LOCUS       NM_015344               3163 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leptin receptor overlapping transcript like 1
            (LEPROTL1), transcript variant 1, mRNA.
ACCESSION   NM_015344
VERSION     NM_015344.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3163)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3163)
  AUTHORS   Mo,H.Y., Kim,M.S., Chung,N.G., Yoo,N.J. and Lee,S.H.
  TITLE     Promoter Mutation Analysis of LEPROTL1 Gene in Acute Leukemias and
            Solid Tumors
  JOURNAL   Acta Haematol 141 (4), 214-215 (2019)
   PUBMED   30943467
  REMARK    GeneRIF: Promoter Mutation Analysis of LEPROTL1 Gene in Acute
            Leukemias and Solid Tumors.
REFERENCE   4  (bases 1 to 3163)
  AUTHORS   Lancel,S., Hesselink,M.K., Woldt,E., Rouille,Y., Dorchies,E.,
            Delhaye,S., Duhem,C., Thorel,Q., Mayeuf-Louchart,A., Pourcet,B.,
            Montel,V., Schaart,G., Beton,N., Picquet,F., Briand,O.,
            Salles,J.P., Duez,H., Schrauwen,P., Bastide,B., Bailleul,B.,
            Staels,B. and Sebti,Y.
  TITLE     Endospanin-2 enhances skeletal muscle energy metabolism and running
            endurance capacity
  JOURNAL   JCI Insight 3 (9), 98081 (2018)
   PUBMED   29720572
  REMARK    GeneRIF: these results identify endospanin-2 as a potentially novel
            player in skeletal muscle metabolism, plasticity, and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3163)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   6  (bases 1 to 3163)
  AUTHORS   Corpeleijn,E., Petersen,L., Holst,C., Saris,W.H., Astrup,A.,
            Langin,D., MacDonald,I., Martinez,J.A., Oppert,J.M., Polak,J.,
            Pedersen,O., Froguel,P., Arner,P., Sorensen,T.I. and Blaak,E.E.
  TITLE     Obesity-related polymorphisms and their associations with the
            ability to regulate fat oxidation in obese Europeans: the NUGENOB
            study
  JOURNAL   Obesity (Silver Spring) 18 (7), 1369-1377 (2010)
   PUBMED   19876004
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3163)
  AUTHORS   Touvier,T., Conte-Auriol,F., Briand,O., Cudejko,C., Paumelle,R.,
            Caron,S., Bauge,E., Rouille,Y., Salles,J.P., Staels,B. and
            Bailleul,B.
  TITLE     LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone
            action in mice
  JOURNAL   J Clin Invest 119 (12), 3830-3838 (2009)
   PUBMED   19907080
  REMARK    GeneRIF: Transgenic mice expressing either human LEPROT or human
            LEPROTL1 displayed growth retardation, reduced plasma IGF1 levels,
            and impaired hepatic sensitivity to GH, as measured by STAT5
            phosphorylation and Socs2 mRNA expression.
REFERENCE   8  (bases 1 to 3163)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3163)
  AUTHORS   Huang,Y., Ying,K., Xie,Y., Zhou,Z., Wang,W., Tang,R., Zhao,W.,
            Zhao,S., Wu,H., Gu,S. and Mao,Y.
  TITLE     Cloning and characterization of a novel human leptin receptor
            overlapping transcript-like 1 gene (LEPROTL1)
  JOURNAL   Biochim Biophys Acta 1517 (2), 327-331 (2001)
   PUBMED   11342119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC044849.12.
            
            On May 17, 2019 this sequence version replaced NM_015344.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.218257.1,
                                           SRR1803612.154911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321250.13/ ENSP00000314625.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC044849.12        129250-129370
            122-197             AC044849.12        135740-135815
            198-384             AC044849.12        138142-138328
            385-3163            AC044849.12        139588-142366
FEATURES             Location/Qualifiers
     source          1..3163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..3163
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="leptin receptor overlapping transcript like 1"
                     /db_xref="GeneID:23484"
                     /db_xref="HGNC:HGNC:6555"
                     /db_xref="MIM:607338"
     exon            1..121
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..501
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endospanin-2"
                     /codon_start=1
                     /product="leptin receptor overlapping transcript-like 1
                     isoform 1"
                     /protein_id="NP_056159.2"
                     /db_xref="CCDS:CCDS6075.1"
                     /db_xref="GeneID:23484"
                     /db_xref="HGNC:HGNC:6555"
                     /db_xref="MIM:607338"
                     /translation="MAGIKALISLSFGGAIGLMFLMLGCALPIYNKYWPLFVLFFYIL
                     SPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARAHLIEWGACALV
                     LTGNTVIFATILGFFLVFGSNDDFSWQQW"
     exon            122..197
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /inference="alignment:Splign:2.1.0"
     exon            198..384
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /inference="alignment:Splign:2.1.0"
     exon            385..3163
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      677..682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="hexamer: ATTAAA"
     polyA_site      703
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="major polyA site"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="hexamer: CATAAA"
     polyA_site      2070
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
     regulatory      2841..2846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
                     /note="hexamer: AATAAA"
     polyA_site      2871
                     /gene="LEPROTL1"
                     /gene_synonym="HSPC112; my047; Vps55"
ORIGIN      
        1 gcacttccgg gtgttgtctg gccgccgtag cgcgtcttgg gtctcccggc tgccgctgct
       61 gccgccgccg cctcgggtcg tggagccagg agcgacgtca ccgccatggc aggcatcaaa
      121 gctttgatta gtttgtcctt tggaggagca atcggactga tgtttttgat gcttggatgt
      181 gcccttccaa tatacaacaa atactggccc ctctttgttc tattttttta catcctttca
      241 cctattccat actgcatagc aagaagatta gtggatgata cagatgctat gagtaacgct
      301 tgtaaggaac ttgccatctt tcttacaacg ggcattgtcg tgtcagcttt tggactccct
      361 attgtatttg ccagagcaca tctgattgag tggggagctt gtgcacttgt tctcacagga
      421 aacacagtca tctttgcaac tatactaggc tttttcttgg tctttggaag caatgacgac
      481 ttcagctggc agcagtggtg aaaagaaatt actgaactat tgtcaaatgg acttcctgtc
      541 atttgttggc cattcacgca cacaggagat ggggcagtta atgctgaatg gtatagcaag
      601 cctcttgggg gtattttagg tgctcccttc tcacttttat tgtaagcata ctattttcac
      661 agagacttgc tgaaggatta aaaggatttt ctcttttgga aaagcttgac tgatttcaca
      721 cttatctata gtatgctttt tgtggtgtcc tgctgaattt aaatatttat gtgtttttcc
      781 tgttaggttg attttttttg gaatcaatat gcaatgttaa acactttttt aatgtaatca
      841 tttgcattgg ttaggaattc agaattccgc cggctctatt actggtcaag tacatctttt
      901 ctcttaaaat tatttagcct ccattattac aaaaaattat aaaaataagt tttcagtcag
      961 tcaggatgac atcactccca atgttatgca gacatacaga cggttggcat acgttataga
     1021 ctgtatactc agtgcaaata tagctgcatt tatacctcag aggggccaag tgttaatgcc
     1081 catgccctcc gttaagggtt gttggtttta ctggtagaca gatgttttgt ggattgaaaa
     1141 ttattttatg gaattgctac agaggagtgc ttttcttctc aattgttaga agaatttatg
     1201 ttaaacttta aggtaagggt gtaaaaacat ttttgagata aggtttttat ttatgtttat
     1261 tattgttaga gtgagttgca atgtgggaag aaatgacatt gaaattccag tttttgaatc
     1321 ctgtttctat ttataagtga aatttgtgat ctcctatcaa cctttcatgt tttaccctgt
     1381 taaaatggac atacatggaa ccactactga tgagggacag ttgtatgttt gcatcatata
     1441 tgccagaaaa ccttcctctg cttcctcctt ttgacttatt tggtatgttg tatatattac
     1501 ataaaataac ttttcaaata tagtttaata acacttagaa gtgtttactt acctggaaaa
     1561 taattgctat gccgtacatt cagagtgccc cctcccctgc aaggccttgc catgattaac
     1621 aagtaacttg ttagtcttac agataattca tgcattaaca gtttaagatt tagaccatgg
     1681 taatagtagt tcttattctc taaggttata tcatatgtaa tttaaaagta tttttaagac
     1741 aagtttcctg tatacctctg aactgttttg attttgagtt catcatgata gatctgctgt
     1801 ttccttataa aaggcatttg ttgtgtgagt taatgcaaag tagccaagtc cagctatata
     1861 gcagcttcag aaacatacct gaccaaaaaa ttcccagtaa ccaggcatga tcaatttata
     1921 gtggtcgttt acatctaata attatcagga cttttttcag gagtgggtta taaaaacatt
     1981 caagttggtc tgacagtatt ttgttaagga tatttgtttg tatgtttatt cagtatactt
     2041 acataaaaat tatttcgcca tcagccaaaa ctcagtaatc atgacagctg tctgttgttt
     2101 tatgaagttt atttctcaag aaaatgggaa taaatttggg atttgttcag cttttttact
     2161 aaagatgcct aaagccacag gttttattgc ctaacttaag ccatgacttt tagatatgag
     2221 atgacgggaa gcaggacgaa atatcggcgt gtggctggag ccttcccact ggaggctgaa
     2281 agtggcttgt ggtattataa tgttcagatt tcaagaggaa ggtgcaggta cacatgagtt
     2341 agagagctgg tgagacagtt gggaactctt tgtgcttgtg atctactgga cttttttttg
     2401 caggaagtgc attctctggt ccttccctat tttctgttct ggatgtcagt gcagtgcact
     2461 gctactgttt tatccacttg gccacagact ttttctaaca gctgcgtatt atttctatat
     2521 actaactgca ttggcagcat tgtgtctttg accttgtata ctagcttgac atagtgctgt
     2581 ctctgatttc taggctagtt acttgagata tgaattttcc atagaatatg cactgataca
     2641 atattaccat tcttctatgg aaagaaaact tttgatgatg aaacaataaa gattttaaat
     2701 atctatttta gtttgtgggt gtttttgaaa tgaaaatata tggcacactt tcattctgaa
     2761 gtgcattaac attctaataa ggtgatgtaa agcaagatga cattggtgta atgttagagt
     2821 tgcagaagtt tccattccaa aataaaatgg aaaccatagt tacagatatt acaatgcagc
     2881 cctgtaattt tgagctgtag taaaaggatt ggtaatctgg gaagtagaat ttttacaaaa
     2941 tcttttacaa aaatagtcat aaaaggtttt gttgacattt aagactacta ctgatctaaa
     3001 ggcaaggtcc tacttcttaa attttcagaa catttttatg acttcttatt atgtatttat
     3061 taccactcat tattatagca tgttactttt tgcaaacatt ttaaacaaaa aatatttctg
     3121 tttggtacac tgtgaagaga gaaaagtact gttctgtatt ttc
//
