LOCUS       NM_033195               1746 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens lactate dehydrogenase A like 6B (LDHAL6B), mRNA.
ACCESSION   NM_033195
VERSION     NM_033195.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Chen,X., Gu,X., Shan,Y., Tang,W., Yuan,J., Zhong,Z., Wang,Y.,
            Huang,W., Wan,B. and Yu,L.
  TITLE     Identification of a novel human lactate dehydrogenase gene LDHAL6A,
            which activates transcriptional activities of AP1(PMA)
  JOURNAL   Mol Biol Rep 36 (4), 669-676 (2009)
   PUBMED   18351441
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Wang,H., Zhou,Z., Lu,L., Xu,Z. and Sha,J.
  TITLE     Cloning and characterization of a novel intronless lactate
            dehydrogenase gene in human testis
  JOURNAL   Int J Mol Med 15 (6), 949-953 (2005)
   PUBMED   15870898
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Pioli,P.A., Hamilton,B.J., Connolly,J.E., Brewer,G. and Rigby,W.F.
  TITLE     Lactate dehydrogenase is an AU-rich element-binding protein that
            directly interacts with AUF1
  JOURNAL   J Biol Chem 277 (38), 35738-35745 (2002)
   PUBMED   12107167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY642121.1 and DB511998.1.
            
            On May 17, 2019 this sequence version replaced NM_033195.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY009108.1, AY642121.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307144.6/ ENSP00000302393.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1673              AY642121.1         21-1693
            1674-1746           DB511998.1         362-434
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..1746
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
                     /note="lactate dehydrogenase A like 6B"
                     /db_xref="GeneID:92483"
                     /db_xref="HGNC:HGNC:21481"
     exon            1..1746
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1244
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
                     /EC_number="1.1.1.27"
                     /note="lactate dehydrogenase A-like 6; testicular tissue
                     protein Li 105"
                     /codon_start=1
                     /product="L-lactate dehydrogenase A-like 6B"
                     /protein_id="NP_149972.1"
                     /db_xref="CCDS:CCDS10171.1"
                     /db_xref="GeneID:92483"
                     /db_xref="HGNC:HGNC:21481"
                     /translation="MSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLF
                     TPVSKMATVKSELIERFTSEKPVHHSKVSIIGTGSVGMACAISILLKGLSDELALVDL
                     DEDKLKGETMDLQHGSPFTKMPNIVCSKDYFVTANSNLVIITAGARQEKGETRLNLVQ
                     RNVAIFKLMISSIVQYSPHCKLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTAR
                     FRFLIGQKLGIHSESCHGWILGEHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQW
                     KNVHKEVTATAYEIIKMKGYTSWAIGLSVADLTESILKNLRRIHPVSTIIKGLYGIDE
                     EVFLSIPCILGENGITNLIKIKLTPEEEAHLKKSAKTLWEIQNKLKL"
     regulatory      1652..1657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
                     /note="hexamer: AATAAA"
     polyA_site      1673
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
                     /note="major polyA site"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
                     /note="hexamer: AATAAA"
     polyA_site      1746
                     /gene="LDHAL6B"
                     /gene_synonym="LDH6B; LDHAL6; LDHL"
ORIGIN      
        1 agagtgctga aggtcctgcc aacggctctc ttggcgtctc aacgttcgga tcagcagctt
       61 ttttccattc tctctctcca cttcttcagt gagcagccat gagttggact gtgcctgttg
      121 tgcgggccag ccagagagtg agctcggtgg gagcgaattt cctatgcctg gggatggccc
      181 tgtgtccgcg tcaagcaacg cgcatcccgc tcaacggcac ctggctcttc acccccgtga
      241 gcaagatggc gactgtgaag agtgagctta ttgagcgttt cacttccgag aagcccgttc
      301 atcacagtaa ggtctccatc ataggaactg gatcggtggg catggcctgc gctatcagca
      361 tcttattaaa aggcttgagt gatgaacttg cccttgtgga tcttgatgaa gacaaactga
      421 agggtgagac gatggatctt caacatggca gccctttcac gaaaatgcca aatattgttt
      481 gtagcaaaga ttactttgtc acagcaaact ccaacctagt gattatcaca gcaggtgcac
      541 gccaagaaaa gggagaaacg cgccttaatt tagtccagcg aaatgtggcc atcttcaagt
      601 taatgatttc cagtattgtc cagtacagcc cccactgcaa actgattatt gtttccaatc
      661 cagtggatat cttaacttat gtagcttgga agttgagtgc atttcccaaa aaccgtatta
      721 ttggaagcgg ctgtaatctg gatactgctc gttttcgttt cttgattgga caaaagcttg
      781 gtatccattc tgaaagctgc catggatgga tcctcggaga gcatggagac tcaagtgttc
      841 ctgtgtggag tggagtgaac atagctggtg tccctttgaa ggatctgaac tctgatatag
      901 gaactgataa agatcctgag caatggaaaa atgtccacaa agaagtgact gcaactgcct
      961 atgagattat taaaatgaaa ggttatactt cttgggccat tggcctatct gtggccgatt
     1021 taacagaaag tattttgaag aatcttagga gaatacatcc agtttccacc ataattaagg
     1081 gcctctatgg aatagatgaa gaagtattcc tcagtattcc ttgtatcctg ggagagaacg
     1141 gtattaccaa ccttataaag ataaagctga cccctgaaga agaggcccat ctgaaaaaaa
     1201 gtgcaaaaac actctgggaa attcagaata agcttaagct ttaaagttgc ctaaaactac
     1261 cattccgaaa ttattgaaga gatcatagat acaggattat ataacgaaat tttgaataaa
     1321 cttgaattcc taaaagatgg aaacaggaaa gtaggtagag tgattttcct atttatttag
     1381 tcctccagct cttttattga gcatccacgt gctggacgat acttatttac aattcctaag
     1441 tatttttggt acctctgatg tagcagcact tgccatgtta tatatatgta gttggcattt
     1501 ggttcccaaa aagtaggatg taggtattta ttgtgttcta gaaattccga ctcttttcat
     1561 tagatatatg ctatttcttt cattcttgct ggtttatacc tatgttcatt tatatgctgt
     1621 aaaaaagtag tagcttcttc tacaatgtaa aaataaatgt acatacaaaa aaatgcagta
     1681 gtatatacaa tcttttgttt tgcttccttt gatagttaat aaattccgtt tgttgaatca
     1741 ataaaa
//
