LOCUS       NM_012317               3895 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LDOC1 regulator of NFKB signaling (LDOC1), mRNA.
ACCESSION   NM_012317
VERSION     NM_012317.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3895)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3895)
  AUTHORS   Wanka,G., Schmoeckel,E., Mayr,D., Fuerst,S., Kuhn,C., Mahner,S.,
            Knabl,J., Karsten,M.M., Dannecker,C., Heidegger,H.H., Vattai,A.,
            Jeschke,U. and Jueckstock,J.
  TITLE     LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients
  JOURNAL   Int J Mol Sci 21 (23), 9287 (2020)
   PUBMED   33291445
  REMARK    GeneRIF: LDOC1 as Negative Prognostic Marker for Vulvar Cancer
            Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3895)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3895)
  AUTHORS   Zhao,S., Zhao,Y., Wang,Q., Li,Z., Ma,X., Wu,L., Li,W., Du,M., Ji,H.
            and Qin,G.
  TITLE     LDOC1 is differentially expressed in thyroid cancer and display
            tumor-suppressive function in papillary thyroid carcinoma
  JOURNAL   Cell Biol Int 44 (4), 985-997 (2020)
   PUBMED   31889386
  REMARK    GeneRIF: LDOC1 is differentially expressed in thyroid cancer and
            display tumor-suppressive function in papillary thyroid carcinoma.
REFERENCE   5  (bases 1 to 3895)
  AUTHORS   Zhao,C., Du,F., Zhao,Y., Wang,S. and Qi,L.
  TITLE     Acute myeloid leukemia cells secrete microRNA-4532-containing
            exosomes to mediate normal hematopoiesis in hematopoietic stem
            cells by activating the LDOC1-dependent STAT3 signaling pathway
  JOURNAL   Stem Cell Res Ther 10 (1), 384 (2019)
   PUBMED   31842997
  REMARK    GeneRIF: Acute myeloid leukemia cells secrete
            microRNA-4532-containing exosomes to mediate normal hematopoiesis
            in hematopoietic stem cells by activating the LDOC1-dependent STAT3
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3895)
  AUTHORS   Inoue,M., Takahashi,K., Niide,O., Shibata,M., Fukuzawa,M. and Ra,C.
  TITLE     LDOC1, a novel MZF-1-interacting protein, induces apoptosis
  JOURNAL   FEBS Lett 579 (3), 604-608 (2005)
   PUBMED   15670815
  REMARK    GeneRIF: MZF-1 was revealed to interact with LDOC1 and enhance the
            activity of LDOC1 for inducing apoptosis
REFERENCE   7  (bases 1 to 3895)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   8  (bases 1 to 3895)
  AUTHORS   Chih,D.Y., Park,D.J., Gross,M., Idos,G., Vuong,P.T., Hirama,T.,
            Chumakov,A.M., Said,J. and Koeffler,H.P.
  TITLE     Protein partners of C/EBPepsilon
  JOURNAL   Exp Hematol 32 (12), 1173-1181 (2004)
   PUBMED   15588942
REFERENCE   9  (bases 1 to 3895)
  AUTHORS   Nagasaki,K., Schem,C., von Kaisenberg,C., Biallek,M., Rosel,F.,
            Jonat,W. and Maass,N.
  TITLE     Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and
            sensitizes pancreatic cancer cells to apoptosis
  JOURNAL   Int J Cancer 105 (4), 454-458 (2003)
   PUBMED   12712434
  REMARK    GeneRIF: These observations suggest that LDOC1 is a novel regulator
            of NF-kappaB that can affect the PMA or TNF-alpha-mediated pathway
            to apoptosis through inhibition of NF-kappaB activation in BxPC3
            pancreatic cancer cells.
REFERENCE   10 (bases 1 to 3895)
  AUTHORS   Nagasaki,K., Manabe,T., Hanzawa,H., Maass,N., Tsukada,T. and
            Yamaguchi,K.
  TITLE     Identification of a novel gene, LDOC1, down-regulated in cancer
            cell lines
  JOURNAL   Cancer Lett 140 (1-2), 227-234 (1999)
   PUBMED   10403563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234778.5.
            
            On May 17, 2019 this sequence version replaced NM_012317.3.
            
            Summary: The protein encoded by this gene contains a leucine
            zipper-like motif and a proline-rich region that shares marked
            similarity with an SH3-binding domain. The protein localizes to the
            nucleus and is down-regulated in some cancer cell lines. It is
            thought to regulate the transcriptional response mediated by the
            nuclear factor kappa B (NF-kappaB). The gene has been proposed as a
            tumor suppressor gene whose protein product may have an important
            role in the development and/or progression of some cancers.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7410570.694082.1,
                                        SRR7410570.694085.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370526.5/ ENSP00000359557.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3895              AC234778.5         169622-173516       c
FEATURES             Location/Qualifiers
     source          1..3895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.1"
     gene            1..3895
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
                     /note="LDOC1 regulator of NFKB signaling"
                     /db_xref="GeneID:23641"
                     /db_xref="HGNC:HGNC:6548"
                     /db_xref="MIM:300402"
     exon            1..3895
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..549
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
                     /note="breast cancer, up-regulated 1; leucine zipper
                     protein down-regulated in cancer cells; leucine zipper
                     downregulated in cancer; leucine zipper down-regulated in
                     cancer 1; Sushi-Ichi retrotransposon homolog 7; mammalian
                     retrotransposon-derived 7; retrotransposon Gag like 7"
                     /codon_start=1
                     /product="protein LDOC1"
                     /protein_id="NP_036449.1"
                     /db_xref="CCDS:CCDS14672.1"
                     /db_xref="GeneID:23641"
                     /db_xref="HGNC:HGNC:6548"
                     /db_xref="MIM:300402"
                     /translation="MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERASLLRQV
                     RPPSCPVPFPETFNGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEE
                     WVVPYIEMDSPILGDYRAFLDEMKQCFGWDDDEDDDDEEEEDDY"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
                     /note="hexamer: AATAAA"
     polyA_site      1381
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
                     /note="major polyA site"
     regulatory      3163..3168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
                     /note="hexamer: AATAAA"
     polyA_site      3186
                     /gene="LDOC1"
                     /gene_synonym="BCUR1; Mar7; Mart7; RTL7; SIRH7"
ORIGIN      
        1 gcccctggcc accaagcgcc tccgtggaca cgcacttcct gcgagggctc cgtgcgcacc
       61 ttggccgagc cgaaccgagc cgagtcctgt ccttccaggc cgttcgcaat ggtggatgag
      121 ttggtgctgc tgctgcacgc gctcctgatg cggcaccgcg ccctgagcat cgagaacagc
      181 cagctcatgg aacagctgcg gctgctggtg tgcgagaggg ccagcctgct gcgccaggta
      241 cgtccgccga gctgcccggt gcccttcccc gaaacgttta atggcgagag ctcccggctc
      301 cccgagttta tcgtgcagac ggcgtcttac atgctcgtga acgagaaccg attctgcaac
      361 gacgccatga aggtggcatt cctaatcagc ctcctcaccg gggaagccga ggagtgggtg
      421 gtgccctaca tcgagatgga tagccccatc ctaggtgatt accgggcctt cctcgatgag
      481 atgaaacagt gctttggctg ggatgacgac gaagacgacg acgacgaaga agaggaggat
      541 gattattagg ccctcgaccc tcgggcctcg ggggggaggg ccctgcacgc cgccaccccc
      601 tccccgcagc cctcaccccg ccaggagcca ctgctctccc ccttgccctc cggtcccctt
      661 acctacccgc gcccgtctgc tctctctctt catttctccg tagtgcttgt ctttgttcca
      721 ggaatagcgc tccagttacc tgctgctggg gtcggggctg gagcctcact cactcggaag
      781 tgcttggaag tgtcatctac cctggccatc cccgggatcc ctcccctgct aatctgaact
      841 gtgtcctgaa ccccagctat tggccaggcc cctgttacaa actgcgcaga ccacccgtag
      901 ccctgctgct gccacctgcc ctgctgccag gcttacatct tcccagagaa ctatgctgcc
      961 acttcacatc cactcaccac atcccaccta cagactacca cctttcgaga tcaggaccaa
     1021 cctggaaaat gccagagttg gctatgcctt ttcagacatt gatttggaca gctcaccaac
     1081 ccctgaaggg gccgttcagc ctggttagtt ttctacctac tccgagtgtc ctcccctgcc
     1141 ccaccagatt gctgcagggg cgcggtgtgc ctggcagcca aattgttgac acttcttttt
     1201 tcctatgcac tggttttaca cagctgtcat ttttctttca aaattgcagc agtcccacag
     1261 atgtgtgcat ttggacaaat agtacttaaa aacaaaacaa acaagcactc agcccagctc
     1321 ctcaatacta cctggaaaaa gcattggcat tattttcaat aaatatcaag cactaaaaaa
     1381 agaaatgatt gtcttttaat ggttaagtgc tatcactggc ctctaccact gtcactctga
     1441 ctaccattat tcccgtggaa atcagggaat acaaccaatc ctagtattcc ccgctgtcat
     1501 ctccaggctg ctggggacag ctacctcagg gctttgtcag ggttctgatg ctcccttcac
     1561 caacgcattt cttaaagccc tggcaaaggg tgtgttctct gggtcctcca gggtggcgtg
     1621 gttaagggtt ggctgagcag acggcaaaga gagcagtatt aataattaga ccataacaat
     1681 aggcgtaaac ctggacatat atatgtaatg ctcctaattc tctgagcttt tggattcctt
     1741 aacactgtgc cagggaagtt ctgcccctta atccttattg cctatgtgca gctgttgagt
     1801 tcagactcca gagagccaac atagtagatt gtcactttca aactccaaat agccaacatg
     1861 tcactttcag gtgctccagc taacattaag tcccggatcc tgggcaagtg cacccataaa
     1921 gatatagcct gatcttaaca aacatttcgt tctccttgga cagacatcct tagaattccc
     1981 actcatagat gtgtcccaga ttcctcccta tggaaattag caagatgctt ggttatctct
     2041 taaatcagac cttgtactgc tatctagggg ctatgctgag atctctgggc ctggagggtt
     2101 cagagcagtg aagggggtgg ctgctgagaa gaagctgcat acctgtgtga ggccattgct
     2161 ccaggttaag tcattgaaat gtttaatgca gagcagcttg gttggggatt tgagaggact
     2221 gcctcttaga aaggtttagg aggatatgag gggttcagag ttctctttta tatctgtcca
     2281 gatgtcctca ttgtaccatg tctggagcca acttgacttt ataaccttta attaatttag
     2341 ataacacatt tccgtactgt ttaaggcctt ttgaggcaag atattgtatt tgtactggta
     2401 aacctcagtg ttgattaaat gagatatggg tcttcatatt aatcacctca taggtgcgga
     2461 ttaaatgaga tcatacccat gaagcattta gaactttccc tgctacatgg tgagcactca
     2521 gcaaaccatg ggctgttact cctgggccag ggaacagaag tctcagaaag caagtctctg
     2581 actctgagcc tggctttagt aggaaaatgt cagcgtgaag aggagcagag caggttcagg
     2641 gagaatggaa atgagagcat gataagaccc catttacttt ttggagtctt atatgaagca
     2701 agaaacaaag ctgttttacg tggtggacag gcaaagttca gggtaggagt tatatctcac
     2761 ccctaggata gctgtttctg gagggtgggg acagggttgc gtatgactta ataaaagagg
     2821 ctgaggcttg ggtggaaatg agatctgggg ctcttcaggg agctgccgcc tccaaatctg
     2881 aatcaaggag acagctggtt atttagaatt cattgatcac ttctcccagt ctccttggaa
     2941 aatatacaaa accccttgga agagagagat tatatttgag acataatatg tgtgaggcca
     3001 gataattaca ctttcttcct aactagaaag gccttgaatt ggggataaat gtggaaaagt
     3061 gagcaagatc taaaaggtaa aggatccagt gagaccaaaa gtcatttatt ccaaactgat
     3121 tatggcccag ttatgctgag tggagttaca gaaacatctt tgaataaaat gtgatctctg
     3181 ccttcatagc gagtccagtc tgctgctttt actgtgccct gggtcagaac tttgatgatt
     3241 agttacagga aagggccagg aagagaatct gggctgtgat tagatctggg aatgaccttt
     3301 ctggggtgga agttgaggac atatgagtag gtgttctgtg gaggaaggga ggttcagtaa
     3361 ggatgccatg ccaaggcagc atctgaatgg catctgggag aactaggcca gggagcttct
     3421 gtgatctgaa gtgtacattt cctgagtatg tgtgcatgtg cacatgagct tgctgtgacc
     3481 cagtatgtgt gtgctctgtg tgtgtgtgtg ttaagtgatg tccttcttac atcatggaca
     3541 aacaggttat gctgtgagat gcagaaaagg gattctggtt actttggggg cagattctgc
     3601 aataaaagcg cagatactgg caagggctcc accacccagg gaggaattca tgataatggc
     3661 ataaagcatg gcaaaaaaga aggaagaagt agaagtatgt ctaaggataa aagtgccact
     3721 ttgatcaaaa ctattaaaaa taggtaggaa tgctgaataa atatgaactt agaccctgaa
     3781 ttctcatttt gggcgtaata gacttgaaat ggccgctgaa attatactat caatgaaatg
     3841 aaattagtca tattaaatgt cgtaatcatt taatcgtatt aaatatacca atata
//
