LOCUS       NM_001004316            2526 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens leucine, glutamate and lysine rich 1 (LEKR1),
            transcript variant 1, mRNA.
ACCESSION   NM_001004316 XM_371674
VERSION     NM_001004316.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Lin,X., Wang,J., Yun,L., Jiang,S., Li,L., Chen,X., Li,Z., Lu,Q.,
            Zhang,Y. and Ma,X.
  TITLE     Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene
            polymorphisms and diabetic retinopathy of type 2 diabetes mellitus
            in the Chinese Han population
  JOURNAL   J Gene Med 18 (10), 282-287 (2016)
   PUBMED   27607899
  REMARK    GeneRIF: Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene
            polymorphisms influence the development of diabetic retinopathy
            (DR).
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Dong,C., Della-Morte,D., Beecham,A., Wang,L., Cabral,D.,
            Blanton,S.H., Sacco,R.L. and Rundek,T.
  TITLE     Genetic variants in LEKR1 and GALNT10 modulate sex-difference in
            carotid intima-media thickness: a genome-wide interaction study
  JOURNAL   Atherosclerosis 240 (2), 462-467 (2015)
   PUBMED   25898001
  REMARK    GeneRIF: SNPs in LEKR1 and GALNT10 modulate sex-difference in
            carotid intima-media thickness.
REFERENCE   3  (bases 1 to 2526)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   4  (bases 1 to 2526)
  AUTHORS   Urbanek,M., Hayes,M.G., Armstrong,L.L., Morrison,J., Lowe,L.P.,
            Badon,S.E., Scheftner,D., Pluzhnikov,A., Levine,D., Laurie,C.C.,
            McHugh,C., Ackerman,C.M., Mirel,D.B., Doheny,K.F., Guo,C.,
            Scholtens,D.M., Dyer,A.R., Metzger,B.E., Reddy,T.E., Cox,N.J. and
            Lowe,W.L. Jr.
  CONSRTM   HAPO Study Cooperative Research Group
  TITLE     The chromosome 3q25 genomic region is associated with measures of
            adiposity in newborns in a multi-ethnic genome-wide association
            study
  JOURNAL   Hum Mol Genet 22 (17), 3583-3596 (2013)
   PUBMED   23575227
REFERENCE   5  (bases 1 to 2526)
  AUTHORS   Boraska,V., Davis,O.S., Cherkas,L.F., Helder,S.G., Harris,J.,
            Krug,I., Liao,T.P., Treasure,J., Ntalla,I., Karhunen,L.,
            Keski-Rahkonen,A., Christakopoulou,D., Raevuori,A., Shin,S.Y.,
            Dedoussis,G.V., Kaprio,J., Soranzo,N., Spector,T.D., Collier,D.A.
            and Zeggini,E.
  TITLE     Genome-wide association analysis of eating disorder-related
            symptoms, behaviors, and personality traits
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 159B (7), 803-811 (2012)
   PUBMED   22911880
REFERENCE   6  (bases 1 to 2526)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2526)
  AUTHORS   Grassi,M.A., Tikhomirov,A., Ramalingam,S., Below,J.E., Cox,N.J. and
            Nicolae,D.L.
  TITLE     Genome-wide meta-analysis for severe diabetic retinopathy
  JOURNAL   Hum Mol Genet 20 (12), 2472-2481 (2011)
   PUBMED   21441570
REFERENCE   8  (bases 1 to 2526)
  AUTHORS   Andersson,E.A., Harder,M.N., Pilgaard,K., Pisinger,C.,
            Stancakova,A., Kuusisto,J., Grarup,N., Faerch,K., Poulsen,P.,
            Witte,D.R., Jorgensen,T., Vaag,A., Laakso,M., Pedersen,O. and
            Hansen,T.
  TITLE     The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1
            associates with elevated insulin release following an oral glucose
            challenge
  JOURNAL   PLoS One 6 (11), e27096 (2011)
   PUBMED   22073261
  REMARK    GeneRIF: birth weight lowering effect of the C-allele of rs900400
            located near LEKR1 and CCNL1 was replicated in the Danish
            population. Furthermore the C-allele was associated with increased
            insulin response following oral glucose stimulation
REFERENCE   9  (bases 1 to 2526)
  AUTHORS   Freathy,R.M., Mook-Kanamori,D.O., Sovio,U., Prokopenko,I.,
            Timpson,N.J., Berry,D.J., Warrington,N.M., Widen,E., Hottenga,J.J.,
            Kaakinen,M., Lange,L.A., Bradfield,J.P., Kerkhof,M., Marsh,J.A.,
            Magi,R., Chen,C.M., Lyon,H.N., Kirin,M., Adair,L.S.,
            Aulchenko,Y.S., Bennett,A.J., Borja,J.B., Bouatia-Naji,N.,
            Charoen,P., Coin,L.J., Cousminer,D.L., de Geus,E.J., Deloukas,P.,
            Elliott,P., Evans,D.M., Froguel,P., Glaser,B., Groves,C.J.,
            Hartikainen,A.L., Hassanali,N., Hirschhorn,J.N., Hofman,A.,
            Holly,J.M., Hypponen,E., Kanoni,S., Knight,B.A., Laitinen,J.,
            Lindgren,C.M., McArdle,W.L., O'Reilly,P.F., Pennell,C.E.,
            Postma,D.S., Pouta,A., Ramasamy,A., Rayner,N.W., Ring,S.M.,
            Rivadeneira,F., Shields,B.M., Strachan,D.P., Surakka,I.,
            Taanila,A., Tiesler,C., Uitterlinden,A.G., van Duijn,C.M.,
            Wijga,A.H., Willemsen,G., Zhang,H., Zhao,J., Wilson,J.F.,
            Steegers,E.A., Hattersley,A.T., Eriksson,J.G., Peltonen,L.,
            Mohlke,K.L., Grant,S.F., Hakonarson,H., Koppelman,G.H.,
            Dedoussis,G.V., Heinrich,J., Gillman,M.W., Palmer,L.J.,
            Frayling,T.M., Boomsma,D.I., Davey Smith,G., Power,C., Jaddoe,V.W.,
            Jarvelin,M.R. and McCarthy,M.I.
  CONSRTM   Genetic Investigation of ANthropometric Traits (GIANT) Consortium;
            Meta-Analyses of Glucose and Insulin-related traits Consortium;
            Wellcome Trust Case Control Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Variants in ADCY5 and near CCNL1 are associated with fetal growth
            and birth weight
  JOURNAL   Nat Genet 42 (5), 430-435 (2010)
   PUBMED   20372150
REFERENCE   10 (bases 1 to 2526)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106708.7, AC092993.3 and AC117392.4.
            
            On Sep 25, 2020 this sequence version replaced NM_001004316.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). It should be noted
            that this exon combination lacks full-length transcript support; it
            is predicted based on partial human and orthologous transcript
            alignments.
            
            Sequence Note: The RefSeq transcript and protein were assembled by
            in silico methods based on transcript alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356539.9/ ENSP00000348936.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC106708.7         5082-5105           c
            25-116              AC106708.7         2081-2172           c
            117-331             AC092993.3         124335-124549       c
            332-451             AC092993.3         56623-56742         c
            452-627             AC092993.3         49713-49888         c
            628-813             AC092993.3         34603-34788         c
            814-895             AC117392.4         143557-143638       c
            896-973             AC117392.4         130102-130179       c
            974-1177            AC117392.4         129555-129758       c
            1178-1271           AC117392.4         111326-111419       c
            1272-1436           AC117392.4         97908-98072         c
            1437-1736           AC117392.4         94430-94729         c
            1737-2526           AC117392.4         76703-77492         c
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..2526
                     /gene="LEKR1"
                     /note="leucine, glutamate and lysine rich 1"
                     /db_xref="GeneID:389170"
                     /db_xref="HGNC:HGNC:33765"
                     /db_xref="MIM:613536"
     exon            1..24
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            25..116
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2147
                     /gene="LEKR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-, glutamate- and lysine-rich protein 1; protein
                     LEKR1"
                     /codon_start=1
                     /product="protein LEKR1 isoform 1"
                     /protein_id="NP_001004316.2"
                     /db_xref="GeneID:389170"
                     /db_xref="HGNC:HGNC:33765"
                     /db_xref="MIM:613536"
                     /translation="MDHHIPMHALPEEIQKMLPEEKVCKYCGVSYLILHEFKAMEEKV
                     KAMEKEMKFYQGSVDREKRLQEKLHSLSQELEQYKIDNKSKTERIYDVGMQLKSQQNE
                     FQKVKKQLSHLQDELKIKYRQSYIFSQRLSEYKYFWNKTLSLLTFTKRELTSIKNEVY
                     DNYQNWTSLKGAVFLQIKSISETALTEIDILNKSLTVSQRNKVCLEKEMKNLKLLSDA
                     AILRSQQIRTSRQQEVNLQTRCYDLQKEVLDLQCLVEALGLKLQKAVTEMDNYKEMLM
                     NKSNEADDCQRELKKLKFESIISESQHTMLLKEKEDSLMTCQQIYKALQEELTVKEKQ
                     EEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQKL
                     LSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQ
                     EELQMKISDLITGATRDLRQEVTTLKEKLHKSHIRYTEESNSKEKEIENLKNLVAEFE
                     SRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRR
                     ECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGERSLAR
                     LNSEKGIQIPNLRGVSKPTTFPTSDKPKRVRSGVPILPQPHPPRGGASSANETRQRLA
                     AILRRRRSQQ"
     exon            117..331
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..451
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..627
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..813
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..895
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..973
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1177
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1271
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1436
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1736
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..2526
                     /gene="LEKR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacccgtcc tagtcgaagt cgagatttcc tttggcttca aagctctctc accatatttt
       61 gggaagttat ggatcatcac attcccatgc atgcgttgcc tgaagaaatc caaaagatgt
      121 tgcctgaaga aaaagtttgt aagtactgtg gagtcagcta tctaattctt catgaattta
      181 aggctatgga agaaaaagtg aaagcaatgg aaaaagagat gaaattttat caaggaagtg
      241 tagatcgtga aaagagactt caagaaaagc tgcattctct tagccaagaa cttgaacagt
      301 acaaaattga caacaaatcc aaaacagaaa gaatttacga tgtaggcatg cagttaaaaa
      361 gtcaacaaaa tgaatttcag aaagtaaaga aacaactgag tcatttgcaa gatgagctaa
      421 aaattaaata tagacaatca tacatcttca gtcaaagatt gtcagagtac aaatatttct
      481 ggaataagac tctttcatta cttactttta ctaaaaggga actaaccagt attaaaaatg
      541 aagtatatga taattaccaa aactggactt cattgaaagg agcagttttt ctacaaatta
      601 aatctataag tgaaacagcc ttgacagaaa tagacatact gaataaaagt ttgacagtat
      661 cccagagaaa taaagtatgc cttgaaaagg aaatgaaaaa tctgaaattg ttgtcagatg
      721 cagccatatt gagatctcag cagattcgga catctagaca acaggaagta aacttgcaaa
      781 ccagatgcta tgatttgcaa aaagaagtac tagatttaca atgtctagta gaggcacttg
      841 gattaaaact tcagaaggcg gtgacagaga tggacaacta taaagaaatg cttatgaata
      901 aatctaatga agctgatgac tgtcaaagag aacttaaaaa actgaagttt gaatccatta
      961 tttctgagtc acagcatact atgctgctta aggaaaaaga agactcttta atgacttgtc
     1021 aacagatata taaagcatta caggaagagc tgactgtgaa agaaaagcaa gaagaagaca
     1081 taaagagaag aattaacctt gcagaaaatg aactggagat aaccaaaact cttctgaatc
     1141 agacaaggga agaggtttta acactgaaaa atgaaaggga attgatgctg atttcacatc
     1201 agaaaagcat cgagcagctg caagaaaccc ttagacagaa gctgctgagt gatgataact
     1261 ggaaggagaa gattgaagca gaacttgcca aggaaagggc ccaacacttg gttgaatttg
     1321 aagagcaagc tcttctcttt aaggaagaaa caaaattgca acttgatatt gaaaaagaaa
     1381 aacaccaaga tgtaatccaa aagtataaga aagaacaaga ggaactacaa atgaagatat
     1441 ctgacttaat cacaggcgct acaagagatc taaggcagga agtgaccact cttaaagaaa
     1501 aacttcacaa atcccatatt cggtacactg aagaatctaa ttcaaaggaa aaagaaattg
     1561 aaaatcttaa aaatttggtt gcagaatttg aatctcgctt gaagaaggaa attgacagta
     1621 atgattcagt ttcagaaaac ttgaggaagg aaatggaaca gaagtcggat gaactgaaaa
     1681 gagtaatgct ggctcaaaca caactgatag agcaatttaa ccagtcccag gaagagaata
     1741 cttttcttca ggagacagtg cgtagagaat gtgaagaacg ctttgaactg acagaggctt
     1801 tgagtcaagc cagagaacag ctcctggagc tcagtaagct tcgtggaagt ttaccattct
     1861 caccgtgttc cctcagcaag ggcagcctaa cctcccctgc tgcagcagtc agtaatcatg
     1921 gagagagaag ccttgcaaga ctgaactctg aaaaaggaat ccaaattccc aacctgcgcg
     1981 gggtgtcaaa acccaccact ttcccaacct cagataagcc gaagagggtt agatcaggcg
     2041 tgcccattct cccccagcca catcctccca ggggtggagc atcttcagca aatgagacta
     2101 gacagagact ggctgccatt cttaggagaa ggcggagtca gcaatgatcc aaaatgagga
     2161 gcaggaagct ccctacagcg tgcacgctct ttcagagagt gccaggaatt cactgtaact
     2221 gagaatgaca atgataaaat tattttcaca gatcaggaag gcatacctat agatgtattt
     2281 aacaaaagac tgtaaaaagc tggaaaattg tgaagcctta tttttcaaga gggttttgat
     2341 agagtaacag atcattaagt tgttggtatt ccagaggtcc gatttctatg tttatgttgg
     2401 aatgtgctct atgaatatag ccttttagag atcacaggta aaatttttca cccataacat
     2461 cttttcaatt tcttgcgcca ctacaagcag atatatttcc acaaaaaaat agattgtttg
     2521 agattt
//
