LOCUS       NM_002303               8211 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens leptin receptor (LEPR), transcript variant 1, mRNA.
ACCESSION   NM_002303
VERSION     NM_002303.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8211)
  AUTHORS   Navari,M., Zarei,F., Sayedsalehi,S., Mahmoudi,T., Rostami,M.,
            Mahban,A., Rezamand,G., Asadi,A., Dabiri,R., Nobakht,H.,
            Farahani,H., Tabaeian,S.P. and Zali,M.R.
  TITLE     The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism
            may be an independent risk factor for nonalcoholic fatty liver
            disease
  JOURNAL   Lab Med 55 (5), 590-594 (2024)
   PUBMED   38522074
  REMARK    GeneRIF: The Arg/Arg genotype of leptin receptor gene Gln223Arg
            polymorphism may be an independent risk factor for nonalcoholic
            fatty liver disease.
REFERENCE   2  (bases 1 to 8211)
  AUTHORS   Feinkohl,I., Janke,J., Slooter,A.J.C., Winterer,G., Spies,C. and
            Pischon,T.
  TITLE     The Association of Plasma Leptin, Soluble Leptin Receptor and Total
            and High-Molecular Weight Adiponectin With the Risk of
            Perioperative Neurocognitive Disorders
  JOURNAL   Am J Geriatr Psychiatry 32 (9), 1119-1129 (2024)
   PUBMED   38637191
  REMARK    GeneRIF: The Association of Plasma Leptin, Soluble Leptin Receptor
            and Total and High-Molecular Weight Adiponectin With the Risk of
            Perioperative Neurocognitive Disorders.
REFERENCE   3  (bases 1 to 8211)
  AUTHORS   Klimont,A., Rucinski,M., Sawicka-Gutaj,N., Szyszka,M.,
            Blatkiewicz,M., Wierzbicki,T., Karczewski,M., Janicka-Jedynska,M.,
            Ruchala,M. and Komarowska,H.
  TITLE     Role of Different Variants of Leptin Receptor in Human Adrenal
            Tumor Types
  JOURNAL   Int J Mol Sci 25 (16), 8682 (2024)
   PUBMED   39201370
  REMARK    GeneRIF: Role of Different Variants of Leptin Receptor in Human
            Adrenal Tumor Types.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8211)
  AUTHORS   Jimenez-Cortegana,C., Lopez-Enriquez,S., Alba,G., Santa-Maria,C.,
            Martin-Nunez,G.M., Moreno-Ruiz,F.J., Valdes,S., Garcia-Serrano,S.,
            Rodriguez-Diaz,C., Ho-Plagaro,A., Fontalba-Romero,M.I.,
            Garcia-Fuentes,E., Garrido-Sanchez,L. and Sanchez-Margalet,V.
  TITLE     The Expression of Genes Related to Reverse Cholesterol Transport
            and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells
            Are Decreased in Morbid Obesity and Related to Liver Function
  JOURNAL   Int J Mol Sci 25 (14), 7549 (2024)
   PUBMED   39062791
  REMARK    GeneRIF: The Expression of Genes Related to Reverse Cholesterol
            Transport and Leptin Receptor Pathways in Peripheral Blood
            Mononuclear Cells Are Decreased in Morbid Obesity and Related to
            Liver Function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8211)
  AUTHORS   Hu,W.Q., Zhou,W.G., Zhou,G.W., Liao,J.X., Shi,J.X., Xie,F.,
            Li,S.H., Wang,Y., Feng,X.H., Gu,X.L. and Chen,B.F.
  TITLE     A Comprehensive Study of the Association between LEPR Gene
            rs1137101 Variant and Risk of Digestive System Cancers
  JOURNAL   Biomed Environ Sci 37 (5), 445-456 (2024)
   PUBMED   38843918
  REMARK    GeneRIF: A Comprehensive Study of the Association between LEPR Gene
            rs1137101 Variant and Risk of Digestive System Cancers.
REFERENCE   6  (bases 1 to 8211)
  AUTHORS   Considine,R.V., Considine,E.L., Williams,C.J., Hyde,T.M. and
            Caro,J.F.
  TITLE     The hypothalamic leptin receptor in humans: identification of
            incidental sequence polymorphisms and absence of the db/db mouse
            and fa/fa rat mutations
  JOURNAL   Diabetes 45 (7), 992-994 (1996)
   PUBMED   8666155
REFERENCE   7  (bases 1 to 8211)
  AUTHORS   Chung,W.K., Power-Kehoe,L., Chua,M. and Leibel,R.L.
  TITLE     Mapping of the OB receptor to 1p in a region of nonconserved gene
            order from mouse and rat to human
  JOURNAL   Genome Res 6 (5), 431-438 (1996)
   PUBMED   8743992
REFERENCE   8  (bases 1 to 8211)
  AUTHORS   Cioffi,J.A., Shafer,A.W., Zupancic,T.J., Smith-Gbur,J., Mikhail,A.,
            Platika,D. and Snodgrass,H.R.
  TITLE     Novel B219/OB receptor isoforms: possible role of leptin in
            hematopoiesis and reproduction
  JOURNAL   Nat Med 2 (5), 585-589 (1996)
   PUBMED   8616721
REFERENCE   9  (bases 1 to 8211)
  AUTHORS   Chen,H., Charlat,O., Tartaglia,L.A., Woolf,E.A., Weng,X.,
            Ellis,S.J., Lakey,N.D., Culpepper,J., Moore,K.J., Breitbart,R.E.,
            Duyk,G.M., Tepper,R.I. and Morgenstern,J.P.
  TITLE     Evidence that the diabetes gene encodes the leptin receptor:
            identification of a mutation in the leptin receptor gene in db/db
            mice
  JOURNAL   Cell 84 (3), 491-495 (1996)
   PUBMED   8608603
REFERENCE   10 (bases 1 to 8211)
  AUTHORS   Tartaglia,L.A., Dembski,M., Weng,X., Deng,N., Culpepper,J.,
            Devos,R., Richards,G.J., Campfield,L.A., Clark,F.T., Deeds,J.,
            Muir,C., Sanker,S., Moriarty,A., Moore,K.J., Smutko,J.S.,
            Mays,G.G., Wool,E.A., Monroe,C.A. and Tepper,R.I.
  TITLE     Identification and expression cloning of a leptin receptor, OB-R
  JOURNAL   Cell 83 (7), 1263-1271 (1995)
   PUBMED   8548812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U43168.1, U66497.1 and
            AC097063.2.
            
            On Nov 21, 2019 this sequence version replaced NM_002303.5.
            
            Summary: The protein encoded by this gene belongs to the gp130
            family of cytokine receptors that are known to stimulate gene
            transcription via activation of cytosolic STAT proteins. This
            protein is a receptor for leptin (an adipocyte-specific hormone
            that regulates body weight), and is involved in the regulation of
            fat metabolism, as well as in a novel hematopoietic pathway that is
            required for normal lymphopoiesis. Mutations in this gene have been
            associated with obesity and pituitary dysfunction. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. It is noteworthy that this gene and LEPROT
            gene (GeneID:54741) share the same promoter and the first 2 exons,
            however, encode distinct proteins (PMID:9207021).[provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U43168.1, SRR1803613.250098.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349533.11/ ENSP00000330393.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                U43168.1           25-97
            74-4145             U66497.1           31-4102
            4146-8211           AC097063.2         124709-128774
FEATURES             Location/Qualifiers
     source          1..8211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..8211
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="leptin receptor"
                     /db_xref="GeneID:3953"
                     /db_xref="HGNC:HGNC:6554"
                     /db_xref="MIM:601007"
     exon            1..73
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            74..149
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            150..209
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3667
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; OB receptor; huB219"
                     /codon_start=1
                     /product="leptin receptor isoform 1 precursor"
                     /protein_id="NP_002294.2"
                     /db_xref="CCDS:CCDS631.1"
                     /db_xref="GeneID:3953"
                     /db_xref="HGNC:HGNC:6554"
                     /db_xref="MIM:601007"
                     /translation="MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTY
                     DYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLC
                     ADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVH
                     LLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSG
                     GVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSEN
                     STTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVI
                     YFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVT
                     FFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWS
                     TSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSG
                     YTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPEN
                     NLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSN
                     WSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVIN
                     HHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI
                     VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIH
                     DHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILL
                     LGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLE
                     PETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEV
                     TYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWE
                     IEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKR
                     ESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFASYMPQFQ
                     TCSTQTHKIMENKMCDLTV"
     exon            210..539
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            540..663
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            664..872
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1018
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1163
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1454
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1572
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1772
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1921
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2081
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2164
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2381
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2564
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2660
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2766
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2842
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..8211
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3750..3755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="hexamer: AAGAAA"
     regulatory      3773..3778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="hexamer: AATAAT"
     polyA_site      3787
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="major polyA site"
     polyA_site      3791
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="major polyA site"
     regulatory      8193..8198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
                     /note="hexamer: AATAAA"
     polyA_site      8211
                     /gene="LEPR"
                     /gene_synonym="CD295; LEP-R; LEPRD; OB-R; OBR"
ORIGIN      
        1 aggctgcccg ggccgtggca ggaagccgga agcagccgcg gccccagttc gggagacatg
       61 gcgggcgtta aagctctcgt ggcattatcc ttcagtgggg ctattggact gacttttctt
      121 atgctgggat gtgccttaga ggattatggg tgtacttctc tgaagtaaga tgatttgtca
      181 aaaattctgt gtggttttgt tacattggga atttatttat gtgataactg cgtttaactt
      241 gtcatatcca attactcctt ggagatttaa gttgtcttgc atgccaccaa attcaaccta
      301 tgactacttc cttttgcctg ctggactctc aaagaatact tcaaattcga atggacatta
      361 tgagacagct gttgaaccta agtttaattc aagtggtact cacttttcta acttatccaa
      421 aacaactttc cactgttgct ttcggagtga gcaagataga aactgctcct tatgtgcaga
      481 caacattgaa ggaaagacat ttgtttcaac agtaaattct ttagtttttc aacaaataga
      541 tgcaaactgg aacatacagt gctggctaaa aggagactta aaattattca tctgttatgt
      601 ggagtcatta tttaagaatc tattcaggaa ttataactat aaggtccatc ttttatatgt
      661 tctgcctgaa gtgttagaag attcacctct ggttccccaa aaaggcagtt ttcagatggt
      721 tcactgcaat tgcagtgttc atgaatgttg tgaatgtctt gtgcctgtgc caacagccaa
      781 actcaacgac actctcctta tgtgtttgaa aatcacatct ggtggagtaa ttttccagtc
      841 acctctaatg tcagttcagc ccataaatat ggtgaagcct gatccaccat taggtttgca
      901 tatggaaatc acagatgatg gtaatttaaa gatttcttgg tccagcccac cattggtacc
      961 atttccactt caatatcaag tgaaatattc agagaattct acaacagtta tcagagaagc
     1021 tgacaagatt gtctcagcta catccctgct agtagacagt atacttcctg ggtcttcgta
     1081 tgaggttcag gtgaggggca agagactgga tggcccagga atctggagtg actggagtac
     1141 tcctcgtgtc tttaccacac aagatgtcat atactttcca cctaaaattc tgacaagtgt
     1201 tgggtctaat gtttcttttc actgcatcta taagaaggaa aacaagattg ttccctcaaa
     1261 agagattgtt tggtggatga atttagctga gaaaattcct caaagccagt atgatgttgt
     1321 gagtgatcat gttagcaaag ttactttttt caatctgaat gaaaccaaac ctcgaggaaa
     1381 gtttacctat gatgcagtgt actgctgcaa tgaacatgaa tgccatcatc gctatgctga
     1441 attatatgtg attgatgtca atatcaatat ctcatgtgaa actgatgggt acttaactaa
     1501 aatgacttgc agatggtcaa ccagtacaat ccagtcactt gcggaaagca ctttgcaatt
     1561 gaggtatcat aggagcagcc tttactgttc tgatattcca tctattcatc ccatatctga
     1621 gcccaaagat tgctatttgc agagtgatgg tttttatgaa tgcattttcc agccaatctt
     1681 cctattatct ggctacacaa tgtggattag gatcaatcac tctctaggtt cacttgactc
     1741 tccaccaaca tgtgtccttc ctgattctgt ggtgaagcca ctgcctccat ccagtgtgaa
     1801 agcagaaatt actataaaca ttggattatt gaaaatatct tgggaaaagc cagtctttcc
     1861 agagaataac cttcaattcc agattcgcta tggtttaagt ggaaaagaag tacaatggaa
     1921 gatgtatgag gtttatgatg caaaatcaaa atctgtcagt ctcccagttc cagacttgtg
     1981 tgcagtctat gctgttcagg tgcgctgtaa gaggctagat ggactgggat attggagtaa
     2041 ttggagcaat ccagcctaca cagttgtcat ggatataaaa gttcctatga gaggacctga
     2101 attttggaga ataattaatg gagatactat gaaaaaggag aaaaatgtca ctttactttg
     2161 gaagcccctg atgaaaaatg actcattgtg cagtgttcag agatatgtga taaaccatca
     2221 tacttcctgc aatggaacat ggtcagaaga tgtgggaaat cacacgaaat tcactttcct
     2281 gtggacagag caagcacata ctgttacggt tctggccatc aattcaattg gtgcttctgt
     2341 tgcaaatttt aatttaacct tttcatggcc tatgagcaaa gtaaatatcg tgcagtcact
     2401 cagtgcttat cctttaaaca gcagttgtgt gattgtttcc tggatactat cacccagtga
     2461 ttacaagcta atgtatttta ttattgagtg gaaaaatctt aatgaagatg gtgaaataaa
     2521 atggcttaga atctcttcat ctgttaagaa gtattatatc catgatcatt ttatccccat
     2581 tgagaagtac cagttcagtc tttacccaat atttatggaa ggagtgggaa aaccaaagat
     2641 aattaatagt ttcactcaag atgatattga aaaacaccag agtgatgcag gtttatatgt
     2701 aattgtgcca gtaattattt cctcttccat cttattgctt ggaacattat taatatcaca
     2761 ccaaagaatg aaaaagctat tttgggaaga tgttccgaac cccaagaatt gttcctgggc
     2821 acaaggactt aattttcaga agccagaaac gtttgagcat ctttttatca agcatacagc
     2881 atcagtgaca tgtggtcctc ttcttttgga gcctgaaaca atttcagaag atatcagtgt
     2941 tgatacatca tggaaaaata aagatgagat gatgccaaca actgtggtct ctctactttc
     3001 aacaacagat cttgaaaagg gttctgtttg tattagtgac cagttcaaca gtgttaactt
     3061 ctctgaggct gagggtactg aggtaaccta tgaggacgaa agccagagac aaccctttgt
     3121 taaatacgcc acgctgatca gcaactctaa accaagtgaa actggtgaag aacaagggct
     3181 tataaatagt tcagtcacca agtgcttctc tagcaaaaat tctccgttga aggattcttt
     3241 ctctaatagc tcatgggaga tagaggccca ggcatttttt atattatcag atcagcatcc
     3301 caacataatt tcaccacacc tcacattctc agaaggattg gatgaacttt tgaaattgga
     3361 gggaaatttc cctgaagaaa ataatgataa aaagtctatc tattatttag gggtcacctc
     3421 aatcaaaaag agagagagtg gtgtgctttt gactgacaag tcaagggtat cgtgcccatt
     3481 cccagccccc tgtttattca cggacatcag agttctccag gacagttgct cacactttgt
     3541 agaaaataat atcaacttag gaacttctag taagaagact tttgcatctt acatgcctca
     3601 attccaaact tgttctactc agactcataa gatcatggaa aacaagatgt gtgacctaac
     3661 tgtgtaattt cactgaagaa accttcagat ttgtgttata atgggtaata taaagtgtaa
     3721 tagattatag ttgtgggtgg gagagagaaa agaaaccaga gtcaaatttg aaaataattg
     3781 ttccaaatga atgttgtctg tttgttctct cttagtaaca tagacaaaaa atttgagaaa
     3841 gccttcataa gcctaccaat gtagacacgc tcttctattt tattcccaag ctctagtggg
     3901 aaggtccctt gtttccagct agaaataagc ccaacagaca ccatcttttg tgagatgtaa
     3961 ttgttttttc agagggcgtg ttgttttacc tcaagttttt gttttgtacc aacacacaca
     4021 cacacacaca ttcttaacac atgtccttgt gtgttttgag agtatattat gtatttatat
     4081 tttgtgctat cagactgtag gatttgaagt aggactttcc taaatgttta agataaacag
     4141 aattcagccc tggcctaagg ggttatactt gtgaagacta atgagccaat tgttatgtac
     4201 caaatctaag atatgtacca tagaatgaaa taacctgcaa gaatggtgat gcccacaatc
     4261 agtattttga tgacaacaca agcacttttg aaaacataat gtcagtttta attcttctct
     4321 ctgaaagatg ttgaagtggt cactttctga taaagttaga ttgccaaatg tcactgtata
     4381 tctctccgga ataattgtct tcccccatcc ccacctggac atatcctatt ttttcccctc
     4441 actgagcatt ctgtctacat aaaccaacca ctgtgcagta ctttacatac cttaacccag
     4501 ttaattattg aaataattgt atgagacatc tgttactatg atactcctta aagatgaaga
     4561 cagtaaataa tttgcccaca gttacagtca gtgggtgatg gaatcagagt tcagatttaa
     4621 atccagattt tttaatgcta atgattatgt ttttaaccta taccctacat agccatcaat
     4681 ttaaaaaaac tgacttgtaa tcaaaattta ttaagtagag gctggcacag tggtgcatgc
     4741 ctgtaatccc agcactttgg gaggctgagg cgggtggatc gcttgagctc agaagtcttg
     4801 aaactagccg gggcaacata gtgaggcctc gtctctacaa aaaacacaaa aattagctga
     4861 gtgtgacaga aaaaataaag attataaaat gtattaagta gaagtataat gctggatgag
     4921 aaattaagtg agaattgcac agatctcatg tttgccttta acaacttaag attaatacat
     4981 aagtttatta tttattcaac ttttggtacg gtaaaaaaat tcaaagacag catattgggc
     5041 aacaaactaa attaagaaac ctgcacattt ggatgttcag tggcaagaag accttcaaga
     5101 atatcagtat catcaaaata agtactttag tgttcaaaaa tatgcctatg ggtttttaaa
     5161 aattatcaga atttcatatt tagaccgaga caagagactc ccaattttac tgttatccta
     5221 aataaatctc tacattccat ctctagtcca gttgtggcta tgaagtgagc agttctaaac
     5281 aatgacaaag attccagacc ccacttgata gatatttttc acactttata atcaatttcc
     5341 actcaggaat caataaagtt attccatgtc ataagtattt ttaagatgtc tcaggatctc
     5401 acatactcaa ctaatgaccc ccttacaaga aataggtaaa gggctgatag caactcatta
     5461 cttgatgtgg tacgagagcc ttagttctat gcaaagataa atggagaagc gtttttttca
     5521 tggataattt tacatggctt tagagacaca gaaacagata aattattaca tgtataaaaa
     5581 ttttagtaaa attgacattt taaatacatg cttatagatt attggtattt aattgaaggt
     5641 acagtacaga agagatagaa aaataaattt tgccccactc tgaaattgaa gactgacctc
     5701 tgagcatgtc cgctgagaca cagtattctc ctgtgatctg ggacccagaa taacaggaaa
     5761 gagaaactga tagatgtttt catcagccca aggatgtatg tatcttactt gagtgaattc
     5821 aacagtccca ggaccactgt agtgctgtag gtctgtgtaa agaaatgtag tgacagcaca
     5881 ttaacctgag atcattgata ccatcttggt tcagcctcag ttccccagat aagtgaacaa
     5941 atgaacaaaa atgcacttca gaaatattga aattccaagg cactatttca tggacagtgc
     6001 tgaacaagta tagtttggcc tattggtatg tatagactta gatcatattt attgtcaatg
     6061 ggcttgaatt ctgatttcca cttttgaaag tttatttcac tatgtatcat tacattttat
     6121 tgggaccttg tgaaaactac ctgccatgaa atactggatt ttcacataat ttagaaaaaa
     6181 tttagaatgt tttatgcctc agaatggtca ggaacttccc atttcttccc acagcttcta
     6241 taaaaaaaat ttaaaaggaa ggaggagctg aaataggggc tatggtcttt taaacttata
     6301 aatctggaat ttttaatatt tcattttaag gccttaaacc gaaacacaag ctactaatca
     6361 gtctttctaa atctgacctt cattgaaagc aactcagaaa ttaataattt gtgctgtggc
     6421 ttcaagttta aatagattgt ttgaagagaa atcatatgtc agggtttgca ggattacagg
     6481 atttctaact taaaccccca agaacaatga aaaagttgac gtacatgtca ctatgaatag
     6541 gcaccttctg ttggatctct gtgtccattt agagatgagc tacaagttga caagaaaaat
     6601 aggagcagtt ttttttttct ttttaaacct agtcaccaaa tggtaaaagg acttggatga
     6661 aattccaata ccagtgtgag attctggatt tagaataagg ttttataacc ttaggcatgt
     6721 cattcttcta cttctcattt ttccctaata aaacttattc tctcttccat aatatcatat
     6781 atatggtcac attacttcag gaatatttat attacctcct ccaaaactga aagaaaataa
     6841 actttaggct gtaagagttg agaattatgc atacagggct cacaggcgga gttggacaat
     6901 atgctgatgg atcaagacat actgcaacca caaagttcca tctcacttag atgtggatga
     6961 aaaaagatct cttgctaaat tattttctgt gaccttaaaa gaaatttgtt tcacttttca
     7021 tctttcaagg gtcatcttga tagttacctt aacaaacctt tctcagctat ttattattga
     7081 gaaagcccat tcttaaattt taagtcacaa aattatagtt gtccactcta ctatgactga
     7141 aagaagcagc attcaagaaa aaatttaaac atagttacca agaaatgtga agaagtattt
     7201 ataaaaggaa gctacataag taggtaattt tactctttct taaccagttt aaaacagtaa
     7261 agcacacctg catctaatca caatgttagg cgaacaactt aaaacatgat cagcctgtat
     7321 gagaactggg atattgttac atattcagcc tgtatgagaa ctgggatatt gttgttacat
     7381 gtatttgtat aaacattagg agatgatttc catggctttt tttttttttt ttttaggaag
     7441 tcttgctctg ttgcccagct ggagtgcagt gatgtgatct cggctcactg caacccctgc
     7501 ttcccaggtt caagcgattc tcctgcctca gcctccccag tagctgggat tacgggcaca
     7561 ccaccatgcc cagcttttat ttatttattt atttattttg gatttttagt agagatgggg
     7621 ttttgccctg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc gccctcattg
     7681 gcctcccaaa gttctgggat tacaggtgtg agagctgccg cgcctagccc ttcatgaggt
     7741 tttatagtga atgaattatt tttctataaa gtttatcaat atttattttg gaaagctgct
     7801 gaaaatgtct ttttcaaaat taattatgct taagatgtat ggcattaaat tcaattttat
     7861 gaggctttct gacatattta ctaaaaaaac ctggaactga gactgaattt ggaagacatt
     7921 taattttgta gtgagatatc tatattgtag atattgtact tttaaaacct gtcattaagt
     7981 gtttggcatg tggttaatac tttctcttta gtcacaactg gtattttaat aaatgttata
     8041 aacgtaagtg ccaagatatg catcactaac tgttctatga aatttgtcta cttctccttt
     8101 atgttcccaa agtcacagag aaagcagtgt actttatgac agtatattta tctttttatc
     8161 attatgaatt ataagcagtg ttaattttga gaaataaaag tccaaaaaga a
//
