LOCUS       NM_017448               2035 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens lactate dehydrogenase C (LDHC), transcript variant 2,
            mRNA.
ACCESSION   NM_017448
VERSION     NM_017448.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Naik,A. and Decock,J.
  TITLE     Targeting of lactate dehydrogenase C dysregulates the cell cycle
            and sensitizes breast cancer cells to DNA damage response targeted
            therapy
  JOURNAL   Mol Oncol 16 (4), 885-903 (2022)
   PUBMED   34050611
  REMARK    GeneRIF: Targeting of lactate dehydrogenase C dysregulates the cell
            cycle and sensitizes breast cancer cells to DNA damage response
            targeted therapy.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Xiao,Z., Gong,R., Chen,X., Xiao,D., Luo,S. and Ji,Y.
  TITLE     Association between serum lactate dehydrogenase and 60-day
            mortality in Chinese Hakka patients with acute myeloid leukemia: A
            cohort study
  JOURNAL   J Clin Lab Anal 35 (12), e24049 (2021)
   PUBMED   34708888
  REMARK    GeneRIF: Association between serum lactate dehydrogenase and 60-day
            mortality in Chinese Hakka patients with acute myeloid leukemia: A
            cohort study.
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Chornyi,S., IJlst,L., van Roermund,C.W.T., Wanders,R.J.A. and
            Waterham,H.R.
  TITLE     Peroxisomal Metabolite and Cofactor Transport in Humans
  JOURNAL   Front Cell Dev Biol 8, 613892 (2021)
   PUBMED   33505966
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   LeVan,K.M. and Goldberg,E.
  TITLE     Properties of human testis-specific lactate dehydrogenase expressed
            from Escherichia coli
  JOURNAL   Biochem J 273 (Pt 3) (Pt 3), 587-592 (1991)
   PUBMED   1996957
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Edwards,Y., West,L., Van Heyningen,V., Cowell,J. and Goldberg,E.
  TITLE     Regional localization of the sperm-specific lactate dehydrogenase,
            LDHC, gene on human chromosome 11
  JOURNAL   Ann Hum Genet 53 (3), 215-219 (1989)
   PUBMED   2596827
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Takano,T. and Li,S.S.
  TITLE     Human testicular lactate dehydrogenase-C gene is interrupted by six
            introns at positions homologous to those of LDH-A (muscle) and
            LDH-B (heart) genes
  JOURNAL   Biochem Biophys Res Commun 159 (2), 579-583 (1989)
   PUBMED   2930531
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Millan,J.L., Driscoll,C.E., LeVan,K.M. and Goldberg,E.
  TITLE     Epitopes of human testis-specific lactate dehydrogenase deduced
            from a cDNA sequence
  JOURNAL   Proc Natl Acad Sci U S A 84 (15), 5311-5315 (1987)
   PUBMED   2440048
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Edwards,Y.H., Povey,S., LeVan,K.M., Driscoll,C.E., Millan,J.L. and
            Goldberg,E.
  TITLE     Locus determining the human sperm-specific lactate dehydrogenase,
            LDHC, is syntenic with LDHA
  JOURNAL   Dev Genet 8 (4), 219-232 (1987)
   PUBMED   2844458
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084117.6 and AC027544.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_017448.4.
            
            Summary:  Lactate dehydrogenase C catalyzes the conversion of
            L-lactate and NAD to pyruvate and NADH in the final step of
            anaerobic glycolysis.  LDHC is testis-specific and belongs to the
            lactate dehydrogenase family.  Two transcript variants have been
            detected which differ in the 5' untranslated region. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1214756.1, AY286300.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000541669.6/ ENSP00000437783.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC084117.6         120692-120782
            92-226              AC084117.6         121083-121217
            227-344             AC084117.6         123558-123675
            345-518             AC027544.11        185977-186150       c
            519-692             AC027544.11        180974-181147       c
            693-810             AC027544.11        177242-177359       c
            811-934             AC027544.11        169554-169677       c
            935-2035            AC027544.11        163824-164924       c
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..2035
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /note="lactate dehydrogenase C"
                     /db_xref="GeneID:3948"
                     /db_xref="HGNC:HGNC:6544"
                     /db_xref="MIM:150150"
     exon            1..91
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     exon            92..226
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1099
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /EC_number="1.1.1.27"
                     /note="cancer/testis antigen 32; lactate dehydrogenase C4;
                     LDH-C; LDH-X; LDH testis subunit; testis secretory
                     sperm-binding protein Li 234P"
                     /codon_start=1
                     /product="L-lactate dehydrogenase C chain"
                     /protein_id="NP_059144.1"
                     /db_xref="CCDS:CCDS7840.1"
                     /db_xref="GeneID:3948"
                     /db_xref="HGNC:HGNC:6544"
                     /db_xref="MIM:150150"
                     /translation="MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDL
                     ADELALVDVALDKLKGEMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQE
                     GETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIG
                     SGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKL
                     GTDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTM
                     VKGLYGIKEELFLSIPCVLGRNGVSDVVKINLNSEEEALFKKSAETLWNIQKDLIF"
     exon            227..344
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     exon            345..518
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     exon            519..692
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     exon            693..810
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     exon            811..934
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     exon            935..2035
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1193..1198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /note="hexamer: AATAAA"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /note="hexamer: AACAAA"
     polyA_site      1218
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /note="major polyA site"
     polyA_site      1223
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
                     /note="hexamer: ATTATA"
     polyA_site      2035
                     /gene="LDHC"
                     /gene_synonym="CT32; LDH3; LDHX"
ORIGIN      
        1 gagtcgcacg gagggcaacc gtcgacgggc ttagcgcctc aactgtcgtt ggtgtatttt
       61 tctggtgtca cttctgtgcc ttccttcaaa ggttctccaa atgtcaactg tcaaggagca
      121 gctaattgag aagctaattg aggatgatga aaactcccag tgtaaaatta ctattgttgg
      181 aactggtgcc gtaggcatgg cttgtgctat tagtatctta ctgaaggatt tggctgatga
      241 acttgccctt gttgatgttg cattggacaa actgaaggga gaaatgatgg atcttcagca
      301 tggcagtctt ttctttagta cttcaaagat tacttctgga aaagattaca gtgtatctgc
      361 aaactccaga atagttattg tcacagcagg tgcaaggcag caggagggag aaactcgcct
      421 tgccctggtc caacgtaatg tggctataat gaaatcaatc attcctgcca tagtccatta
      481 tagtcctgat tgtaaaattc ttgttgtttc aaatccagtg gatattttga catatatagt
      541 ctggaagata agtggcttac ctgtaactcg tgtaattgga agtggttgta atctagactc
      601 tgcccgtttc cgttacctaa ttggagaaaa gttgggtgtc caccccacaa gctgccatgg
      661 ttggattatt ggagaacatg gtgattctag tgtgccctta tggagtgggg tgaatgttgc
      721 tggtgttgct ctgaagactc tggaccctaa attaggaacg gattcagata aggaacactg
      781 gaaaaatatc cataaacaag ttattcaaag tgcctatgaa attatcaagc tgaaggggta
      841 tacctcttgg gctattggac tgtctgtgat ggatttggta ggatccattt tgaaaaatct
      901 taggagagtg cacccagttt ccaccatggt taagggatta tatggaataa aagaagaact
      961 ctttctcagt atcccttgtg tcttggggcg gaatggtgtc tcagatgttg tgaaaattaa
     1021 cttgaattct gaggaggagg cccttttcaa gaagagtgca gaaacacttt ggaatattca
     1081 aaaggatcta atattttaaa ttaaagcctt ctaatgttcc actgtttgga gaacagaaga
     1141 tagcaggctg tgtattttaa attttgaaag tattttcatt tgatctttaa aaaataaaaa
     1201 caaattggag acctgtgaca taactctagt ctctcaagat tagaacgagc aaatggtaaa
     1261 gagattttcc tctttaagaa tcatttatag ctctattcta atgataccca atctgtacag
     1321 gtgtaagtta tacttctgag gtatgtcaca tatgttagag tgccttcaga tgtagtagaa
     1381 tatgtataat cactataata cagagctttg attcttttca caaaccaagc cctttttcta
     1441 gtattacaat tttatcttgt actttcatcc gttagagtac cagcatattc acttcattac
     1501 attagcgtca tatgtttatg tataatcatt ataaatgtgg ccgggcactg cagcctgggt
     1561 gaaagagtga ggctctgtct caaaaaaaat cattataaat gcttattttt aagaccatat
     1621 atatcaaaaa gaaataaaaa gctgagtgct gtggctcatg gctgtaatcc cagtgctttg
     1681 ggagggtgag gcaagaggat cacatgagtc caggagtttg agaccagcct tggcaacata
     1741 gcaacacccc atctctacaa aaataaagaa attagatgtg gtggcctgca tctgtagtcc
     1801 agctacttgg gagactgaga ccagtagata acttgagccc aggagttcaa ggctatgatt
     1861 gtgtcactgc actccagcct gggccacaga ggaagactca gactcaaaag aagaagaaga
     1921 acacagaaga aaagcagaaa caagaagaag atacagatgt aactttacga tgtaaaaaat
     1981 ctaaataaga ttgtattcaa ctctgcaagt attatactag tcatataaac tcaaa
//
