LOCUS       NM_174902               3814 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens low density lipoprotein receptor class A domain
            containing 3 (LDLRAD3), transcript variant 1, mRNA.
ACCESSION   NM_174902
VERSION     NM_174902.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3814)
  AUTHORS   Zhang,B., Peng,Y. and Zhou,L.
  TITLE     Circ-LDLRAD3/miR-655-3p/MAPK1 axis enhances cell migration and
            invasion in papillary thyroid carcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (2), 150-155 (2024)
   PUBMED   38430029
  REMARK    GeneRIF: Circ-LDLRAD3/miR-655-3p/MAPK1 axis enhances cell migration
            and invasion in papillary thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3814)
  AUTHORS   Liang,Q., Chu,F., Zhang,L., Jiang,Y., Li,L. and Wu,H.
  TITLE     circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and
            Inhibits the Development of Gastric Cancer with Cisplatin
            Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition
  JOURNAL   Gut Liver 17 (3), 389-403 (2023)
   PUBMED   35975639
  REMARK    GeneRIF: circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance
            and Inhibits the Development of Gastric Cancer with Cisplatin
            Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
REFERENCE   3  (bases 1 to 3814)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 3814)
  AUTHORS   Ma,B., Huang,C., Ma,J., Xiang,Y. and Zhang,X.
  TITLE     Structure of Venezuelan equine encephalitis virus with its receptor
            LDLRAD3
  JOURNAL   Nature 598 (7882), 677-681 (2021)
   PUBMED   34646021
  REMARK    GeneRIF: Structure of Venezuelan equine encephalitis virus with its
            receptor LDLRAD3.
REFERENCE   5  (bases 1 to 3814)
  AUTHORS   Basore,K., Ma,H., Kafai,N.M., Mackin,S., Kim,A.S., Nelson,C.A.,
            Diamond,M.S. and Fremont,D.H.
  TITLE     Structure of Venezuelan equine encephalitis virus in complex with
            the LDLRAD3 receptor
  JOURNAL   Nature 598 (7882), 672-676 (2021)
   PUBMED   34646020
  REMARK    GeneRIF: Structure of Venezuelan equine encephalitis virus in
            complex with the LDLRAD3 receptor.
REFERENCE   6  (bases 1 to 3814)
  AUTHORS   Yao,J., Zhang,C., Chen,Y. and Gao,S.
  TITLE     Downregulation of circular RNA circ-LDLRAD3 suppresses pancreatic
            cancer progression through miR-137-3p/PTN axis
  JOURNAL   Life Sci 239, 116871 (2019)
   PUBMED   31521692
  REMARK    GeneRIF: Increased expression of circ-LDLRAD3 was indicative of a
            poor prognosis in patients with pancreatic cancer. Knockdown of
            circ-LDLRAD3 repressed the growth of pancreatic cancer in vitro and
            in vivo. miR-137-3p was identified as a direct target of
            circ-LDLRAD3.  Upregulation of circ-LDLRAD3 could mitigate the
            inhibitory effect of miR-137-3p on the proliferation, migration and
            invasion of pancreatic cancer tissue and cells.
REFERENCE   7  (bases 1 to 3814)
  AUTHORS   Yang,F., Liu,D.Y., Guo,J.T., Ge,N., Zhu,P., Liu,X., Wang,S.,
            Wang,G.X. and Sun,S.Y.
  TITLE     Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic
            cancer
  JOURNAL   World J Gastroenterol 23 (47), 8345-8354 (2017)
   PUBMED   29307994
  REMARK    GeneRIF: Data suggest that circular RNA circ-LDLRAD3 may be a
            biomarker in the diagnosis of pancreatic cancer.
REFERENCE   8  (bases 1 to 3814)
  AUTHORS   Noyes,N.C., Hampton,B., Migliorini,M. and Strickland,D.K.
  TITLE     Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by
            LRAD3
  JOURNAL   Biochemistry 55 (8), 1204-1213 (2016)
   PUBMED   26854353
  REMARK    GeneRIF: LRAD3 is a component of pathways that function effectively
            to modulate Itch and Nedd4 auto-ubiquitination and levels.
REFERENCE   9  (bases 1 to 3814)
  AUTHORS   Ranganathan,S., Noyes,N.C., Migliorini,M., Winkles,J.A.,
            Battey,F.D., Hyman,B.T., Smith,E., Yepes,M., Mikhailenko,I. and
            Strickland,D.K.
  TITLE     LRAD3, a novel low-density lipoprotein receptor family member that
            modulates amyloid precursor protein trafficking
  JOURNAL   J Neurosci 31 (30), 10836-10846 (2011)
   PUBMED   21795536
  REMARK    GeneRIF: LRAD3 that modulates amyloid precursor protein
            trafficking.
REFERENCE   10 (bases 1 to 3814)
  AUTHORS   Kantojarvi,K., Onkamo,P., Vanhala,R., Alen,R., Hedman,M.,
            Sajantila,A., Nieminen-von Wendt,T. and Jarvela,I.
  TITLE     Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders:
            rs1340513 in the JMJD2C gene is associated with ASDs in Finnish
            sample
  JOURNAL   Psychiatr Genet 20 (3), 102-108 (2010)
   PUBMED   20410850
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC136286.1, AK075546.1, BY997532.1, CK904050.1 and BC042754.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174902.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042754.1, SRR1660809.258899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315571.6/ ENSP00000318607.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1945              BC136286.1         82-2026
            1946-2969           AK075546.1         1946-2969
            2970-3424           BY997532.1         76-530
            3425-3664           CK904050.1         59-298
            3665-3814           BC042754.1         3649-3798
FEATURES             Location/Qualifiers
     source          1..3814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..3814
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /note="low density lipoprotein receptor class A domain
                     containing 3"
                     /db_xref="GeneID:143458"
                     /db_xref="HGNC:HGNC:27046"
                     /db_xref="MIM:617986"
     exon            1..83
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1075
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /note="low-density lipoprotein receptor class A
                     domain-containing protein 3; LDLR class A
                     domain-containing protein 3"
                     /codon_start=1
                     /product="low-density lipoprotein receptor class A
                     domain-containing protein 3 precursor"
                     /protein_id="NP_777562.1"
                     /db_xref="CCDS:CCDS31462.1"
                     /db_xref="GeneID:143458"
                     /db_xref="HGNC:HGNC:27046"
                     /db_xref="MIM:617986"
                     /translation="MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIP
                     GAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSD
                     EENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFV
                     TSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLS
                     RLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPP
                     PYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPR
                     DSEPSQGTEEV"
     exon            84..230
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..356
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /inference="alignment:Splign:2.1.0"
     exon            357..491
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..837
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..3814
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3792..3797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /note="hexamer: AATAAA"
     polyA_site      3814
                     /gene="LDLRAD3"
                     /gene_synonym="LRAD3"
                     /note="major polyA site"
ORIGIN      
        1 agcaacgacg ccgggcagcg ggagcggcgg ccgcgccatg tggctgctgg ggccgctgtg
       61 cctgctgctg agcagcgccg cggagagcca gctgctcccc gggaacaact tcaccaatga
      121 gtgcaacata ccaggcaact tcatgtgcag caatggacgg tgcatcccgg gcgcctggca
      181 gtgtgacggg ctgcctgact gcttcgacaa gagtgatgag aaggagtgcc ccaaggctaa
      241 gtcgaaatgt ggcccaacct tcttcccctg tgccagcggc atccattgca tcattggtcg
      301 cttccggtgc aatgggtttg aggactgtcc cgatggcagc gatgaagaga actgcacagc
      361 aaaccctctg ctttgctcca ccgcccgcta ccactgcaag aacggcctct gtattgacaa
      421 gagcttcatc tgcgatggac agaataactg tcaagacaac agtgatgagg aaagctgtga
      481 aagttctcaa gaacccggca gtgggcaggt gtttgtgact tcagagaacc aacttgtgta
      541 ttaccccagc atcacctatg ccatcatcgg cagctccgtc atttttgtgc tggtggtggc
      601 cctgctggca ctggtcttgc accaccagcg gaagcggaac aacctcatga cgctgcccgt
      661 gcaccggctg cagcaccctg tgctgctgtc ccgcctggtg gtcctggacc acccccacca
      721 ctgcaacgtc acctacaacg tcaataatgg catccagtat gtggccagcc aggcggagca
      781 gaatgcgtcg gaagtaggct ccccaccctc ctactccgag gccttgctgg accagaggcc
      841 tgcgtggtat gaccttcctc caccgcccta ctcttctgac acggaatctc tgaaccaagc
      901 cgacctgccc ccctaccgct cccggtccgg gagtgccaac agtgccagct cccaggcagc
      961 cagcagcctc ctgagcgtgg aagacaccag ccacagcccg gggcagcctg gcccccagga
     1021 gggcactgct gagcccaggg actctgagcc cagccagggc actgaagaag tataagtccc
     1081 agttattcca aagtccatat gggttaatct gctctgactt gttgccattc taacaatttg
     1141 tgctcatggg aagctcttta agcacctgta agggtgtctc aagttacagt ttgggatatt
     1201 aactatctct gcattcccct cctcccccag acttcagaga tgtttttctg gcgtctcagt
     1261 tgacatgatc tgttgtgcgt cttttctgtc aggtcactct tcccttggga cccgagatca
     1321 caccctcatt tttcacatta ttctgtttct gttggagaga cagcatataa aacagtattg
     1381 aaataggctg ggagagagca atgtttctgt gctatattgg atgctcagaa gtgcaggaga
     1441 cgctggaccc aattctctct gctgggtagt taccttatag catttgggga tttgggttag
     1501 atgatctaac caggaggcca tcactggatg gtcacccccc caaaaaaatt ccatttgagc
     1561 atcaaaacct gctttgcaca atcctatttg atgcccccag ttcagcagag tcagtggcca
     1621 aagaaaactt tggacgtgag taacaccctt cagcagtcgc aacgttattt tggttttgtg
     1681 aaggactctg aaaccatcta ccctgtataa attctggctt tagaaatttg cccaagaatg
     1741 ctcattctga gagctttcct cagcagcata tatcatcagc ctcatcctaa aataggcagg
     1801 gagcccctcc catgagttta tccaagttct cagctcctaa aatgcaggct gccaagaccc
     1861 tacacctgcc ctggctctac agccacttac ctggtttctg gactgtcacc ctcccagctg
     1921 acctgcccgt agccaaggaa tgaggaccta acttgagttg gcccaaagtc tgacctggct
     1981 gtatgtccct gtggcccaca cccagcctgt cttgctcatt catgcagcct caacactggc
     2041 ctccaaagtt cccttaacac ttgcaaagtc ctttttacct gtgcatttgg acttgaggac
     2101 actggtttct atcacaggtg agagccatgt tcaatacctc cagcaagctc tcctggctcc
     2161 ctgcactgtg cacgctcctc ttcccaaggt cccaatacca gcacctctag ttagagttag
     2221 ggtcagggtc aggcctctcc caacatccca gtagtttctc ctctgagaca catgggcaag
     2281 agacaatttg gagtcaagat tttccatttg gatctatttt aaatctttta gaaatgcatt
     2341 tgaaacagtg tgtttgtttt ttcccttcta gttaagggac tatttatatg tgtataggaa
     2401 agctgtctct ttttttgttt ttcctttaac aaggtccaaa gaaagatgca aaaggagatc
     2461 acacccttgc cccgctgagc cccgtgataa caagtcactc cagactaacc tgtgtgccag
     2521 acatttgtgc attgttgcac tttgaggtta ttatttatca agttcttgaa ggaagcagaa
     2581 agagggactc ctctctccct ccgtgtatag tctctatgtt tgtgctagtt tttctttttt
     2641 ttctctgtgt ccagtcagcc acagggcccg cctccctgca ggaataaggg gtaaaacgtt
     2701 aggtgttgtt tggcaagaaa ccacactgac tgatgagggg taaaatggaa ccaggtagag
     2761 ccactccggg cagctgtcac ccattcagaa cttctttccg cagctgaaga aatgttcagt
     2821 aacctgtttg acgctaatta aaacagagcc tgcaggaagt ggggctaaag tggcattcag
     2881 tgatcctgtt ctgtagactt ttctttcttt ttttaaccaa atccaaagga tgttacagaa
     2941 aagctagcca ctggtatttt gttttgttta aaaaaaaaaa gaaagaaaga aagaaagaaa
     3001 aacggaaagg aacctagctg cctgtatctt tcatttttaa aatagcactt gagttatttt
     3061 ctgagtaatc caataaagaa cttttgatga cagccagaat gtgttagaac tctggctgaa
     3121 catttcatct cctgtgagtc agaagggctt tatttctccc tttgatgggg ccccttcttc
     3181 tttctggtgc tctggaagtt gtttagagga aagaattcta attttaatta attgcgcagt
     3241 gagttaatct cactcgcttt tctgcttcca ggcatcttag gaaaaacaaa tggttttagt
     3301 agataaggga tgcctactaa tgctttttta aaacaaacag ggacattttt attatagatt
     3361 tgattttttt aatgaatgtt tttaaaaata tataaatagg acaccaaagc ggcagggttt
     3421 ttttgggggg gagggggttt gttttccaac tcaagatggc acattagtgg ccagcaatat
     3481 tttttaactc attccaacca ggaagctttt ttatacattg cctaaatcta cgccaaccag
     3541 aaaatagtct catctctttt tttctcaaat gagatccgtg ttttatttta gcattaaatt
     3601 agttacactg tgatgactgg cctattacct gactcagctc cctctacctt gaaattgaca
     3661 tttttaaaaa atgcaactaa gtggttaata gtgtgtgacg ctcaaagtta atgtaaactg
     3721 gaaaggttgt gtgtcgttgc tttttgtgtt ttggttaggc ttggttttgt tttttaattt
     3781 ttatactttc taataaattt gcagtttcat tctt
//
