LOCUS       NM_001286819            2856 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens leucine zipper and EF-hand containing transmembrane
            protein 2 (LETM2), transcript variant 5, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001286819 XM_005273406
VERSION     NM_001286819.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Tamai,S., Iida,H., Yokota,S., Sayano,T., Kiguchiya,S., Ishihara,N.,
            Hayashi,J., Mihara,K. and Oka,T.
  TITLE     Characterization of the mitochondrial protein LETM1, which
            maintains the mitochondrial tubular shapes and interacts with the
            AAA-ATPase BCS1L
  JOURNAL   J Cell Sci 121 (Pt 15), 2588-2600 (2008)
   PUBMED   18628306
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Stec,I., van Ommen,G.J. and den Dunnen,J.T.
  TITLE     WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and
            maps to a duplicated region shared with 4p16.3
  JOURNAL   Genomics 76 (1-3), 5-8 (2001)
   PUBMED   11549311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087623.21.
            
            On Feb 27, 2020 this sequence version replaced NM_001286819.1.
            
            Transcript Variant: This variant (5) uses two alternate splice
            sites in the coding region which results in the use of an upstream
            AUG, compared to variant 1. The encoded isoform (4) has a longer
            N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on partial human alignments and orthologous
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2661583.1,
                                           SRR18074967.3370000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000379957.9/
                                                  ENSP00000369291.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC087623.21        125756-125848       c
            94-174              AC087623.21        124294-124374       c
            175-628             AC087623.21        119329-119782       c
            629-772             AC087623.21        118083-118226       c
            773-910             AC087623.21        111915-112052       c
            911-1111            AC087623.21        111271-111471       c
            1112-1231           AC087623.21        109680-109799       c
            1232-1345           AC087623.21        107818-107931       c
            1346-1438           AC087623.21        105286-105378       c
            1439-1540           AC087623.21        104861-104962       c
            1541-2856           AC087623.21        102797-104112       c
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..2856
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /note="leucine zipper and EF-hand containing transmembrane
                     protein 2"
                     /db_xref="GeneID:137994"
                     /db_xref="HGNC:HGNC:14648"
                     /db_xref="MIM:620380"
     exon            1..93
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..174
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1603
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /note="isoform 4 is encoded by transcript variant 5; LETM1
                     domain-containing protein LETM2, mitochondrial; leucine
                     zipper-EF-hand containing transmembrane protein 1-like
                     protein; LETM1 and EF-hand domain-containing protein 2;
                     leucine zipper-EF-hand containing transmembrane protein 2"
                     /codon_start=1
                     /product="LETM1 domain-containing protein LETM2,
                     mitochondrial isoform 4"
                     /protein_id="NP_001273748.1"
                     /db_xref="CCDS:CCDS69466.1"
                     /db_xref="GeneID:137994"
                     /db_xref="HGNC:HGNC:14648"
                     /db_xref="MIM:620380"
                     /translation="MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLN
                     KTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQV
                     TSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVL
                     TRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEK
                     QKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRF
                     SKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEG
                     VTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLI
                     DVKPKPIEIPLSGEAPKTDILVELPTFTESKENMVDLAPQLKGTKDEDFIQPPPVTSS
                     PITPSTPISLPKGPITSSEEPTLQAKSQMTAQNSKASSKGA"
     exon            175..628
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..772
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..910
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1111
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1231
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1345
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1438
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1540
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..2856
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /note="hexamer: TATAAA"
     polyA_site      1873
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /note="major polyA site"
     polyA_site      2317
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /note="hexamer: AATAAG"
     polyA_site      2388
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
ORIGIN      
        1 gtagagactt ggcttcgggc ccttctagct tgggggtccc gggaaggagc tgggaggacc
       61 taggcggccg ttccgcggag cccggccgag gaggtcccta tgttaactac ttgagacaaa
      121 aataaatatg gccttctaca gttataattc agttctggct attgctcgaa caagattccc
      181 tagccatttt gtccatccta cctgctcttc ttattcccca tcatgtgcat ttcttcactt
      241 gccagattcc catttaaata agacatgtat gaagaactat gagagcaaga agtactcgga
      301 tcctagtcag ccaggcaata cagtacttca cccaggaact agactaatac aaaagctaca
      361 cacatccact tgctggctgc aagaagttcc tggcaaacct cagctggagc aagccacaaa
      421 acatccacag gtgacaagcc ctcaggccac aaaagaaact ggcatggaga ttaaagaagg
      481 caaacaatct tatagacaaa aaatcatgga tgaactaaaa tattattaca atggattcta
      541 cttactttgg attgacgcca aagttgctgc cagaatggtt tggaggctgt tgcatggaca
      601 ggtcctgacc agacgagaga gacgaaggct gttgagaact tgtgttgatt tcttccgcct
      661 ggttccattt atggtgttct taattgtacc cttcatggaa ttcttattac cagtgtttct
      721 gaaactcttc ccagagatgt tgccatcaac ttttgaaagt gaatccaaaa aggaagaaaa
      781 acagaaaaag aaaatggctg taaagttgga actagcaaaa tttcttcaag aaaccatgac
      841 agaaatggca aggaggaaca gagccaagat gggcgatgcc tctacacagc tctcatccta
      901 cgtgaagcag gtccagacag gccacaagcc cagcacaaag gagatagttc gcttctccaa
      961 actatttgag gaccagctgg ccctggaaca cttagatcgc cctcagctgg ttgccctttg
     1021 caaactgctg gaattgcaga catttggaac caacaacctg ctccgctttc agctcctgat
     1081 gaaactgaag tctataaaag cagatgatga aataattgcc aaggaagggg tgacagcatt
     1141 gagtgtatca gaactacagg ctgcctgtag ggcccgaggg atgagatcac tgggtctcac
     1201 ggaggaacaa ctgcgacaac agctcacgga gtggcaggac ctccacctga aggagaacgt
     1261 ccctccttcc cttttgctcc tgtcccgcac cttctacctg atagatgtga agcccaagcc
     1321 gattgagata ccactcagtg gggaggctcc aaagactgat attcttgtgg aattacctac
     1381 tttcactgaa tctaaagaga acatggtgga tcttgcacct caactgaagg gaactaagga
     1441 tgaagacttt atacagccgc caccagttac atcatcaccc ataacaccat caacacctat
     1501 ttcattacct aaaggaccca tcacttcttc tgaagaacct acactccagg ccaaatcaca
     1561 aatgacggcc cagaacagca aggctagttc aaaaggagca taaaggacta cttgaggatg
     1621 gagctcactc tcttcagctt ccggccctca acagtggcat ctgtaaagga cctcccagat
     1681 aagactgtct ggcttcagag agcggatcag ctgtttagcc cgtggggcag tcctttgagg
     1741 cctggtaacc attccaggtg atgtgggtag tgagaccaag ttcagaccac ttagaaaaat
     1801 ataattgcaa agtcccattt cctctgtacc attgtcaccc cactcaactt tgtataaagc
     1861 ccacccccca tcatgttgtt tttttagttt catgtgtacg tcccttcaga gaggaaattt
     1921 tttgcacaat ggaatcagct tggcacctta gatacctgtc tcctatggct tggaattctg
     1981 agtaagaact tggaagttcc aaaaaccatt ttaggagcac ctgattaact ttctgaatga
     2041 tccaccagta ggatcagcac cctggaaaca aagtacctta tgagatggga tggatatact
     2101 ccccagtaag atctttctgg atataatgaa gcttcctgga gaaacagact ggcaatcaga
     2161 aagatttggc tgcttccgac acctccatct tgggcctgca gaggctgcag caatctgtga
     2221 ggcagccgca atctgcgagg cagccactct tctagcacat atggctttca ttagccacca
     2281 ttttgctagg aagcataatt aagggtttaa gccttaacca tgtttgtgtt gggtgtgtgt
     2341 gtttctggcc agtttgtctt tcacaaataa gactattagt catagggatt gtgaaagtct
     2401 gatataatcc ctgtgctacc cagcaacaag tattacatta ggatatttat gcttggtgtt
     2461 ttcagtatta ataatatgaa ataatagata gactgccatg cagctgacca agggctttct
     2521 tcccctgggg agtggttaga aggccaaagg tatttcagcc tgtaggtgat aaaattagat
     2581 ttctttactt gctgtggtta gacagcagtc agttaaaaca agtaaaactc cactgtcctg
     2641 tctgggatca cctaaatgag gaatgtcacc agcacttcac agcaagaata tgcattctac
     2701 aatgctttct aaatttgtgc tccatcagag aagccccacc atgtcccact aatgaagccc
     2761 agttctttgg gaatgatgaa tccctactgt gcacatacag caatcatgga tcctgcctat
     2821 cgaggtgatt cacaatacac tttcccattt caaaaa
//
