LOCUS       NM_024316               1381 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leukocyte receptor cluster member 1 (LENG1), mRNA.
ACCESSION   NM_024316
VERSION     NM_024316.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1381)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1381)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1381)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1381)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1381)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   6  (bases 1 to 1381)
  AUTHORS   Wende,H., Volz,A. and Ziegler,A.
  TITLE     Extensive gene duplications and a large inversion characterize the
            human leukocyte receptor cluster
  JOURNAL   Immunogenetics 51 (8-9), 703-713 (2000)
   PUBMED   10941842
  REMARK    Erratum:[Immunogenetics 2001;52(3-4):308]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP870984.1, BC014986.1 and AC245052.3.
            
            On May 17, 2019 this sequence version replaced NM_024316.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014986.1, DRR138506.14041.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222224.4/ ENSP00000222224.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP870984.1         24-36
            14-314              BC014986.1         1-301
            315-315             AC245052.3         86845-86845         c
            316-903             BC014986.1         303-890
            904-1381            AC245052.3         83701-84178         c
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1381
                     /gene="LENG1"
                     /note="leukocyte receptor cluster member 1"
                     /db_xref="GeneID:79165"
                     /db_xref="HGNC:HGNC:15502"
     exon            1..158
                     /gene="LENG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..821
                     /gene="LENG1"
                     /note="leukocyte receptor cluster (LRC) member 1"
                     /codon_start=1
                     /product="leukocyte receptor cluster member 1"
                     /protein_id="NP_077292.2"
                     /db_xref="CCDS:CCDS12881.1"
                     /db_xref="GeneID:79165"
                     /db_xref="HGNC:HGNC:15502"
                     /translation="MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQE
                     ARTEFLRKKARHQNSLPELEAAEAGAPGSGPVDLFRELLEEGKGVIRGNKEYKEEKRQ
                     EKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGRGGPPPGPAPDEKIKSRLDPLREM
                     QKHLGKKRQHGGDEGSRSRKEKEGSEKQRPKEPPSLDQLRAERLRREAAERSRAEALL
                     ARVQGRALQEGQPEEDETDDRRRRYNSQFNPQLARRPRQQDPHLTH"
     exon            159..338
                     /gene="LENG1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..601
                     /gene="LENG1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1381
                     /gene="LENG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      880..885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LENG1"
                     /note="hexamer: CATAAA"
     regulatory      896..901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LENG1"
                     /note="hexamer: AATGAA"
     polyA_site      903
                     /gene="LENG1"
                     /note="major polyA site"
     polyA_site      919
                     /gene="LENG1"
ORIGIN      
        1 gccagtccct ggacagctac gacgccatga atatcttgcc caagaagagc tggcacgtcc
       61 ggaacaagga caatgtcgcc cgcgtgcggc gtgacgaggc ccaggcccgg gaggaggaga
      121 aggagcgtga gcggagggtg ctgctggctc agcaagaggc ccgtacagaa ttcctacgga
      181 agaaagccag acatcagaac tcactgcctg agcttgaagc agcagaggcg ggagccccag
      241 gttctggccc tgtggacctg tttcgggagc tgctggagga agggaaagga gtgatcagag
      301 gcaataaaga gtacaaggaa gaaaagcgac aggagaaaga gaggcaagag aaagctctgg
      361 gcatcctgac atacctgggc cagagtgcag cggaggcaca gactcaaccc ccttggtacc
      421 agctaccccc agggcgaggg ggccccccgc ccggcccagc cccagatgag aagatcaaga
      481 gccgtctgga ccctctgcgg gagatgcaga agcatctggg gaagaagaga cagcacggcg
      541 gtgatgaagg cagtcgcagc agaaaggaaa aggaggggtc tgagaagcag cgacccaagg
      601 agcctccatc cctggaccag cttcgagctg aacgtctgcg gagggaagca gctgagaggt
      661 ctcgggcaga ggccctgctg gcccgggtcc aaggccgggc actacaggag ggtcagccgg
      721 aagaagacga gacggatgac cggcggcggc ggtacaactc ccaattcaac ccccagctgg
      781 cccggcgccc ccgccagcag gaccctcacc ttactcactg actcctgagg gggtacagga
      841 gaggccgctg ctgccagccg tcatataaaa ctatttattc ataaatattt tccaaaatga
      901 aaataggttt accaaaaaat gtccctcact ggggagggga ggagggggca gccctcgccc
      961 ccgggccccc agggtggggc tgagaggaaa acctcccggc cccctccctg cttcctggga
     1021 gagggggatg ccccgtggct tggggcctcc ctccagtctt ccagggcagg gccctcacct
     1081 gggcaggggg atcagcatgc gggggaaggg ggtgggtaga gggaggggcc ggtgtcactg
     1141 gaggtcccgg tcctccaggt agcggtactc aaaggtgaag ccttccttct tccgctggcc
     1201 ccacttctcg tagtcaaagt agatgtaggt gccctggccg ggggagaagg cggtcagtga
     1261 gtggacgagg aggtggtctg ggatctgggc cggaccaaca gacaaagggg acaattctta
     1321 gggctgtgga tgtgtcaggc accgggccag ctgccctgca cgcacacact ctcatccatc
     1381 c
//
