LOCUS       NM_020997               1626 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens left-right determination factor 1 (LEFTY1), mRNA.
ACCESSION   NM_020997
VERSION     NM_020997.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Ashiq,S. and Sabar,M.F.
  TITLE     Association of maternal hypertension and diabetes with variants of
            the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital
            heart defects: a case-control study from Pakistani Population
  JOURNAL   Mol Biol Rep 50 (6), 5013-5020 (2023)
   PUBMED   37097539
  REMARK    GeneRIF: Association of maternal hypertension and diabetes with
            variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with
            congenital heart defects: a case-control study from Pakistani
            Population.
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Skok,D.J., Hauptman,N., Jerala,M. and Zidar,N.
  TITLE     Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could
            Distinguish between Ulcerative Colitis and Crohn's Disease
  JOURNAL   Genes (Basel) 12 (10), 1477 (2021)
   PUBMED   34680872
  REMARK    GeneRIF: Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and
            INSL5 Could Distinguish between Ulcerative Colitis and Crohn's
            Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Matsumoto,T., Chino,H., Akiya,M., Hashimura,M., Yokoi,A.,
            Tochimoto,M., Nakagawa,M., Jiang,Z. and Saegusa,M.
  TITLE     Requirements of LEFTY and Nodal overexpression for tumor cell
            survival under hypoxia in glioblastoma
  JOURNAL   Mol Carcinog 59 (12), 1409-1419 (2020)
   PUBMED   33111989
  REMARK    GeneRIF: Requirements of LEFTY and Nodal overexpression for tumor
            cell survival under hypoxia in glioblastoma.
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Raghuwanshi,S., Dahariya,S., Sharma,D.S., Kovuru,N., Sahu,I. and
            Gutti,R.K.
  TITLE     RUNX1 and TGF-beta signaling cross talk regulates Ca2+ ion channels
            expression and activity during megakaryocyte development
  JOURNAL   FEBS J 287 (24), 5411-5438 (2020)
   PUBMED   32281291
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Gambichler,T., Ardabili,S., Lang,K., Dreissigacker,M., Scheel,C.,
            Brand-Saberi,B., Skrygan,M., Stockfleth,E., Kafferlein,H.U.,
            Bruning,T. and Becker,J.C.
  TITLE     Expression of Lefty predicts Merkel cell carcinoma-specific death
  JOURNAL   J Eur Acad Dermatol Venereol 34 (9), 2016-2020 (2020)
   PUBMED   32022949
  REMARK    GeneRIF: Expression of Lefty predicts Merkel cell
            carcinoma-specific death.
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Dvash,T., Sharon,N., Yanuka,O. and Benvenisty,N.
  TITLE     Molecular analysis of LEFTY-expressing cells in early human
            embryoid bodies
  JOURNAL   Stem Cells 25 (2), 465-472 (2007)
   PUBMED   17038673
  REMARK    GeneRIF: LEFTY proteins, which are known to play a major role
            during mouse gastrulation, are transiently expressed during human
            embryonic stem cell differentiation.
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Besser,D.
  TITLE     Expression of nodal, lefty-a, and lefty-B in undifferentiated human
            embryonic stem cells requires activation of Smad2/3
  JOURNAL   J Biol Chem 279 (43), 45076-45084 (2004)
   PUBMED   15308665
  REMARK    GeneRIF: nodal and the inhibitors of Nodal signaling, lefty-A and
            lefty-B, are down-regulated very early upon differentiation of
            human embryonic stem cells
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Yashiro,K., Saijoh,Y., Sakuma,R., Tada,M., Tomita,N., Amano,K.,
            Matsuda,Y., Monden,M., Okada,S. and Hamada,H.
  TITLE     Distinct transcriptional regulation and phylogenetic divergence of
            human LEFTY genes
  JOURNAL   Genes Cells 5 (5), 343-357 (2000)
   PUBMED   10886363
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Kosaki,K., Bassi,M.T., Kosaki,R., Lewin,M., Belmont,J., Schauer,G.
            and Casey,B.
  TITLE     Characterization and mutation analysis of human LEFTY A and LEFTY
            B, homologues of murine genes implicated in left-right axis
            development
  JOURNAL   Am J Hum Genet 64 (3), 712-721 (1999)
   PUBMED   10053005
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK222714.1 and AF081512.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020997.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate the mature protein, which
            plays a role in left-right asymmetry determination of organ systems
            during development. This gene is closely linked to both a related
            family member and a related pseudogene. [provided by RefSeq, Aug
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222714.1, AY358873.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272134.5/ ENSP00000272134.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK222714.1         1-10
            11-1528             AF081512.1         1-1518
            1529-1626           AK222714.1         1529-1626
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..1626
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /note="left-right determination factor 1"
                     /db_xref="GeneID:10637"
                     /db_xref="HGNC:HGNC:6552"
                     /db_xref="MIM:603037"
     exon            1..330
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1181
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /note="protein lefty-1; protein lefty-B; left-right
                     determination factor B"
                     /codon_start=1
                     /product="left-right determination factor 1 preproprotein"
                     /protein_id="NP_066277.1"
                     /db_xref="CCDS:CCDS1548.1"
                     /db_xref="GeneID:10637"
                     /db_xref="HGNC:HGNC:6552"
                     /db_xref="MIM:603037"
                     /translation="MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLD
                     RADMEELVIPTHVRAQYVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLVFG
                     MEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRT
                     SLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKL
                     VRFASQGAPAGLGEPQLELHTLDLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMK
                     WAENWVLEPPGFLAYECVGTCRQPPEALAFKWPFLGPRQCIASETDSLPMIVSIKEGG
                     RTRPQVVSLPNMRVQKCSCASDGALVPRRLQP"
     exon            331..577
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /inference="alignment:Splign:2.1.0"
     exon            578..817
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1626
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="LEFTY1"
                     /gene_synonym="LEFTB; LEFTYB"
                     /note="major polyA site"
ORIGIN      
        1 acatccagct gcctgagacc ctcctgcagc cttctcaagg gacagcccca ctctgcctct
       61 tgctcctcca gggcagcacc atgcagcccc tgtggctctg ctgggcactc tgggtgttgc
      121 ccctggccag ccccggggcc gccctgaccg gggagcagct cctgggcagc ctgctgcggc
      181 agctgcagct caaagaggtg cccaccctgg acagggccga catggaggag ctggtcatcc
      241 ccacccacgt gagggcccag tacgtggccc tgctgcagcg cagccacggg gaccgctccc
      301 gcggaaagag gttcagccag agcttccgag aggtggccgg caggttcctg gcgttggagg
      361 ccagcacaca cctgctggtg ttcggcatgg agcagcggct gccgcccaac agcgagctgg
      421 tgcaggccgt gctgcggctc ttccaggagc cggtccccaa ggccgcgctg cacaggcacg
      481 ggcggctgtc cccgcgcagc gcccgggccc gggtgaccgt cgagtggctg cgcgtccgcg
      541 acgacggctc caaccgcacc tccctcatcg actccaggct ggtgtccgtc cacgagagcg
      601 gctggaaggc cttcgacgtg accgaggccg tgaacttctg gcagcagctg agccggcccc
      661 ggcagccgct gctgctacag gtgtcggtgc agagggagca tctgggcccg ctggcgtccg
      721 gcgcccacaa gctggtccgc tttgcctcgc agggggcgcc agccgggctt ggggagcccc
      781 agctggagct gcacaccctg gaccttgggg actatggagc tcagggcgac tgtgaccctg
      841 aagcaccaat gaccgagggc acccgctgct gccgccagga gatgtacatt gacctgcagg
      901 ggatgaagtg ggccgagaac tgggtgctgg agcccccggg cttcctggct tatgagtgtg
      961 tgggcacctg ccggcagccc ccggaggccc tggccttcaa gtggccgttt ctggggcctc
     1021 gacagtgcat cgcctcggag actgactcgc tgcccatgat cgtcagcatc aaggagggag
     1081 gcaggaccag gccccaggtg gtcagcctgc ccaacatgag ggtgcagaag tgcagctgtg
     1141 cctcggatgg tgcgctcgtg ccaaggaggc tccagccata ggcgcctagt gtagccatcg
     1201 agggacttga cttgtgtgtg tttctgaagt gttcgagggt accaggagag ctggcgatga
     1261 ctgaactgct gatggacaaa tgctctgtgc tctctagtga gccctgaatt tgcttcctct
     1321 gacaagttac ctcacctaat ttttgcttct caggaatgag aatctttggc cactggagag
     1381 cccttgctca gttttctcta ttcttattat tcactgcact atattctaag cacttacatg
     1441 tggagatact gtaacctgag ggcagaaagc ccaatgtgtc attgtttact tgtcctgtca
     1501 ctggatctgg gctaaagtcc tccaccacca ctctggacct aagacctggg gttaagtgtg
     1561 ggttgtgcat ccccaatcca gataataaag actttgtaaa acatgaataa aacacatttt
     1621 attcta
//
