LOCUS       NP_001273748             491 aa            linear   PRI 30-APR-2025
DEFINITION  LETM1 domain-containing protein LETM2, mitochondrial isoform 4
            [Homo sapiens].
ACCESSION   NP_001273748 XP_005273463
VERSION     NP_001273748.1
DBSOURCE    REFSEQ: accession NM_001286819.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 491)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 491)
  AUTHORS   Tamai,S., Iida,H., Yokota,S., Sayano,T., Kiguchiya,S., Ishihara,N.,
            Hayashi,J., Mihara,K. and Oka,T.
  TITLE     Characterization of the mitochondrial protein LETM1, which
            maintains the mitochondrial tubular shapes and interacts with the
            AAA-ATPase BCS1L
  JOURNAL   J Cell Sci 121 (Pt 15), 2588-2600 (2008)
   PUBMED   18628306
REFERENCE   3  (residues 1 to 491)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
REFERENCE   4  (residues 1 to 491)
  AUTHORS   Stec,I., van Ommen,G.J. and den Dunnen,J.T.
  TITLE     WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and
            maps to a duplicated region shared with 4p16.3
  JOURNAL   Genomics 76 (1-3), 5-8 (2001)
   PUBMED   11549311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087623.21.
            
            On Nov 16, 2013 this sequence version replaced XP_005273463.1.
            
            Transcript Variant: This variant (5) uses two alternate splice
            sites in the coding region which results in the use of an upstream
            AUG, compared to variant 1. The encoded isoform (4) has a longer
            N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on partial human alignments and orthologous
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2661583.1,
                                           SRR18074967.3370000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000379957.9/
                                                  ENSP00000369291.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     Protein         1..491
                     /product="LETM1 domain-containing protein LETM2,
                     mitochondrial isoform 4"
                     /note="LETM1 domain-containing protein LETM2,
                     mitochondrial; leucine zipper-EF-hand containing
                     transmembrane protein 1-like protein; LETM1 and EF-hand
                     domain-containing protein 2; leucine zipper-EF-hand
                     containing transmembrane protein 2"
                     /calculated_mol_wt=53026
     Region          1..111
                     /region_name="LETM2_N"
                     /note="LETM1 domain-containing protein LETM2 N-terminus;
                     pfam19324"
                     /db_xref="CDD:466042"
     transit_peptide 1..25
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q2VYF4.2)"
                     /calculated_mol_wt=2913
     mat_peptide     26..491
                     /product="LETM1 domain-containing protein LETM2,
                     mitochondrial. /id=PRO_0000307137"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VYF4.2)"
                     /calculated_mol_wt=53026
     Region          94..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VYF4.2)"
     Region          174..390
                     /region_name="LETM1_RBD"
                     /note="LETM1-like, RBD; pfam07766"
                     /db_xref="CDD:462258"
     Site            178..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VYF4.2)"
     Region          435..491
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2VYF4.2)"
     CDS             1..491
                     /gene="LETM2"
                     /gene_synonym="SLC55A2"
                     /coded_by="NM_001286819.2:128..1603"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS69466.1"
                     /db_xref="GeneID:137994"
                     /db_xref="HGNC:HGNC:14648"
                     /db_xref="MIM:620380"
ORIGIN      
        1 mafysynsvl aiartrfpsh fvhptcssys pscaflhlpd shlnktcmkn yeskkysdps
       61 qpgntvlhpg trliqklhts tcwlqevpgk pqleqatkhp qvtspqatke tgmeikegkq
      121 syrqkimdel kyyyngfyll widakvaarm vwrllhgqvl trrerrrllr tcvdffrlvp
      181 fmvflivpfm efllpvflkl fpemlpstfe seskkeekqk kkmavklela kflqetmtem
      241 arrnrakmgd astqlssyvk qvqtghkpst keivrfsklf edqlalehld rpqlvalckl
      301 lelqtfgtnn llrfqllmkl ksikaddeii akegvtalsv selqaacrar gmrslgltee
      361 qlrqqltewq dlhlkenvpp sllllsrtfy lidvkpkpie iplsgeapkt dilvelptft
      421 eskenmvdla pqlkgtkded fiqpppvtss pitpstpisl pkgpitssee ptlqaksqmt
      481 aqnskasskg a
//
