LOCUS       NM_001013693            4016 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens low density lipoprotein receptor class A domain
            containing 2 (LDLRAD2), mRNA.
ACCESSION   NM_001013693 XM_377577
VERSION     NM_001013693.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Li,J., Huang,W., Han,Q., Xiong,J. and Song,Z.
  TITLE     LDLRAD2 promotes pancreatic cancer progression through Akt/mTOR
            signaling pathway
  JOURNAL   Med Oncol 38 (1), 2 (2021)
   PUBMED   33392788
  REMARK    GeneRIF: LDLRAD2 promotes pancreatic cancer progression through
            Akt/mTOR signaling pathway.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590103.12.
            
            On May 17, 2019 this sequence version replaced NM_001013693.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127275.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344642.7/ ENSP00000340988.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AL590103.12        89400-89671
            273-698             AL590103.12        91533-91958
            699-830             AL590103.12        93078-93209
            831-992             AL590103.12        98585-98746
            993-4016            AL590103.12        99337-102360
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..4016
                     /gene="LDLRAD2"
                     /note="low density lipoprotein receptor class A domain
                     containing 2"
                     /db_xref="GeneID:401944"
                     /db_xref="HGNC:HGNC:32071"
     exon            1..272
                     /gene="LDLRAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1006
                     /gene="LDLRAD2"
                     /note="low density lipoprotein receptor A domain
                     containing 2; low-density lipoprotein receptor class A
                     domain-containing protein 2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor class A
                     domain-containing protein 2 precursor"
                     /protein_id="NP_001013715.2"
                     /db_xref="CCDS:CCDS30624.1"
                     /db_xref="GeneID:401944"
                     /db_xref="HGNC:HGNC:32071"
                     /translation="MEACCLLQLPQRLLLLGAAALTATALETADLAELCGQTWQGDGL
                     LLRSHAASRRFYFVAPDTDCGLWVQAAAPGDRIRFQFRFFLVYSLTPAPPALNTSSPA
                     PADPCAPGSYLQFYEGPPGAPRPLGSPLCGLNIPVPVASSGPFLGLRLVTRGRQPRVD
                     FVGEVTSFRLGPCGAYFRCQNGRCIPSSLVCDPWGMDNCGDGSDQGSWSPADCRGPSP
                     VPSQTGSTDAHTSRSLTPSPALGSAGSLWIAAERSSPAGRDPTRQDAALEGSTE"
     exon            273..698
                     /gene="LDLRAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..830
                     /gene="LDLRAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..992
                     /gene="LDLRAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..4016
                     /gene="LDLRAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDLRAD2"
                     /note="hexamer: AAGAAA"
     polyA_site      1069
                     /gene="LDLRAD2"
                     /note="major polyA site"
     polyA_site      1075
                     /gene="LDLRAD2"
                     /note="major polyA site"
     regulatory      3977..3982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDLRAD2"
                     /note="hexamer: AATAAA"
     polyA_site      4016
                     /gene="LDLRAD2"
                     /note="major polyA site"
ORIGIN      
        1 ctgaaccaaa tgaagaggat ctggaaggca aagcactaag atcatagtga agacttgcct
       61 cccccttctc cttgtgtccc accagcctcc ctgctggcct gaccaggccc catactccag
      121 tctccccaga gaccccaagc tgaagattct gtgggtctgc cccattgctg ggcacagcag
      181 agcctggatg gaggcttgtt gtcttctgca gttgccccaa aggttgctct tgctgggggc
      241 agccgccctg actgcaactg ctttggagac agccgacctg gcggaactgt gcgggcagac
      301 gtggcagggg gacgggctgc tgctgcgctc gcacgccgca tcgcgcaggt tctacttcgt
      361 ggctccggac accgactgcg ggctctgggt gcaggcggca gcccccggcg accggatccg
      421 cttccagttc cgcttcttcc tggtctacag cctgaccccc gcgcccccgg cgctcaacac
      481 ctcctccccg gccccggccg acccgtgcgc ccccggctcc tacctgcagt tctacgaggg
      541 cccgccgggg gcgccccggc ccctggggtc cccactgtgc ggcctgaaca tcccggtgcc
      601 tgtggcatcc tccggaccct ttctaggcct gcgcctggtc acgagaggcc gccagccccg
      661 cgtggacttc gtgggcgaag tcacctcttt ccgtctggga ccttgtggtg cctacttccg
      721 ctgccagaat ggcaggtgca tcccctcaag cctcgtgtgt gacccctggg gcatggacaa
      781 ctgtggcgat ggcagtgacc agggctcctg gtcaccagct gactgcagag gtccctctcc
      841 ggtgcccagc cagacaggaa gtacagatgc ccatacctcc agatccctga ctccctcccc
      901 agctctcggg tctgcaggat ccctctggat tgcagctgag aggagttccc cagcaggcag
      961 ggaccccacg agacaagacg cagctttgga aggctccact gagtgaagcc ctcatcaaag
     1021 actcaggagg cccctggcgg ggatagcacc gtttattaag aaaaatcaag acaaagacca
     1081 caggagggtc ccttctagga cacagaggcc aggcgtccca accccacagt ctgggggcca
     1141 ctggcaggat ggcacttgag ctggatcttc aggctcctgc agatggggca gggtggtcat
     1201 atccccctcc tctctctctc agtcgtgagt cctgccttcc cccacctaag gcactagctc
     1261 ttcctgagca ccagcggcat ccgtccgtcc gttgtctgtt ggaggagtcc ctgggccttc
     1321 acttccagat gggtggggat gtggcctggg gtgggcgggg cccggtgggc ggggccctat
     1381 cagtgctggg ctctgcctgt agcagctcct ggtaagagtt ggggtgggcc ttcccttaca
     1441 gcccctgagg gagggacccc aggctgtgtg ctggcaggag ggggtgggaa tgcaggccag
     1501 gaggacgtgg taggaggggg agtctgccag aggaggtgcc aggggctggg tggaggtggg
     1561 tgggggtgct gaaaaacgag ctggtgggga tggggaccgc ctgcccaggg gtgagctgcc
     1621 ttttgctcca cagccggcac taaagacaat tcccaatcct gagtgggtgg cagagactcc
     1681 tgcgatgccc gtctcaggta gctgtggggc accagcccac aagccgaggt tggctctcct
     1741 aggagtgaga actgcccaag ggctgcagaa acaggccacc cagctctatc tgggggctcc
     1801 atcggtgggt agggggacag tgggggcagt tctgggccca cccagccact gttcctgacc
     1861 ccaagtcctg gtgactttct gaggtgccca ctcccatcca acctgccttg ctggccagcc
     1921 ttgtggcttt gcccagctgt gtgtgtgagg gtggcatgcc cacctccagt ccagcccagg
     1981 gcggtagcag caaagcgtgg catcgcctcg gtttcttaca aaaattcata ataatattaa
     2041 taataatata ctcgacattg tcgggctggg gcgtggcccg ggagtccgtg tggggcaggc
     2101 aggtgcctac gaggggcagg ggcgtgtgtt ggccccggcc tgggcgcggt gctgcaggtc
     2161 caggggctgt gggggcgggg cgccgggtcg ggccgagtgc agcaccaggt tcttgacaca
     2221 gcctgtgatg cctgaggaga atctgccccc ggtcagcgtg gccacgtcag gggctccgcc
     2281 tgccgggagg tgagaggaca gggcctgtgg gctccagcag cccaggaggc gaggaaggct
     2341 gggcgagctc tagccctaag ggagtgccgt tcctgcccct gccctgagaa ggagccccag
     2401 acttaccgat gtagacgctg cccttggcgt tgactgccac gttgggacct ggggaccggc
     2461 cgctgaccag ctcctcaccg tcgacttgga tggaacctct gcggccctcc ctgcagtgga
     2521 actgggtcag gcccctttcc acaaacttcc tggtcctccc cggccccacg acagagtccc
     2581 ctccctctga tatcgagact ccagactcag aagtctgtcc ctgtttccca agctctttct
     2641 ttcccccgct gaacgagaga tcgggcccca caaacacagc ttcctcattt ctgcacccag
     2701 gtttcctccc actcctgggg cactcgcctg cccccagcgg agttcagtcc gagatggaag
     2761 cccgagccct ggctggtggg ttctcccctc ccctggcttc aagttctgtc tccacagagc
     2821 tcaatacctg cctctctgcc catggtaggg ggcgtcctgc cccactccag aacgctgggc
     2881 cccatcccga gtgcccggca gggtccctta ccgcagtgct gtcacccggt gccactcgcc
     2941 gtcattgatg gggtcctcag agaccaggcg ggcctcccca ctacccagct ggtacctgca
     3001 gtcatccagg cccaagaagt atgagctggg gcaggaccgg ggggtggggt gctgggacca
     3061 gggaagggag aggaagggcc aggtgccagg acctacctga agacaaggtg cccgtcttga
     3121 agcccgaggc tgatgaagtc cttgccttgg ccggcctctc ccacctcctg ccagggaagc
     3181 acagggtctc tggggtcccc agcctggaga gcagaggctg ccgaggccag ggggctctgc
     3241 tttcccctcc ccccaccact ccggccacca ggaagccagc ttcctgcccc aggagcccca
     3301 agagcccagc cggataccca cactcaccac accctgccag agcaggaggc cactggctgt
     3361 gctggtccga acctccagct cgatggtctc gggcacctcg ggcaggctgc ggaggaagag
     3421 cgggtgaggg gacagaagtc ccagattccc atcctcccca ttaggcccat gggcccttcc
     3481 aatgccagtc tcacctcctg gagaagacat ggccagggaa ggcgaggaag ccatcatcgt
     3541 ggaaataggc tccgtactgc ccaggggcat ctgtgggaga gaggagggtg gtgccatacc
     3601 tgctgcatca ggcatcaaaa tcccccgtca gttcccctga cccccacctc cacgccaaca
     3661 tgcaggacta gggggctccg agcctgcagt ccctggggac ccacgggggc tgccaacaga
     3721 attcagggag cctatgacct tggatgggaa agcattacac ctcaatttca ctcacttctc
     3781 actgaaattg agcagttctt tcaatgagat gtaggcaaga aaccaaagta gcagtggtag
     3841 gacctgcaac tttgttacta gtatttgctt atcacatgac agtagctgca aatatttcaa
     3901 aatatcattt acacatattg ctgctttgaa attgtggtag ctactgagat caccagatct
     3961 tgttatttga tgtgttaata aagaagcaca tatatagcaa gtcaggaaac ttaaaa
//
