LOCUS       XM_047438831            1933 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens low density lipoprotein receptor (LDLR),
            transcript variant X2, mRNA.
ACCESSION   XM_047438831
VERSION     XM_047438831.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000019.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
     gene            1..1933
                     /gene="LDLR"
                     /gene_synonym="FH; FHC; FHCL1; LDLCQ2"
                     /note="low density lipoprotein receptor; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 65 ESTs, 345 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     79 samples with support for all annotated introns"
                     /db_xref="GeneID:3949"
                     /db_xref="HGNC:HGNC:6547"
                     /db_xref="MIM:606945"
     CDS             87..1877
                     /gene="LDLR"
                     /gene_synonym="FH; FHC; FHCL1; LDLCQ2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor isoform X2"
                     /protein_id="XP_047294787.1"
                     /db_xref="GeneID:3949"
                     /db_xref="HGNC:HGNC:6547"
                     /db_xref="MIM:606945"
                     /translation="MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKW
                     VCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQ
                     GCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTC
                     IPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDG
                     GPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLC
                     EGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKI
                     GYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKAC
                     KAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRM
                     ICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR
                     KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGI
                     TLGQSILDRYHQRSHFQCQPPHRFRCQLVG"
ORIGIN      
        1 gtgcaatcgc gggaagccag ggtttccagc taggacacag caggtcgtga tccgggtcgg
       61 gacactgcct ggcagaggct gcgagcatgg ggccctgggg ctggaaattg cgctggaccg
      121 tcgccttgct cctcgccgcg gcggggactg cagtgggcga cagatgcgaa agaaacgagt
      181 tccagtgcca agacgggaaa tgcatctcct acaagtgggt ctgcgatggc agcgctgagt
      241 gccaggatgg ctctgatgag tcccaggaga cgtgcttgtc tgtcacctgc aaatccgggg
      301 acttcagctg tgggggccgt gtcaaccgct gcattcctca gttctggagg tgcgatggcc
      361 aagtggactg cgacaacggc tcagacgagc aaggctgtcc ccccaagacg tgctcccagg
      421 acgagtttcg ctgccacgat gggaagtgca tctctcggca gttcgtctgt gactcagacc
      481 gggactgctt ggacggctca gacgaggcct cctgcccggt gctcacctgt ggtcccgcca
      541 gcttccagtg caacagctcc acctgcatcc cccagctgtg ggcctgcgac aacgaccccg
      601 actgcgaaga tggctcggat gagtggccgc agcgctgtag gggtctttac gtgttccaag
      661 gggacagtag cccctgctcg gccttcgagt tccactgcct aagtggcgag tgcatccact
      721 ccagctggcg ctgtgatggt ggccccgact gcaaggacaa atctgacgag gaaaactgcg
      781 ctgtggccac ctgtcgccct gacgaattcc agtgctctga tggaaactgc atccatggca
      841 gccggcagtg tgaccgggaa tatgactgca aggacatgag cgatgaagtt ggctgcgtta
      901 atgtgacact ctgcgaggga cccaacaagt tcaagtgtca cagcggcgaa tgcatcaccc
      961 tggacaaagt ctgcaacatg gctagagact gccgggactg gtcagatgaa cccatcaaag
     1021 agtgcgggac caacgaatgc ttggacaaca acggcggctg ttcccacgtc tgcaatgacc
     1081 ttaagatcgg ctacgagtgc ctgtgccccg acggcttcca gctggtggcc cagcgaagat
     1141 gcgaagatat cgatgagtgt caggatcccg acacctgcag ccagctctgc gtgaacctgg
     1201 agggtggcta caagtgccag tgtgaggaag gcttccagct ggacccccac acgaaggcct
     1261 gcaaggctgt gggctccatc gcctacctct tcttcaccaa ccggcacgag gtcaggaaga
     1321 tgacgctgga ccggagcgag tacaccagcc tcatccccaa cctgaggaac gtggtcgctc
     1381 tggacacgga ggtggccagc aatagaatct actggtctga cctgtcccag agaatgatct
     1441 gcagcaccca gcttgacaga gcccacggcg tctcttccta tgacaccgtc atcagcagag
     1501 acatccaggc ccccgacggg ctggctgtgg actggatcca cagcaacatc tactggaccg
     1561 actctgtcct gggcactgtc tctgttgcgg ataccaaggg cgtgaagagg aaaacgttat
     1621 tcagggagaa cggctccaag ccaagggcca tcgtggtgga tcctgttcat ggcttcatgt
     1681 actggactga ctggggaact cccgccaaga tcaagaaagg gggcctgaat ggtgtggaca
     1741 tctactcgct ggtgactgaa aacattcagt ggcccaatgg catcacccta ggacaaagta
     1801 ttttggacag atatcatcaa cgaagccatt ttcagtgcca accgcctcac aggttccgat
     1861 gtcaacttgt tggctgaaaa cctactgtcc ccagaggata tggttctctt ccacaacctc
     1921 acccagccaa gag
//
