LOCUS       NM_001394530             730 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens lens epithelial protein (LENEP), transcript variant 2,
            mRNA.
ACCESSION   NM_001394530
VERSION     NM_001394530.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 730)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 730)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   3  (bases 1 to 730)
  AUTHORS   Wen,Y., Ibaraki,N., Reddy,V.N. and Sachs,G.
  TITLE     Functional analysis of the promoter and chromosomal localization
            for human LEP503, a novel lens epithelium gene
  JOURNAL   Gene 269 (1-2), 61-71 (2001)
   PUBMED   11376938
REFERENCE   4  (bases 1 to 730)
  AUTHORS   Wen,Y., Sachs,G. and Athmann,C.
  TITLE     A novel lens epithelium gene, LEP503, is highly conserved in
            different vertebrate species and is developmentally regulated in
            postnatal rat lens
  JOURNAL   Exp Eye Res 70 (2), 159-168 (2000)
   PUBMED   10655141
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451085.20.
            
            Summary: The ocular lens is a tissue of epithelial origin and
            devoid of blood vessels and nerves. Cells of the lens epithelium
            are responsible for the growth and maintenance of the lens through
            mitosis, protein synthesis, and active transport of ions and
            metabolites across the lens capsule. Lens epithelial protein is
            expressed exclusively in lens epithelial cells and may play a role
            in cell differentiation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC098253.1, AB451457.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392487.2/ ENSP00000376278.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AL451085.20        122024-122753
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..730
                     /gene="LENEP"
                     /gene_synonym="LEP503"
                     /note="lens epithelial protein"
                     /db_xref="GeneID:55891"
                     /db_xref="HGNC:HGNC:14429"
                     /db_xref="MIM:607377"
     exon            1..730
                     /gene="LENEP"
                     /gene_synonym="LEP503"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..208
                     /gene="LENEP"
                     /gene_synonym="LEP503"
                     /codon_start=1
                     /product="lens epithelial cell protein LEP503"
                     /protein_id="NP_001381459.1"
                     /db_xref="CCDS:CCDS1080.1"
                     /db_xref="GeneID:55891"
                     /db_xref="HGNC:HGNC:14429"
                     /db_xref="MIM:607377"
                     /translation="MQPRTQPLAQTLPFFLGGAPRDTGLRVPVIKMGTGWEGFQRTLK
                     EVAYILLCCWCIKELLD"
ORIGIN      
        1 cttcctcgga actgttgccc acatgcagcc ccggacacag cccctagccc aaaccctacc
       61 cttcttcctc ggaggggccc ctcgagacac tgggctgcgg gtgcctgtca ttaagatggg
      121 cacagggtgg gagggcttcc agcggaccct gaaggaagtc gcctacatcc tcctctgctg
      181 ctggtgtatc aaggaactgc tggattaatg gtagcaggga actgcctcct ctccccacca
      241 gcaccatggc tggcatcgct caggtgggca gggtagagta aacaggaggc atagctgcag
      301 cttctgtggc agagcttgcc ttagcttctc attctcttct ttagccccca gcccaattgc
      361 catcaagact cctgaagcca gctgtgcttg accaaggatg ggccataaac aatgagtaaa
      421 cagtaaagtg tggatcctgc tttgagctgt gtcatctagc agacctgcct catctctgag
      481 cctccttcat tcccaacccc tgcctctggt ggacctctgg tgggcaggag cttggactgc
      541 tctggctagg accccagtaa gattgtggca agacctggca ctcctccaag cttggcacag
      601 tgagcccacc agctcagatg gttgatctta ccataccctc atagtaccaa gaatggactg
      661 ccccctaaga aacctgtttg agaatcactg aattataaat ataatccata ggccttgagg
      721 cccaagatta
//
