LOCUS       NM_138792               2165 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component
            (LEO1), transcript variant 1, mRNA.
ACCESSION   NM_138792
VERSION     NM_138792.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Laurent,M., Cordeddu,L., Zahedi,Y. and Ekwall,K.
  TITLE     LEO1 Is Required for Efficient Entry into Quiescence, Control of
            H3K9 Methylation and Gene Expression in Human Fibroblasts
  JOURNAL   Biomolecules 13 (11), 1662 (2023)
   PUBMED   38002344
  REMARK    GeneRIF: LEO1 Is Required for Efficient Entry into Quiescence,
            Control of H3K9 Methylation and Gene Expression in Human
            Fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Qiu,M., Yin,Z., Wang,H., Lei,L., Li,C., Cui,Y., Dai,R., Yang,P.,
            Xiang,Y., Li,Q., Lv,J., Hu,Z., Chen,M., Zhou,H.B., Fang,P., Xiao,R.
            and Liang,K.
  TITLE     CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation
            for processive transcription elongation
  JOURNAL   Sci Adv 9 (20), eadf8698 (2023)
   PUBMED   37205756
  REMARK    GeneRIF: CDK12 and Integrator-PP2A complex modulates LEO1
            phosphorylation for processive transcription elongation.
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Tiwari,V., Kulikowicz,T., Wilson,D.M. 3rd and Bohr,V.A.
  TITLE     LEO1 is a partner for Cockayne syndrome protein B (CSB) in response
            to transcription-blocking DNA damage
  JOURNAL   Nucleic Acids Res 49 (11), 6331-6346 (2021)
   PUBMED   34096589
  REMARK    GeneRIF: LEO1 is a partner for Cockayne syndrome protein B (CSB) in
            response to transcription-blocking DNA damage.
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2165)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   7  (bases 1 to 2165)
  AUTHORS   Zhu,B., Mandal,S.S., Pham,A.D., Zheng,Y., Erdjument-Bromage,H.,
            Batra,S.K., Tempst,P. and Reinberg,D.
  TITLE     The human PAF complex coordinates transcription with events
            downstream of RNA synthesis
  JOURNAL   Genes Dev 19 (14), 1668-1673 (2005)
   PUBMED   16024656
REFERENCE   8  (bases 1 to 2165)
  AUTHORS   Yart,A., Gstaiger,M., Wirbelauer,C., Pecnik,M., Anastasiou,D.,
            Hess,D. and Krek,W.
  TITLE     The HRPT2 tumor suppressor gene product parafibromin associates
            with human PAF1 and RNA polymerase II
  JOURNAL   Mol Cell Biol 25 (12), 5052-5060 (2005)
   PUBMED   15923622
REFERENCE   9  (bases 1 to 2165)
  AUTHORS   Zhao,L., Tong,T. and Zhang,Z.
  TITLE     Expression of the Leo1-like domain of replicative senescence
            down-regulated Leo1-like (RDL) protein promotes senescence of 2BS
            fibroblasts
  JOURNAL   FASEB J 19 (6), 521-532 (2005)
   PUBMED   15791002
REFERENCE   10 (bases 1 to 2165)
  AUTHORS   Rozenblatt-Rosen,O., Hughes,C.M., Nannepaga,S.J., Shanmugam,K.S.,
            Copeland,T.D., Guszczynski,T., Resau,J.H. and Meyerson,M.
  TITLE     The parafibromin tumor suppressor protein is part of a human Paf1
            complex
  JOURNAL   Mol Cell Biol 25 (2), 612-620 (2005)
   PUBMED   15632063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090971.3 and BC018147.2.
            
            On Nov 23, 2018 this sequence version replaced NM_138792.3.
            
            Summary: LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366),
            and PAF1 (MIM 610506) form the PAF protein complex that associates
            with the RNA polymerase II subunit POLR2A (MIM 180660) and with a
            histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
            [PubMed 15632063]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY302186.1, SRR1660807.83920.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299601.10/ ENSP00000299601.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC090971.3         177530-177546       c
            18-2165             BC018147.2         1-2148
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..2165
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /note="LEO1 homolog, Paf1/RNA polymerase II complex
                     component"
                     /db_xref="GeneID:123169"
                     /db_xref="HGNC:HGNC:30401"
                     /db_xref="MIM:610507"
     exon            1..91
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2034
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     polymerase-associated protein LEO1; replicative senescence
                     down-regulated leo1-like protein; Leo1, Paf1/RNA
                     polymerase II complex component, homolog; Leo1 Paf1/RNA
                     polymerase II complex component"
                     /codon_start=1
                     /product="RNA polymerase-associated protein LEO1 isoform
                     1"
                     /protein_id="NP_620147.1"
                     /db_xref="CCDS:CCDS10146.1"
                     /db_xref="GeneID:123169"
                     /db_xref="HGNC:HGNC:30401"
                     /db_xref="MIM:610507"
                     /translation="MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSE
                     SDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPS
                     DVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQ
                     NSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPV
                     ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARG
                     SDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTP
                     GQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQ
                     YYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSL
                     HLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSL
                     ADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLS
                     ASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLK
                     AKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD"
     exon            92..847
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            848..952
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1047
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1193
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1278
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1373
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1508
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1644
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1831
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1929
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2165
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /note="hexamer: AATAAA"
     polyA_site      2165
                     /gene="LEO1"
                     /gene_synonym="RDL"
                     /note="major polyA site"
ORIGIN      
        1 ccctaaccga ggcagcagcg gacgtgagcg ataatggcgg atatggagga tctcttcggg
       61 agcgacgccg acagcgaagc tgagcgtaaa gattctgatt ctggatctga ctcagattct
      121 gatcaagaga atgctgcctc tggcagtaat gcctctggaa gtgaaagtga tcaggatgaa
      181 agaggtgatt caggacaacc aagtaataag gaactgtttg gagatgacag tgaggacgag
      241 ggagcttcac atcatagtgg tagtgataat cactctgaaa gatcagacaa tagatcagaa
      301 gcttctgagc gttctgacca tgaggacaat gacccctcag atgtagatca gcacagtgga
      361 tcagaagccc ctaatgatga tgaagacgaa ggtcatagat cggatggagg gagccatcat
      421 tcagaagcag aaggttctga aaaagcacat tcagatgatg aaaaatgggg cagagaagat
      481 aaaagtgacc agtcagatga tgaaaagata caaaattctg atgatgagga gagggcacaa
      541 ggatctgatg aagataagct gcagaattct gacgatgatg agaaaatgca gaacacagat
      601 gatgaggaga ggcctcagct ttccgatgat gagagacaac agctatctga ggaggaaaag
      661 gctaattctg atgatgaacg gccggtagct tctgataatg atgatgagaa acagaattct
      721 gatgatgaag aacaaccaca gctgtctgat gaagagaaaa tgcaaaattc tgatgatgaa
      781 aggccacagg cctcagatga agaacacagg cattcagatg atgaagagga acaggatcat
      841 aaatcagaat ctgcaagagg cagtgatagt gaagatgaag ttttacgaat gaaacgcaag
      901 aatgcgattg catctgattc agaagcggat agtgacactg aggtgccaaa agataatagt
      961 ggaaccatgg atttatttgg aggtgcagat gatatctctt cagggagtga tggagaagac
     1021 aaaccaccta ctccaggaca gcctgttgat gaaaatggat tgcctcagga tcaacaggaa
     1081 gaggagccaa ttcctgagac cagaatagaa gtagaaatac ccaaagtaaa cactgattta
     1141 ggaaacgact tatattttgt taaactgccc aactttctca gtgtagagcc cagacctttt
     1201 gatcctcagt attatgaaga tgaatttgaa gatgaagaaa tgctggatga agaaggtaga
     1261 accaggttaa aattaaaggt agaaaatact ataagatgga ggatacgccg agatgaagaa
     1321 ggaaatgaaa ttaaagaaag caatgctcgg atagtcaagt ggtcagatgg aagcatgtcc
     1381 ctgcatttag gcaatgaagt gtttgatgtg tacaaagccc cactgcaggg cgaccacaat
     1441 catcttttta taagacaagg tactggtcta cagggacaag cagtctttaa aacgaaactc
     1501 accttcagac ctcactctac ggacagtgcc acacatagaa agatgactct gtcacttgca
     1561 gataggtgtt caaagacaca gaagattaga atcttgccaa tggctggtcg tgatcctgaa
     1621 tgccaacgca cagaaatgat taagaaagaa gaagaacgtt tgagggcttc catacgtagg
     1681 gaatctcagc agcgccgaat gagagagaaa cagcaccagc gggggctgag cgccagttac
     1741 ctggaacctg atcgatacga tgaggaggag gaaggcgagg agtccatcag cttggctgcc
     1801 attaaaaacc gatataaagg gggcattcga gaggaacgag ccagaatcta ttcatcagac
     1861 agtgatgagg gatcagaaga agataaagct caaagattac tcaaagcaaa gaaacttacc
     1921 agtgatgagg aaggtgaacc ttccggaaag agaaaagcag aagatgatga taaagcaaat
     1981 aaaaagcata agaagtatgt gatcagcgat gaagaggaag aagatgatga ttgaagtatg
     2041 aaatatgaaa acattttata tattttattg tacagttata aatatgtaaa catgagttat
     2101 tttgattgaa atgaatcgat ttgcttttgt gtaattttaa ttgtaataaa acaatttaaa
     2161 agcaa
//
