko,J., Lee,Y.H., Hwang,S.Y., Lee,Y.S., Shin,S.M., Hwang,J.H.,
            Kim,J., Kim,Y.W., Jang,S.W., Ryoo,Z.Y., Kim,I.K., Namkoong,S.E. and
            Kim,J.W.
  TITLE     Identification and differential expression of novel human cervical
            cancer oncogene HCCR-2 in human cancers and its involvement in p53
            stabilization
  JOURNAL   Oncogene 22 (30), 4679-4689 (2003)
   PUBMED   12879013
  REMARK    GeneRIF: HCCR-2 probably represents a new oncogene that is related
            to tumorigenesis, functioning as a negative regulator of the p53
            tumor suppressor
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Qi,Z.Y., Li,Y., Ying,K., Wu,C.Q., Tang,R., Zhou,Z.X., Chen,Z.P.,
            Hui,G.Z. and Xie,Y.
  TITLE     Isolation of novel differentially expressed genes related to human
            glioma using cDNA microarray and characterizations of two novel
            full-length genes
  JOURNAL   J Neurooncol 56 (3), 197-208 (2002)
   PUBMED   12061725
  REMARK    GeneRIF: Human, similar to bacterial ribosomal protein L14 and
            yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087884.18.
            
            On May 31, 2019 this sequence version replaced NM_001243689.1.
            
            Summary: This gene encodes a mitochondrial outer membrane protein.
            It has a potential role in tumorigenesis, which may result from
            negative regulation of the p53 tumor suppressor gene. Alternatively
            spliced transcript variants have been noted for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            donor splice site at an internal exon in the 5' coding region
            compared to variant 1. This results in a longer isoform (b, also
            known as 3) containing a 13 aa protein segment not found in isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127540.1, SRR1803616.187914.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18045496; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC087884.18        120991-121142       c
            153-304             AC087884.18        120284-120435       c
            305-459             AC087884.18        117223-117377       c
            460-542             AC087884.18        115609-115691       c
            543-729             AC087884.18        113448-113634       c
            730-831             AC087884.18        113224-113325       c
            832-984             AC087884.18        112967-113119       c
            985-1081            AC087884.18        111341-111437       c
            1082-2145           AC087884.18        109045-110108       c
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2145
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="LETM1 domain containing 1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
     exon            1..152
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1152
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="isoform b is encoded by transcript variant 3;
                     regulator of TP53; cervical cancer proto-oncogene 2
                     protein; cervical cancer 1 proto-oncogene protein p40;
                     human cervical cancer oncogene; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="LETM1 domain-containing protein 1 isoform b"
                     /protein_id="NP_001230618.1"
                     /db_xref="CCDS:CCDS58231.1"
                     /db_xref="GeneID:25875"
                     /db_xref="HGNC:HGNC:24241"
                     /db_xref="MIM:619070"
                     /translation="MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSK
                     LHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKK
                     ARRIKTNMWKHNIKFHQLPYREMEHLRQVWARGRYPEVHGEFRQDVTKCLFLGIISIP
                     PFANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLI
                     SDAGLRWRLTDLCTKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLL
                     TSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGEDR
                     CRTWLGEWLQISCSLKEAELSLLLHNVVLLSTNYLGTRR"
     exon            153..304
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..459
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..542
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..729
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            730..831
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..984
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1081
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..2145
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="hexamer: AGTAAA"
     polyA_site      2145
                     /gene="LETMD1"
                     /gene_synonym="1110019O13Rik; HCCR; HCCR-1; HCCR-2; HCCR1;
                     HCCR2; HCRR-2; SLC55A3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctctc ccgcttctct cgctgtgaag atggcgctct ccagggtgtg ctgggctcgg
       61 tcggctgtgt ggggctcggc agtcacccct ggacattttg tcacccggag gctgcaactt
      121 ggtcgctctg gcctggcttg gggggcccct cggtcttcaa agcttcacct ttctccaaag
      181 gcagatgtga agaacttgat gtcttatgtg gtaaccaaga caaaagcgat taatgggaaa
      241 taccatcgtt tcttgggtcg tcatttcccc cgcttctatg tcctgtacac aatcttcatg
      301 aaaggattgc agatgttatg ggctgatgcc aaaaaggcta gaagaataaa gacaaatatg
      361 tggaagcaca atataaagtt tcatcaactt ccataccggg agatggagca tttgagacag
      421 gtatgggcca ggggcagata tccagaagtt catggtgagt tccgccaaga cgtcaccaag
      481 tgtcttttcc taggtattat ttccattcca ccttttgcca actacctggt cttcttgcta
      541 atgtacctgt ttcccaggca actactgatc aggcatttct ggaccccaaa acaacaaact
      601 gatttcttag atatctatca tgctttccgg aagcagtccc acccagaaat tattagttat
      661 ttagaaaagg tcatccctct catttctgat gcaggactcc ggtggcgtct gacagatctg
      721 tgcaccaaga tacagcgtgg tacccaccca gcaatacatg atatcttggc tctgagagag
      781 tgtttctcta accatcctct gggcatgaac caactccagg ctttgcacgt gaaagccttg
      841 agccgggcca tgcttctcac atcttacctg cctcctccct tgttgagaca tcgtttgaag
      901 actcatacaa ctgtgattca ccaactggac aaggctttgg caaagctggg gattggccag
      961 ctgactgctc aggaagtaaa atcggcttgt tatctccgtg gcctgaattc tacgcatatt
     1021 ggtgaagata ggtgtcgaac ttggctggga gaatggctgc agatttcctg cagcctgaaa
     1081 gaagctgagc tgtctctctt gctgcacaac gtggtcctgc tctccaccaa ctaccttggg
     1141 acaaggcgct gaatgaacca tggagcggat ggcattgtcc tgcagtcgta tagtatagca
     1201 gtgcaggaac aaacagcact tgccagcaaa gtctgtgtgt actgttaagt gtgtgggagg
     1261 cagagagagg agcaggggcc atgggcttca cagcatggca cacatgtggg aactgcagac
     1321 attcctctca cagctagaac tgaaacaaac cctcttgcta ggggtggtcc gtgtgaggtg
     1381 tcatcctgtc cccctcataa ttactaatag ctggaactgg cagcagcctc tactgggctt
     1441 ttactgtgat gtgttcagtt catgtcctag gaagtcagct tttgccccag gtgggaatcc
     1501 ttatttggct taggactgat ccacttccat gttacttaca tctgtgggtt tttgttgttg
     1561 ctgttagaaa atttgtggct ggtgaaaaca gcactccttt ggctggagca catgtgtccg
     1621 tgcatgtact tgggtgtttc cctccatcct ttctgatatg accaaaaatc aagttgtttt
     1681 gttttttgtc accttcactg gcatgggcta accacttctt tttcaaaccc tctgaacacc
     1741 tttttctgat gggtaacttg caggaatatt ctattggaaa agataacagg aagtacaagt
     1801 gcttcttgac cccttcctca atgtttctag ccttcactct ccattgtctt ttctgggctg
     1861 tattacagcc ctctgtggat cttcaactct gctgcctcca ctgtgatgca gcagtccaac
     1921 tgtaactgac agtggctgcc ttctctgggc catggatcac acctgtaagg tactaattac
     1981 tgcccagcct ggggagatca ggagaggtct gcatagttag taagttgggt ttagcttttg
     2041 tgtgtgcatc agtgacttag agttctgtaa taacttattg taaatgcatg aagcactgtt
     2101 tttaaaccca agtaaagact gcttgaaacc tgttgatgga aatga
//
