LOCUS       NM_002302               1033 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.
ACCESSION   NM_002302
VERSION     NM_002302.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1033)
  AUTHORS   Liu,Z., Jiang,X., Zhao,K., Ruan,H., Ma,Y., Ma,Y., Zhou,Q.,
            Zhang,J., Sun,X., Ma,W. and Xu,S.
  TITLE     Role of LECT2 in exacerbating atopic dermatitis: insight from in
            vivo and in vitro models via NF-kappaB signaling pathway
  JOURNAL   Front Immunol 15, 1439367 (2024)
   PUBMED   39206203
  REMARK    GeneRIF: Role of LECT2 in exacerbating atopic dermatitis: insight
            from in vivo and in vitro models via NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1033)
  AUTHORS   Paine-Cabrera,D., Harvey,L.K., Robarts,D.R., Pritchard,M.T.,
            Thyfault,J., Weinman,S.A., Apte,U. and Slowik,V.
  TITLE     Leukocyte cell-derived chemotaxin 2 correlates with pediatric
            non-alcoholic fatty liver disease
  JOURNAL   Clin Transl Sci 16 (12), 2719-2728 (2023)
   PUBMED   37877453
  REMARK    GeneRIF: Leukocyte cell-derived chemotaxin 2 correlates with
            pediatric non-alcoholic fatty liver disease.
REFERENCE   3  (bases 1 to 1033)
  AUTHORS   Richards,L.S., Flores,M.D., Zink,S., Schibrowsky,N.A., Sawaya,M.R.
            and Rodriguez,J.A.
  TITLE     Cryo-EM structure of a human LECT2 amyloid fibril reveals a network
            of polar ladders at its core
  JOURNAL   Structure 31 (11), 1386-1393 (2023)
   PUBMED   37657439
  REMARK    GeneRIF: Cryo-EM structure of a human LECT2 amyloid fibril reveals
            a network of polar ladders at its core.
REFERENCE   4  (bases 1 to 1033)
  AUTHORS   Wang,Q., Xu,F., Chen,J., Xie,Y.Q., Xu,S.L. and He,W.M.
  TITLE     Serum Leukocyte Cell-Derived Chemotaxin 2 (LECT2) Level Is
            Associated with Osteoporosis
  JOURNAL   Lab Med 54 (1), 106-111 (2023)
   PUBMED   35976970
  REMARK    GeneRIF: Serum Leukocyte Cell-Derived Chemotaxin 2 (LECT2) Level Is
            Associated with Osteoporosis.
REFERENCE   5  (bases 1 to 1033)
  AUTHORS   Chu,T.H., Ko,C.Y., Tai,P.H., Chang,Y.C., Huang,C.C., Wu,T.Y.,
            Chan,H.H., Wu,P.H., Weng,C.H., Lin,Y.W., Kung,M.L., Fang,C.C.,
            Wu,J.C., Wen,Z.H., Lee,Y.K., Hu,T.H. and Tai,M.H.
  TITLE     Leukocyte cell-derived chemotaxin 2 regulates
            epithelial-mesenchymal transition and cancer stemness in
            hepatocellular carcinoma
  JOURNAL   J Biol Chem 298 (10), 102442 (2022)
   PUBMED   36055405
  REMARK    GeneRIF: Leukocyte cell-derived chemotaxin 2 regulates
            epithelial-mesenchymal transition and cancer stemness in
            hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1033)
  AUTHORS   Nagai,H., Hamada,T., Uchida,T., Yamagoe,S. and Suzuki,K.
  TITLE     Systemic expression of a newly recognized protein, LECT2, in the
            human body
  JOURNAL   Pathol Int 48 (11), 882-886 (1998)
   PUBMED   9832057
REFERENCE   7  (bases 1 to 1033)
  AUTHORS   Yamagoe,S., Kameoka,Y., Hashimoto,K., Mizuno,S. and Suzuki,K.
  TITLE     Molecular cloning, structural characterization, and chromosomal
            mapping of the human LECT2 gene
  JOURNAL   Genomics 48 (3), 324-329 (1998)
   PUBMED   9545637
REFERENCE   8  (bases 1 to 1033)
  AUTHORS   Yamagoe,S., Mizuno,S. and Suzuki,K.
  TITLE     Molecular cloning of human and bovine LECT2 having a neutrophil
            chemotactic activity and its specific expression in the liver
  JOURNAL   Biochim Biophys Acta 1396 (1), 105-113 (1998)
   PUBMED   9524238
REFERENCE   9  (bases 1 to 1033)
  AUTHORS   Yamagoe,S., Akasaka,T., Uchida,T., Hachiya,T., Okabe,T.,
            Yamakawa,Y., Arai,T., Mizuno,S. and Suzuki,K.
  TITLE     Expression of a neutrophil chemotactic protein LECT2 in human
            hepatocytes revealed by immunochemical studies using polyclonal and
            monoclonal antibodies to a recombinant LECT2
  JOURNAL   Biochem Biophys Res Commun 237 (1), 116-120 (1997)
   PUBMED   9266841
REFERENCE   10 (bases 1 to 1033)
  AUTHORS   Yamagoe,S., Yamakawa,Y., Matsuo,Y., Minowada,J., Mizuno,S. and
            Suzuki,K.
  TITLE     Purification and primary amino acid sequence of a novel neutrophil
            chemotactic factor LECT2
  JOURNAL   Immunol Lett 52 (1), 9-13 (1996)
   PUBMED   8877413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002428.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002302.2.
            
            Summary: This gene encodes a secreted, 16 kDa protein that acts as
            a chemotactic factor to neutrophils and stimulates the growth of
            chondrocytes and osteoblasts. This protein has high sequence
            similarity to the chondromodulin repeat regions of the chicken
            myb-induced myeloid 1 protein. A polymorphism in this gene may be
            associated with rheumatoid arthritis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63521.1, SRR5189664.25165.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274507.6/ ENSP00000274507.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC002428.1         64953-65148
            197-293             AC002428.1         66969-67065
            294-439             AC002428.1         68568-68713
            440-1033            AC002428.1         72439-73032
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..1033
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /note="leukocyte cell derived chemotaxin 2"
                     /db_xref="GeneID:3950"
                     /db_xref="HGNC:HGNC:6550"
                     /db_xref="MIM:602882"
     exon            1..196
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..606
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /note="chondromodulin-II"
                     /codon_start=1
                     /product="leukocyte cell-derived chemotaxin-2 precursor"
                     /protein_id="NP_002293.2"
                     /db_xref="CCDS:CCDS4190.1"
                     /db_xref="GeneID:3950"
                     /db_xref="HGNC:HGNC:6550"
                     /db_xref="MIM:602882"
                     /translation="MFSTKALLLAGLISTALAGPWANICAGKSSNEIRTCDRHGCGQY
                     SAQRSQRPHQGVDILCSAGSTVYAPFTGMIVGQEKPYQNKNAINNGVRISGRGFCVKM
                     FYIKPIKYKGPIKKGEKLGTLLPLQKVYPGIQSHVHIENCDSSDPTAYL"
     exon            197..293
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..439
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..1033
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      634..639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /note="hexamer: AATAAA"
     polyA_site      656
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /note="major polyA site"
     regulatory      1010..1015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
                     /note="hexamer: AATAAA"
     polyA_site      1033
                     /gene="LECT2"
                     /gene_synonym="chm-II; chm2"
ORIGIN      
        1 taaacttttt gtgtctcaca ctaaagaaat gagagatgca gaattctaag gctaaatagc
       61 taggaagtat tcattcaaac ttgaatattc ttcaaagaga gtgtgggggc aactctaatc
      121 agaggaagaa actaaaggaa gtaaaaccag atgttttcca ccaaagccct ccttttggct
      181 ggtctgattt ctaccgcact ggcagggcca tgggctaata tatgtgctgg caagtcttcc
      241 aatgagatcc ggacgtgtga ccgccatggc tgtggacagt actctgctca aagaagtcag
      301 aggcctcacc agggtgtgga catcttgtgc tctgctggat ctactgtgta cgcaccattc
      361 actggaatga ttgtgggcca ggagaaacct tatcaaaaca agaatgctat caataatggt
      421 gttcgaatat ctggaagagg tttttgtgtc aaaatgttct acattaagcc aattaagtat
      481 aaaggtccta ttaagaaggg agaaaaactt ggaactctat tgcccttgca gaaagtttat
      541 cctggcatac aatcgcatgt gcacattgaa aactgtgact cgagtgaccc tactgcatac
      601 ctgtaaatcg aaggccaatg gtcagatctt caaaataaaa agtcatctta aaaacctgga
      661 tgcataccct tctcttcaag aaatttgtgt tcacaaagga aaaatgcatg aagggatgga
      721 taccccattt tccatgacat gattattaca cattgcatgc ctgtatcaaa acatctcacg
      781 tacctcataa acaaatacac ctatgtaccc acaaaaattt tttaattaaa aaaaggaaat
      841 ttgagtttaa atagaaacat gataaatgca agaaagaaaa cattttgatt ttaactcatt
      901 gtcactctga tgttcatgtg aactggttgc ttcgggctct ttgatctgtc acctatggaa
      961 tctgagtggt tttatttttt agatttctca gtcccgaaga tctaagataa ataaacaaga
     1021 gaacttacgc tgg
//
