LOCUS       NM_001010978            2376 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens low density lipoprotein receptor class A domain
            containing 1 (LDLRAD1), transcript variant 1, mRNA.
ACCESSION   NM_001010978 XM_371253
VERSION     NM_001010978.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF887342.1, BC127708.1, BC103740.1 and BM977091.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001010978.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF887342.1, ERR279844.5335.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371360.2/ ENSP00000360411.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CF887342.1         1-3
            4-730               BC127708.1         1-727
            731-2371            BC103740.1         452-2092
            2372-2376           BM977091.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2376
                     /gene="LDLRAD1"
                     /note="low density lipoprotein receptor class A domain
                     containing 1"
                     /db_xref="GeneID:388633"
                     /db_xref="HGNC:HGNC:32069"
     exon            1..95
                     /gene="LDLRAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..692
                     /gene="LDLRAD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     low-density lipoprotein receptor class A domain-containing
                     protein 1"
                     /codon_start=1
                     /product="low-density lipoprotein receptor class A
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001010978.2"
                     /db_xref="CCDS:CCDS30725.1"
                     /db_xref="GeneID:388633"
                     /db_xref="HGNC:HGNC:32069"
                     /translation="MNKVFPQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSASLL
                     LLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTC
                     THGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVC
                     PPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYACPGP"
     exon            96..147
                     /gene="LDLRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..276
                     /gene="LDLRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..414
                     /gene="LDLRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..543
                     /gene="LDLRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..2376
                     /gene="LDLRAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2229..2234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDLRAD1"
                     /note="hexamer: AATAAA"
     polyA_site      2245
                     /gene="LDLRAD1"
     regulatory      2354..2359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDLRAD1"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="LDLRAD1"
                     /note="major polyA site"
ORIGIN      
        1 cttggtgaca atgcagggaa cccgtgctga gctctctgca cacagcccca gtcgggcagc
       61 aggaaaccga agacatgaac aaggtcttcc cccagggaga gaatggctac actgctgctg
      121 aatccaaagc ccaccctgga ggggaagcag gcggcggcca cctctgctgc tcacgtcgcg
      181 gggcctgcct ctctgcctct ctgctgctcc tcctggcaac tgtggcggcc ctcatcgcct
      241 tggtcaccat tcttggactc ccatcatgca ccccaggagc ccaagcttgt ataacactga
      301 caaacaggac aggcttcttg tgccatgacc agaggagctg cattccagcc agtggggtct
      361 gtgatggcgt tcgcacctgt acccacggcg aggacgagga tgagagcttg tgccgagatg
      421 tgccccagag cctcccccac ttccttgtgg cccactgtgg agacccggcc tcctggatct
      481 actcagacca aaaatgtgat ggcactaaca actgcgggga ctgttcagat gaactgagcc
      541 cagtaactgt gtgcccaccc tgcggccctg ggtggtggcg ctgtccttca accttcttca
      601 agtactgcga ctgtataccg aggcatctct gccgcgacca tgtacagcac tgctccgact
      661 ggtccgatga gtatgcctgt cccggaccct gagtgggcca ctcaggccag catggaaggc
      721 tggctggaat ggcactgata acccttcaca tgaaaatcaa atcctagcgc acaagggcag
      781 gaagcagcct ttgaaatggg atctacacat catttctgaa taggaatttt ctctcctcct
      841 ttcaagttgt tcagcctctg cttgaatgct tccaatgacc aggagctcat taccatgtta
      901 ggtggcttct aacaaagatg atgtggtgga accccgtctc taccaaaaat acaaaaatta
      961 gccaggcatg gcggtgcaca cctatagtcc cagctactag ggaggctgag gtgggaggac
     1021 tgtgtgaacc caggaggtca aggctgcagt gagctgtgac cacaccactg cactccagcc
     1081 tgagcaacac agtgagaccc tgtctcaaaa aaaaaatgaa acaaaacaca aacacaaaca
     1141 aagacgaagg gaatctgctt ccatgatttc atgcctgtct ctggggccac acagaggaaa
     1201 tctgctaact gctccaaggc atacttgtgg atcctaatct cgtcatccct tagagtgatg
     1261 acatgtctgg ggcttaaatg acaagccgag tttagccttc atggatggca catacgtgaa
     1321 acatatgcca cttcctaccc ctttggtacc taaggcagat atactgggct tggatgcaac
     1381 tttagcatct tccccagttt agttaaccca gcaggctcta ctgatttaac caagtgacac
     1441 agcacatgaa acaggatatc tggcatccta ccagtgggaa gccaccccag gaagctctga
     1501 gctgtagaat agaagatctg gagaaagagc agcttgaagg gctcctcacc agtcttctgt
     1561 ctgtccaacc tgctctccac cccagcactc cccaccctcc actctatgcc cagctgcccg
     1621 cctaaacagc ccagttttct ggaagtaggg actatatttt gatcctggag cctgaatgag
     1681 ctgcttctgt gcttatcttt ccagcttcac accacccagg caggcaagga tgaatatttc
     1741 cattagatgg atgagaaaac tgaggcccag agagggcgat gacttgtcca gaatcataga
     1801 gcaaagtcag cgctggaact ggaacccaaa tacagcctat ggcaccccag cccagaaggc
     1861 tttccagcta ccagtgtgat tataccttgg ccagggcagt ctctgcgggg tattttaaaa
     1921 gtgagcttgt caggtgcact ggctcatgcc tatgatccca gcactttggg acactgaggt
     1981 ggaagtgtcc cacttgagcc caggagttcg agaccagcct gggcaacata gggagaacct
     2041 gtctctacaa aaaataggaa aaaagtagct gggtggggtg gtgcatgctt gtagtcccag
     2101 ccactcagaa agctaagatg ggaggatcgt ttgagcctgg gagattgagg ctgcaatgag
     2161 gcatgatcat gccactgcac tccagcctgg gcaacaaacc ctgtctcaaa aaatttcttt
     2221 ttaataaaaa taaaataaaa catgagattg agggtcagca agtgtgacac ccatattctg
     2281 aaagagagac ttgggatctg cctgatggga gggctcctgt cgagggagac agacatatcc
     2341 ccactgaaaa attaataaaa ttggttttac atatca
//
