LOCUS       NM_052925               3658 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens leukocyte receptor cluster member 8 (LENG8),
            transcript variant 3, mRNA.
ACCESSION   NM_052925
VERSION     NM_052925.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3658)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3658)
  AUTHORS   Dou,Y., Kalmykova,S., Pashkova,M., Oghbaie,M., Jiang,H.,
            Molloy,K.R., Chait,B.T., Rout,M.P., Fenyo,D., Jensen,T.H.,
            Altukhov,I. and LaCava,J.
  TITLE     Affinity proteomic dissection of the human nuclear cap-binding
            complex interactome
  JOURNAL   Nucleic Acids Res 48 (18), 10456-10469 (2020)
   PUBMED   32960270
REFERENCE   3  (bases 1 to 3658)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3658)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3658)
  AUTHORS   Farias,T.D.J., Augusto,D.G., de Almeida,R.C., Malheiros,D. and
            Petzl-Erler,M.L.
  TITLE     Screening the full leucocyte receptor complex genomic region
            revealed associations with pemphigus that might be explained by
            gene regulation
  JOURNAL   Immunology 156 (1), 86-93 (2019)
   PUBMED   30216441
  REMARK    GeneRIF: genetic polymorphism is associated with pemphigus
            foliaceus
REFERENCE   6  (bases 1 to 3658)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   7  (bases 1 to 3658)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 3658)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
REFERENCE   9  (bases 1 to 3658)
  AUTHORS   Wende,H., Volz,A. and Ziegler,A.
  TITLE     Extensive gene duplications and a large inversion characterize the
            human leukocyte receptor cluster
  JOURNAL   Immunogenetics 51 (8-9), 703-713 (2000)
   PUBMED   10941842
  REMARK    Erratum:[Immunogenetics 2001;52(3-4):308]
REFERENCE   10 (bases 1 to 3658)
  AUTHORS   Abbott,W.M., Mellor,A., Edwards,Y. and Feizi,T.
  TITLE     Soluble bovine galactose-binding lectin. cDNA cloning reveals the
            complete amino acid sequence and an antigenic relationship with the
            major encephalitogenic domain of myelin basic protein
  JOURNAL   Biochem J 259 (1), 283-290 (1989)
   PUBMED   2470348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY032958.1 and BC028048.1.
            
            On Jun 2, 2019 this sequence version replaced NM_052925.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028048.1, SRR11853560.15263.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326764.10/ ENSP00000318374.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                HY032958.1         38-61
            25-3658             BC028048.1         13-3646
FEATURES             Location/Qualifiers
     source          1..3658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3658
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /note="leukocyte receptor cluster member 8"
                     /db_xref="GeneID:114823"
                     /db_xref="HGNC:HGNC:15500"
                     /db_xref="MIM:616575"
     exon            1..112
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            113..205
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2570
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /note="isoform 3 is encoded by transcript variant 3;
                     leukocyte receptor cluster (LRC) member 8"
                     /codon_start=1
                     /product="leukocyte receptor cluster member 8 isoform 3"
                     /protein_id="NP_443157.1"
                     /db_xref="CCDS:CCDS12894.1"
                     /db_xref="GeneID:114823"
                     /db_xref="HGNC:HGNC:15500"
                     /db_xref="MIM:616575"
                     /translation="MAANVGDQRSTDWSSQYSMVAGAGRENGMETPMHENPEWEKARQ
                     ALASISKSGAAGGSAKSSSNGPVASAQYVSQAEASALQQQQYYQWYQQYNYAYPYSYY
                     YPMSMYQSYGSPSQYGMAGSYGSATPQQPSAPQHQGTLNQPPVPGMDESMSYQAPPQQ
                     LPSAQPPQPSNPPHGAHTLNSGPQPGTAPATQHSQAGPATGQAYGPHTYTEPAKPKKG
                     QQLWNRMKPAPGTGGLKFNIQKRPFAVTTQSFGSNAEGQHSGFGPQPNPEKVQNHSGS
                     SARGNLSGKPDDWPQDMKEYVERCFTACESEEDKDRTEKLLKEVLQARLQDGSAYTID
                     WSREPLPGLTREPVAESPKKKRWEAASSLHPPRGAGSATRGGGAPSQRGTPGAGGAGR
                     ARGNSFTKFGNRNVFMKDNSSSSSTDSRSRSSSRSPTRHFRRSDSHSDSDSSYSGNEC
                     HPVGRRNPPPKGRGGRGAHMDRGRGRAQRGKRHDLAPTKRSRKKMAALECEDPERELK
                     KQKRAARFQHGHSRRLRLEPLVLQMSSLESSGADPDWQELQIVGTCPDITKHYLRLTC
                     APDPSTVRPVAVLKKSLCMVKCHWKEKQDYAFACEQMKSIRQDLTVQGIRTEFTVEVY
                     ETHARIALEKGDHEEFNQCQTQLKSLYAENLPGNVGEFTAYRILYYIFTKNSGDITTE
                     LAYLTRELKADPCVAHALALRTAWALGNYHRFFRLYCHAPCMSGYLVDKFADRERKVA
                     LKAMIKTFRPALPVSYLQAELAFEGEAACRAFLEPLGLAYTGPDNSSIDCRLSLAQLS
                     AF"
     exon            206..380
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            381..482
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            483..593
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            594..846
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            847..988
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1192
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1471
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1612
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1898
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2000
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2069
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2199
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2407
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..3658
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /note="hexamer: ATTAAA"
     polyA_site      3658
                     /gene="LENG8"
                     /gene_synonym="pp13842"
                     /note="major polyA site"
ORIGIN      
        1 cgtcgaagcc aaagaagacc agagccagcc gggtggcaca gcggtgtcgt ggccgtgttg
       61 ctgatcgcct gggtggttgt tggcgtgtcc ctgcagcgaa ggatcctggt tgacagtgaa
      121 aaagcagtct ggctcccgag gtccacccct tataccccaa ggtccagatg gcggccaacg
      181 tgggtgatca acgtagcaca gattggtctt ctcagtacag catggtggct ggggcaggcc
      241 gagagaatgg catggagacg ccgatgcacg agaacccgga gtgggagaag gcccgtcagg
      301 ccctggccag catcagcaag tcaggagctg ccggcggctc tgccaagtcc agcagcaatg
      361 ggcctgtggc cagtgcacag tacgtgtccc aggcagaagc ctcagctttg cagcagcagc
      421 agtactacca gtggtaccag cagtacaact atgcctaccc ctacagctac tactatccca
      481 tgagcatgta ccagagctat ggctcccctt cccagtatgg gatggccggc tcctatggct
      541 cagccacacc ccagcagcca tccgcacccc aacaccaagg gactctgaac cagcccccag
      601 tccccggcat ggatgagagc atgtcctacc aggctccccc tcagcagctg ccgtcggctc
      661 agccccctca gccctcaaat cccccacatg gggctcacac gctgaacagt ggccctcagc
      721 ctgggacagc tccagccaca cagcacagcc aggcggggcc cgccacgggc caggcctatg
      781 ggccacacac ctacaccgaa cctgccaagc ccaagaaggg ccaacagctg tggaaccgca
      841 tgaaacccgc ccctgggact ggaggtctca agttcaacat ccagaagcga ccctttgctg
      901 ttaccaccca gagctttggc tccaacgcag agggccagca cagtggtttt ggcccccagc
      961 ccaaccctga gaaagttcag aaccacagcg ggtcctctgc ccgggggaac ctgtctggga
     1021 agccggatga ctggccccag gacatgaaag agtatgtgga gcgctgcttc accgcctgtg
     1081 agtcggagga ggacaaggac cgcacggaaa agctgctcaa ggaggtgctg caggcgcggc
     1141 tgcaggacgg ctcggcctat accattgact ggagccggga gcccttgccg gggctgaccc
     1201 gggagcctgt ggctgagagc cctaagaaga agcggtggga ggccgctagc agccttcacc
     1261 ctcctagagg ggcaggctcg gcgacaaggg gcgggggtgc cccgtcccag cgagggacgc
     1321 ccggggctgg gggtgccggt cgagcccggg gcaacagctt caccaagttt ggcaaccgca
     1381 acgtcttcat gaaggacaac agctcttctt ccagcacaga ctcccgctcc cgctcctcct
     1441 ccaggtcccc gacgcgccac ttccgcagaa gtgactccca ctcagactcc gacagctcct
     1501 actcagggaa tgagtgtcac cctgtgggcc gcaggaaccc gccccctaag ggccggggcg
     1561 gtcgaggggc ccatatggat cggggccgag gcagggcgca gcgtgggaag aggcacgatc
     1621 tggcgcccac caagcgcagt cgaaagaaga tggcggcgct ggagtgtgag gacccggagc
     1681 gagagctgaa gaagcagaag cgggcagccc gcttccagca cggacactcc cgccgcctgc
     1741 gcctcgagcc cctggtgctg cagatgagca gcctggagag cagtggggct gaccctgact
     1801 ggcaggagct gcagatcgtg ggcacctgcc ctgacatcac caagcactac ctgcgcctca
     1861 cctgtgcccc cgacccgtcc accgtgcgcc ctgtggcagt tttgaaaaag tcgctgtgca
     1921 tggtcaagtg ccactggaaa gagaagcagg actacgcgtt tgcctgcgag cagatgaagt
     1981 cgatccggca ggatctgacg gtgcagggca tccgcaccga gttcacggtg gaggtgtacg
     2041 agacccatgc ccggatcgcc ttggagaagg gtgaccatga agagtttaac cagtgccaga
     2101 cgcagctcaa gtcgctgtac gccgagaact tgcctggcaa tgtgggcgag tttactgcct
     2161 accgaatcct ctactacatc ttcaccaaga actcgggaga catcaccacg gagctggcat
     2221 acctcacacg agaactgaag gcagatcctt gcgtggccca cgccttggca ttaaggacag
     2281 cctgggccct gggcaactac caccgctttt tccggctcta ctgccatgca ccctgcatgt
     2341 ctggctacct cgtggacaag tttgcagatc gggagcgcaa ggtcgccctc aaggccatga
     2401 tcaaaacctt ccgccctgcg ctgccagtct cctacctgca ggccgagctg gccttcgagg
     2461 gcgaggccgc ctgccgggcc ttcctagagc ccctgggcct ggcctacacg ggcccggaca
     2521 actccagcat cgactgccgc ctcagcctgg cgcagctgtc agccttctga gcacccagcg
     2581 aggaggggcg ggggcagggg ctgcagcccc cagcgctgcc tttgcggatt ctgtttttga
     2641 gccgtggact tgggttgtaa atttatttgt ggggagtgcg ctccaggaag agccaccatc
     2701 cctgcccccg ttttcccacc ggggagtctg tacagagatt tttctacgtt tttatttttt
     2761 gcctcagagg gatgggattg gggaggaggg gatgggcagc ggagggttgg gggcatggtc
     2821 tgcaggctca tctgtgtccg cctttcactc cactaatgct gtctcagtgt tttctctctc
     2881 tctctttcga gcttgcactc cggtacccga cccggcgccc tggcccatcc catgccgggg
     2941 ggccagtgga aagaagacag gccgtccagc ccgtgcccgc ctgcggcggg ggcacccagc
     3001 aagcccgccc accgcccgct gcctcacctg cttcgccaca gactcttgtt cccagcccct
     3061 tggggcctcc gtgtttgggg tgggggagct gcttagagac tgtgcccgtc ctcggccccc
     3121 caccctgaag tgccagcacc accagcacca gatcctccgc cgccacaccg cactgaggac
     3181 acgccggccg ggccgcctcg tctcaagttg tataaagttg tctccgtgtc ccctcctccc
     3241 tctgccccca gtgtttcttc tgattttttt ttcccctttc cctccctccc tctccgcatt
     3301 cttcccttgg ttcagcacag gtaaaacggt tcccctccct ccctgccttc atggatcacc
     3361 agctcacgtc atgttgcctt ctcttttctt tgtgtgtgtg tttatttaag ttatttttct
     3421 tcctcctctc ccttttcttt ttggccctcc ctccctccct cttctgccat gtaactggag
     3481 gatgtgctat gagtttgcaa acagctggac tgtcaggctg ctttttttcc agatgttcct
     3541 cctctgcctc cccttcccct cctctcccct ccttttcctt ccttccttcc tttccttgga
     3601 gcactgagca ccatttggaa gcttgagaga aaccaaaatt aaagagagaa agagagag
//
